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Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'Myc proto-oncogene protein' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myc proto-oncogene protein


(Homo sapiens)
BDBM93880
PNG
(4-(7-Nitro-benzo[1,2,5]oxadiazol-4-ylamino)-benzoi...)
Show SMILES OC(=O)c1ccc(Nc2ccc([N+]([O-])=O)c3nonc23)cc1
Show InChI InChI=1S/C13H8N4O5/c18-13(19)7-1-3-8(4-2-7)14-9-5-6-10(17(20)21)12-11(9)15-22-16-12/h1-6,14H,(H,18,19)
PDB
MMDB

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PC sid
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Article
PubMed
n/an/a 3.30E+4n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimer...


Citation and Details
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
PDB
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Article
n/an/a 6.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction


Citation and Details
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM50431277
PNG
((Z)-3,4,3'',5''-Tetramethoxystilbene | (Z)-3,4,3',...)
Show SMILES COc1cc(OC)cc(\C=C/c2ccc(OC)c(OC)c2)c1
Show InChI InChI=1S/C18H20O4/c1-19-15-9-14(10-16(12-15)20-2)6-5-13-7-8-17(21-3)18(11-13)22-4/h5-12H,1-4H3/b6-5-
PDB
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PC sid
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Article
n/an/a 6.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Myc signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction


Citation and Details
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM50423921
PNG
(CHEMBL2312756)
Show SMILES [O-][N+](=O)c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12
Show InChI InChI=1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
PDB
MMDB

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CHEMBL
PC cid
PC sid
UniChem
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Article
PubMed
n/an/a 1.46E+5n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimer...


Citation and Details
More data for this
Ligand-Target Pair
Myc proto-oncogene protein


(Homo sapiens)
BDBM50423921
PNG
(CHEMBL2312756)
Show SMILES [O-][N+](=O)c1ccc(Nc2ccccc2-c2ccccc2)c2nonc12
Show InChI InChI=1S/C18H12N4O3/c23-22(24)16-11-10-15(17-18(16)21-25-20-17)19-14-9-5-4-8-13(14)12-6-2-1-3-7-12/h1-11,19H
PDB
MMDB

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CHEMBL
PC cid
PC sid
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Article
PubMed
n/an/an/a 2.80E+3n/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Binding affinity to human c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarizatio...


Citation and Details
More data for this
Ligand-Target Pair