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Found 373 hits Enz. Inhib. hit(s) with Target = 'N-acylethanolamine-hydrolyzing acid amidase '   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233790
PNG
(US9353075, 47)
Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C17H23NO4/c1-2-14-15(16(19)22-14)18-17(20)21-12-8-4-7-11-13-9-5-3-6-10-13/h3,5-6,9-10,14-15H,2,4,7-8,11-12H2,1H3,(H,18,20)/t14-,15-/m1/s1
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n/an/a 4n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 5n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
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n/an/a 5n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233791
PNG
(US9353075, 48)
Show SMILES CC[C@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-2-16-17(18(21)24-16)20-19(22)23-12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17H,2,12H2,1H3,(H,20,22)/t16-,17-/m1/s1
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n/an/a 6n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032458
PNG
(CHEMBL3354144 | US9353075, 42)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C18H23NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h7-10,12,14,16H,2-6,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50151154
PNG
(CHEMBL3770896)
Show SMILES CCCCc1ccc(COC(=O)N[C@H]2CNC2=O)cc1
Show InChI InChI=1S/C15H20N2O3/c1-2-3-4-11-5-7-12(8-6-11)10-20-15(19)17-13-9-16-14(13)18/h5-8,13H,2-4,9-10H2,1H3,(H,16,18)(H,17,19)/t13-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Italian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysis


Eur J Med Chem 111: 138-59 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.046
BindingDB Entry DOI: 10.7270/Q2GQ70MX
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032458
PNG
(CHEMBL3354144 | US9353075, 42)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C18H23NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h7-10,12,14,16H,2-6,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 7n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032458
PNG
(CHEMBL3354144 | US9353075, 42)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C18H23NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h7-10,12,14,16H,2-6,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/a7.4n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/a7.4n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Sprague Dawley rat lung native NAAA enzyme using heptadecenoylethanolamide as substrate preincubated for 30 mins followed by substrate ...


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439664
PNG
(CHEMBL2419814 | US9353075, 17)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H17NO4/c1-12-16(17(20)23-12)19-18(21)22-11-13-7-9-15(10-8-13)14-5-3-2-4-6-14/h2-10,12,16H,11H2,1H3,(H,19,21)/t12-,16+/m0/s1
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n/an/a 7.20n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 7.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His6-tagged NAAA expressed in HEK293 cells using 10-cis-heptadecenoylethanolamide as substrate after 30 mins by UPLC/...


ACS Med Chem Lett 3: 422-426 (2012)


Article DOI: 10.1021/ml300056y
BindingDB Entry DOI: 10.7270/Q29W0GKS
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 8n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 9n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233792
PNG
(US9353075, 49)
Show SMILES CC[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C17H23NO4/c1-2-14-15(16(19)22-14)18-17(20)21-12-8-4-7-11-13-9-5-3-6-10-13/h3,5-6,9-10,14-15H,2,4,7-8,11-12H2,1H3,(H,18,20)/t14-,15+/m0/s1
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n/an/a 9n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233776
PNG
(US9353075, 8)
Show SMILES CC(OC(=O)N[C@@H]1[C@H](C)OC1=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-12(24-19(22)20-17-13(2)23-18(17)21)14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-13,17H,1-2H3,(H,20,22)/t12?,13-,17+/m0/s1
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n/an/a 10n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032456
PNG
(CHEMBL3354145)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H16FNO4/c1-11-16(17(21)24-11)20-18(22)23-10-12-2-4-13(5-3-12)14-6-8-15(19)9-7-14/h2-9,11,16H,10H2,1H3,(H,20,22)/t11-,16+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032456
PNG
(CHEMBL3354145)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccc(F)cc1
Show InChI InChI=1S/C18H16FNO4/c1-11-16(17(21)24-11)20-18(22)23-10-12-2-4-13(5-3-12)14-6-8-15(19)9-7-14/h2-9,11,16H,10H2,1H3,(H,20,22)/t11-,16+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50151242
PNG
(CHEMBL3770525)
Show SMILES O=C(N[C@H]1CNC1=O)OCc1ccc(cc1)C1CCCCC1
Show InChI InChI=1S/C17H22N2O3/c20-16-15(10-18-16)19-17(21)22-11-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h6-9,13,15H,1-5,10-11H2,(H,18,20)(H,19,21)/t15-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Italian Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant human NAAA expressed in HEK293 cells after 30 mins by UPLC/MS analysis


Eur J Med Chem 111: 138-59 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.046
BindingDB Entry DOI: 10.7270/Q2GQ70MX
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233798
PNG
(US9353075, 55)
Show SMILES CC(C)[C@H]1OC(=O)[C@@H]1NC(=O)OC(C)(C)CCCCc1ccccc1
Show InChI InChI=1S/C20H29NO4/c1-14(2)17-16(18(22)24-17)21-19(23)25-20(3,4)13-9-8-12-15-10-6-5-7-11-15/h5-7,10-11,14,16-17H,8-9,12-13H2,1-4H3,(H,21,23)/t16-,17-/m1/s1
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n/an/a 12n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032448
PNG
(CHEMBL3354153)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1cc2cc(C)ccc2s1
Show InChI InChI=1S/C15H15NO4S/c1-8-3-4-12-10(5-8)6-11(21-12)7-19-15(18)16-13-9(2)20-14(13)17/h3-6,9,13H,7H2,1-2H3,(H,16,18)/t9-,13+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032448
PNG
(CHEMBL3354153)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1cc2cc(C)ccc2s1
Show InChI InChI=1S/C15H15NO4S/c1-8-3-4-12-10(5-8)6-11(21-12)7-19-15(18)16-13-9(2)20-14(13)17/h3-6,9,13H,7H2,1-2H3,(H,16,18)/t9-,13+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 13n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Sprague Dawley rat lung native NAAA enzyme using heptadecenoylethanolamide as substrate preincubated for 30 mins followed by substrate ...


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233783
PNG
(US9353075, 22)
Show SMILES CC(CCCCc1ccccc1)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C17H23NO4/c1-12(8-6-7-11-14-9-4-3-5-10-14)21-17(20)18-15-13(2)22-16(15)19/h3-5,9-10,12-13,15H,6-8,11H2,1-2H3,(H,18,20)/t12?,13-,15+/m0/s1
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n/an/a 14n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50389023
PNG
(CHEMBL2064166 | US9353075, 6)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 14n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032459
PNG
(CHEMBL3353551)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCC#Cc1ccccc1
Show InChI InChI=1S/C14H13NO4/c1-10-12(13(16)19-10)15-14(17)18-9-5-8-11-6-3-2-4-7-11/h2-4,6-7,10,12H,9H2,1H3,(H,15,17)/t10-,12+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032451
PNG
(CHEMBL3354150)
Show SMILES CCCCc1ccc(COC(=O)N[C@@H]2[C@H](C)OC2=O)cc1
Show InChI InChI=1S/C16H21NO4/c1-3-4-5-12-6-8-13(9-7-12)10-20-16(19)17-14-11(2)21-15(14)18/h6-9,11,14H,3-5,10H2,1-2H3,(H,17,19)/t11-,14+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032451
PNG
(CHEMBL3354150)
Show SMILES CCCCc1ccc(COC(=O)N[C@@H]2[C@H](C)OC2=O)cc1
Show InChI InChI=1S/C16H21NO4/c1-3-4-5-12-6-8-13(9-7-12)10-20-16(19)17-14-11(2)21-15(14)18/h6-9,11,14H,3-5,10H2,1-2H3,(H,17,19)/t11-,14+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233793
PNG
(US9353075, 50)
Show SMILES CC[C@@H]1OC(=O)[C@@H]1NC(=O)OCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H19NO4/c1-2-16-17(18(21)24-16)20-19(22)23-12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17H,2,12H2,1H3,(H,20,22)/t16-,17+/m0/s1
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n/an/a 15n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Sprague Dawley rat lung native NAAA enzyme using heptadecenoylethanolamide as substrate preincubated for 30 mins followed by substrate ...


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439649
PNG
(CHEMBL2419811 | US9353075, 7)
Show SMILES CCCCCCC[C@H](C)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C14H25NO4/c1-4-5-6-7-8-9-10(2)18-14(17)15-12-11(3)19-13(12)16/h10-12H,4-9H2,1-3H3,(H,15,17)/t10-,11-,12+/m0/s1
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n/an/a 16n/an/an/an/a7.4n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439653
PNG
(CHEMBL2419830 | US9353075, 35)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCCC1CCCCC1
Show InChI InChI=1S/C16H27NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h12-14H,2-11H2,1H3,(H,17,19)/t12-,14+/m0/s1
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n/an/a 16n/an/an/an/a7.4n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM319796
PNG
(US10174015, Compound 9)
Show SMILES Clc1cccc(CCCCCC(=O)N2CCOC2=O)c1
Show InChI InChI=1S/C15H18ClNO3/c16-13-7-4-6-12(11-13)5-2-1-3-8-14(18)17-9-10-20-15(17)19/h4,6-7,11H,1-3,5,8-10H2
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n/an/a 18n/an/an/an/an/an/a



Xiamen University

US Patent


Assay Description
In the Experimental example, endocannabinoid hydrolases used were Fatty Acid Amide Hydrolase (FAAH) and N-acylethanolamide hydrolyzing acid amidase (...


US Patent US10174015 (2019)

More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439665
PNG
(CHEMBL2419819 | US9353075, 38)
Show SMILES C[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14-/m1/s1
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n/an/a 18n/an/an/an/a7.4n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439655
PNG
(CHEMBL2419828 | US9353075, 18)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCOCc1ccccc1
Show InChI InChI=1S/C15H19NO5/c1-11-13(14(17)21-11)16-15(18)20-9-5-8-19-10-12-6-3-2-4-7-12/h2-4,6-7,11,13H,5,8-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 18n/an/an/an/a4.537



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
NAAA protein preparation (10 ug) was pre-incubated with various concentrations of test compound or vehicle control in 100 mM NaH2PO4, 100 mM Tri Sodi...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439651
PNG
(CHEMBL2419808)
Show SMILES CC(CCCCc1ccccc1)OC(=O)N[C@@H]1[C@H](C)OC1=O
Show InChI InChI=1S/C17H23NO4/c1-12(8-6-7-11-14-9-4-3-5-10-14)21-17(20)18-15-13(2)22-16(15)19/h3-5,9-10,12-13,15H,6-8,11H2,1-2H3,(H,18,20)/t12?,13-,15+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Sprague Dawley rat lung native NAAA enzyme using heptadecenoylethanolamide as substrate preincubated for 30 mins followed by substrate ...


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM233794
PNG
(US9353075, 51)
Show SMILES CC(C)[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C18H25NO4/c1-13(2)16-15(17(20)23-16)19-18(21)22-12-8-4-7-11-14-9-5-3-6-10-14/h3,5-6,9-10,13,15-16H,4,7-8,11-12H2,1-2H3,(H,19,21)/t15-,16-/m1/s1
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n/an/a 19n/an/an/an/a4.5n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
The assay was run in Optiplate 96-wells black plates, in a total reaction volume of 200 μL. NAAA protein preparation (4.0 μg) was pre-incub...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolysis of 10-cis-heptadecenoylethanolamide by UPLC/MS method


J Med Chem 57: 10101-11 (2014)


Article DOI: 10.1021/jm501455s
BindingDB Entry DOI: 10.7270/Q26111W8
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase


(Homo sapiens (Human))
BDBM50439655
PNG
(CHEMBL2419828 | US9353075, 18)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCOCc1ccccc1
Show InChI InChI=1S/C15H19NO5/c1-11-13(14(17)21-11)16-15(18)20-9-5-8-19-10-12-6-3-2-4-7-12/h2-4,6-7,11,13H,5,8-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-6-tagged recombinant human spleen NAAA enzyme expressed in HEK293 cells


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50439665
PNG
(CHEMBL2419819 | US9353075, 38)
Show SMILES C[C@H]1OC(=O)[C@@H]1NC(=O)OCCCCCc1ccccc1
Show InChI InChI=1S/C16H21NO4/c1-12-14(15(18)21-12)17-16(19)20-11-7-3-6-10-13-8-4-2-5-9-13/h2,4-5,8-9,12,14H,3,6-7,10-11H2,1H3,(H,17,19)/t12-,14-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Istituto Italiano di Tecnologia

Curated by ChEMBL


Assay Description
Inhibition of Sprague Dawley rat lung native NAAA enzyme using heptadecenoylethanolamide as substrate preincubated for 30 mins followed by substrate ...


J Med Chem 56: 6917-34 (2013)


Article DOI: 10.1021/jm400739u
BindingDB Entry DOI: 10.7270/Q2F47QK0
More data for this
Ligand-Target Pair
N-acylethanolamine-hydrolyzing acid amidase (NAAA)


(Rattus norvegicus (Rat))
BDBM50032463
PNG
(CHEMBL3353547 | US9353075, 19)
Show SMILES C[C@@H]1OC(=O)[C@@H]1NC(=O)OCCCCC1CCCCC1
Show InChI InChI=1S/C15H25NO4/c1-11-13(14(17)20-11)16-15(18)19-10-6-5-9-12-7-3-2-4-8-12/h11-13H,2-10H2,1H3,(H,16,18)/t11-,13+/m0/s1
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n/an/a 20n/an/an/an/a7.4n/a



The Regents of the University of California; Fondazione Istituto Italiano Di Technologia; Universita Degli Studi Di Parma; Universita Degli Studi Di Urbino “Carlo Bo”

US Patent


Assay Description
Lysosomal NAAA protein preparation were obtained by homogenizing male Sprague-Dawley rat lungs (Charles River) in 20 mM Tris-HCl buffer pH 7.4 contai...


US Patent US9353075 (2016)


BindingDB Entry DOI: 10.7270/Q23N229Q
More data for this
Ligand-Target Pair
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