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Found 75 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M5' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CHRM5


(RAT)
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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0.860n/an/an/an/an/an/an/an/a



DVanderbilt Program in Drug Discovery

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting


Nat Chem Biol 4: 42-50 (2007)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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1.80n/an/an/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from rat muscarinic M5 receptor expressed in CHO cells


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50231845
PNG
(CHEMBL255523 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCC2CCCC2)cc1Cl
Show InChI InChI=1S/C20H30ClN3O/c1-2-23-11-13-24(14-12-23)19-9-8-17(15-18(19)21)22-20(25)10-7-16-5-3-4-6-16/h8-9,15-16H,2-7,10-14H2,1H3,(H,22,25)
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85.7n/an/an/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from rat muscarinic M5 receptor expressed in CHO cells


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50094703
PNG
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1156-64 (2000)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50426242
PNG
(CHEMBL2312346)
Show SMILES COc1ccc(CCOC(=O)C2=C(CCN(C)C2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H27NO4/c1-24-13-11-19(18-7-5-4-6-8-18)20(16-24)23(25)28-14-12-17-9-10-21(26-2)22(15-17)27-3/h4-10,15H,11-14,16H2,1-3H3
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n/an/a 0.450n/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Orthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 100 uM oxotremorine-evoked [3H]DA release


J Med Chem 56: 1693-703 (2013)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028290
PNG
((+)-cis-2-Methyl-7-phenyl-1,3,4,6,7,11b-hexahydro-...)
Show SMILES CN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H22N2/c1-20-11-12-21-13-18(15-7-3-2-4-8-15)16-9-5-6-10-17(16)19(21)14-20/h2-10,18-19H,11-14H2,1H3
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50042441
PNG
(CHEMBL3353290)
Show SMILES COc1ccc(cc1C)[C@]12N(CCN1C(=O)c1ccccc21)C(=O)c1cc(F)c(F)c(F)c1
Show InChI InChI=1/C25H19F3N2O3/c1-14-11-16(7-8-21(14)33-2)25-18-6-4-3-5-17(18)24(32)30(25)10-9-29(25)23(31)15-12-19(26)22(28)20(27)13-15/h3-8,11-13H,9-10H2,1-2H3/t25-/s2
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n/an/a 516n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Bioorg Med Chem Lett 25: 690-4 (2015)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445222
PNG
(CHEMBL3105228)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3[C@@]12c1ccc(Cl)cc1
Show InChI InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2/t23-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


J Med Chem 56: 9351-5 (2013)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028294
PNG
(CHEMBL6445 | cis-7-Phenyl-1,3,4,6,7,11b-hexahydro-...)
Show SMILES C1CN2CC(c3ccccc3)c3ccccc3C2CN1
Show InChI InChI=1S/C18H20N2/c1-2-6-14(7-3-1)17-13-20-11-10-19-12-18(20)16-9-5-4-8-15(16)17/h1-9,17-19H,10-13H2
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n/an/a 860n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028293
PNG
(CHEMBL6459 | cis-7-(4-Chloro-phenyl)-2-methyl-1,3,...)
Show SMILES CN1CCN2CC(c3ccc(Cl)cc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H21ClN2/c1-21-10-11-22-12-18(14-6-8-15(20)9-7-14)16-4-2-3-5-17(16)19(22)13-21/h2-9,18-19H,10-13H2,1H3
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n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50042442
PNG
(CHEMBL3353277)
Show SMILES COc1ccc(cc1C)C12N(CCN1C(=O)c1ccccc21)C(=O)c1cc(F)c(F)c(F)c1
Show InChI InChI=1/C25H19F3N2O3/c1-14-11-16(7-8-21(14)33-2)25-18-6-4-3-5-17(18)24(32)30(25)10-9-29(25)23(31)15-12-19(26)22(28)20(27)13-15/h3-8,11-13H,9-10H2,1-2H3
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n/an/a 963n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Bioorg Med Chem Lett 25: 690-4 (2015)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50231845
PNG
(CHEMBL255523 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCC2CCCC2)cc1Cl
Show InChI InChI=1S/C20H30ClN3O/c1-2-23-11-13-24(14-12-23)19-9-8-17(15-18(19)21)22-20(25)10-7-16-5-3-4-6-16/h8-9,15-16H,2-7,10-14H2,1H3,(H,22,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445224
PNG
(CHEMBL3105213)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3C12c1ccc(Cl)cc1
Show InChI InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


J Med Chem 56: 9351-5 (2013)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028301
PNG
(CHEMBL6528 | cis-Dimethyl-(2-methyl-4-phenyl-1,2,3...)
Show SMILES CN(C)CC1N(C)CC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-19-17-12-8-7-11-16(17)18(13-21(19)3)15-9-5-4-6-10-15/h4-12,18-19H,13-14H2,1-3H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028292
PNG
(CHEMBL6747 | cis-2-Ethyl-7-phenyl-1,3,4,6,7,11b-he...)
Show SMILES CCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C20H24N2/c1-2-21-12-13-22-14-19(16-8-4-3-5-9-16)17-10-6-7-11-18(17)20(22)15-21/h3-11,19-20H,2,12-15H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028295
PNG
(CHEMBL540195 | cis-4-(2-Methyl-1,3,4,6,7,11b-hexah...)
Show SMILES CN1CCN2CC(c3ccc(O)cc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-12-18(14-6-8-15(22)9-7-14)16-4-2-3-5-17(16)19(21)13-20/h2-9,18-19,22H,10-13H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445223
PNG
(CHEMBL3105208)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3C12c1ccccc1
Show InChI InChI=1S/C23H16F2N2O2/c24-19-11-10-15(14-20(19)25)21(28)26-12-13-27-22(29)17-8-4-5-9-18(17)23(26,27)16-6-2-1-3-7-16/h1-11,14H,12-13H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


J Med Chem 56: 9351-5 (2013)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028291
PNG
(CHEMBL6649 | cis-Methyl-(4-phenyl-1,2,3,4-tetrahyd...)
Show SMILES CNCC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C17H20N2/c1-18-12-17-15-10-6-5-9-14(15)16(11-19-17)13-7-3-2-4-8-13/h2-10,16-19H,11-12H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028304
PNG
(CHEMBL266801 | cis-2-Methyl-7-(4-nitro-phenyl)-1,3...)
Show SMILES CN1CCN2CC(c3ccc(cc3)[N+]([O-])=O)c3ccccc3C2C1
Show InChI InChI=1S/C19H21N3O2/c1-20-10-11-21-12-18(14-6-8-15(9-7-14)22(23)24)16-4-2-3-5-17(16)19(21)13-20/h2-9,18-19H,10-13H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50263887
PNG
(1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-b...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Bioorg Med Chem Lett 23: 223-7 (2012)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028306
PNG
(CHEMBL414182 | cis-Dimethyl-(4-phenyl-1,2,3,4-tetr...)
Show SMILES CN(C)CC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C18H22N2/c1-20(2)13-18-16-11-7-6-10-15(16)17(12-19-18)14-8-4-3-5-9-14/h3-11,17-19H,12-13H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028297
PNG
(CHEMBL6455 | cis-4-(2-Methyl-1,3,4,6,7,11b-hexahyd...)
Show SMILES CN1CCN2CC(c3ccc(N)cc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H23N3/c1-21-10-11-22-12-18(14-6-8-15(20)9-7-14)16-4-2-3-5-17(16)19(22)13-21/h2-9,18-19H,10-13,20H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028300
PNG
(CHEMBL6446 | cis-7-(4-Methoxy-phenyl)-2-methyl-1,3...)
Show SMILES COc1ccc(cc1)C1CN2CCN(C)CC2c2ccccc12
Show InChI InChI=1S/C20H24N2O/c1-21-11-12-22-13-19(15-7-9-16(23-2)10-8-15)17-5-3-4-6-18(17)20(22)14-21/h3-10,19-20H,11-14H2,1-2H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445225
PNG
(CHEMBL1459098)
Show SMILES Fc1ccc(cc1)C(=O)N1CCN2C(=O)c3ccccc3C12c1ccccc1
Show InChI InChI=1S/C23H17FN2O2/c24-18-12-10-16(11-13-18)21(27)25-14-15-26-22(28)19-8-4-5-9-20(19)23(25,26)17-6-2-1-3-7-17/h1-13H,14-15H2
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n/an/a 5.67E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


J Med Chem 56: 9351-5 (2013)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028291
PNG
(CHEMBL6649 | cis-Methyl-(4-phenyl-1,2,3,4-tetrahyd...)
Show SMILES CNCC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C17H20N2/c1-18-12-17-15-10-6-5-9-14(15)16(11-19-17)13-7-3-2-4-8-13/h2-10,16-19H,11-12H2,1H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028305
PNG
(CHEMBL404992 | cis-7-Phenyl-2-propyl-1,3,4,6,7,11b...)
Show SMILES CCCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C21H26N2/c1-2-12-22-13-14-23-15-20(17-8-4-3-5-9-17)18-10-6-7-11-19(18)21(23)16-22/h3-11,20-21H,2,12-16H2,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028303
PNG
(CHEMBL6603 | cis-Ethyl-(4-phenyl-1,2,3,4-tetrahydr...)
Show SMILES CCNCC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C18H22N2/c1-2-19-13-18-16-11-7-6-10-15(16)17(12-20-18)14-8-4-3-5-9-14/h3-11,17-20H,2,12-13H2,1H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028290
PNG
((+)-cis-2-Methyl-7-phenyl-1,3,4,6,7,11b-hexahydro-...)
Show SMILES CN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H22N2/c1-20-11-12-21-13-18(15-7-3-2-4-8-15)16-9-5-6-10-17(16)19(21)14-20/h2-10,18-19H,11-14H2,1H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373834
PNG
(CHEMBL255169)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCc2ccccc2)cc1Cl
Show InChI InChI=1S/C21H26ClN3O/c1-2-24-12-14-25(15-13-24)20-10-9-18(16-19(20)22)23-21(26)11-8-17-6-4-3-5-7-17/h3-7,9-10,16H,2,8,11-15H2,1H3,(H,23,26)
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n/an/a 7.60E+3n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424122
PNG
(CHEMBL2315676)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CC2CC(CC2C1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C27H34N4O/c1-19-6-2-3-7-20(19)16-29-12-10-23(11-13-29)30-17-21-14-24(15-22(21)18-30)31-26-9-5-4-8-25(26)28-27(31)32/h2-9,21-24H,10-18H2,1H3,(H,28,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Bioorg Med Chem Lett 23: 223-7 (2012)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424117
PNG
(CHEMBL2315680)
Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C20H27F3N4O3/c1-2-30-19(29)26-10-7-16(8-11-26)27-9-3-4-15(13-27)25-18(28)14-5-6-17(24-12-14)20(21,22)23/h5-6,12,15-16H,2-4,7-11,13H2,1H3,(H,25,28)/t15-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Bioorg Med Chem Lett 23: 223-7 (2012)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424114
PNG
(CHEMBL2315675)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(C(F)C1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-6-2-3-7-19(18)16-28-13-10-20(11-14-28)29-15-12-23(21(26)17-29)30-24-9-5-4-8-22(24)27-25(30)31/h2-9,20-21,23H,10-17H2,1H3,(H,27,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Bioorg Med Chem Lett 23: 223-7 (2012)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424114
PNG
(CHEMBL2315675)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(C(F)C1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-6-2-3-7-19(18)16-28-13-10-20(11-14-28)29-15-12-23(21(26)17-29)30-24-9-5-4-8-22(24)27-25(30)31/h2-9,20-21,23H,10-17H2,1H3,(H,27,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Bioorg Med Chem Lett 23: 223-7 (2012)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373836
PNG
(CHEMBL271704)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc1Cl
Show InChI InChI=1S/C22H26ClN3O/c1-2-25-10-12-26(13-11-25)21-9-8-17(14-20(21)23)24-22(27)19-15-18(19)16-6-4-3-5-7-16/h3-9,14,18-19H,2,10-13,15H2,1H3,(H,24,27)/t18-,19+/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028299
PNG
(CHEMBL6482 | cis-2-Butyl-7-phenyl-1,3,4,6,7,11b-he...)
Show SMILES CCCCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C22H28N2/c1-2-3-13-23-14-15-24-16-21(18-9-5-4-6-10-18)19-11-7-8-12-20(19)22(24)17-23/h4-12,21-22H,2-3,13-17H2,1H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028296
PNG
(CHEMBL6638 | cis-2-Hexyl-7-phenyl-1,3,4,6,7,11b-he...)
Show SMILES CCCCCCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C24H32N2/c1-2-3-4-10-15-25-16-17-26-18-23(20-11-6-5-7-12-20)21-13-8-9-14-22(21)24(26)19-25/h5-9,11-14,23-24H,2-4,10,15-19H2,1H3
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028307
PNG
(CHEMBL6575 | cis-2-Methyl-10-nitro-7-(4-nitro-phen...)
Show SMILES CN1CCN2CC(c3ccc(cc3)[N+]([O-])=O)c3ccc(cc3C2C1)[N+]([O-])=O
Show InChI InChI=1S/C19H20N4O4/c1-20-8-9-21-11-18(13-2-4-14(5-3-13)22(24)25)16-7-6-15(23(26)27)10-17(16)19(21)12-20/h2-7,10,18-19H,8-9,11-12H2,1H3
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n/an/a 4.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028298
PNG
(CHEMBL6574 | cis-2-Benzyl-7-phenyl-1,3,4,6,7,11b-h...)
Show SMILES C(N1CCN2CC(c3ccccc3)c3ccccc3C2C1)c1ccccc1
Show InChI InChI=1S/C25H26N2/c1-3-9-20(10-4-1)17-26-15-16-27-18-24(21-11-5-2-6-12-21)22-13-7-8-14-23(22)25(27)19-26/h1-14,24-25H,15-19H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028302
PNG
(CHEMBL266039 | cis-2-Phenethyl-7-phenyl-1,3,4,6,7,...)
Show SMILES C(Cc1ccccc1)N1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C26H28N2/c1-3-9-21(10-4-1)15-16-27-17-18-28-19-25(22-11-5-2-6-12-22)23-13-7-8-14-24(23)26(28)20-27/h1-14,25-26H,15-20H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50231856
PNG
(CHEMBL271519 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C19H22ClN3O/c1-2-22-10-12-23(13-11-22)18-9-8-16(14-17(18)20)21-19(24)15-6-4-3-5-7-15/h3-9,14H,2,10-13H2,1H3,(H,21,24)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373833
PNG
(CHEMBL404874)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CC(C)(C)C)cc1Cl
Show InChI InChI=1S/C18H28ClN3O/c1-5-21-8-10-22(11-9-21)16-7-6-14(12-15(16)19)20-17(23)13-18(2,3)4/h6-7,12H,5,8-11,13H2,1-4H3,(H,20,23)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373840
PNG
(CHEMBL258281)
Show SMILES CCCC(=O)Nc1ccc(N2CCN(CC)CC2)c(Cl)c1
Show InChI InChI=1S/C16H24ClN3O/c1-3-5-16(21)18-13-6-7-15(14(17)12-13)20-10-8-19(4-2)9-11-20/h6-7,12H,3-5,8-11H2,1-2H3,(H,18,21)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373837
PNG
(CHEMBL429320)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C2CCCCC2)cc1Cl
Show InChI InChI=1S/C19H28ClN3O/c1-2-22-10-12-23(13-11-22)18-9-8-16(14-17(18)20)21-19(24)15-6-4-3-5-7-15/h8-9,14-15H,2-7,10-13H2,1H3,(H,21,24)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373832
PNG
(CHEMBL429780)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)COc2ccccc2)cc1Cl
Show InChI InChI=1S/C20H24ClN3O2/c1-2-23-10-12-24(13-11-23)19-9-8-16(14-18(19)21)22-20(25)15-26-17-6-4-3-5-7-17/h3-9,14H,2,10-13,15H2,1H3,(H,22,25)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373839
PNG
(CHEMBL438706)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)Cc2ccc(F)cc2)cc1Cl
Show InChI InChI=1S/C20H23ClFN3O/c1-2-24-9-11-25(12-10-24)19-8-7-17(14-18(19)21)23-20(26)13-15-3-5-16(22)6-4-15/h3-8,14H,2,9-13H2,1H3,(H,23,26)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373838
PNG
(CHEMBL258335)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)COCc2ccccc2)cc1Cl
Show InChI InChI=1S/C21H26ClN3O2/c1-2-24-10-12-25(13-11-24)20-9-8-18(14-19(20)22)23-21(26)16-27-15-17-6-4-3-5-7-17/h3-9,14H,2,10-13,15-16H2,1H3,(H,23,26)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373835
PNG
(CHEMBL256202)
Show SMILES CCCCCC(=O)Nc1ccc(N2CCN(CC)CC2)c(Cl)c1
Show InChI InChI=1S/C18H28ClN3O/c1-3-5-6-7-18(23)20-15-8-9-17(16(19)14-15)22-12-10-21(4-2)11-13-22/h8-9,14H,3-7,10-13H2,1-2H3,(H,20,23)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Bioorg Med Chem Lett 18: 885-90 (2008)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM43822
PNG
(4-[2-(o-toluoylamino)ethylamino]piperidine-1-carbo...)
Show SMILES CCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1C
Show InChI InChI=1S/C18H27N3O3/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at rat muscarinic M5 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6451-5 (2011)

More data for this
Ligand-Target Pair
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