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Found 367 hits Enz. Inhib. hit(s) with Target = 'Myristoyl-CoA:protein N-myristoyltransferase (Nmt)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50027680
PNG
(CHEMBL3357975)
Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)c(NC(=O)Cc2ccc(F)cc2)c1)Cc1ccc(Cl)cc1
Show InChI InChI=1/C29H30Cl2FN3O3/c30-22-6-1-18(2-7-22)11-24(33)14-29(38)35-15-21(17-36)25(16-35)20-5-10-26(31)27(13-20)34-28(37)12-19-3-8-23(32)9-4-19/h1-10,13,21,24-25,36H,11-12,14-17,33H2,(H,34,37)/t21-,24-,25-/s2
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27n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50027677
PNG
(CHEMBL3344387)
Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1
Show InChI InChI=1/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19-,20-/s2
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631n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384914
PNG
(CHEMBL2036496 | CHEMBL2079453)
Show SMILES CCCCc1c(C)nc2ccc(OC)cc2c1SCCC#N
Show InChI InChI=1S/C18H22N2OS/c1-4-5-7-15-13(2)20-17-9-8-14(21-3)12-16(17)18(15)22-11-6-10-19/h8-9,12H,4-7,11H2,1-3H3
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1.69E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50027681
PNG
(CHEMBL3357976)
Show SMILES OC[C@H]1CN(C[C@@H]1c1ccc(Cl)c(NC(=O)Cc2ccc(F)cc2)c1)C(=O)CC(O)Cc1ccc(Cl)cc1
Show InChI InChI=1/C29H29Cl2FN2O4/c30-22-6-1-18(2-7-22)11-24(36)14-29(38)34-15-21(17-35)25(16-34)20-5-10-26(31)27(13-20)33-28(37)12-19-3-8-23(32)9-4-19/h1-10,13,21,24-25,35-36H,11-12,14-17H2,(H,33,37)/t21-,24?,25-/s2
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1.71E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50423890
PNG
(CHEMBL2312449)
Show SMILES COc1cccc(COC(=O)c2sc3ccccc3c2OC2CCNCC2)c1
Show InChI InChI=1S/C22H23NO4S/c1-25-17-6-4-5-15(13-17)14-26-22(24)21-20(27-16-9-11-23-12-10-16)18-7-2-3-8-19(18)28-21/h2-8,13,16,23H,9-12,14H2,1H3
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3.20E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50423892
PNG
(CHEMBL2312447)
Show SMILES O=C(OCc1ccccc1)c1sc2ccccc2c1OC1CCNCC1
Show InChI InChI=1S/C21H21NO3S/c23-21(24-14-15-6-2-1-3-7-15)20-19(25-16-10-12-22-13-11-16)17-8-4-5-9-18(17)26-20/h1-9,16,22H,10-14H2
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4.41E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50423891
PNG
(CHEMBL2312448)
Show SMILES O=C(NCc1ccccc1)c1sc2ccccc2c1OC1CCNCC1
Show InChI InChI=1S/C21H22N2O2S/c24-21(23-14-15-6-2-1-3-7-15)20-19(25-16-10-12-22-13-11-16)17-8-4-5-9-18(17)26-20/h1-9,16,22H,10-14H2,(H,23,24)
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4.76E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50027679
PNG
(CHEMBL3344389)
Show SMILES CC(=O)Nc1cc(ccc1Cl)[C@H]1CN(C[C@@H]1CO)C(=O)C[C@H](N)Cc1ccc(Cl)cc1
Show InChI InChI=1/C23H27Cl2N3O3/c1-14(30)27-22-9-16(4-7-21(22)25)20-12-28(11-17(20)13-29)23(31)10-19(26)8-15-2-5-18(24)6-3-15/h2-7,9,17,19-20,29H,8,10-13,26H2,1H3,(H,27,30)/t17-,19-,20-/s2
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4.91E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384916
PNG
(CHEMBL2036504)
Show SMILES CCOC(=O)c1c(C)nc2ccccc2c1SCCC#N
Show InChI InChI=1S/C16H16N2O2S/c1-3-20-16(19)14-11(2)18-13-8-5-4-7-12(13)15(14)21-10-6-9-17/h4-5,7-8H,3,6,10H2,1-2H3
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1.08E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50027678
PNG
(CHEMBL3344388)
Show SMILES N[C@@H](CC(=O)N1C[C@@H](CO)[C@@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1
Show InChI InChI=1/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19+,20-/s2
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1.09E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384911
PNG
(CHEMBL2036500)
Show SMILES CCc1c(C)nc2ccc(OC)cc2c1SCCC#N
Show InChI InChI=1S/C16H18N2OS/c1-4-13-11(2)18-15-7-6-12(19-3)10-14(15)16(13)20-9-5-8-17/h6-7,10H,4-5,9H2,1-3H3
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1.56E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384912
PNG
(CHEMBL2036502)
Show SMILES CCOC(=O)c1cnc2ccc(OC)cc2c1SCCC#N
Show InChI InChI=1S/C16H16N2O3S/c1-3-21-16(19)13-10-18-14-6-5-11(20-2)9-12(14)15(13)22-8-4-7-17/h5-6,9-10H,3-4,8H2,1-2H3
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1.94E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384924
PNG
(CHEMBL2036637)
Show SMILES CCOC(=O)c1cnc2ccc(C)cc2c1SCCC#N
Show InChI InChI=1S/C16H16N2O2S/c1-3-20-16(19)13-10-18-14-6-5-11(2)9-12(14)15(13)21-8-4-7-17/h5-6,9-10H,3-4,8H2,1-2H3
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2.75E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50027676
PNG
(CHEMBL3344386)
Show SMILES Fc1ccc(CC(=O)Nc2ccc3[nH]cc(C4CCNCC4)c3c2)cc1
Show InChI InChI=1S/C21H22FN3O/c22-16-3-1-14(2-4-16)11-21(26)25-17-5-6-20-18(12-17)19(13-24-20)15-7-9-23-10-8-15/h1-6,12-13,15,23-24H,7-11H2,(H,25,26)
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2.85E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384923
PNG
(CHEMBL2036636)
Show SMILES CCOC(=O)c1cnc2ccc(F)cc2c1SCCC#N
Show InChI InChI=1S/C15H13FN2O2S/c1-2-20-15(19)12-9-18-13-5-4-10(16)8-11(13)14(12)21-7-3-6-17/h4-5,8-9H,2-3,7H2,1H3
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3.35E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384920
PNG
(CHEMBL2036508)
Show SMILES CCCCc1c(C)nc2ccc(OC)cc2c1SCCCC#N
Show InChI InChI=1S/C19H24N2OS/c1-4-5-8-16-14(2)21-18-10-9-15(22-3)13-17(18)19(16)23-12-7-6-11-20/h9-10,13H,4-8,12H2,1-3H3
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4.76E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384917
PNG
(CHEMBL2036505)
Show SMILES CCOC(=O)c1c(CC)nc2ccccc2c1SCCC#N
Show InChI InChI=1S/C17H18N2O2S/c1-3-13-15(17(20)21-4-2)16(22-11-7-10-18)12-8-5-6-9-14(12)19-13/h5-6,8-9H,3-4,7,11H2,1-2H3
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4.79E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384922
PNG
(CHEMBL1339047)
Show SMILES CCCCc1c(C)nc2ccccc2c1SCCC#N
Show InChI InChI=1S/C17H20N2S/c1-3-4-8-14-13(2)19-16-10-6-5-9-15(16)17(14)20-12-7-11-18/h5-6,9-10H,3-4,7-8,12H2,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50423894
PNG
(CHEMBL2312445)
Show SMILES CCOC(=O)c1oc2ccccc2c1OC1CCNCC1
Show InChI InChI=1S/C16H19NO4/c1-2-19-16(18)15-14(20-11-7-9-17-10-8-11)12-5-3-4-6-13(12)21-15/h3-6,11,17H,2,7-10H2,1H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50397525
PNG
(CHEMBL2171240)
Show SMILES CCOC(=O)c1oc2cccc(OC3CCNCC3)c2c1C
Show InChI InChI=1S/C17H21NO4/c1-3-20-17(19)16-11(2)15-13(5-4-6-14(15)22-16)21-12-7-9-18-10-8-12/h4-6,12,18H,3,7-10H2,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384918
PNG
(CHEMBL2036506)
Show SMILES CCCc1nc2ccccc2c(SCCC#N)c1C(=O)OCC
Show InChI InChI=1S/C18H20N2O2S/c1-3-8-15-16(18(21)22-4-2)17(23-12-7-11-19)13-9-5-6-10-14(13)20-15/h5-6,9-10H,3-4,7-8,12H2,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384915
PNG
(CHEMBL2036503)
Show SMILES CCOC(=O)c1cnc2ccccc2c1SCCC#N
Show InChI InChI=1S/C15H14N2O2S/c1-2-19-15(18)12-10-17-13-7-4-3-6-11(13)14(12)20-9-5-8-16/h3-4,6-7,10H,2,5,9H2,1H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384913
PNG
(CHEMBL2036501)
Show SMILES COc1ccc2nc(C)cc(SCCC#N)c2c1
Show InChI InChI=1S/C14H14N2OS/c1-10-8-14(18-7-3-6-15)12-9-11(17-2)4-5-13(12)16-10/h4-5,8-9H,3,7H2,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384919
PNG
(CHEMBL2036507)
Show SMILES CCCCc1c(C)nc2ccc(OC)cc2c1SCCC#C
Show InChI InChI=1S/C19H23NOS/c1-5-7-9-16-14(3)20-18-11-10-15(21-4)13-17(18)19(16)22-12-8-6-2/h2,10-11,13H,5,7-9,12H2,1,3-4H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384921
PNG
(CHEMBL2036510)
Show SMILES CCCCc1c(C)nc2ccc(OC)cc2c1SCCCO
Show InChI InChI=1S/C18H25NO2S/c1-4-5-7-15-13(2)19-17-9-8-14(21-3)12-16(17)18(15)22-11-6-10-20/h8-9,12,20H,4-7,10-11H2,1-3H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50423889
PNG
(CHEMBL2312450)
Show SMILES COc1cccc(CNC(=O)c2sc3ccccc3c2OC2CCNCC2)c1
Show InChI InChI=1S/C22H24N2O3S/c1-26-17-6-4-5-15(13-17)14-24-22(25)21-20(27-16-9-11-23-12-10-16)18-7-2-3-8-19(18)28-21/h2-8,13,16,23H,9-12,14H2,1H3,(H,24,25)
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50384925
PNG
(CHEMBL2036638)
Show SMILES CCOC(=O)c1cnc2ccc(Cl)cc2c1SCCC#N
Show InChI InChI=1S/C15H13ClN2O2S/c1-2-20-15(19)12-9-18-13-5-4-10(16)8-11(13)14(12)21-7-3-6-17/h4-5,8-9H,2-3,7H2,1H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM33749
PNG
(3-(6-Bromo-3-butyl-2-methyl-quinolin-4-ylsulfanyl)...)
Show SMILES CCCCc1c(C)nc2ccc(Br)cc2c1SCCC#N
Show InChI InChI=1S/C17H19BrN2S/c1-3-4-6-14-12(2)20-16-8-7-13(18)11-15(16)17(14)21-10-5-9-19/h7-8,11H,3-6,10H2,1-2H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using human pp60Src92-16 amino acids) as substrate


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50423893
PNG
(CHEMBL2312446)
Show SMILES CCOC(=O)c1sc2ccccc2c1OC1CCNCC1
Show InChI InChI=1S/C16H19NO3S/c1-2-19-16(18)15-14(20-11-7-9-17-10-8-11)12-5-3-4-6-13(12)21-15/h3-6,11,17H,2,7-10H2,1H3
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>1.00E+5n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Binding affinity to human NMT1 after 10 to 20 mins by CPM fluorescence assay


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM185107
PNG
(US9156811, DDD100868)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCCN(C)Cc2c1
Show InChI InChI=1S/C26H34N4O2S/c1-18(2)15-25-26(19(3)30(5)27-25)28-33(31,32)24-12-10-21(11-13-24)22-9-8-20-7-6-14-29(4)17-23(20)16-22/h8-13,16,18H,6-7,14-15,17H2,1-5H3,(H-,28,31,32)
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n/an/a 2n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184977
PNG
(US9156811, DDD88646)
Show SMILES CCN(c1c(C)nn(C)c1C)[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C23H28Cl2N6O2S/c1-5-31(22-15(2)28-29(4)16(22)3)34(32,33)23-19(24)12-18(13-20(23)25)17-6-7-27-21(14-17)30-10-8-26-9-11-30/h6-7,12-14,26H,5,8-11H2,1-4H3
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n/an/a 3n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50364113
PNG
(CHEMBL1230468)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
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n/an/a 3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50364113
PNG
(CHEMBL1230468)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
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n/an/a 3n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184848
PNG
(US9156811, DDD85646)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24H,6-9H2,1-3H3,(H-,27,30,31)
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n/an/a 3n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184854
PNG
(US9156811, DDD86206)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H25ClN6O2S/c1-14-21(15(2)27(3)25-14)26-31(29,30)19-5-4-16(12-18(19)22)17-6-7-24-20(13-17)28-10-8-23-9-11-28/h4-7,12-13,23H,8-11H2,1-3H3,(H-,26,29,30)
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n/an/a 3n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184902
PNG
(US9156811, DDD86481)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C24H30Cl2N6O2S/c1-15(2)11-21-23(16(3)31(4)29-21)30-35(33,34)24-19(25)12-18(13-20(24)26)17-5-6-28-22(14-17)32-9-7-27-8-10-32/h5-6,12-15,27H,7-11H2,1-4H3,(H-,30,33,34)
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n/an/a 3n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM185101
PNG
(US9156811, DDD100807)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C22H30Cl2F2N4O2S/c1-14-20(15(2)29(3)28-14)30(22(25)26)33(31,32)21-18(23)12-17(13-19(21)24)7-5-4-6-16-8-10-27-11-9-16/h12-13,16,22,27H,4-11H2,1-3H3
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n/an/a 4n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184978
PNG
(US9156811, DDD90022)
Show SMILES CN(c1c(C)nn(C)c1C)[S+]([O-])(=O)c1c(Cl)cc(CCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C21H30Cl2N4O2S/c1-14-20(15(2)26(3)25-14)27(4)30(28,29)21-18(22)12-17(13-19(21)23)7-5-6-16-8-10-24-11-9-16/h12-13,16,24H,5-11H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM185092
PNG
(US9156811, DDD100798)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCCNCc2c1
Show InChI InChI=1S/C25H32N4O2S/c1-17(2)14-24-25(18(3)29(4)27-24)28-32(30,31)23-11-9-20(10-12-23)21-8-7-19-6-5-13-26-16-22(19)15-21/h7-12,15,17,26H,5-6,13-14,16H2,1-4H3,(H-,28,30,31)
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n/an/a 4n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033418
PNG
(CHEMBL3357685)
Show SMILES CC(C)Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C24H30Cl2N6O2S/c1-15(2)11-21-23(16(3)31(4)29-21)30-35(33,34)24-19(25)12-18(13-20(24)26)17-5-6-28-22(14-17)32-9-7-27-8-10-32/h5-6,12-15,27,30H,7-11H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033480
PNG
(CHEMBL3357697)
Show SMILES CN1CCC(CCCCc2cc(Cl)c(c(Cl)c2)S(=O)(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C22H32Cl2N4O2S/c1-15-21(16(2)28(4)25-15)26-31(29,30)22-19(23)13-18(14-20(22)24)8-6-5-7-17-9-11-27(3)12-10-17/h13-14,17,26H,5-12H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033485
PNG
(CHEMBL3357702)
Show SMILES CN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C22H26Cl2N6O2S/c1-14-21(15(2)28(3)27-14)29(4)33(31,32)22-18(23)11-17(12-19(22)24)16-5-6-26-20(13-16)30-9-7-25-8-10-30/h5-6,11-13,25H,7-10H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033616
PNG
(CHEMBL3358119)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C22H30Cl2F2N4O2S/c1-14-20(15(2)29(3)28-14)30(22(25)26)33(31,32)21-18(23)12-17(13-19(21)24)7-5-4-6-16-8-10-27-11-9-16/h12-13,16,22,27H,4-11H2,1-3H3
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n/an/a 4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184988
PNG
(US9156811, DDD90107)
Show SMILES CN1CCC(Cc2cccc(c2)-c2ccc(cc2)[S+]([O-])(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C25H32N4O2S/c1-18-25(19(2)29(4)26-18)27-32(30,31)24-10-8-22(9-11-24)23-7-5-6-21(17-23)16-20-12-14-28(3)15-13-20/h5-11,17,20H,12-16H2,1-4H3,(H-,27,30,31)
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184992
PNG
(US9156811, DDD90118)
Show SMILES CN(c1c(C)nn(C)c1C)[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1cccc(CN2CCN(C)CC2)c1
Show InChI InChI=1S/C25H31Cl2N5O2S/c1-17-24(18(2)30(4)28-17)31(5)35(33,34)25-22(26)14-21(15-23(25)27)20-8-6-7-19(13-20)16-32-11-9-29(3)10-12-32/h6-8,13-15H,9-12,16H2,1-5H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM185083
PNG
(US9156811, DDD100169)
Show SMILES CN1CCC(CC1)OCCCc1cc(Cl)c(c(Cl)c1)[S+]([O-])(=O)N(C(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C22H30Cl2F2N4O3S/c1-14-20(15(2)29(4)27-14)30(22(25)26)34(31,32)21-18(23)12-16(13-19(21)24)6-5-11-33-17-7-9-28(3)10-8-17/h12-13,17,22H,5-11H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033482
PNG
(CHEMBL3357699)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C21H30Cl2N4O2S/c1-14-20(15(2)27(3)25-14)26-30(28,29)21-18(22)12-17(13-19(21)23)7-5-4-6-16-8-10-24-11-9-16/h12-13,16,24,26H,4-11H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033617
PNG
(CHEMBL3358120)
Show SMILES CN1CCC(CCCCc2cc(Cl)c(c(Cl)c2)S(=O)(=O)N(C(F)F)c2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C23H32Cl2F2N4O2S/c1-15-21(16(2)30(4)28-15)31(23(26)27)34(32,33)22-19(24)13-18(14-20(22)25)8-6-5-7-17-9-11-29(3)12-10-17/h13-14,17,23H,5-12H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM50033618
PNG
(CHEMBL3358121)
Show SMILES CN1CCC(CC1)OCCCc1cc(Cl)c(c(Cl)c1)S(=O)(=O)N(C(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C22H30Cl2F2N4O3S/c1-14-20(15(2)29(4)27-14)30(22(25)26)34(31,32)21-18(23)12-16(13-19(21)24)6-5-11-33-17-7-9-28(3)10-8-17/h12-13,17,22H,5-11H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...


Citation and Details
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184943
PNG
(US9156811, DDD88193)
Show SMILES CN(c1c(C)nn(C)c1C)[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C22H26Cl2N6O2S/c1-14-21(15(2)28(3)27-14)29(4)33(31,32)22-18(23)11-17(12-19(22)24)16-5-6-26-20(13-16)30-9-7-25-8-10-30/h5-6,11-13,25H,7-10H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
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