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Found 72 hits Enz. Inhib. hit(s) with Target = 'N-myristoyltransferase (NMT1)' AND taxid = 5664   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM184964
PNG
(US9156811, DDD88557)
Show SMILES CN1CCC(CCCc2cc(Cl)c(c(Cl)c2)[S+]([O-])(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C21H30Cl2N4O2S/c1-14-20(15(2)27(4)24-14)25-30(28,29)21-18(22)12-17(13-19(21)23)7-5-6-16-8-10-26(3)11-9-16/h12-13,16H,5-11H2,1-4H3,(H-,25,28,29)
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n/an/a 1n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185101
PNG
(US9156811, DDD100807)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C22H30Cl2F2N4O2S/c1-14-20(15(2)29(3)28-14)30(22(25)26)33(31,32)21-18(23)12-17(13-19(21)24)7-5-4-6-16-8-10-27-11-9-16/h12-13,16,22,27H,4-11H2,1-3H3
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n/an/a 1n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185083
PNG
(US9156811, DDD100169)
Show SMILES CN1CCC(CC1)OCCCc1cc(Cl)c(c(Cl)c1)[S+]([O-])(=O)N(C(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C22H30Cl2F2N4O3S/c1-14-20(15(2)29(4)27-14)30(22(25)26)34(31,32)21-18(23)12-16(13-19(21)24)6-5-11-33-17-7-9-28(3)10-8-17/h12-13,17,22H,5-11H2,1-4H3
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n/an/a 1n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185061
PNG
(US9156811, DDD100144)
Show SMILES CN1CCC(CCCCc2cc(Cl)c(c(Cl)c2)[S+]([O-])(=O)N(C(F)F)c2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C23H32Cl2F2N4O2S/c1-15-21(16(2)30(4)28-15)31(23(26)27)34(32,33)22-19(24)13-18(14-20(22)25)8-6-5-7-17-9-11-29(3)12-10-17/h13-14,17,23H,5-12H2,1-4H3
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n/an/a 1n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM50364113
PNG
(CHEMBL1230468)
Show SMILES Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C21H24Cl2N6O2S/c1-13-20(14(2)28(3)26-13)27-32(30,31)21-17(22)10-16(11-18(21)23)15-4-5-25-19(12-15)29-8-6-24-7-9-29/h4-5,10-12,24,27H,6-9H2,1-3H3
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n/an/a 2n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of Leishmania major N-myristoyltransferase using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins ...


J Med Chem 55: 140-52 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185089
PNG
(US9156811, DDD100795)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCCCn2ccnc2C)cc1Cl
Show InChI InChI=1S/C23H29Cl2F2N5O2S/c1-15-21(16(2)30(4)29-15)32(23(26)27)35(33,34)22-19(24)13-18(14-20(22)25)9-7-5-6-8-11-31-12-10-28-17(31)3/h10,12-14,23H,5-9,11H2,1-4H3
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n/an/a 2n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185058
PNG
(US9156811, DDD100141)
Show SMILES Cc1nn(C)c(C)c1N(CC(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C23H32Cl2F2N4O2S/c1-15-22(16(2)30(3)29-15)31(14-21(26)27)34(32,33)23-19(24)12-18(13-20(23)25)7-5-4-6-17-8-10-28-11-9-17/h12-13,17,21,28H,4-11,14H2,1-3H3
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n/an/a 3n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185107
PNG
(US9156811, DDD100868)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCCN(C)Cc2c1
Show InChI InChI=1S/C26H34N4O2S/c1-18(2)15-25-26(19(3)30(5)27-25)28-33(31,32)24-12-10-21(11-13-24)22-9-8-20-7-6-14-29(4)17-23(20)16-22/h8-13,16,18H,6-7,14-15,17H2,1-5H3,(H-,28,31,32)
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n/an/a 4n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185097
PNG
(US9156811, DDD100803)
Show SMILES CN1CCC(CC1)OCCCc1cc(Cl)c(c(Cl)c1)[S+]([O-])(=O)N(CC(F)(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H31Cl2F3N4O3S/c1-15-21(16(2)31(4)29-15)32(14-23(26,27)28)36(33,34)22-19(24)12-17(13-20(22)25)6-5-11-35-18-7-9-30(3)10-8-18/h12-13,18H,5-11,14H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185096
PNG
(US9156811, DDD100802)
Show SMILES CN1CCCN(CCCc2cc(Cl)c(c(Cl)c2)[S+]([O-])(=O)N(CC(F)F)c2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C23H33Cl2F2N5O2S/c1-16-22(17(2)30(4)28-16)32(15-21(26)27)35(33,34)23-19(24)13-18(14-20(23)25)7-5-9-31-10-6-8-29(3)11-12-31/h13-14,21H,5-12,15H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185127
PNG
(US9156811, DDD100888)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1ccc(cc1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C22H26F2N6O2S/c1-15-21(16(2)28(3)27-15)30(22(23)24)33(31,32)19-6-4-17(5-7-19)18-8-9-26-20(14-18)29-12-10-25-11-13-29/h4-9,14,22,25H,10-13H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185078
PNG
(US9156811, DDD100164)
Show SMILES CN1CCCN(CCCc2cc(Cl)c(c(Cl)c2)[S+]([O-])(=O)N(C(F)F)c2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C22H31Cl2F2N5O2S/c1-15-20(16(2)29(4)27-15)31(22(25)26)34(32,33)21-18(23)13-17(14-19(21)24)7-5-9-30-10-6-8-28(3)11-12-30/h13-14,22H,5-12H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185111
PNG
(US9156811, DDD100872)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCOC2CN3CCC2CC3)cc1Cl
Show InChI InChI=1/C23H30Cl2F2N4O3S/c1-14-21(15(2)29(3)28-14)31(23(26)27)35(32,33)22-18(24)11-16(12-19(22)25)5-4-10-34-20-13-30-8-6-17(20)7-9-30/h11-12,17,20,23H,4-10,13H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185135
PNG
(US9156811, DDD100972)
Show SMILES CC(C)Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(cc1)-c1cccc(CN(C)C)c1
Show InChI InChI=1S/C24H32N4O2S/c1-17(2)14-23-24(18(3)28(6)25-23)26-31(29,30)22-12-10-20(11-13-22)21-9-7-8-19(15-21)16-27(4)5/h7-13,15,17,26H,14,16H2,1-6H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185126
PNG
(US9156811, DDD100887)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C22H24Cl2F2N6O2S/c1-13-20(14(2)30(3)29-13)32(22(25)26)35(33,34)21-17(23)10-16(11-18(21)24)15-4-5-28-19(12-15)31-8-6-27-7-9-31/h4-5,10-12,22,27H,6-9H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185042
PNG
(US9156811, DDD99833)
Show SMILES CN(c1c(C)nn(C)c1C)[S+]([O-])(=O)c1c(Cl)cc(CCCCCCn2ccnc2)cc1Cl
Show InChI InChI=1S/C22H29Cl2N5O2S/c1-16-21(17(2)27(3)26-16)28(4)32(30,31)22-19(23)13-18(14-20(22)24)9-7-5-6-8-11-29-12-10-25-15-29/h10,12-15H,5-9,11H2,1-4H3
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n/an/a 9n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185040
PNG
(US9156811, DDD99830)
Show SMILES CN1CCC(CCCCc2ccc(cc2)[S+]([O-])(=O)Nc2c(C)nn(C)c2C)CC1
Show InChI InChI=1S/C22H34N4O2S/c1-17-22(18(2)26(4)23-17)24-29(27,28)21-11-9-19(10-12-21)7-5-6-8-20-13-15-25(3)16-14-20/h9-12,20H,5-8,13-16H2,1-4H3,(H-,24,27,28)
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n/an/a 11n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185095
PNG
(US9156811, DDD100801)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCNCc2c1
Show InChI InChI=1S/C24H30N4O2S/c1-16(2)13-23-24(17(3)28(4)26-23)27-31(29,30)22-9-7-18(8-10-22)20-6-5-19-11-12-25-15-21(19)14-20/h5-10,14,16,25H,11-13,15H2,1-4H3,(H-,27,29,30)
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n/an/a 11n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185131
PNG
(US9156811, DDD100966)
Show SMILES CCCc1nn(C)c(C)c1NS(=O)(=O)c1ccc(CCCC2CCN(C)CC2)cc1
Show InChI InChI=1S/C23H36N4O2S/c1-5-7-22-23(18(2)27(4)24-22)25-30(28,29)21-12-10-19(11-13-21)8-6-9-20-14-16-26(3)17-15-20/h10-13,20,25H,5-9,14-17H2,1-4H3
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n/an/a 12n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185108
PNG
(US9156811, DDD100869)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CNCCc2cccnc2)c1
Show InChI InChI=1S/C29H35N5O2S/c1-21(2)17-28-29(22(3)34(4)32-28)33-37(35,36)27-12-10-25(11-13-27)26-9-5-7-24(18-26)20-31-16-14-23-8-6-15-30-19-23/h5-13,15,18-19,21,31H,14,16-17,20H2,1-4H3,(H-,33,35,36)
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n/an/a 19n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185088
PNG
(US9156811, DDD100794)
Show SMILES CCc1nccn1CCCCCCc1cc(Cl)c(c(Cl)c1)[S+]([O-])(=O)N(C(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C24H31Cl2F2N5O2S/c1-5-21-29-11-13-32(21)12-9-7-6-8-10-18-14-19(25)23(20(26)15-18)36(34,35)33(24(27)28)22-16(2)30-31(4)17(22)3/h11,13-15,24H,5-10,12H2,1-4H3
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n/an/a 24n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185092
PNG
(US9156811, DDD100798)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCCNCc2c1
Show InChI InChI=1S/C25H32N4O2S/c1-17(2)14-24-25(18(3)29(4)27-24)28-32(30,31)23-11-9-20(10-12-23)21-8-7-19-6-5-13-26-16-22(19)15-21/h7-12,15,17,26H,5-6,13-14,16H2,1-4H3,(H-,28,30,31)
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n/an/a 25n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185130
PNG
(US9156811, DDD100965)
Show SMILES CC(C)Cc1nn(C)c(C)c1N(C)S(=O)(=O)c1ccc(cc1)-c1ccc2CCNCc2c1
Show InChI InChI=1S/C25H32N4O2S/c1-17(2)14-24-25(18(3)28(4)27-24)29(5)32(30,31)23-10-8-19(9-11-23)21-7-6-20-12-13-26-16-22(20)15-21/h6-11,15,17,26H,12-14,16H2,1-5H3
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n/an/a 26n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185136
PNG
(US9156811, DDD100974)
Show SMILES CN(C)Cc1cccc(c1)-c1ccc(cc1)S(=O)(=O)Nc1c(Cc2ccccc2)nn(C)c1C
Show InChI InChI=1S/C27H30N4O2S/c1-20-27(26(28-31(20)4)18-21-9-6-5-7-10-21)29-34(32,33)25-15-13-23(14-16-25)24-12-8-11-22(17-24)19-30(2)3/h5-17,29H,18-19H2,1-4H3
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n/an/a 28n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185062
PNG
(US9156811, DDD100145)
Show SMILES Cc1nn(C)c(C)c1N(CC(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCC2CCNCC2)cc1Cl
Show InChI InChI=1S/C22H30Cl2F2N4O2S/c1-14-21(15(2)29(3)28-14)30(13-20(25)26)33(31,32)22-18(23)11-17(12-19(22)24)6-4-5-16-7-9-27-10-8-16/h11-12,16,20,27H,4-10,13H2,1-3H3
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n/an/a 35n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185007
PNG
(US9156811, DDD99742)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CN(C)C)c1
Show InChI InChI=1S/C24H32N4O2S/c1-17(2)14-23-24(18(3)28(6)25-23)26-31(29,30)22-12-10-20(11-13-22)21-9-7-8-19(15-21)16-27(4)5/h7-13,15,17H,14,16H2,1-6H3,(H-,26,29,30)
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n/an/a 35n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185037
PNG
(US9156811, DDD99825)
Show SMILES CN(C)CCCCCCCc1ccc(cc1)[S+]([O-])(=O)N(C)c1c(C)nn(C)c1C
Show InChI InChI=1S/C22H36N4O2S/c1-18-22(19(2)25(5)23-18)26(6)29(27,28)21-15-13-20(14-16-21)12-10-8-7-9-11-17-24(3)4/h13-16H,7-12,17H2,1-6H3
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n/an/a 39n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185137
PNG
(US9156811, DDD100978)
Show SMILES CN1C(C)(C)CC(CC1(C)C)OCCCc1cc(Cl)c(c(Cl)c1)S(=O)(=O)N(C(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C26H38Cl2F2N4O3S/c1-16-22(17(2)32(7)31-16)34(24(29)30)38(35,36)23-20(27)12-18(13-21(23)28)10-9-11-37-19-14-25(3,4)33(8)26(5,6)15-19/h12-13,19,24H,9-11,14-15H2,1-8H3
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n/an/a 40n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185133
PNG
(US9156811, DDD100969)
Show SMILES CN(C)Cc1cccc(c1)-c1ccc(cc1)S(=O)(=O)Nc1c(CC2CC2)nn(C)c1C
Show InChI InChI=1S/C24H30N4O2S/c1-17-24(23(25-28(17)4)15-18-8-9-18)26-31(29,30)22-12-10-20(11-13-22)21-7-5-6-19(14-21)16-27(2)3/h5-7,10-14,18,26H,8-9,15-16H2,1-4H3
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n/an/a 44n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185085
PNG
(US9156811, DDD100791)
Show SMILES CC(C)c1nccn1CCCCCCc1cc(Cl)c(c(Cl)c1)[S+]([O-])(=O)N(C(F)F)c1c(C)nn(C)c1C
Show InChI InChI=1S/C25H33Cl2F2N5O2S/c1-16(2)24-30-11-13-33(24)12-9-7-6-8-10-19-14-20(26)23(21(27)15-19)37(35,36)34(25(28)29)22-17(3)31-32(5)18(22)4/h11,13-16,25H,6-10,12H2,1-5H3
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n/an/a 44n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185132
PNG
(US9156811, DDD100968)
Show SMILES CCCc1nn(C)c(C)c1NS(=O)(=O)c1ccc(CCCCC2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H38N4O2S/c1-5-8-23-24(19(2)28(4)25-23)26-31(29,30)22-13-11-20(12-14-22)9-6-7-10-21-15-17-27(3)18-16-21/h11-14,21,26H,5-10,15-18H2,1-4H3
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n/an/a 45n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185109
PNG
(US9156811, DDD100870)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(c1)C(C)(C)N
Show InChI InChI=1S/C24H32N4O2S/c1-16(2)14-22-23(17(3)28(6)26-22)27-31(29,30)21-12-10-18(11-13-21)19-8-7-9-20(15-19)24(4,5)25/h7-13,15-16H,14,25H2,1-6H3,(H-,27,29,30)
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n/an/a 45n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185129
PNG
(US9156811, DDD100891)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1ccc(cc1)-c1cccc(c1)C1CCNCC1
Show InChI InChI=1S/C24H28F2N4O2S/c1-16-23(17(2)29(3)28-16)30(24(25)26)33(31,32)22-9-7-18(8-10-22)20-5-4-6-21(15-20)19-11-13-27-14-12-19/h4-10,15,19,24,27H,11-14H2,1-3H3
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n/an/a 45n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185070
PNG
(US9156811, DDD100156)
Show SMILES Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(CCCCCCn2ccnc2)cc1Cl
Show InChI InChI=1S/C22H27Cl2F2N5O2S/c1-15-20(16(2)29(3)28-15)31(22(25)26)34(32,33)21-18(23)12-17(13-19(21)24)8-6-4-5-7-10-30-11-9-27-14-30/h9,11-14,22H,4-8,10H2,1-3H3
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n/an/a 48n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185143
PNG
(US9156811, DDD100991)
Show SMILES CC(C)Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(cc1)-c1cccc(c1)C(C)(C)N1CCCC1
Show InChI InChI=1S/C28H38N4O2S/c1-20(2)18-26-27(21(3)31(6)29-26)30-35(33,34)25-14-12-22(13-15-25)23-10-9-11-24(19-23)28(4,5)32-16-7-8-17-32/h9-15,19-20,30H,7-8,16-18H2,1-6H3
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n/an/a 50n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185105
PNG
(US9156811, DDD100866)
Show SMILES CCCCc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CN(C)C)c1
Show InChI InChI=1S/C24H32N4O2S/c1-6-7-11-23-24(18(2)28(5)25-23)26-31(29,30)22-14-12-20(13-15-22)21-10-8-9-19(16-21)17-27(3)4/h8-10,12-16H,6-7,11,17H2,1-5H3,(H-,26,29,30)
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n/an/a 54n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185115
PNG
(US9156811, DDD100876)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc2CCN(C)Cc2c1
Show InChI InChI=1S/C25H32N4O2S/c1-17(2)14-24-25(18(3)29(5)26-24)27-32(30,31)23-10-8-19(9-11-23)21-7-6-20-12-13-28(4)16-22(20)15-21/h6-11,15,17H,12-14,16H2,1-5H3,(H-,27,30,31)
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n/an/a 59n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185094
PNG
(US9156811, DDD100800)
Show SMILES CCCNCc1cccc(c1)-c1ccc(cc1)[S+]([O-])(=O)Nc1c(CC(C)C)nn(C)c1C
Show InChI InChI=1S/C25H34N4O2S/c1-6-14-26-17-20-8-7-9-22(16-20)21-10-12-23(13-11-21)32(30,31)28-25-19(4)29(5)27-24(25)15-18(2)3/h7-13,16,18,26H,6,14-15,17H2,1-5H3,(H-,28,30,31)
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n/an/a 73n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185106
PNG
(US9156811, DDD100867)
Show SMILES CCCc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CN(C)C)c1
Show InChI InChI=1S/C23H30N4O2S/c1-6-8-22-23(17(2)27(5)24-22)25-30(28,29)21-13-11-19(12-14-21)20-10-7-9-18(15-20)16-26(3)4/h7,9-15H,6,8,16H2,1-5H3,(H-,25,28,29)
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n/an/a 74n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185098
PNG
(US9156811, DDD100804)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CN2CCCC2C)c1
Show InChI InChI=1/C27H36N4O2S/c1-19(2)16-26-27(21(4)30(5)28-26)29-34(32,33)25-13-11-23(12-14-25)24-10-6-9-22(17-24)18-31-15-7-8-20(31)3/h6,9-14,17,19-20H,7-8,15-16,18H2,1-5H3,(H-,29,32,33)
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n/an/a 77n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185103
PNG
(US9156811, DDD100863)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(c1)C(C)(C)N(C)C
Show InChI InChI=1S/C26H36N4O2S/c1-18(2)16-24-25(19(3)30(8)27-24)28-33(31,32)23-14-12-20(13-15-23)21-10-9-11-22(17-21)26(4,5)29(6)7/h9-15,17-18H,16H2,1-8H3,(H-,28,31,32)
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n/an/a 91n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185142
PNG
(US9156811, DDD100990)
Show SMILES CCCCc1nn(C)c(C)c1NS(=O)(=O)c1ccc(CCCCC2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H40N4O2S/c1-5-6-11-24-25(20(2)29(4)26-24)27-32(30,31)23-14-12-21(13-15-23)9-7-8-10-22-16-18-28(3)19-17-22/h12-15,22,27H,5-11,16-19H2,1-4H3
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n/an/a 130n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185139
PNG
(US9156811, DDD100980)
Show SMILES CN1CCC(CCCc2ccc(cc2)S(=O)(=O)Nc2c(CC3CC3)nn(C)c2C)CC1
Show InChI InChI=1S/C24H36N4O2S/c1-18-24(23(25-28(18)3)17-21-7-8-21)26-31(29,30)22-11-9-19(10-12-22)5-4-6-20-13-15-27(2)16-14-20/h9-12,20-21,26H,4-8,13-17H2,1-3H3
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n/an/a 130n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185141
PNG
(US9156811, DDD100986)
Show SMILES CCCCc1nn(C)c(C)c1NS(=O)(=O)c1ccc(CCCC2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H38N4O2S/c1-5-6-10-23-24(19(2)28(4)25-23)26-31(29,30)22-13-11-20(12-14-22)8-7-9-21-15-17-27(3)18-16-21/h11-14,21,26H,5-10,15-18H2,1-4H3
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n/an/a 160n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185125
PNG
(US9156811, DDD100886)
Show SMILES CC(C)Cc1nn(C)c(C)c1N(C(F)F)[S+]([O-])(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C25H30Cl2F2N6O2S/c1-15(2)11-21-23(16(3)33(4)32-21)35(25(28)29)38(36,37)24-19(26)12-18(13-20(24)27)17-5-6-31-22(14-17)34-9-7-30-8-10-34/h5-6,12-15,25,30H,7-11H2,1-4H3
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n/an/a 160n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185124
PNG
(US9156811, DDD100885)
Show SMILES CN(C)Cc1cccc(c1)-c1ccc(cc1)[S+]([O-])(=O)Nc1c(CCc2ccccc2)nn(C)c1C
Show InChI InChI=1S/C28H32N4O2S/c1-21-28(27(29-32(21)4)18-13-22-9-6-5-7-10-22)30-35(33,34)26-16-14-24(15-17-26)25-12-8-11-23(19-25)20-31(2)3/h5-12,14-17,19H,13,18,20H2,1-4H3,(H-,30,33,34)
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n/an/a 211n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185100
PNG
(US9156811, DDD100806)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1ccc(F)c(CN2CCCC2)c1
Show InChI InChI=1S/C26H33FN4O2S/c1-18(2)15-25-26(19(3)30(4)28-25)29-34(32,33)23-10-7-20(8-11-23)21-9-12-24(27)22(16-21)17-31-13-5-6-14-31/h7-12,16,18H,5-6,13-15,17H2,1-4H3,(H-,29,32,33)
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n/an/a 224n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185086
PNG
(US9156811, DDD100792)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CN2CCC2)c1
Show InChI InChI=1S/C25H32N4O2S/c1-18(2)15-24-25(19(3)28(4)26-24)27-32(30,31)23-11-9-21(10-12-23)22-8-5-7-20(16-22)17-29-13-6-14-29/h5,7-12,16,18H,6,13-15,17H2,1-4H3,(H-,27,30,31)
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n/an/a 230n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185091
PNG
(US9156811, DDD100797)
Show SMILES COCCNCc1cccc(c1)-c1ccc(cc1)[S+]([O-])(=O)Nc1c(C)n(C)nc1CC(C)C
Show InChI InChI=1S/C25H34N4O3S/c1-18(2)15-24-25(19(3)29(4)27-24)28-33(30,31)23-11-9-21(10-12-23)22-8-6-7-20(16-22)17-26-13-14-32-5/h6-12,16,18,26H,13-15,17H2,1-5H3,(H-,28,30,31)
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n/an/a 270n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185084
PNG
(US9156811, DDD100790)
Show SMILES CC(C)Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(cc1)-c1cccc(CN2[C@@H](C)CC[C@@H]2C)c1
Show InChI InChI=1/C28H38N4O2S/c1-19(2)16-27-28(22(5)31(6)29-27)30-35(33,34)26-14-12-24(13-15-26)25-9-7-8-23(17-25)18-32-20(3)10-11-21(32)4/h7-9,12-15,17,19-21H,10-11,16,18H2,1-6H3,(H-,30,33,34)/t20-,21-/s2
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n/an/a 350n/an/an/an/an/an/a



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)

More data for this
Ligand-Target Pair
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