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Compile Data Set for Download or QSAR

Found 107 hits Enz. Inhib. hit(s) with Target = 'NADPH oxidase 4' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NADPH oxidase 4


(Homo sapiens)
BDBM50330742
PNG
(2-(2-Chlorophenyl)-5-[(1-methyl-1H-pyrazol-3-yl)me...)
Show SMILES CN(Cc1ccccc1)Cc1n(Cc2ccn(C)n2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C26H25ClN6O2/c1-30(15-18-8-4-3-5-9-18)17-23-25-21(14-24(34)32(23)16-19-12-13-31(2)28-19)29-33(26(25)35)22-11-7-6-10-20(22)27/h3-14,29H,15-17H2,1-2H3
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47n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330740
PNG
(2-(2-chlorophenyl)-4-((4-(3-methoxyphenyl)piperazi...)
Show SMILES COc1cccc(c1)N1CCN(Cc2n(C)c(=O)cc3[nH]n(-c4ccccc4Cl)c(=O)c23)CC1
Show InChI InChI=1S/C25H26ClN5O3/c1-28-22(16-29-10-12-30(13-11-29)17-6-5-7-18(14-17)34-2)24-20(15-23(28)32)27-31(25(24)33)21-9-4-3-8-19(21)26/h3-9,14-15,27H,10-13,16H2,1-2H3
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65n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359519
PNG
(CHEMBL1927157)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccn4)Cc3c2c1=O
Show InChI InChI=1S/C22H20ClN5O2/c23-16-7-1-2-8-18(16)28-22(30)21-17(25-28)12-20(29)27-11-5-10-26(14-19(21)27)13-15-6-3-4-9-24-15/h1-4,6-9,12,25H,5,10-11,13-14H2
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67n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359523
PNG
(CHEMBL1927147)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccc4)Cc3c2c1=O
Show InChI InChI=1S/C23H21ClN4O2/c24-17-9-4-5-10-19(17)28-23(30)22-18(25-28)13-21(29)27-12-6-11-26(15-20(22)27)14-16-7-2-1-3-8-16/h1-5,7-10,13,25H,6,11-12,14-15H2
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72n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359528
PNG
(CHEMBL1927149)
Show SMILES Clc1ccccc1CN1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C23H20Cl2N4O2/c24-16-7-2-1-6-15(16)13-27-10-5-11-28-20(14-27)22-18(12-21(28)30)26-29(23(22)31)19-9-4-3-8-17(19)25/h1-4,6-9,12,26H,5,10-11,13-14H2
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76n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330744
PNG
(4-((2-chlorobenzyloxy)methyl)-2-(2-chlorophenyl)-5...)
Show SMILES Cn1c(COCc2ccccc2Cl)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C21H17Cl2N3O3/c1-25-18(12-29-11-13-6-2-3-7-14(13)22)20-16(10-19(25)27)24-26(21(20)28)17-9-5-4-8-15(17)23/h2-10,24H,11-12H2,1H3
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82n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359525
PNG
(CHEMBL1927146)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCNCc3c2c1=O
Show InChI InChI=1S/C16H15ClN4O2/c17-10-4-1-2-5-12(10)21-16(23)15-11(19-21)8-14(22)20-7-3-6-18-9-13(15)20/h1-2,4-5,8,18-19H,3,6-7,9H2
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87n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359520
PNG
(CHEMBL1927158)
Show SMILES COc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccn4)Cc3c2c1=O
Show InChI InChI=1S/C23H23N5O3/c1-31-20-9-3-2-8-18(20)28-23(30)22-17(25-28)13-21(29)27-12-6-11-26(15-19(22)27)14-16-7-4-5-10-24-16/h2-5,7-10,13,25H,6,11-12,14-15H2,1H3
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93n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359518
PNG
(CHEMBL1927156)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4cccnc4)Cc3c2c1=O
Show InChI InChI=1S/C22H20ClN5O2/c23-16-6-1-2-7-18(16)28-22(30)21-17(25-28)11-20(29)27-10-4-9-26(14-19(21)27)13-15-5-3-8-24-12-15/h1-3,5-8,11-12,25H,4,9-10,13-14H2
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94n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330743
PNG
(4-(benzyloxymethyl)-2-(2-chlorophenyl)-5-(pyrazin-...)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n(Cc3cnccn3)c(COCc3ccccc3)c2c1=O
Show InChI InChI=1S/C25H20ClN5O3/c26-19-8-4-5-9-21(19)31-25(33)24-20(29-31)12-23(32)30(14-18-13-27-10-11-28-18)22(24)16-34-15-17-6-2-1-3-7-17/h1-13,29H,14-16H2
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95n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359529
PNG
(CHEMBL1927150)
Show SMILES Clc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C23H20Cl2N4O2/c24-16-6-3-5-15(11-16)13-27-9-4-10-28-20(14-27)22-18(12-21(28)30)26-29(23(22)31)19-8-2-1-7-17(19)25/h1-3,5-8,11-12,26H,4,9-10,13-14H2
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101n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359530
PNG
(CHEMBL1927151)
Show SMILES Clc1ccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C23H20Cl2N4O2/c24-16-8-6-15(7-9-16)13-27-10-3-11-28-20(14-27)22-18(12-21(28)30)26-29(23(22)31)19-5-2-1-4-17(19)25/h1-2,4-9,12,26H,3,10-11,13-14H2
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103n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359524
PNG
(CHEMBL1927145)
Show SMILES CC(C)(C)OC(=O)N1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C21H23ClN4O4/c1-21(2,3)30-20(29)24-9-6-10-25-16(12-24)18-14(11-17(25)27)23-26(19(18)28)15-8-5-4-7-13(15)22/h4-5,7-8,11,23H,6,9-10,12H2,1-3H3
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103n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359534
PNG
(CHEMBL1927155)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccoc4)Cc3c2c1=O
Show InChI InChI=1S/C21H19ClN4O3/c22-15-4-1-2-5-17(15)26-21(28)20-16(23-26)10-19(27)25-8-3-7-24(12-18(20)25)11-14-6-9-29-13-14/h1-2,4-6,9-10,13,23H,3,7-8,11-12H2
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111n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359531
PNG
(CHEMBL1927152)
Show SMILES COc1ccccc1CN1CCCn2c(C1)c1c(cc2=O)[nH]n(-c2ccccc2Cl)c1=O
Show InChI InChI=1S/C24H23ClN4O3/c1-32-21-10-5-2-7-16(21)14-27-11-6-12-28-20(15-27)23-18(13-22(28)30)26-29(24(23)31)19-9-4-3-8-17(19)25/h2-5,7-10,13,26H,6,11-12,14-15H2,1H3
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111n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359532
PNG
(CHEMBL1927153)
Show SMILES COc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)c1
Show InChI InChI=1S/C24H23ClN4O3/c1-32-17-7-4-6-16(12-17)14-27-10-5-11-28-21(15-27)23-19(13-22(28)30)26-29(24(23)31)20-9-3-2-8-18(20)25/h2-4,6-9,12-13,26H,5,10-11,14-15H2,1H3
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112n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330738
PNG
(2-(2-chloro-4-fluorophenyl)-5-(2-(pyridin-2-yl)eth...)
Show SMILES Fc1ccc(c(Cl)c1)-n1[nH]c2cc(=O)n(CCc3ccccn3)c(CN3CCCC3)c2c1=O
Show InChI InChI=1S/C24H23ClFN5O2/c25-18-13-16(26)6-7-20(18)31-24(33)23-19(28-31)14-22(32)30(12-8-17-5-1-2-9-27-17)21(23)15-29-10-3-4-11-29/h1-2,5-7,9,13-14,28H,3-4,8,10-12,15H2
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114n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330745
PNG
(2-(2-chlorophenyl)-4-((4-fluorophenoxy)methyl)-5-m...)
Show SMILES Cn1c(COc2ccc(F)cc2)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C20H15ClFN3O3/c1-24-17(11-28-13-8-6-12(22)7-9-13)19-15(10-18(24)26)23-25(20(19)27)16-5-3-2-4-14(16)21/h2-10,23H,11H2,1H3
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114n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359533
PNG
(CHEMBL1927154)
Show SMILES COc1ccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3Cl)c2=O)cc1
Show InChI InChI=1S/C24H23ClN4O3/c1-32-17-9-7-16(8-10-17)14-27-11-4-12-28-21(15-27)23-19(13-22(28)30)26-29(24(23)31)20-6-3-2-5-18(20)25/h2-3,5-10,13,26H,4,11-12,14-15H2,1H3
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116n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330746
PNG
(2-(2-chlorophenyl)-4-(2-fluorophenyl)-5-methyl-1H-...)
Show SMILES Cn1c(-c2ccccc2F)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C19H13ClFN3O2/c1-23-16(25)10-14-17(18(23)11-6-2-4-8-13(11)21)19(26)24(22-14)15-9-5-3-7-12(15)20/h2-10,22H,1H3
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128n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359521
PNG
(CHEMBL1927159)
Show SMILES COc1cccc(CN2CCCn3c(C2)c2c(cc3=O)[nH]n(-c3ccccc3OC)c2=O)c1
Show InChI InChI=1S/C25H26N4O4/c1-32-18-8-5-7-17(13-18)15-27-11-6-12-28-21(16-27)24-19(14-23(28)30)26-29(25(24)31)20-9-3-4-10-22(20)33-2/h3-5,7-10,13-14,26H,6,11-12,15-16H2,1-2H3
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131n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359526
PNG
(CHEMBL1926690)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCN(Cc4ccccc4)Cc3c2c1=O
Show InChI InChI=1S/C22H19ClN4O2/c23-16-8-4-5-9-18(16)27-22(29)21-17(24-27)12-20(28)26-11-10-25(14-19(21)26)13-15-6-2-1-3-7-15/h1-9,12,24H,10-11,13-14H2
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142n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359527
PNG
(CHEMBL1927148)
Show SMILES COc1ccccc1-n1[nH]c2cc(=O)n3CCCN(Cc4ccccc4)Cc3c2c1=O
Show InChI InChI=1S/C24H24N4O3/c1-31-21-11-6-5-10-19(21)28-24(30)23-18(25-28)14-22(29)27-13-7-12-26(16-20(23)27)15-17-8-3-2-4-9-17/h2-6,8-11,14,25H,7,12-13,15-16H2,1H3
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144n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330739
PNG
(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Show SMILES CN(Cc1n(Cc2ccncc2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12)c1ccccc1
Show InChI InChI=1S/C26H22ClN5O2/c1-30(19-7-3-2-4-8-19)17-23-25-21(15-24(33)31(23)16-18-11-13-28-14-12-18)29-32(26(25)34)22-10-6-5-9-20(22)27/h2-15,29H,16-17H2,1H3
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151n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330737
PNG
(4-((4-fluorophenoxy)methyl)-5-(2-methoxyethyl)-2-(...)
Show SMILES COCCn1c(COc2ccc(F)cc2)c2c(cc1=O)[nH]n(CCN1CCOCC1)c2=O
Show InChI InChI=1S/C22H27FN4O5/c1-30-11-10-26-19(15-32-17-4-2-16(23)3-5-17)21-18(14-20(26)28)24-27(22(21)29)7-6-25-8-12-31-13-9-25/h2-5,14,24H,6-13,15H2,1H3
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153n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50359522
PNG
(CHEMBL1927160)
Show SMILES Clc1ccccc1-n1[nH]c2cc(=O)n3CCOCc3c2c1=O
Show InChI InChI=1S/C15H12ClN3O3/c16-9-3-1-2-4-11(9)19-15(21)14-10(17-19)7-13(20)18-5-6-22-8-12(14)18/h1-4,7,17H,5-6,8H2
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156n/an/an/an/an/an/an/an/a



Genkyotex S.A.

Curated by ChEMBL


Assay Description
Antagonist activity at human NOX4 expressed in CHO cell membrane coexpressing tetracylin repressor assessed as inhibition of ROS production after 20 ...


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330718
PNG
(2-(2-chlorophenyl)-4-methyl-5-(3-phenylprop-2-ynyl...)
Show SMILES Cc1n(CC#Cc2ccccc2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C22H16ClN3O2/c1-15-21-18(24-26(22(21)28)19-12-6-5-11-17(19)23)14-20(27)25(15)13-7-10-16-8-3-2-4-9-16/h2-6,8-9,11-12,14,24H,13H2,1H3
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158n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330736
PNG
(4-((benzyl(methyl)amino)methyl)-2-(2-chloro-4-fluo...)
Show SMILES COCCCn1c(CN(C)Cc2ccccc2)c2c(cc1=O)[nH]n(-c1ccc(F)cc1Cl)c2=O
Show InChI InChI=1S/C25H26ClFN4O3/c1-29(15-17-7-4-3-5-8-17)16-22-24-20(14-23(32)30(22)11-6-12-34-2)28-31(25(24)33)21-10-9-18(27)13-19(21)26/h3-5,7-10,13-14,28H,6,11-12,15-16H2,1-2H3
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165n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330722
PNG
(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C19H15ClN4O2/c1-12-18-15(10-17(25)23(12)11-13-6-4-5-9-21-13)22-24(19(18)26)16-8-3-2-7-14(16)20/h2-10,22H,11H2,1H3
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165n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330741
PNG
(2-(2-chlorophenyl)-4-((methyl(phenyl)amino)methyl)...)
Show SMILES CN(Cc1n(CCc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12)c1ccccc1
Show InChI InChI=1S/C27H24ClN5O2/c1-31(20-10-3-2-4-11-20)18-24-26-22(30-33(27(26)35)23-13-6-5-12-21(23)28)17-25(34)32(24)16-14-19-9-7-8-15-29-19/h2-13,15,17,30H,14,16,18H2,1H3
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172n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330734
PNG
(4-Methyl-2-(2-methylphenyl)-5-(pyridine-2-ylmethyl...)
Show SMILES Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccn3)c(C)c2c1=O
Show InChI InChI=1S/C20H18N4O2/c1-13-7-3-4-9-17(13)24-20(26)19-14(2)23(18(25)11-16(19)22-24)12-15-8-5-6-10-21-15/h3-11,22H,12H2,1-2H3
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173n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330709
PNG
(2-(2-chloro-4-fluorophenyl)-4,5-dimethyl-1H-pyrazo...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3ccc(F)cc3Cl)c(=O)c12
Show InChI InChI=1S/C14H11ClFN3O2/c1-7-13-10(6-12(20)18(7)2)17-19(14(13)21)11-4-3-8(16)5-9(11)15/h3-6,17H,1-2H3
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213n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330704
PNG
(2-(2-chlorophenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C14H12ClN3O2/c1-8-13-10(7-12(19)17(8)2)16-18(14(13)20)11-6-4-3-5-9(11)15/h3-7,16H,1-2H3
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215n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330729
PNG
(2-(2,5-dichlorobenzyl)-4-methyl-5-(pyridin-2-ylmet...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(Cc3cc(Cl)ccc3Cl)c(=O)c12
Show InChI InChI=1S/C20H16Cl2N4O2/c1-12-19-17(9-18(27)25(12)11-15-4-2-3-7-23-15)24-26(20(19)28)10-13-8-14(21)5-6-16(13)22/h2-9,24H,10-11H2,1H3
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218n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330719
PNG
(CHEMBL1276857 | N-(2-(2-chlorophenyl)-4-methyl-3,6...)
Show SMILES Cc1n(NC(=O)COc2ccc(F)cc2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C21H16ClFN4O4/c1-12-20-16(24-27(21(20)30)17-5-3-2-4-15(17)22)10-19(29)26(12)25-18(28)11-31-14-8-6-13(23)7-9-14/h2-10,24H,11H2,1H3,(H,25,28)
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218n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330733
PNG
(2-(2-chloro-4-fluorophenyl)-4-methyl-5-(pyridin-2-...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccc(F)cc3Cl)c(=O)c12
Show InChI InChI=1S/C19H14ClFN4O2/c1-11-18-15(9-17(26)24(11)10-13-4-2-3-7-22-13)23-25(19(18)27)16-6-5-12(21)8-14(16)20/h2-9,23H,10H2,1H3
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235n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330716
PNG
(2-(2-chlorophenyl)-5-(2-(dimethylamino)ethyl)-4-me...)
Show SMILES CN(C)CCn1c(C)c2c(cc1=O)[nH]n(-c1ccccc1Cl)c2=O
Show InChI InChI=1S/C17H19ClN4O2/c1-11-16-13(10-15(23)21(11)9-8-20(2)3)19-22(17(16)24)14-7-5-4-6-12(14)18/h4-7,10,19H,8-9H2,1-3H3
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235n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330723
PNG
(2-(2-chlorophenyl)-4-methyl-5-((6-morpholinopyridi...)
Show SMILES Cc1n(Cc2cccc(n2)N2CCOCC2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C23H22ClN5O3/c1-15-22-18(26-29(23(22)31)19-7-3-2-6-17(19)24)13-21(30)28(15)14-16-5-4-8-20(25-16)27-9-11-32-12-10-27/h2-8,13,26H,9-12,14H2,1H3
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236n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330703
PNG
(1-acetyl-2-(2-chlorophenyl)-4-methyl-5-(pyridin-3-...)
Show SMILES CC(=O)n1n(-c2ccccc2Cl)c(=O)c2c(C)n(Cc3cccnc3)c(=O)cc12
Show InChI InChI=1S/C21H17ClN4O3/c1-13-20-18(10-19(28)24(13)12-15-6-5-9-23-11-15)25(14(2)27)26(21(20)29)17-8-4-3-7-16(17)22/h3-11H,12H2,1-2H3
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240n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330732
PNG
(2-(4-chlorobenzyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(Cc3ccc(Cl)cc3)c(=O)c12
Show InChI InChI=1S/C20H17ClN4O2/c1-13-19-17(10-18(26)24(13)12-16-4-2-3-9-22-16)23-25(20(19)27)11-14-5-7-15(21)8-6-14/h2-10,23H,11-12H2,1H3
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259n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330721
PNG
(4-((2-(2-chlorophenyl)-4-methyl-3,6-dioxo-2,3-dihy...)
Show SMILES Cc1n(Cc2ccc(cc2)S(N)(=O)=O)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
Show InChI InChI=1S/C20H17ClN4O4S/c1-12-19-16(23-25(20(19)27)17-5-3-2-4-15(17)21)10-18(26)24(12)11-13-6-8-14(9-7-13)30(22,28)29/h2-10,23H,11H2,1H3,(H2,22,28,29)
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259n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330701
PNG
(1-(2-(3-methoxyphenyl)acetyl)-4-methyl-2-phenyl-5-...)
Show SMILES COc1cccc(CC(=O)n2n(-c3ccccc3)c(=O)c3c(C)n(Cc4cccnc4)c(=O)cc23)c1
Show InChI InChI=1S/C28H24N4O4/c1-19-27-24(16-25(33)30(19)18-21-9-7-13-29-17-21)32(31(28(27)35)22-10-4-3-5-11-22)26(34)15-20-8-6-12-23(14-20)36-2/h3-14,16-17H,15,18H2,1-2H3
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285n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330711
PNG
(3-(4,5-dimethyl-3,6-dioxo-5,6-dihydro-1H-pyrazolo[...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3cccc(c3)C#N)c(=O)c12
Show InChI InChI=1S/C15H12N4O2/c1-9-14-12(7-13(20)18(9)2)17-19(15(14)21)11-5-3-4-10(6-11)8-16/h3-7,17H,1-2H3
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293n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330705
PNG
(2-(2-fluorophenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3ccccc3F)c(=O)c12
Show InChI InChI=1S/C14H12FN3O2/c1-8-13-10(7-12(19)17(8)2)16-18(14(13)20)11-6-4-3-5-9(11)15/h3-7,16H,1-2H3
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308n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330725
PNG
(2-(2-methoxyethyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Show SMILES COCCn1[nH]c2cc(=O)n(Cc3ccccn3)c(C)c2c1=O
Show InChI InChI=1S/C16H18N4O3/c1-11-15-13(18-20(16(15)22)7-8-23-2)9-14(21)19(11)10-12-5-3-4-6-17-12/h3-6,9,18H,7-8,10H2,1-2H3
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313n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330728
PNG
(2-(2-(4-chlorophenoxy)ethyl)-4-methyl-5-(pyridin-2...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(CCOc3ccc(Cl)cc3)c(=O)c12
Show InChI InChI=1S/C21H19ClN4O3/c1-14-20-18(12-19(27)25(14)13-16-4-2-3-9-23-16)24-26(21(20)28)10-11-29-17-7-5-15(22)6-8-17/h2-9,12,24H,10-11,13H2,1H3
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326n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330713
PNG
(CHEMBL1275631 | N-(3-(4,5-dimethyl-3,6-dioxo-5,6-d...)
Show SMILES CC(=O)Nc1cccc(c1)-n1[nH]c2cc(=O)n(C)c(C)c2c1=O
Show InChI InChI=1S/C16H16N4O3/c1-9-15-13(8-14(22)19(9)3)18-20(16(15)23)12-6-4-5-11(7-12)17-10(2)21/h4-8,18H,1-3H3,(H,17,21)
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328n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330727
PNG
(4-methyl-2-phenethyl-5-(pyridin-2-ylmethyl)-1H-pyr...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(CCc3ccccc3)c(=O)c12
Show InChI InChI=1S/C21H20N4O2/c1-15-20-18(13-19(26)24(15)14-17-9-5-6-11-22-17)23-25(21(20)27)12-10-16-7-3-2-4-8-16/h2-9,11,13,23H,10,12,14H2,1H3
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334n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330712
PNG
(2-(3-chlorophenyl)-4,5-dimethyl-1H-pyrazolo[4,3-c]...)
Show SMILES Cc1n(C)c(=O)cc2[nH]n(-c3cccc(Cl)c3)c(=O)c12
Show InChI InChI=1S/C14H12ClN3O2/c1-8-13-11(7-12(19)17(8)2)16-18(14(13)20)10-5-3-4-9(15)6-10/h3-7,16H,1-2H3
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340n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
NADPH oxidase 4


(Homo sapiens)
BDBM50330731
PNG
(2-(2-chloro-4-fluorobenzyl)-4-methyl-5-(pyridin-2-...)
Show SMILES Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(Cc3ccc(F)cc3Cl)c(=O)c12
Show InChI InChI=1S/C20H16ClFN4O2/c1-12-19-17(9-18(27)25(12)11-15-4-2-3-7-23-15)24-26(20(19)28)10-13-5-6-14(22)8-16(13)21/h2-9,24H,10-11H2,1H3
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342n/an/an/an/an/an/an/an/a



Genkyotex, S.A.

Curated by ChEMBL


Assay Description
Inhibition of human NOX4 overexpressed in human PMN cell membrane assessed as ROS production by cell free assay in presence of NADPH


Citation and Details
More data for this
Ligand-Target Pair
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