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Compile Data Set for Download or QSAR

Found 75 hits Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M5' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CHRM5


(RAT)
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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0.860n/an/an/an/an/an/an/an/a



DVanderbilt Program in Drug Discovery

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from rat recombinant muscarinic M5 receptor expressed in CHO cells after 2 hrs by microplate scintillation counting


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50403547
PNG
(ATROPEN | ATROPINE)
Show SMILES CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c1ccccc1
Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
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1.80n/an/an/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from rat muscarinic M5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50231845
PNG
(CHEMBL255523 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCC2CCCC2)cc1Cl
Show InChI InChI=1S/C20H30ClN3O/c1-2-23-11-13-24(14-12-23)19-9-8-17(15-18(19)21)22-20(25)10-7-16-5-3-4-6-16/h8-9,15-16H,2-7,10-14H2,1H3,(H,22,25)
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85.7n/an/an/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Displacement of [3H]NMS from rat muscarinic M5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50094703
PNG
(5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-y...)
Show SMILES Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by PDSP Ki Database




J Pharmacol Exp Ther 295: 1156-64 (2000)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50426242
PNG
(CHEMBL2312346)
Show SMILES COc1ccc(CCOC(=O)C2=C(CCN(C)C2)c2ccccc2)cc1OC
Show InChI InChI=1S/C23H27NO4/c1-24-13-11-19(18-7-5-4-6-8-18)20(16-24)23(25)28-14-12-17-9-10-21(26-2)22(15-17)27-3/h4-10,15H,11-14,16H2,1-3H3
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n/an/a 0.450n/an/an/an/an/an/a



University of Arkansas for Medical Sciences

Curated by ChEMBL


Assay Description
Orthosteric antagonist activity at M5 muscarinic receptor in rat striatal slices assessed as inhibition of 100 uM oxotremorine-evoked [3H]DA release


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028290
PNG
((+)-cis-2-Methyl-7-phenyl-1,3,4,6,7,11b-hexahydro-...)
Show SMILES CN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H22N2/c1-20-11-12-21-13-18(15-7-3-2-4-8-15)16-9-5-6-10-17(16)19(21)14-20/h2-10,18-19H,11-14H2,1H3
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
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n/an/a 300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50042441
PNG
(CHEMBL3353290)
Show SMILES COc1ccc(cc1C)[C@]12N(CCN1C(=O)c1ccccc21)C(=O)c1cc(F)c(F)c(F)c1
Show InChI InChI=1/C25H19F3N2O3/c1-14-11-16(7-8-21(14)33-2)25-18-6-4-3-5-17(18)24(32)30(25)10-9-29(25)23(31)15-12-19(26)22(28)20(27)13-15/h3-8,11-13H,9-10H2,1-2H3/t25-/s2
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n/an/a 516n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445222
PNG
(CHEMBL3105228)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3[C@@]12c1ccc(Cl)cc1
Show InChI InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2/t23-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028294
PNG
(CHEMBL6445 | cis-7-Phenyl-1,3,4,6,7,11b-hexahydro-...)
Show SMILES C1CN2CC(c3ccccc3)c3ccccc3C2CN1
Show InChI InChI=1S/C18H20N2/c1-2-6-14(7-3-1)17-13-20-11-10-19-12-18(20)16-9-5-4-8-15(16)17/h1-9,17-19H,10-13H2
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n/an/a 860n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028293
PNG
(CHEMBL6459 | cis-7-(4-Chloro-phenyl)-2-methyl-1,3,...)
Show SMILES CN1CCN2CC(c3ccc(Cl)cc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H21ClN2/c1-21-10-11-22-12-18(14-6-8-15(20)9-7-14)16-4-2-3-5-17(16)19(22)13-21/h2-9,18-19H,10-13H2,1H3
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n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50042442
PNG
(CHEMBL3353277)
Show SMILES COc1ccc(cc1C)C12N(CCN1C(=O)c1ccccc21)C(=O)c1cc(F)c(F)c(F)c1
Show InChI InChI=1/C25H19F3N2O3/c1-14-11-16(7-8-21(14)33-2)25-18-6-4-3-5-17(18)24(32)30(25)10-9-29(25)23(31)15-12-19(26)22(28)20(27)13-15/h3-8,11-13H,9-10H2,1-2H3
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n/an/a 963n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50231845
PNG
(CHEMBL255523 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCC2CCCC2)cc1Cl
Show InChI InChI=1S/C20H30ClN3O/c1-2-23-11-13-24(14-12-23)19-9-8-17(15-18(19)21)22-20(25)10-7-16-5-3-4-6-16/h8-9,15-16H,2-7,10-14H2,1H3,(H,22,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445224
PNG
(CHEMBL3105213)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3C12c1ccc(Cl)cc1
Show InChI InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028301
PNG
(CHEMBL6528 | cis-Dimethyl-(2-methyl-4-phenyl-1,2,3...)
Show SMILES CN(C)CC1N(C)CC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-19-17-12-8-7-11-16(17)18(13-21(19)3)15-9-5-4-6-10-15/h4-12,18-19H,13-14H2,1-3H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028292
PNG
(CHEMBL6747 | cis-2-Ethyl-7-phenyl-1,3,4,6,7,11b-he...)
Show SMILES CCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C20H24N2/c1-2-21-12-13-22-14-19(16-8-4-3-5-9-16)17-10-6-7-11-18(17)20(22)15-21/h3-11,19-20H,2,12-15H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM31005
PNG
(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Show SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028295
PNG
(CHEMBL540195 | cis-4-(2-Methyl-1,3,4,6,7,11b-hexah...)
Show SMILES CN1CCN2CC(c3ccc(O)cc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H22N2O/c1-20-10-11-21-12-18(14-6-8-15(22)9-7-14)16-4-2-3-5-17(16)19(21)13-20/h2-9,18-19,22H,10-13H2,1H3
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n/an/a 2.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445223
PNG
(CHEMBL3105208)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3C12c1ccccc1
Show InChI InChI=1S/C23H16F2N2O2/c24-19-11-10-15(14-20(19)25)21(28)26-12-13-27-22(29)17-8-4-5-9-18(17)23(26,27)16-6-2-1-3-7-16/h1-11,14H,12-13H2
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n/an/a 2.10E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028291
PNG
(CHEMBL6649 | cis-Methyl-(4-phenyl-1,2,3,4-tetrahyd...)
Show SMILES CNCC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C17H20N2/c1-18-12-17-15-10-6-5-9-14(15)16(11-19-17)13-7-3-2-4-8-13/h2-10,16-19H,11-12H2,1H3
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n/an/a 2.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028304
PNG
(CHEMBL266801 | cis-2-Methyl-7-(4-nitro-phenyl)-1,3...)
Show SMILES CN1CCN2CC(c3ccc(cc3)[N+]([O-])=O)c3ccccc3C2C1
Show InChI InChI=1S/C19H21N3O2/c1-20-10-11-21-12-18(14-6-8-15(9-7-14)22(23)24)16-4-2-3-5-17(16)19(21)13-20/h2-9,18-19H,10-13H2,1H3
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n/an/a 3.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50263887
PNG
(1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-b...)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
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n/an/a 3.97E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028297
PNG
(CHEMBL6455 | cis-4-(2-Methyl-1,3,4,6,7,11b-hexahyd...)
Show SMILES CN1CCN2CC(c3ccc(N)cc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H23N3/c1-21-10-11-22-12-18(14-6-8-15(20)9-7-14)16-4-2-3-5-17(16)19(22)13-21/h2-9,18-19H,10-13,20H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028306
PNG
(CHEMBL414182 | cis-Dimethyl-(4-phenyl-1,2,3,4-tetr...)
Show SMILES CN(C)CC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C18H22N2/c1-20(2)13-18-16-11-7-6-10-15(16)17(12-19-18)14-8-4-3-5-9-14/h3-11,17-19H,12-13H2,1-2H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028300
PNG
(CHEMBL6446 | cis-7-(4-Methoxy-phenyl)-2-methyl-1,3...)
Show SMILES COc1ccc(cc1)C1CN2CCN(C)CC2c2ccccc12
Show InChI InChI=1S/C20H24N2O/c1-21-11-12-22-13-19(15-7-9-16(23-2)10-8-15)17-5-3-4-6-18(17)20(22)14-21/h3-10,19-20H,11-14H2,1-2H3
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n/an/a 5.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50445225
PNG
(CHEMBL1459098)
Show SMILES Fc1ccc(cc1)C(=O)N1CCN2C(=O)c3ccccc3C12c1ccccc1
Show InChI InChI=1S/C23H17FN2O2/c24-18-12-10-16(11-13-18)21(27)25-14-15-26-22(28)19-8-4-5-9-20(19)23(25,26)17-6-2-1-3-7-17/h1-13H,14-15H2
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n/an/a 5.67E+3n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028291
PNG
(CHEMBL6649 | cis-Methyl-(4-phenyl-1,2,3,4-tetrahyd...)
Show SMILES CNCC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C17H20N2/c1-18-12-17-15-10-6-5-9-14(15)16(11-19-17)13-7-3-2-4-8-13/h2-10,16-19H,11-12H2,1H3
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n/an/a 6.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028305
PNG
(CHEMBL404992 | cis-7-Phenyl-2-propyl-1,3,4,6,7,11b...)
Show SMILES CCCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C21H26N2/c1-2-12-22-13-14-23-15-20(17-8-4-3-5-9-17)18-10-6-7-11-19(18)21(23)16-22/h3-11,20-21H,2,12-16H2,1H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028303
PNG
(CHEMBL6603 | cis-Ethyl-(4-phenyl-1,2,3,4-tetrahydr...)
Show SMILES CCNCC1NCC(c2ccccc2)c2ccccc12
Show InChI InChI=1S/C18H22N2/c1-2-19-13-18-16-11-7-6-10-15(16)17(12-20-18)14-8-4-3-5-9-14/h3-11,17-20H,2,12-13H2,1H3
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n/an/a 7.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028290
PNG
((+)-cis-2-Methyl-7-phenyl-1,3,4,6,7,11b-hexahydro-...)
Show SMILES CN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C19H22N2/c1-20-11-12-21-13-18(15-7-3-2-4-8-15)16-9-5-6-10-17(16)19(21)14-20/h2-10,18-19H,11-14H2,1H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373834
PNG
(CHEMBL255169)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CCc2ccccc2)cc1Cl
Show InChI InChI=1S/C21H26ClN3O/c1-2-24-12-14-25(15-13-24)20-10-9-18(16-19(20)22)23-21(26)11-8-17-6-4-3-5-7-17/h3-7,9-10,16H,2,8,11-15H2,1H3,(H,23,26)
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n/an/a 7.60E+3n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424114
PNG
(CHEMBL2315675)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(C(F)C1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-6-2-3-7-19(18)16-28-13-10-20(11-14-28)29-15-12-23(21(26)17-29)30-24-9-5-4-8-22(24)27-25(30)31/h2-9,20-21,23H,10-17H2,1H3,(H,27,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424117
PNG
(CHEMBL2315680)
Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C20H27F3N4O3/c1-2-30-19(29)26-10-7-16(8-11-26)27-9-3-4-15(13-27)25-18(28)14-5-6-17(24-12-14)20(21,22)23/h5-6,12,15-16H,2-4,7-11,13H2,1H3,(H,25,28)/t15-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424122
PNG
(CHEMBL2315676)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CC2CC(CC2C1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C27H34N4O/c1-19-6-2-3-7-20(19)16-29-12-10-23(11-13-29)30-17-21-14-24(15-22(21)18-30)31-26-9-5-4-8-25(26)28-27(31)32/h2-9,21-24H,10-18H2,1H3,(H,28,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50424114
PNG
(CHEMBL2315675)
Show SMILES Cc1ccccc1CN1CCC(CC1)N1CCC(C(F)C1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C25H31FN4O/c1-18-6-2-3-7-19(18)16-28-13-10-20(11-14-28)29-15-12-23(21(26)17-29)30-24-9-5-4-8-22(24)27-25(30)31/h2-9,20-21,23H,10-17H2,1H3,(H,27,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells assessed as inhibition of Ach-induced calcium response


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373836
PNG
(CHEMBL271704)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)[C@H]2C[C@@H]2c2ccccc2)cc1Cl
Show InChI InChI=1S/C22H26ClN3O/c1-2-25-10-12-26(13-11-25)21-9-8-17(14-20(21)23)24-22(27)19-15-18(19)16-6-4-3-5-7-16/h3-9,14,18-19H,2,10-13,15H2,1H3,(H,24,27)/t18-,19+/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028299
PNG
(CHEMBL6482 | cis-2-Butyl-7-phenyl-1,3,4,6,7,11b-he...)
Show SMILES CCCCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C22H28N2/c1-2-3-13-23-14-15-24-16-21(18-9-5-4-6-10-18)19-11-7-8-12-20(19)22(24)17-23/h4-12,21-22H,2-3,13-17H2,1H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028296
PNG
(CHEMBL6638 | cis-2-Hexyl-7-phenyl-1,3,4,6,7,11b-he...)
Show SMILES CCCCCCN1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C24H32N2/c1-2-3-4-10-15-25-16-17-26-18-23(20-11-6-5-7-12-20)21-13-8-9-14-22(21)24(26)19-25/h5-9,11-14,23-24H,2-4,10,15-19H2,1H3
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028307
PNG
(CHEMBL6575 | cis-2-Methyl-10-nitro-7-(4-nitro-phen...)
Show SMILES CN1CCN2CC(c3ccc(cc3)[N+]([O-])=O)c3ccc(cc3C2C1)[N+]([O-])=O
Show InChI InChI=1S/C19H20N4O4/c1-20-8-9-21-11-18(13-2-4-14(5-3-13)22(24)25)16-7-6-15(23(26)27)10-17(16)19(21)12-20/h2-7,10,18-19H,8-9,11-12H2,1H3
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n/an/a 4.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028302
PNG
(CHEMBL266039 | cis-2-Phenethyl-7-phenyl-1,3,4,6,7,...)
Show SMILES C(Cc1ccccc1)N1CCN2CC(c3ccccc3)c3ccccc3C2C1
Show InChI InChI=1S/C26H28N2/c1-3-9-21(10-4-1)15-16-27-17-18-28-19-25(22-11-5-2-6-12-22)23-13-7-8-14-24(23)26(28)20-27/h1-14,25-26H,15-20H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50028298
PNG
(CHEMBL6574 | cis-2-Benzyl-7-phenyl-1,3,4,6,7,11b-h...)
Show SMILES C(N1CCN2CC(c3ccccc3)c3ccccc3C2C1)c1ccccc1
Show InChI InChI=1S/C25H26N2/c1-3-9-20(10-4-1)17-26-15-16-27-18-24(21-11-5-2-6-12-21)22-13-7-8-14-23(22)25(27)19-26/h1-14,24-25H,15-19H2
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TBA

Curated by ChEMBL


Assay Description
Binding affinity towards muscarinic acetylcholine receptor by inhibiting specific binding of [3H]-quinuclidinyl benzilate (0.8 nM) in vitro to membra...


J Med Chem 27: 995-1003 (1984)

More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373833
PNG
(CHEMBL404874)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)CC(C)(C)C)cc1Cl
Show InChI InChI=1S/C18H28ClN3O/c1-5-21-8-10-22(11-9-21)16-7-6-14(12-15(16)19)20-17(23)13-18(2,3)4/h6-7,12H,5,8-11,13H2,1-4H3,(H,20,23)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373832
PNG
(CHEMBL429780)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)COc2ccccc2)cc1Cl
Show InChI InChI=1S/C20H24ClN3O2/c1-2-23-10-12-24(13-11-23)19-9-8-16(14-18(19)21)22-20(25)15-26-17-6-4-3-5-7-17/h3-9,14H,2,10-13,15H2,1H3,(H,22,25)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373838
PNG
(CHEMBL258335)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)COCc2ccccc2)cc1Cl
Show InChI InChI=1S/C21H26ClN3O2/c1-2-24-10-12-25(13-11-24)20-9-8-18(14-19(20)22)23-21(26)16-27-15-17-6-4-3-5-7-17/h3-9,14H,2,10-13,15-16H2,1H3,(H,23,26)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373839
PNG
(CHEMBL438706)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)Cc2ccc(F)cc2)cc1Cl
Show InChI InChI=1S/C20H23ClFN3O/c1-2-24-9-11-25(12-10-24)19-8-7-17(14-18(19)21)23-20(26)13-15-3-5-16(22)6-4-15/h3-8,14H,2,9-13H2,1H3,(H,23,26)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373840
PNG
(CHEMBL258281)
Show SMILES CCCC(=O)Nc1ccc(N2CCN(CC)CC2)c(Cl)c1
Show InChI InChI=1S/C16H24ClN3O/c1-3-5-16(21)18-13-6-7-15(14(17)12-13)20-10-8-19(4-2)9-11-20/h6-7,12H,3-5,8-11H2,1-2H3,(H,18,21)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50231856
PNG
(CHEMBL271519 | N-(3-chloro-4-(4-ethylpiperazin-1-y...)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C19H22ClN3O/c1-2-22-10-12-23(13-11-22)18-9-8-16(14-17(18)20)21-19(24)15-6-4-3-5-7-15/h3-9,14H,2,10-13H2,1H3,(H,21,24)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373835
PNG
(CHEMBL256202)
Show SMILES CCCCCC(=O)Nc1ccc(N2CCN(CC)CC2)c(Cl)c1
Show InChI InChI=1S/C18H28ClN3O/c1-3-5-6-7-18(23)20-15-8-9-17(16(19)14-15)22-12-10-21(4-2)11-13-22/h8-9,14H,3-7,10-13H2,1-2H3,(H,20,23)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50373837
PNG
(CHEMBL429320)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C2CCCCC2)cc1Cl
Show InChI InChI=1S/C19H28ClN3O/c1-2-22-10-12-23(13-11-22)18-9-8-16(14-17(18)20)21-19(24)15-6-4-3-5-7-15/h8-9,14-15H,2-7,10-13H2,1H3,(H,21,24)
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n/an/a>1.50E+5n/an/an/an/an/an/a



Vanderbilt Institute of Chemical Biology

Curated by ChEMBL


Assay Description
Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells by calcium mobilization assay


Citation and Details
More data for this
Ligand-Target Pair
CHRM5


(RAT)
BDBM50356966
PNG
(CHEMBL1916224)
Show SMILES CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)c1ccccc1C
Show InChI InChI=1S/C21H31N3O3/c1-3-27-21(26)23-13-10-18(11-14-23)24-12-6-8-17(15-24)22-20(25)19-9-5-4-7-16(19)2/h4-5,7,9,17-18H,3,6,8,10-15H2,1-2H3,(H,22,25)/t17-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Agonist activity at rat muscarinic M5 receptor expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
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