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Compile Data Set for Download or QSAR

Found 105 hits Enz. Inhib. hit(s) with Target = 'NPFF2' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NPFF2


(HUMAN)
BDBM50029138
PNG
(CHEMBL3360830)
Show SMILES CC(C)C[C@@H](N(C)C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)/t37-,38+,39+,40+,41+,42+,43+,44-/s2
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0.470n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50159227
PNG
(CHEMBL3786309)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C65H91N17O16/c1-34(2)28-47(79-62(96)50(33-83)81-61(95)49(31-39-32-72-43-15-9-8-14-41(39)43)80-60(94)48(30-38-18-20-40(84)21-19-38)78-56(90)42(66)22-25-53(86)87)59(93)73-35(3)55(89)74-36(4)64(98)82-27-11-17-51(82)63(97)76-45(23-24-52(67)85)58(92)75-44(16-10-26-71-65(69)70)57(91)77-46(54(68)88)29-37-12-6-5-7-13-37/h5-9,12-15,18-21,32,34-36,42,44-51,72,83-84H,10-11,16-17,22-31,33,66H2,1-4H3,(H2,67,85)(H2,68,88)(H,73,93)(H,74,89)(H,75,92)(H,76,97)(H,77,91)(H,78,90)(H,79,96)(H,80,94)(H,81,95)(H,86,87)(H4,69,70,71)/t35-,36-,42-,44-,45-,46-,47-,48-,49-,50-,51-/s2
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0.530n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]EYE from human NPFF2 receptor expressed in CHO cell membranes after 1 hr by liquid scintillation spectrophotometric counting


J Med Chem 59: 1925-45 (2016)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029138
PNG
(CHEMBL3360830)
Show SMILES CC(C)C[C@@H](N(C)C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)/t37-,38+,39+,40+,41+,42+,43+,44-/s2
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0.800n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [125I]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50037557
PNG
(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]EYE from human NPFF2 receptor expressed in CHO cell membranes after 1 hr by liquid scintillation spectrophotometric counting


J Med Chem 59: 1925-45 (2016)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402444
PNG
(CHEMBL2208319)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H34N6O3/c30-26(36)24(19-20-11-4-1-5-12-20)35-27(37)23(17-10-18-33-29(31)32)34-28(38)25(21-13-6-2-7-14-21)22-15-8-3-9-16-22/h1-9,11-16,23-25H,10,17-19H2,(H2,30,36)(H,34,38)(H,35,37)(H4,31,32,33)/t23-,24+/m1/s1
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4n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402453
PNG
(CHEMBL2208338)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-10-3-1-4-11-19)34-27(37)23(16-9-17-32-28(30)31)33-26(36)22-15-8-7-14-21(22)20-12-5-2-6-13-20/h1-8,10-15,23-24H,9,16-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24+/m1/s1
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4n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86140
PNG
(CAS_123797 | NPFF | NSC_123797)
Show SMILES CC(C)CC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)
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5.20n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86142
PNG
(1DMe-Y8Fa | CAS_132709 | NSC_132709)
Show SMILES CC(C)CC(N(C)C(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C55H78N14O11/c1-32(2)28-44(68(3)53(79)37(56)29-35-18-20-36(70)21-19-35)52(78)67-42(31-34-14-8-5-9-15-34)50(76)65-40(23-25-46(58)72)54(80)69-27-11-17-43(69)51(77)64-39(22-24-45(57)71)49(75)63-38(16-10-26-62-55(60)61)48(74)66-41(47(59)73)30-33-12-6-4-7-13-33/h4-9,12-15,18-21,32,37-44,70H,10-11,16-17,22-31,56H2,1-3H3,(H2,57,71)(H2,58,72)(H2,59,73)(H,63,75)(H,64,77)(H,65,76)(H,66,74)(H,67,78)(H4,60,61,62)
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5.30n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402451
PNG
(CHEMBL2208322)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1cccc(c1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(17-19-9-3-1-4-10-19)34-27(37)23(15-8-16-32-28(30)31)33-26(36)22-14-7-13-21(18-22)20-11-5-2-6-12-20/h1-7,9-14,18,23-24H,8,15-17H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24+/m1/s1
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9n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86147
PNG
(CAS_68615 | FMRFamide | NSC_68615)
Show SMILES CSCCC(NC(=O)C(N)Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H42N8O4S/c1-42-16-14-23(35-26(39)21(30)17-19-9-4-2-5-10-19)28(41)36-22(13-8-15-34-29(32)33)27(40)37-24(25(31)38)18-20-11-6-3-7-12-20/h2-7,9-12,21-24H,8,13-18,30H2,1H3,(H2,31,38)(H,35,39)(H,36,41)(H,37,40)(H4,32,33,34)
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13n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86145
PNG
(L-Met-L-Pro-L-His-L-Serr-L-Phe-L-Ala-L-Asn-L-Leu-L...)
Show SMILES CSCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C64H96N18O12S/c1-36(2)28-45(57(88)74-43(20-13-24-71-64(68)69)55(86)75-44(53(67)84)30-39-16-9-7-10-17-39)78-61(92)51-22-15-26-82(51)63(94)49(29-37(3)4)80-59(90)48(33-52(66)83)76-54(85)38(5)73-56(87)46(31-40-18-11-8-12-19-40)77-58(89)47(32-41-34-70-35-72-41)79-60(91)50-21-14-25-81(50)62(93)42(65)23-27-95-6/h7-12,16-19,34-38,42-51H,13-15,20-33,65H2,1-6H3,(H2,66,83)(H2,67,84)(H,70,72)(H,73,87)(H,74,88)(H,75,86)(H,76,85)(H,77,89)(H,78,92)(H,79,91)(H,80,90)(H4,68,69,71)/t38-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1
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15n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86139
PNG
(CAS_235433-36-0 | CAS_99566-27-5 | NPSF | NSC_0 | ...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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19n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402457
PNG
(CHEMBL2208340)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C22H28N6O3/c23-19(29)18(14-15-8-3-1-4-9-15)28-21(31)17(12-7-13-26-22(24)25)27-20(30)16-10-5-2-6-11-16/h1-6,8-11,17-18H,7,12-14H2,(H2,23,29)(H,27,30)(H,28,31)(H4,24,25,26)/t17-,18+/m1/s1
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22n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86148
PNG
(CAS_222988-10-5 | PrRP20)
Show SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C104H158N32O26/c1-10-53(5)82(97(158)124-66(29-19-39-116-104(112)113)99(160)134-40-21-32-74(134)94(155)131-81(52(3)4)95(156)119-49-77(142)123-65(28-18-38-115-103(110)111)88(149)125-67(85(107)146)43-58-23-13-12-14-24-58)130-78(143)51-118-87(148)64(27-17-37-114-102(108)109)122-76(141)50-120-96(157)84(57(9)138)133-90(151)68(44-59-33-35-61(139)36-34-59)127-89(150)69(45-60-48-117-63-26-16-15-25-62(60)63)126-86(147)55(7)121-92(153)72-30-20-41-135(72)100(161)71(46-75(105)140)129-98(159)83(54(6)11-2)132-91(152)70(47-79(144)145)128-93(154)73-31-22-42-136(73)101(162)80(106)56(8)137/h12-16,23-26,33-36,48,52-57,64-74,80-84,117,137-139H,10-11,17-22,27-32,37-47,49-51,106H2,1-9H3,(H2,105,140)(H2,107,146)(H,118,148)(H,119,156)(H,120,157)(H,121,153)(H,122,141)(H,123,142)(H,124,158)(H,125,149)(H,126,147)(H,127,150)(H,128,154)(H,129,159)(H,130,143)(H,131,155)(H,132,152)(H,133,151)(H,144,145)(H4,108,109,114)(H4,110,111,115)(H4,112,113,116)/t53-,54-,55-,56+,57+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,80-,81-,82-,83-,84-/m0/s1
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23n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50159225
PNG
(CHEMBL3786583)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN\C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C70H101N19O17.3C2HF3O2/c1-38(2)32-51(85-66(103)54(37-90)87-65(102)53(35-43-36-78-47-17-9-8-16-45(43)47)86-64(101)52(34-42-20-22-44(91)23-21-42)84-60(97)46(72)24-27-57(93)94)63(100)79-39(3)59(96)80-40(4)68(105)89-31-13-19-55(89)67(104)82-49(25-26-56(73)92)62(99)81-48(18-12-30-76-69(75)88-70(106)77-29-11-10-28-71)61(98)83-50(58(74)95)33-41-14-6-5-7-15-41;3*3-2(4,5)1(6)7/h5-9,14-17,20-23,36,38-40,46,48-55,78,90-91H,10-13,18-19,24-35,37,71-72H2,1-4H3,(H2,73,92)(H2,74,95)(H,79,100)(H,80,96)(H,81,99)(H,82,104)(H,83,98)(H,84,97)(H,85,103)(H,86,101)(H,87,102)(H,93,94)(H4,75,76,77,88,106);3*(H,6,7)/t39-,40-,46-,48-,49-,50-,51-,52-,53-,54-,55-;;;/s2
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27n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]EYE from human NPFF2 receptor expressed in CHO cell membranes after 1 hr by liquid scintillation spectrophotometric counting


J Med Chem 59: 1925-45 (2016)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029097
PNG
(CHEMBL3361433)
Show SMILES NC(=N)NCC(=O)NCC1(Cc2cccc3ccccc23)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H33N5O/c28-26(29)30-18-25(33)31-20-27(17-23-11-6-10-22-9-4-5-12-24(22)23)13-15-32(16-14-27)19-21-7-2-1-3-8-21/h1-12H,13-20H2,(H,31,33)(H4,28,29,30)
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30n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86146
PNG
(CAS_0 | NSC_0 | PrRP24-31)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C42H67N13O9/c1-23(2)19-29(53-37(60)28(21-32(43)56)52-39(62)31-15-10-18-55(31)41(64)34(44)24(3)4)40(63)54-17-9-14-30(54)38(61)49-22-33(57)50-26(13-8-16-48-42(46)47)36(59)51-27(35(45)58)20-25-11-6-5-7-12-25/h5-7,11-12,23-24,26-31,34H,8-10,13-22,44H2,1-4H3,(H2,43,56)(H2,45,58)(H,49,61)(H,50,57)(H,51,59)(H,52,62)(H,53,60)(H4,46,47,48)/t26-,27-,28-,29-,30-,31-,34-/m0/s1
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32n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86139
PNG
(CAS_235433-36-0 | CAS_99566-27-5 | NPSF | NSC_0 | ...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C54H76N14O10/c1-32(2)28-41(66-47(72)36(55)29-33-14-6-3-7-15-33)50(75)67-42(31-35-18-10-5-11-19-35)51(76)64-39(23-25-45(57)70)53(78)68-27-13-21-43(68)52(77)63-38(22-24-44(56)69)49(74)62-37(20-12-26-61-54(59)60)48(73)65-40(46(58)71)30-34-16-8-4-9-17-34/h3-11,14-19,32,36-43H,12-13,20-31,55H2,1-2H3,(H2,56,69)(H2,57,70)(H2,58,71)(H,62,74)(H,63,77)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,59,60,61)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
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37n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50159226
PNG
(CHEMBL3786376)
Show SMILES OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCC(=O)NCCCCNC(=O)\N=C(\N)NCCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C73H105N19O18.2C2HF3O2/c1-6-59(96)78-30-12-13-31-80-73(110)91-72(77)79-32-14-20-50(64(102)86-52(61(76)99)35-43-16-8-7-9-17-43)84-65(103)51(27-28-58(75)95)85-70(108)57-21-15-33-92(57)71(109)42(5)83-62(100)41(4)82-66(104)53(34-40(2)3)88-69(107)56(39-93)90-68(106)55(37-45-38-81-49-19-11-10-18-47(45)49)89-67(105)54(36-44-22-24-46(94)25-23-44)87-63(101)48(74)26-29-60(97)98;2*3-2(4,5)1(6)7/h7-11,16-19,22-25,38,40-42,48,50-57,81,93-94H,6,12-15,20-21,26-37,39,74H2,1-5H3,(H2,75,95)(H2,76,99)(H,78,96)(H,82,104)(H,83,100)(H,84,103)(H,85,108)(H,86,102)(H,87,101)(H,88,107)(H,89,105)(H,90,106)(H,97,98)(H4,77,79,80,91,110);2*(H,6,7)/t41-,42-,48-,50-,51-,52-,53-,54-,55-,56-,57-;;/s2
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41n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]EYE from human NPFF2 receptor expressed in CHO cell membranes after 1 hr by liquid scintillation spectrophotometric counting


J Med Chem 59: 1925-45 (2016)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50336912
PNG
(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
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43n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402447
PNG
(CHEMBL2208312)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C25H29N7O3/c26-22(33)21(15-16-7-2-1-3-8-16)32-23(34)19(11-6-14-29-25(27)28)31-24(35)20-13-12-17-9-4-5-10-18(17)30-20/h1-5,7-10,12-13,19,21H,6,11,14-15H2,(H2,26,33)(H,31,35)(H,32,34)(H4,27,28,29)/t19-,21-/m0/s1
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47n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM86143
PNG
(L-Val-L-Pro-L-Asn-L-Leu-L-Pro-L-Gln-L-Arg-L-Phe-NH...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C45H72N14O10/c1-24(2)21-31(57-40(65)30(23-35(47)61)56-42(67)33-15-10-20-59(33)44(69)36(48)25(3)4)43(68)58-19-9-14-32(58)41(66)54-28(16-17-34(46)60)39(64)53-27(13-8-18-52-45(50)51)38(63)55-29(37(49)62)22-26-11-6-5-7-12-26/h5-7,11-12,24-25,27-33,36H,8-10,13-23,48H2,1-4H3,(H2,46,60)(H2,47,61)(H2,49,62)(H,53,64)(H,54,66)(H,55,63)(H,56,67)(H,57,65)(H4,50,51,52)/t27-,28-,29-,30-,31-,32-,33-,36-/m0/s1
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55n/an/an/an/an/an/an/an/a



Juvantia Pharma, Ltd.

Curated by PDSP Ki Database




J Pharmacol Exp Ther 305: 825-32 (2003)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029111
PNG
(CHEMBL3360829)
Show SMILES CC(=N)NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1/C27H39N5O3/c1-17(28)30-9-5-8-22(25(34)31-23(24(29)33)13-18-6-3-2-4-7-18)32-26(35)27-14-19-10-20(15-27)12-21(11-19)16-27/h2-4,6-7,19-23H,5,8-16H2,1H3,(H2,28,30)(H2,29,33)(H,31,34)(H,32,35)/t19?,20?,21?,22-,23-,27?/s2
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75n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Antagonist activity at human NPFF2 receptor expressed in African green monkey COS-1 cells


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029132
PNG
(CHEMBL3361434)
Show SMILES NC(=N)NCC(=O)NCC1(Cc2ccc(Cl)c(Cl)c2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H29Cl2N5O/c24-19-7-6-18(12-20(19)25)13-23(16-29-21(31)14-28-22(26)27)8-10-30(11-9-23)15-17-4-2-1-3-5-17/h1-7,12H,8-11,13-16H2,(H,29,31)(H4,26,27,28)
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82n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029110
PNG
(CHEMBL3361423)
Show SMILES NC(=N)NCC(=O)NCC1(Cc2ccccc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C23H31N5O/c24-22(25)26-16-21(29)27-18-23(15-19-7-3-1-4-8-19)11-13-28(14-12-23)17-20-9-5-2-6-10-20/h1-10H,11-18H2,(H,27,29)(H4,24,25,26)
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84n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402458
PNG
(CHEMBL2208339)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C22H28N6O3/c23-19(29)18(14-15-8-3-1-4-9-15)28-21(31)17(12-7-13-26-22(24)25)27-20(30)16-10-5-2-6-11-16/h1-6,8-11,17-18H,7,12-14H2,(H2,23,29)(H,27,30)(H,28,31)(H4,24,25,26)/t17-,18-/m0/s1
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92n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402449
PNG
(CHEMBL2208325)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-8-3-1-4-9-19)34-27(37)23(12-7-17-32-28(30)31)33-26(36)22-15-13-21(14-16-22)20-10-5-2-6-11-20/h1-6,8-11,13-16,23-24H,7,12,17-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24+/m1/s1
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94n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402442
PNG
(CHEMBL2208303)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C=Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C24H30N6O3/c25-22(32)20(16-18-10-5-2-6-11-18)30-23(33)19(12-7-15-28-24(26)27)29-21(31)14-13-17-8-3-1-4-9-17/h1-6,8-11,13-14,19-20H,7,12,15-16H2,(H2,25,32)(H,29,31)(H,30,33)(H4,26,27,28)/t19-,20+/m1/s1
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117n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029126
PNG
(CHEMBL3361429)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2cccc3ccccc23)CC1)Nc1ccccc1
Show InChI InChI=1S/C26H32N6O/c27-25(28)29-17-24(33)30-19-26(31-22-10-2-1-3-11-22)13-15-32(16-14-26)18-21-9-6-8-20-7-4-5-12-23(20)21/h1-12,31H,13-19H2,(H,30,33)(H4,27,28,29)
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129n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402436
PNG
(CHEMBL2208296)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1ccc2cc[nH]c2c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C24H29N7O3/c25-21(32)20(13-15-5-2-1-3-6-15)31-23(34)18(7-4-11-29-24(26)27)30-22(33)17-9-8-16-10-12-28-19(16)14-17/h1-3,5-6,8-10,12,14,18,20,28H,4,7,11,13H2,(H2,25,32)(H,30,33)(H,31,34)(H4,26,27,29)/t18-,20-/m0/s1
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136n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402437
PNG
(CHEMBL2208294)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H30N6O3/c27-23(33)22(16-17-8-2-1-3-9-17)32-25(35)21(14-7-15-30-26(28)29)31-24(34)20-13-6-11-18-10-4-5-12-19(18)20/h1-6,8-13,21-22H,7,14-16H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t21-,22-/m0/s1
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141n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402440
PNG
(CHEMBL2208305)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21+,26?/m1/s1
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142n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402452
PNG
(CHEMBL2208320)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-10-3-1-4-11-19)34-27(37)23(16-9-17-32-28(30)31)33-26(36)22-15-8-7-14-21(22)20-12-5-2-6-13-20/h1-8,10-15,23-24H,9,16-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24-/m1/s1
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155n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029135
PNG
(CHEMBL3361435)
Show SMILES NC(=N)NCC(=O)NCC1(Cc2ccc3ccccc3c2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C27H33N5O/c28-26(29)30-18-25(33)31-20-27(17-22-10-11-23-8-4-5-9-24(23)16-22)12-14-32(15-13-27)19-21-6-2-1-3-7-21/h1-11,16H,12-15,17-20H2,(H,31,33)(H4,28,29,30)
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205n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402455
PNG
(CHEMBL2208334)
Show SMILES COc1cccc(c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C23H30N6O4/c1-33-17-10-5-9-16(14-17)21(31)28-18(11-6-12-27-23(25)26)22(32)29-19(20(24)30)13-15-7-3-2-4-8-15/h2-5,7-10,14,18-19H,6,11-13H2,1H3,(H2,24,30)(H,28,31)(H,29,32)(H4,25,26,27)/t18-,19-/m0/s1
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206n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402438
PNG
(CHEMBL2208307)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m1/s1
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208n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402443
PNG
(CHEMBL2208299)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C29H34N6O3/c30-26(36)24(19-20-11-4-1-5-12-20)35-27(37)23(17-10-18-33-29(31)32)34-28(38)25(21-13-6-2-7-14-21)22-15-8-3-9-16-22/h1-9,11-16,23-25H,10,17-19H2,(H2,30,36)(H,34,38)(H,35,37)(H4,31,32,33)/t23-,24-/m1/s1
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227n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029124
PNG
(CHEMBL3361427)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(CC2CCCCC2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H36N6O/c23-21(24)25-15-20(29)26-17-22(27-19-9-5-2-6-10-19)11-13-28(14-12-22)16-18-7-3-1-4-8-18/h2,5-6,9-10,18,27H,1,3-4,7-8,11-17H2,(H,26,29)(H4,23,24,25)
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298n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029185
PNG
(CHEMBL3360834)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)NCC1(CCN(Cc2ccc3ccccc3c2)CC1)Nc1ccccc1
Show InChI InChI=1/C29H39N7O/c30-26(11-6-16-33-28(31)32)27(37)34-21-29(35-25-9-2-1-3-10-25)14-17-36(18-15-29)20-22-12-13-23-7-4-5-8-24(23)19-22/h1-5,7-10,12-13,19,26,35H,6,11,14-18,20-21,30H2,(H,34,37)(H4,31,32,33)/t26-/s2
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304n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [125I]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029098
PNG
(CHEMBL3361418)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccccc2)CC1)Nc1cccc2ccccc12
Show InChI InChI=1S/C26H32N6O/c27-25(28)29-17-24(33)30-19-26(31-23-12-6-10-21-9-4-5-11-22(21)23)13-15-32(16-14-26)18-20-7-2-1-3-8-20/h1-12,31H,13-19H2,(H,30,33)(H4,27,28,29)
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309n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029125
PNG
(CHEMBL3361428)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(CCc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C23H32N6O/c24-22(25)26-17-21(30)27-18-23(28-20-9-5-2-6-10-20)12-15-29(16-13-23)14-11-19-7-3-1-4-8-19/h1-10,28H,11-18H2,(H,27,30)(H4,24,25,26)
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330n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029336
PNG
(CHEMBL3361416)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccccc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H30N6O/c23-21(24)25-15-20(29)26-17-22(27-19-9-5-2-6-10-19)11-13-28(14-12-22)16-18-7-3-1-4-8-18/h1-10,27H,11-17H2,(H,26,29)(H4,23,24,25)
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405n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029120
PNG
(CHEMBL3361421)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccccc2)CC1)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H28Cl2N6O/c23-18-7-6-17(12-19(18)24)29-22(15-28-20(31)13-27-21(25)26)8-10-30(11-9-22)14-16-4-2-1-3-5-16/h1-7,12,29H,8-11,13-15H2,(H,28,31)(H4,25,26,27)
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409n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402448
PNG
(CHEMBL2208326)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-8-3-1-4-9-19)34-27(37)23(12-7-17-32-28(30)31)33-26(36)22-15-13-21(14-16-22)20-10-5-2-6-11-20/h1-6,8-11,13-16,23-24H,7,12,17-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24-/m1/s1
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417n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402439
PNG
(CHEMBL2208306)
Show SMILES NC(N)=NCCC[C@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21+,26?/m0/s1
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424n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402446
PNG
(CHEMBL2208316)
Show SMILES NC(N)=NCCC[C@@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C23H30N6O3/c24-21(31)19(14-16-8-3-1-4-9-16)29-22(32)18(12-7-13-27-23(25)26)28-20(30)15-17-10-5-2-6-11-17/h1-6,8-11,18-19H,7,12-15H2,(H2,24,31)(H,28,30)(H,29,32)(H4,25,26,27)/t18-,19+/m1/s1
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425n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029128
PNG
(CHEMBL3361431)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccc(Br)cc2)CC1)Nc1ccccc1
Show InChI InChI=1S/C22H29BrN6O/c23-18-8-6-17(7-9-18)15-29-12-10-22(11-13-29,28-19-4-2-1-3-5-19)16-27-20(30)14-26-21(24)25/h1-9,28H,10-16H2,(H,27,30)(H4,24,25,26)
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454n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029122
PNG
(CHEMBL3361424)
Show SMILES NC(=N)NCC(=O)NCC1(CCc2ccccc2)CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C24H33N5O/c25-23(26)27-17-22(30)28-19-24(12-11-20-7-3-1-4-8-20)13-15-29(16-14-24)18-21-9-5-2-6-10-21/h1-10H,11-19H2,(H,28,30)(H4,25,26,27)
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465n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50029127
PNG
(CHEMBL3361430)
Show SMILES NC(=N)NCC(=O)NCC1(CCN(Cc2ccc3ccccc3c2)CC1)Nc1ccccc1
Show InChI InChI=1S/C26H32N6O/c27-25(28)29-17-24(33)30-19-26(31-23-8-2-1-3-9-23)12-14-32(15-13-26)18-20-10-11-21-6-4-5-7-22(21)16-20/h1-11,16,31H,12-15,17-19H2,(H,30,33)(H4,27,28,29)
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504n/an/an/an/an/an/an/an/a



The University of Mississippi

Curated by ChEMBL


Assay Description
Displacement of [3H]EYF from human NPFF2 receptor expressed in CHO cells after 1 hr by liquid scintillation counting analysis


J Med Chem 57: 8903-27 (2014)

More data for this
Ligand-Target Pair
NPFF2


(HUMAN)
BDBM50402454
PNG
(CHEMBL2208337)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H32N6O3/c29-25(35)24(18-19-10-3-1-4-11-19)34-27(37)23(16-9-17-32-28(30)31)33-26(36)22-15-8-7-14-21(22)20-12-5-2-6-13-20/h1-8,10-15,23-24H,9,16-18H2,(H2,29,35)(H,33,36)(H,34,37)(H4,30,31,32)/t23-,24-/m0/s1
UniProtKB/SwissProt

antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
590n/an/an/an/an/an/an/an/a



University of Strasbourg

Curated by ChEMBL


Assay Description
Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting


Bioorg Med Chem Lett 22: 7471-4 (2012)

More data for this
Ligand-Target Pair
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