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Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with Target = 'NPFF' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NPFF


(RAT)
BDBM86140
PNG
(CAS_123797 | NPFF | NSC_123797)
Show SMILES CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)
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Article
PubMed
0.130n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037567
PNG
(2-[(Pyrrolidine-2-carbonyl)-amino]-pentanedioic ac...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C55H78N14O11/c1-32(2)28-42(67-48(74)37(56)29-35-18-20-36(70)21-19-35)53(79)68(3)44(31-34-14-8-5-9-15-34)52(78)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)50(76)63-38(16-10-26-62-55(60)61)49(75)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,76)(H,64,77)(H,65,78)(H,66,75)(H,67,74)(H4,60,61,62)/t37-,38+,39+,40+,41+,42+,43+,44+/m1/s1
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0.160n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037568
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-(p-hydroxyphenyl)-propio...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N(C)[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C55H78N14O11/c1-32(2)28-42(67-48(74)37(56)29-35-18-20-36(70)21-19-35)53(79)68(3)44(31-34-14-8-5-9-15-34)52(78)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)50(76)63-38(16-10-26-62-55(60)61)49(75)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,76)(H,64,77)(H,65,78)(H,66,75)(H,67,74)(H4,60,61,62)/t37-,38+,39+,40+,41+,42-,43+,44+/m1/s1
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0.190n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037559
PNG
((S)-2-[((S)-1-{(S)-2-[(S)-2-((S)-2-Amino-4-methyl-...)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H67N13O9/c1-26(2)23-29(46)39(62)57-34(25-28-13-7-4-8-14-28)42(65)55-32(18-20-37(48)60)44(67)58-22-10-16-35(58)43(66)54-31(17-19-36(47)59)41(64)53-30(15-9-21-52-45(50)51)40(63)56-33(38(49)61)24-27-11-5-3-6-12-27/h3-8,11-14,26,29-35H,9-10,15-25,46H2,1-2H3,(H2,47,59)(H2,48,60)(H2,49,61)(H,53,64)(H,54,66)(H,55,65)(H,56,63)(H,57,62)(H4,50,51,52)/t29-,30-,31-,32-,33-,34-,35-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037575
PNG
(2-Amino-pentanedioic acid 5-amide 1-{[1-(1-carbamo...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O11/c1-31(2)27-41(66-47(73)36(55)28-34-17-19-35(69)20-18-34)50(76)67-42(30-33-13-7-4-8-14-33)51(77)64-39(22-24-45(57)71)53(79)68-26-10-16-43(68)52(78)63-38(21-23-44(56)70)49(75)62-37(15-9-25-61-54(59)60)48(74)65-40(46(58)72)29-32-11-5-3-6-12-32/h3-8,11-14,17-20,31,36-43,69H,9-10,15-16,21-30,55H2,1-2H3,(H2,56,70)(H2,57,71)(H2,58,72)(H,62,75)(H,63,78)(H,64,77)(H,65,74)(H,66,73)(H,67,76)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037557
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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0.210n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037572
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-(p-hydroxyphenyl)-propio...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O11/c1-31(2)27-41(66-47(73)36(55)28-32-11-5-3-6-12-32)50(76)67-42(30-34-17-19-35(69)20-18-34)51(77)64-39(22-24-45(57)71)53(79)68-26-10-16-43(68)52(78)63-38(21-23-44(56)70)49(75)62-37(15-9-25-61-54(59)60)48(74)65-40(46(58)72)29-33-13-7-4-8-14-33/h3-8,11-14,17-20,31,36-43,69H,9-10,15-16,21-30,55H2,1-2H3,(H2,56,70)(H2,57,71)(H2,58,72)(H,62,75)(H,63,78)(H,64,77)(H,65,74)(H,66,73)(H,67,76)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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0.220n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037565
PNG
((S)-2-({(S)-1-[(S)-2-((S)-2-Amino-3-phenyl-propion...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C39H56N12O8/c40-25(21-23-9-3-1-4-10-23)34(55)49-28(16-18-32(42)53)38(59)51-20-8-14-30(51)37(58)48-27(15-17-31(41)52)36(57)47-26(13-7-19-46-39(44)45)35(56)50-29(33(43)54)22-24-11-5-2-6-12-24/h1-6,9-12,25-30H,7-8,13-22,40H2,(H2,41,52)(H2,42,53)(H2,43,54)(H,47,57)(H,48,58)(H,49,55)(H,50,56)(H4,44,45,46)/t25-,26-,27-,28-,29-,30-/m0/s1
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0.430n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037563
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-(p-hydroxyphenyl)-propio...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O11/c1-31(2)27-41(66-47(73)36(55)28-34-17-19-35(69)20-18-34)50(76)67-42(30-33-13-7-4-8-14-33)51(77)64-39(22-24-45(57)71)53(79)68-26-10-16-43(68)52(78)63-38(21-23-44(56)70)49(75)62-37(15-9-25-61-54(59)60)48(74)65-40(46(58)72)29-32-11-5-3-6-12-32/h3-8,11-14,17-20,31,36-43,69H,9-10,15-16,21-30,55H2,1-2H3,(H2,56,70)(H2,57,71)(H2,58,72)(H,62,75)(H,63,78)(H,64,77)(H,65,74)(H,66,73)(H,67,76)(H4,59,60,61)/t36-,37+,38+,39+,40+,41-,42+,43+/m1/s1
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0.5n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037576
PNG
(1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4-met...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C51H71N13O9/c1-31(2)26-39(62-45(68)35(52)27-32-14-6-3-7-15-32)47(70)63-40(29-34-18-10-5-11-19-34)48(71)60-37(22-23-42(53)65)50(73)64-25-13-21-41(64)49(72)58-30-43(66)59-36(20-12-24-57-51(55)56)46(69)61-38(44(54)67)28-33-16-8-4-9-17-33/h3-11,14-19,31,35-41H,12-13,20-30,52H2,1-2H3,(H2,53,65)(H2,54,67)(H,58,72)(H,59,66)(H,60,71)(H,61,69)(H,62,68)(H,63,70)(H4,55,56,57)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037564
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-(p-hydroxyphenyl)-propio...)
Show SMILES CC(C)C[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O11/c1-31(2)27-41(66-47(73)36(55)28-34-17-19-35(69)20-18-34)50(76)67-42(30-33-13-7-4-8-14-33)51(77)64-39(22-24-45(57)71)53(79)68-26-10-16-43(68)52(78)63-38(21-23-44(56)70)49(75)62-37(15-9-25-61-54(59)60)48(74)65-40(46(58)72)29-32-11-5-3-6-12-32/h3-8,11-14,17-20,31,36-43,69H,9-10,15-16,21-30,55H2,1-2H3,(H2,56,70)(H2,57,71)(H2,58,72)(H,62,75)(H,63,78)(H,64,77)(H,65,74)(H,66,73)(H,67,76)(H4,59,60,61)/t36-,37+,38+,39+,40+,41-,42-,43+/m1/s1
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CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037569
PNG
(2-(2-Amino-3-phenyl-propionylamino)-4-methyl-penta...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C51H72N14O10/c1-30(2)25-39(64-45(70)34(52)26-31-13-6-3-7-14-31)49(74)65-40(28-33-17-10-5-11-18-33)50(75)62-36(20-22-41(53)66)46(71)59-29-43(68)60-37(21-23-42(54)67)48(73)61-35(19-12-24-58-51(56)57)47(72)63-38(44(55)69)27-32-15-8-4-9-16-32/h3-11,13-18,30,34-40H,12,19-29,52H2,1-2H3,(H2,53,66)(H2,54,67)(H2,55,69)(H,59,71)(H,60,68)(H,61,73)(H,62,75)(H,63,72)(H,64,70)(H,65,74)(H4,56,57,58)/t34-,35-,36-,37-,38-,39-,40-/m0/s1
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CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86147
PNG
(CAS_68615 | FMRFamide | NSC_68615)
Show SMILES CSCCC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H42N8O4S/c1-42-16-14-23(35-26(39)21(30)17-19-9-4-2-5-10-19)28(41)36-22(13-8-15-34-29(32)33)27(40)37-24(25(31)38)18-20-11-6-3-7-12-20/h2-7,9-12,21-24H,8,13-18,30H2,1H3,(H2,31,38)(H,35,39)(H,36,41)(H,37,40)(H4,32,33,34)
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2.20n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86148
PNG
(CAS_222988-10-5 | PrRP20)
Show SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C104H158N32O26/c1-10-53(5)82(97(158)124-66(29-19-39-116-104(112)113)99(160)134-40-21-32-74(134)94(155)131-81(52(3)4)95(156)119-49-77(142)123-65(28-18-38-115-103(110)111)88(149)125-67(85(107)146)43-58-23-13-12-14-24-58)130-78(143)51-118-87(148)64(27-17-37-114-102(108)109)122-76(141)50-120-96(157)84(57(9)138)133-90(151)68(44-59-33-35-61(139)36-34-59)127-89(150)69(45-60-48-117-63-26-16-15-25-62(60)63)126-86(147)55(7)121-92(153)72-30-20-41-135(72)100(161)71(46-75(105)140)129-98(159)83(54(6)11-2)132-91(152)70(47-79(144)145)128-93(154)73-31-22-42-136(73)101(162)80(106)56(8)137/h12-16,23-26,33-36,48,52-57,64-74,80-84,117,137-139H,10-11,17-22,27-32,37-47,49-51,106H2,1-9H3,(H2,105,140)(H2,107,146)(H,118,148)(H,119,156)(H,120,157)(H,121,153)(H,122,141)(H,123,142)(H,124,158)(H,125,149)(H,126,147)(H,127,150)(H,128,154)(H,129,159)(H,130,143)(H,131,155)(H,132,152)(H,133,151)(H,144,145)(H4,108,109,114)(H4,110,111,115)(H4,112,113,116)/t53-,54-,55-,56+,57+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,80-,81-,82-,83-,84-/m0/s1
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2.30n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86139
PNG
(CAS_235433-36-0 | CAS_99566-27-5 | NPSF | NSC_0 | ...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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5.20n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86139
PNG
(CAS_235433-36-0 | CAS_99566-27-5 | NPSF | NSC_0 | ...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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5.90n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037558
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C51H71N13O9/c1-31(2)26-39(62-45(68)35(52)27-32-14-6-3-7-15-32)49(72)63-40(29-34-18-10-5-11-19-34)46(69)58-30-43(66)64-25-13-21-41(64)50(73)60-37(22-23-42(53)65)48(71)59-36(20-12-24-57-51(55)56)47(70)61-38(44(54)67)28-33-16-8-4-9-17-33/h3-11,14-19,31,35-41H,12-13,20-30,52H2,1-2H3,(H2,53,65)(H2,54,67)(H,58,69)(H,59,71)(H,60,73)(H,61,70)(H,62,68)(H,63,72)(H4,55,56,57)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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10n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86146
PNG
(CAS_0 | NSC_0 | PrRP24-31)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H67N13O9/c1-23(2)19-29(53-37(60)28(21-32(43)56)52-39(62)31-15-10-18-55(31)41(64)34(44)24(3)4)40(63)54-17-9-14-30(54)38(61)49-22-33(57)50-26(13-8-16-48-42(46)47)36(59)51-27(35(45)58)20-25-11-6-5-7-12-25/h5-7,11-12,23-24,26-31,34H,8-10,13-22,44H2,1-4H3,(H2,43,56)(H2,45,58)(H,49,61)(H,50,57)(H,51,59)(H,52,62)(H,53,60)(H4,46,47,48)/t26-,27-,28-,29-,30-,31-,34-/m0/s1
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11n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86145
PNG
(L-Met-L-Pro-L-His-L-Serr-L-Phe-L-Ala-L-Asn-L-Leu-L...)
Show SMILES CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C64H96N18O12S/c1-36(2)28-45(57(88)74-43(20-13-24-71-64(68)69)55(86)75-44(53(67)84)30-39-16-9-7-10-17-39)78-61(92)51-22-15-26-82(51)63(94)49(29-37(3)4)80-59(90)48(33-52(66)83)76-54(85)38(5)73-56(87)46(31-40-18-11-8-12-19-40)77-58(89)47(32-41-34-70-35-72-41)79-60(91)50-21-14-25-81(50)62(93)42(65)23-27-95-6/h7-12,16-19,34-38,42-51H,13-15,20-33,65H2,1-6H3,(H2,66,83)(H2,67,84)(H,70,72)(H,73,87)(H,74,88)(H,75,86)(H,76,85)(H,77,89)(H,78,92)(H,79,91)(H,80,90)(H4,68,69,71)/t38-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1
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15n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037573
PNG
((S)-2-[((S)-Pyrrolidine-2-carbonyl)-amino]-pentane...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C25H39N9O5/c26-20(35)11-10-18(33-22(37)16-8-4-12-30-16)24(39)32-17(9-5-13-31-25(28)29)23(38)34-19(21(27)36)14-15-6-2-1-3-7-15/h1-3,6-7,16-19,30H,4-5,8-14H2,(H2,26,35)(H2,27,36)(H,32,39)(H,33,37)(H,34,38)(H4,28,29,31)/t16-,17-,18-,19-/m0/s1
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15.5n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86143
PNG
(L-Val-L-Pro-L-Asn-L-Leu-L-Pro-L-Gln-L-Arg-L-Phe-NH...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
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19n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037562
PNG
((S)-2-{[(S)-1-((S)-2-Amino-4-carbamoyl-butyryl)-py...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H47N11O7/c31-18(10-12-23(32)42)29(48)41-15-5-9-22(41)28(47)39-20(11-13-24(33)43)27(46)38-19(8-4-14-37-30(35)36)26(45)40-21(25(34)44)16-17-6-2-1-3-7-17/h1-3,6-7,18-22H,4-5,8-16,31H2,(H2,32,42)(H2,33,43)(H2,34,44)(H,38,46)(H,39,47)(H,40,45)(H4,35,36,37)/t18-,19-,20-,21-,22-/m0/s1
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20.9n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037561
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-(p-hydroxyphenyl)-propio...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O11/c1-31(2)27-41(66-47(73)36(55)28-34-17-19-35(69)20-18-34)50(76)67-42(30-33-13-7-4-8-14-33)51(77)64-39(22-24-45(57)71)53(79)68-26-10-16-43(68)52(78)63-38(21-23-44(56)70)49(75)62-37(15-9-25-61-54(59)60)48(74)65-40(46(58)72)29-32-11-5-3-6-12-32/h3-8,11-14,17-20,31,36-43,69H,9-10,15-16,21-30,55H2,1-2H3,(H2,56,70)(H2,57,71)(H2,58,72)(H,62,75)(H,63,78)(H,64,77)(H,65,74)(H,66,73)(H,67,76)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43+/m0/s1
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30n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037570
PNG
((S)-2-[((R)-1-{(S)-2-[(S)-2-((S)-2-Amino-4-methyl-...)
Show SMILES CC(C)C[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H67N13O9/c1-26(2)23-29(46)39(62)57-34(25-28-13-7-4-8-14-28)42(65)55-32(18-20-37(48)60)44(67)58-22-10-16-35(58)43(66)54-31(17-19-36(47)59)41(64)53-30(15-9-21-52-45(50)51)40(63)56-33(38(49)61)24-27-11-5-3-6-12-27/h3-8,11-14,26,29-35H,9-10,15-25,46H2,1-2H3,(H2,47,59)(H2,48,60)(H2,49,61)(H,53,64)(H,54,66)(H,55,65)(H,56,63)(H,57,62)(H4,50,51,52)/t29-,30-,31-,32-,33-,34-,35+/m0/s1
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33n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037560
PNG
((S)-2-({(R)-1-[(S)-2-((S)-2-Amino-3-phenyl-propion...)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C39H56N12O8/c40-25(21-23-9-3-1-4-10-23)34(55)49-28(16-18-32(42)53)38(59)51-20-8-14-30(51)37(58)48-27(15-17-31(41)52)36(57)47-26(13-7-19-46-39(44)45)35(56)50-29(33(43)54)22-24-11-5-2-6-12-24/h1-6,9-12,25-30H,7-8,13-22,40H2,(H2,41,52)(H2,42,53)(H2,43,54)(H,47,57)(H,48,58)(H,49,55)(H,50,56)(H4,44,45,46)/t25-,26-,27-,28-,29-,30+/m0/s1
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45n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037566
PNG
((S)-2-{[(R)-1-((S)-2-Amino-4-carbamoyl-butyryl)-py...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C30H47N11O7/c31-18(10-12-23(32)42)29(48)41-15-5-9-22(41)28(47)39-20(11-13-24(33)43)27(46)38-19(8-4-14-37-30(35)36)26(45)40-21(25(34)44)16-17-6-2-1-3-7-17/h1-3,6-7,18-22H,4-5,8-16,31H2,(H2,32,42)(H2,33,43)(H2,34,44)(H,38,46)(H,39,47)(H,40,45)(H4,35,36,37)/t18-,19-,20-,21-,22+/m0/s1
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64n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037574
PNG
((S)-2-[((R)-Pyrrolidine-2-carbonyl)-amino]-pentane...)
Show SMILES NC(=O)CC[C@H](NC(=O)[C@H]1CCCN1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C25H39N9O5/c26-20(35)11-10-18(33-22(37)16-8-4-12-30-16)24(39)32-17(9-5-13-31-25(28)29)23(38)34-19(21(27)36)14-15-6-2-1-3-7-15/h1-3,6-7,16-19,30H,4-5,8-14H2,(H2,26,35)(H2,27,36)(H,32,39)(H,33,37)(H,34,38)(H4,28,29,31)/t16-,17+,18+,19+/m1/s1
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94n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50037571
PNG
((S)-2-Amino-pentanedioic acid 5-amide 1-{[(S)-1-((...)
Show SMILES N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C20H32N8O4/c21-13(8-9-16(22)29)18(31)27-14(7-4-10-26-20(24)25)19(32)28-15(17(23)30)11-12-5-2-1-3-6-12/h1-3,5-6,13-15H,4,7-11,21H2,(H2,22,29)(H2,23,30)(H,27,31)(H,28,32)(H4,24,25,26)/t13-,14-,15-/m0/s1
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300n/an/an/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Binding affinity for NPPF receptor in rat spinal cord membranes using the radioligand [125I]-[Tyr1]NPFF


J Med Chem 37: 3477-81 (1994)

More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM84996
PNG
(BIBP3226 | CAS_5311023 | NSC_5311023)
Show SMILES NC(N)=NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1
Show InChI InChI=1S/C27H31N5O3/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30)
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390n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50099301
PNG
(CHEMBL384262 | Desaminotyrosyl-Phe-Leu-Phe-Gln-Pro...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C54H75N13O11/c1-32(2)29-40(65-50(75)41(30-34-11-5-3-6-12-34)61-46(71)26-19-33-17-20-36(68)21-18-33)49(74)66-42(31-35-13-7-4-8-14-35)51(76)64-39(23-25-45(56)70)53(78)67-28-10-16-43(67)52(77)63-38(22-24-44(55)69)48(73)62-37(47(57)72)15-9-27-60-54(58)59/h3-8,11-14,17-18,20-21,32,37-43,68H,9-10,15-16,19,22-31H2,1-2H3,(H2,55,69)(H2,56,70)(H2,57,72)(H,61,71)(H,62,73)(H,63,77)(H,64,76)(H,65,75)(H,66,74)(H4,58,59,60)/t37-,38-,39-,40-,41-,42-,43-/m0/s1
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840n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards NPFF receptor was measured by the displacement of [125I]-YLFQPQRF-NH2


J Med Chem 44: 1623-6 (2001)

More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM82285
PNG
(NPY 18-36 | NPY18-36 | NPY18-36, porcine)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C112H174N36O27/c1-12-57(7)87(106(173)144-83(51-86(115)156)102(169)139-78(45-56(5)6)103(170)147-88(58(8)13-2)107(174)148-89(61(11)150)108(175)136-74(21-17-43-129-112(123)124)93(160)135-75(38-39-85(114)155)97(164)133-72(19-15-41-127-110(119)120)94(161)137-76(90(116)157)46-62-22-30-67(151)31-23-62)146-104(171)81(49-65-28-36-70(154)37-29-65)142-101(168)82(50-66-52-125-54-130-66)143-96(163)73(20-16-42-128-111(121)122)134-98(165)77(44-55(3)4)138-92(159)60(10)131-105(172)84(53-149)145-100(167)80(48-64-26-34-69(153)35-27-64)141-99(166)79(47-63-24-32-68(152)33-25-63)140-95(162)71(132-91(158)59(9)113)18-14-40-126-109(117)118/h22-37,52,54-61,71-84,87-89,149-154H,12-21,38-51,53,113H2,1-11H3,(H2,114,155)(H2,115,156)(H2,116,157)(H,125,130)(H,131,172)(H,132,158)(H,133,164)(H,134,165)(H,135,160)(H,136,175)(H,137,161)(H,138,159)(H,139,169)(H,140,162)(H,141,166)(H,142,168)(H,143,163)(H,144,173)(H,145,167)(H,146,171)(H,147,170)(H,148,174)(H4,117,118,126)(H4,119,120,127)(H4,121,122,128)(H4,123,124,129)/t57-,58-,59-,60-,61+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,87-,88-,89-/m0/s1
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860n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM50015490
PNG
(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Show InChI InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
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920n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50099302
PNG
(2-{2-[2-(5-Dimethylamino-naphthalene-1-sulfonylami...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)NCC(=O)NC(CO)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C23H34N8O6S/c1-31(2)18-9-3-7-15-14(18)6-4-10-19(15)38(36,37)28-12-20(33)29-17(13-32)22(35)30-16(21(24)34)8-5-11-27-23(25)26/h3-4,6-7,9-10,16-17,28,32H,5,8,11-13H2,1-2H3,(H2,24,34)(H,29,33)(H,30,35)(H4,25,26,27)
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1.40E+3n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards NPFF receptor was measured by the displacement of [125I]-YLFQPQRF-NH2


J Med Chem 44: 1623-6 (2001)

More data for this
Ligand-Target Pair
NPFF


(RAT)
BDBM86144
PNG
(CAS_0 | NPFF-OH | NSC_0)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C54H75N13O11/c1-32(2)28-40(64-46(70)36(55)29-33-14-6-3-7-15-33)49(73)65-41(30-34-16-8-4-9-17-34)50(74)63-39(23-25-45(57)69)52(76)67-27-13-21-43(67)51(75)62-38(22-24-44(56)68)48(72)61-37(20-12-26-60-54(58)59)47(71)66-42(53(77)78)31-35-18-10-5-11-19-35/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,68)(H2,57,69)(H,61,72)(H,62,75)(H,63,74)(H,64,70)(H,65,73)(H,66,71)(H,77,78)(H4,58,59,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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2.40E+3n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50015490
PNG
(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Show InChI InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
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4.00E+3n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
NPFF2


(RAT)
BDBM50099303
PNG
(2-{[1-(5-Dimethylamino-naphthalene-1-sulfonyl)-pyr...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(N)=N)C(N)=O
Show InChI InChI=1S/C28H41N9O6S/c1-36(2)21-10-3-8-18-17(21)7-4-12-23(18)44(42,43)37-16-6-11-22(37)27(41)35-20(13-14-24(29)38)26(40)34-19(25(30)39)9-5-15-33-28(31)32/h3-4,7-8,10,12,19-20,22H,5-6,9,11,13-16H2,1-2H3,(H2,29,38)(H2,30,39)(H,34,40)(H,35,41)(H4,31,32,33)
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1.36E+4n/an/an/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards NPFF receptor was measured by the displacement of [125I]-YLFQPQRF-NH2


J Med Chem 44: 1623-6 (2001)

More data for this
Ligand-Target Pair