BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 195 hits Enz. Inhib. hit(s) with Target = 'NR1/NR2A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NR1/NR2A


(Homo sapiens (Human))
BDBM50130937
PNG
(DEXOXADROL | Dexoxadrol | Dioxadrol)
Show SMILES C1OC(O[C@H]1[C@@H]1CCCCN1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H23NO2/c1-3-9-16(10-4-1)20(17-11-5-2-6-12-17)22-15-19(23-20)18-13-7-8-14-21-18/h1-6,9-12,18-19,21H,7-8,13-15H2/t18-,19+/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
19n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Inhibition of [3H]-U-69,593 binding to Opioid receptor kappa 1


J Med Chem 58: 8601-15 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01214
BindingDB Entry DOI: 10.7270/Q2GM894Q
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50130938
PNG
(ETOXADROL | Etoxadrol)
Show SMILES CC[C@@]1(OC[C@@H](O1)[C@@H]1CCCCN1)c1ccccc1
Show InChI InChI=1S/C16H23NO2/c1-2-16(13-8-4-3-5-9-13)18-12-15(19-16)14-10-6-7-11-17-14/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3/t14-,15+,16-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
22n/an/an/an/an/an/an/an/a



Universit£ di Camerino

Curated by ChEMBL


Assay Description
Binding affinity to NMDA receptor (unknown origin)


J Med Chem 58: 8601-15 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01214
BindingDB Entry DOI: 10.7270/Q2GM894Q
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50033369
PNG
(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)
Show SMILES NC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
1.00E+4n/an/an/an/an/an/an/an/a



Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H]-(+)-MK-801 from phencyclidine binding site of NMDA receptor in human frontal cortex after 22 hrs by scintillation counting analy...


Bioorg Med Chem 23: 4277-85 (2015)


Article DOI: 10.1016/j.bmc.2015.06.030
BindingDB Entry DOI: 10.7270/Q29Z96NG
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451503
PNG
(CHEMBL12513)
Show SMILES Oc1nc2cc(cc(CP(O)(O)=O)c2nc1O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClN2O5P/c16-11-3-1-8(2-4-11)9-5-10(7-24(21,22)23)13-12(6-9)17-14(19)15(20)18-13/h1-6H,7H2,(H,17,19)(H,18,20)(H2,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.200n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50062599
PNG
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | MEM...)
Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2
Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PubMed
n/an/a 0.950n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451505
PNG
(CHEMBL274422)
Show SMILES OC(c1cccc2nc(O)c(O)nc12)P(O)(O)=O
Show InChI InChI=1S/C9H9N2O6P/c12-7-8(13)11-6-4(9(14)18(15,16)17)2-1-3-5(6)10-7/h1-3,9,14H,(H,10,12)(H,11,13)(H2,15,16,17)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50492253
PNG
(CHEMBL2398522)
Show SMILES C(CCCCCCNCCCCCCNCC(c1ccccc1)c1ccccc1)CCCCCNCCCCCCNCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C52H78N4/c1(3-5-7-25-39-53-41-27-9-11-29-43-55-45-51(47-31-17-13-18-32-47)48-33-19-14-20-34-48)2-4-6-8-26-40-54-42-28-10-12-30-44-56-46-52(49-35-21-15-22-36-49)50-37-23-16-24-38-50/h13-24,31-38,51-56H,1-12,25-30,39-46H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 4.20n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451498
PNG
(CHEMBL536107)
Show SMILES Oc1nc2cccc(C(NCc3ccccc3)P(O)(O)=O)c2nc1O
Show InChI InChI=1S/C16H16N3O5P.BrH/c20-14-15(21)19-13-11(7-4-8-12(13)18-14)16(25(22,23)24)17-9-10-5-2-1-3-6-10;/h1-8,16-17H,9H2,(H,18,20)(H,19,21)(H2,22,23,24);1H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50492252
PNG
(CHEMBL55568)
Show SMILES C(CCCCNCCCCCCNCC(c1ccccc1)c1ccccc1)CCCNCCCCCCNCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C48H70N4/c1(3-21-35-49-37-23-5-7-25-39-51-41-47(43-27-13-9-14-28-43)44-29-15-10-16-30-44)2-4-22-36-50-38-24-6-8-26-40-52-42-48(45-31-17-11-18-32-45)46-33-19-12-20-34-46/h9-20,27-34,47-52H,1-8,21-26,35-42H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 11n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451509
PNG
(CHEMBL268920)
Show SMILES C[C@H](NC(c1cccc2nc(O)c(O)nc12)P(O)(O)=O)c1ccccc1
Show InChI InChI=1S/C17H18N3O5P/c1-10(11-6-3-2-4-7-11)18-17(26(23,24)25)12-8-5-9-13-14(12)20-16(22)15(21)19-13/h2-10,17-18H,1H3,(H,19,21)(H,20,22)(H2,23,24,25)/t10-,17?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451518
PNG
(CHEMBL12256)
Show SMILES Oc1nc2cccc(C(NCCc3ccccc3)P(O)(O)=O)c2nc1O
Show InChI InChI=1S/C17H18N3O5P/c21-15-16(22)20-14-12(7-4-8-13(14)19-15)17(26(23,24)25)18-10-9-11-5-2-1-3-6-11/h1-8,17-18H,9-10H2,(H,19,21)(H,20,22)(H2,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50329477
PNG
((S)-N-(3-(4-(3-aminopropylamino)butylamino)propyl)...)
Show SMILES NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)Cc1cccc2ccccc12
Show InChI InChI=1S/C31H49N5O2/c32-17-9-20-33-18-6-7-19-34-21-10-22-35-31(38)29(23-25-11-2-1-3-12-25)36-30(37)24-27-15-8-14-26-13-4-5-16-28(26)27/h4-5,8,13-16,25,29,33-34H,1-3,6-7,9-12,17-24,32H2,(H,35,38)(H,36,37)/t29-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...


J Med Chem 53: 7441-51 (2010)


Article DOI: 10.1021/jm100886h
BindingDB Entry DOI: 10.7270/Q2125SX4
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451506
PNG
(CHEMBL543489)
Show SMILES Oc1nc2cc(cc(C(NCc3ccccc3)P(O)(=O)Cc3ccccc3)c2nc1O)[N+]([O-])=O
Show InChI InChI=1S/C23H21N4O6P.BrH/c28-21-22(29)26-20-18(11-17(27(30)31)12-19(20)25-21)23(24-13-15-7-3-1-4-8-15)34(32,33)14-16-9-5-2-6-10-16;/h1-12,23-24H,13-14H2,(H,25,28)(H,26,29)(H,32,33);1H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451513
PNG
(CHEMBL273686)
Show SMILES C[C@@H](NC(c1cccc2nc(O)c(O)nc12)P(O)(O)=O)c1ccccc1
Show InChI InChI=1S/C17H18N3O5P/c1-10(11-6-3-2-4-7-11)18-17(26(23,24)25)12-8-5-9-13-14(12)20-16(22)15(21)19-13/h2-10,17-18H,1H3,(H,19,21)(H,20,22)(H2,23,24,25)/t10-,17?/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451515
PNG
(CHEMBL12301)
Show SMILES Oc1nc2cccc(C(N[C@H]3CCc4ccccc34)P(O)(O)=O)c2nc1O
Show InChI InChI=1S/C18H18N3O5P/c22-16-17(23)21-15-12(6-3-7-14(15)19-16)18(27(24,25)26)20-13-9-8-10-4-1-2-5-11(10)13/h1-7,13,18,20H,8-9H2,(H,19,22)(H,21,23)(H2,24,25,26)/t13-,18?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476423
PNG
(CHEMBL228435)
Show SMILES NCCCCNCCCCNCCCCNC(=O)N1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C27H41N5O/c28-17-5-6-18-29-19-7-8-20-30-21-9-10-22-31-27(33)32-25-13-3-1-11-23(25)15-16-24-12-2-4-14-26(24)32/h1-4,11-14,29-30H,5-10,15-22,28H2,(H,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 72n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476427
PNG
(CHEMBL228436)
Show SMILES NCCCCNCCCNCCCCNC(=O)N1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C24H35N5OS/c25-14-5-6-15-26-17-9-18-27-16-7-8-19-28-24(30)29-20-10-1-3-12-22(20)31-23-13-4-2-11-21(23)29/h1-4,10-13,26-27H,5-9,14-19,25H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 78n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50492255
PNG
(CHEMBL2009741)
Show SMILES COc1ccccc1CNCCCCCNCCCCCCCCCCNCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-17-27-37-25-15-7-5-3-4-6-8-16-26-38-28-18-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 89n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451507
PNG
(CHEMBL543252)
Show SMILES CCCNC(c1cc(cc2nc(O)c(O)nc12)[N+]([O-])=O)P(O)(O)=O
Show InChI InChI=1S/C12H15N4O7P.ClH/c1-2-3-13-12(24(21,22)23)7-4-6(16(19)20)5-8-9(7)15-11(18)10(17)14-8;/h4-5,12-13H,2-3H2,1H3,(H,14,17)(H,15,18)(H2,21,22,23);1H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50329480
PNG
((S)-N-(20-amino-2,7-dioxo-1-phenyl-3,8,12,17-tetra...)
Show SMILES NCCCNCCCCNCCCNC(=O)[C@H](CCNC(=O)Cc1ccccc1)NC(=O)c1ccccc1
Show InChI InChI=1S/C29H44N6O3/c30-16-9-19-31-17-7-8-18-32-20-10-21-34-29(38)26(35-28(37)25-13-5-2-6-14-25)15-22-33-27(36)23-24-11-3-1-4-12-24/h1-6,11-14,26,31-32H,7-10,15-23,30H2,(H,33,36)(H,34,38)(H,35,37)/t26-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 106n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...


J Med Chem 53: 7441-51 (2010)


Article DOI: 10.1021/jm100886h
BindingDB Entry DOI: 10.7270/Q2125SX4
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451512
PNG
(CHEMBL268714)
Show SMILES COC(=O)NC(c1cc(cc2nc(O)c(O)nc12)[N+]([O-])=O)P(O)(O)=O
Show InChI InChI=1S/C11H11N4O9P/c1-24-11(18)14-10(25(21,22)23)5-2-4(15(19)20)3-6-7(5)13-9(17)8(16)12-6/h2-3,10H,1H3,(H,12,16)(H,13,17)(H,14,18)(H2,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476430
PNG
(CHEMBL388315)
Show SMILES NCCCCNCCCCNCCCCNC(=O)n1c2ccccc2c2ccccc12
Show InChI InChI=1S/C25H37N5O/c26-15-5-6-16-27-17-7-8-18-28-19-9-10-20-29-25(31)30-23-13-3-1-11-21(23)22-12-2-4-14-24(22)30/h1-4,11-14,27-28H,5-10,15-20,26H2,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 111n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476424
PNG
(CHEMBL228380)
Show SMILES NCCCCNCCCNCCCCNC(=O)N1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C26H39N5O/c27-16-5-6-17-28-19-9-20-29-18-7-8-21-30-26(32)31-24-12-3-1-10-22(24)14-15-23-11-2-4-13-25(23)31/h1-4,10-13,28-29H,5-9,14-21,27H2,(H,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 117n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476432
PNG
(CHEMBL228437)
Show SMILES NCCCCNCCCCNCCCCNC(=O)N1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C25H37N5OS/c26-15-5-6-16-27-17-7-8-18-28-19-9-10-20-29-25(31)30-21-11-1-3-13-23(21)32-24-14-4-2-12-22(24)30/h1-4,11-14,27-28H,5-10,15-20,26H2,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 127n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50064176
PNG
(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Show SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a 138n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476433
PNG
(CHEMBL228486)
Show SMILES NCCCNCCCCNCCCNC(=O)n1c2ccccc2c2ccccc12
Show InChI InChI=1S/C23H33N5O/c24-13-7-16-25-14-5-6-15-26-17-8-18-27-23(29)28-21-11-3-1-9-19(21)20-10-2-4-12-22(20)28/h1-4,9-12,25-26H,5-8,13-18,24H2,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 145n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451520
PNG
(CHEMBL276670)
Show SMILES Oc1nc2cccc(C(NC(c3ccccc3)c3ccccc3)P(O)(O)=O)c2nc1O
Show InChI InChI=1S/C22H20N3O5P/c26-20-21(27)24-19-16(12-7-13-17(19)23-20)22(31(28,29)30)25-18(14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-13,18,22,25H,(H,23,26)(H,24,27)(H2,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476425
PNG
(CHEMBL228325)
Show SMILES NCCCCNCCCNCCCCNC(=O)N1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C26H37N5O/c27-16-5-6-17-28-19-9-20-29-18-7-8-21-30-26(32)31-24-12-3-1-10-22(24)14-15-23-11-2-4-13-25(23)31/h1-4,10-15,28-29H,5-9,16-21,27H2,(H,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 198n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451517
PNG
(CHEMBL536106)
Show SMILES CP(O)(=O)C(NCc1ccccc1)c1cc(cc2nc(O)c(O)nc12)[N+]([O-])=O
Show InChI InChI=1S/C17H17N4O6P.BrH/c1-28(26,27)17(18-9-10-5-3-2-4-6-10)12-7-11(21(24)25)8-13-14(12)20-16(23)15(22)19-13;/h2-8,17-18H,9H2,1H3,(H,19,22)(H,20,23)(H,26,27);1H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476422
PNG
(CHEMBL390304)
Show SMILES NCCCNCCCCNCCCNC(=O)N1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C25H35N5O/c26-15-7-18-27-16-5-6-17-28-19-8-20-29-25(31)30-23-11-3-1-9-21(23)13-14-22-10-2-4-12-24(22)30/h1-4,9-14,27-28H,5-8,15-20,26H2,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 203n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476431
PNG
(CHEMBL390521)
Show SMILES NCCCCNCCCNCCCCNC(=O)n1c2ccccc2c2ccccc12
Show InChI InChI=1S/C24H35N5O/c25-14-5-6-15-26-17-9-18-27-16-7-8-19-28-24(30)29-22-12-3-1-10-20(22)21-11-2-4-13-23(21)29/h1-4,10-13,26-27H,5-9,14-19,25H2,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 211n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476426
PNG
(CHEMBL390305)
Show SMILES NCCCNCCCCNCCCNC(=O)N1c2ccccc2Sc2ccccc12
Show InChI InChI=1S/C23H33N5OS/c24-13-7-16-25-14-5-6-15-26-17-8-18-27-23(29)28-19-9-1-3-11-21(19)30-22-12-4-2-10-20(22)28/h1-4,9-12,25-26H,5-8,13-18,24H2,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 215n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476421
PNG
(CHEMBL228378)
Show SMILES NCCCCNCCCCNCCCCNC(=O)N1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C27H39N5O/c28-17-5-6-18-29-19-7-8-20-30-21-9-10-22-31-27(33)32-25-13-3-1-11-23(25)15-16-24-12-2-4-14-26(24)32/h1-4,11-16,29-30H,5-10,17-22,28H2,(H,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 240n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50492256
PNG
(CHEMBL2398521)
Show SMILES COc1ccccc1CNCCCCCCCCNCCCCCCNCCCCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C38H66N4O2/c1-43-37-25-15-13-23-35(37)33-41-31-21-9-5-3-7-17-27-39-29-19-11-12-20-30-40-28-18-8-4-6-10-22-32-42-34-36-24-14-16-26-38(36)44-2/h13-16,23-26,39-42H,3-12,17-22,27-34H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 257n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50111396
PNG
(CHEMBL273636 | [[(S)-1-(4-Bromo-phenyl)-ethylamino...)
Show SMILES C[C@H](NC(c1cccc2[nH]c(=O)c(=O)[nH]c12)P(O)(O)=O)c1ccc(Br)cc1
Show InChI InChI=1S/C17H17BrN3O5P/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26)/t9-,17?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 270n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50492254
PNG
(CHEMBL2398520)
Show SMILES COc1ccccc1CNCCCCCNCCCCCCNCCCCCNCc1ccccc1OC
Show InChI InChI=1S/C32H54N4O2/c1-37-31-19-9-7-17-29(31)27-35-25-15-5-13-23-33-21-11-3-4-12-22-34-24-14-6-16-26-36-28-30-18-8-10-20-32(30)38-2/h7-10,17-20,33-36H,3-6,11-16,21-28H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 315n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...


Bioorg Med Chem Lett 23: 3901-4 (2013)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476428
PNG
(CHEMBL228324)
Show SMILES NCCCNCCCCNCCCNC(=O)c1ccc2C(=O)c3ccccc3C(=O)c2c1
Show InChI InChI=1S/C25H32N4O3/c26-11-5-14-27-12-3-4-13-28-15-6-16-29-25(32)18-9-10-21-22(17-18)24(31)20-8-2-1-7-19(20)23(21)30/h1-2,7-10,17,27-28H,3-6,11-16,26H2,(H,29,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 392n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM83449
PNG
(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Show SMILES C1CCN(CC1)C1(CCCCC1)c1ccccc1
Show InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

PubMed
n/an/a 398n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay


Bioorg Med Chem Lett 21: 2059-63 (2011)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451510
PNG
(CHEMBL12546)
Show SMILES Oc1nc2cccc(C(Nc3ccccc3)P(O)(O)=O)c2nc1O
Show InChI InChI=1S/C15H14N3O5P/c19-13-14(20)18-12-10(7-4-8-11(12)17-13)15(24(21,22)23)16-9-5-2-1-3-6-9/h1-8,15-16H,(H,17,19)(H,18,20)(H2,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451519
PNG
(CHEMBL12733)
Show SMILES CN(Cc1ccccc1)C(c1cccc2nc(O)c(O)nc12)P(O)(O)=O
Show InChI InChI=1S/C17H18N3O5P/c1-20(10-11-6-3-2-4-7-11)17(26(23,24)25)12-8-5-9-13-14(12)19-16(22)15(21)18-13/h2-9,17H,10H2,1H3,(H,18,21)(H,19,22)(H2,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50498430
PNG
(CHEMBL3594112)
Show SMILES c1ccncc1.C[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](CC[C@]4(C)[C@H]3CC[C@]12C)OS(O)(=O)=O
Show InChI InChI=1S/C20H34O4S.C5H5N/c1-13-4-7-17-16-6-5-14-12-15(24-25(21,22)23)8-10-20(14,3)18(16)9-11-19(13,17)2;1-2-4-6-5-3-1/h13-18H,4-12H2,1-3H3,(H,21,22,23);1-5H/t13-,14+,15+,16-,17-,18-,19+,20-;/m0./s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 600n/an/an/an/an/an/a



Academy of Sciences of the Czech Republic v.v.i.

Curated by ChEMBL


Assay Description
Inhibition of recombinant GluN1/GluN2A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of glutamate-evoked current by whol...


J Med Chem 58: 5950-66 (2015)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50329475
PNG
((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Show SMILES NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)C1CCCCC1
Show InChI InChI=1S/C26H51N5O2/c27-15-9-18-28-16-7-8-17-29-19-10-20-30-26(33)24(21-22-11-3-1-4-12-22)31-25(32)23-13-5-2-6-14-23/h22-24,28-29H,1-21,27H2,(H,30,33)(H,31,32)/t24-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 656n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...


J Med Chem 53: 7441-51 (2010)


Article DOI: 10.1021/jm100886h
BindingDB Entry DOI: 10.7270/Q2125SX4
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM45440
PNG
(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Show SMILES NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 720n/an/an/an/a7.6n/a



Xavier University of Louisiana

Curated by ChEMBL


Assay Description
Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...


Bioorg Med Chem 22: 1983-92 (2014)


Article DOI: 10.1016/j.bmc.2014.02.049
BindingDB Entry DOI: 10.7270/Q2N29ZGG
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50451526
PNG
(CHEMBL12728)
Show SMILES CNC(c1cccc2nc(O)c(O)nc12)P(O)(O)=O
Show InChI InChI=1S/C10H12N3O5P/c1-11-10(19(16,17)18)5-3-2-4-6-7(5)13-9(15)8(14)12-6/h2-4,10-11H,1H3,(H,12,14)(H,13,15)(H2,16,17,18)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 790n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptor


Bioorg Med Chem Lett 12: 1099-102 (2002)


Article DOI: 10.1016/s0960-894x(02)00074-4
BindingDB Entry DOI: 10.7270/Q24B31V2
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50329478
PNG
((S)-2-(2-Adamantan-1-yl-acetylamino)-N-{3-[4-(3-am...)
Show SMILES NCCCNCCCCNCCCNC(=O)[C@H](CC1CCCCC1)NC(=O)CC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C31H57N5O2/c32-10-6-13-33-11-4-5-12-34-14-7-15-35-30(38)28(19-24-8-2-1-3-9-24)36-29(37)23-31-20-25-16-26(21-31)18-27(17-25)22-31/h24-28,33-34H,1-23,32H2,(H,35,38)(H,36,37)/t25?,26?,27?,28-,31?/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 794n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...


J Med Chem 53: 7441-51 (2010)


Article DOI: 10.1021/jm100886h
BindingDB Entry DOI: 10.7270/Q2125SX4
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50062599
PNG
(3,5-Dimethyl-adamantan-1-ylamine | CHEMBL807 | MEM...)
Show SMILES CC12CC3CC(C)(C1)CC(N)(C3)C2
Show InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PubMed
n/an/a 911n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50476429
PNG
(CHEMBL228379)
Show SMILES NCCCNCCCCNCCCNC(=O)N1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C25H37N5O/c26-15-7-18-27-16-5-6-17-28-19-8-20-29-25(31)30-23-11-3-1-9-21(23)13-14-22-10-2-4-12-24(22)30/h1-4,9-12,27-28H,5-8,13-20,26H2,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/a 958n/an/an/an/an/an/a



Chiba University

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant NR1/NR2A receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem Lett 17: 4729-32 (2007)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50329481
PNG
((S)-N-(21-amino-2,8-dioxo-1-phenyl-3,9,13,18-tetra...)
Show SMILES NCCCNCCCCNCCCNC(=O)[C@H](CCCNC(=O)Cc1ccccc1)NC(=O)C1CCCCC1
Show InChI InChI=1S/C30H52N6O3/c31-17-10-20-32-18-7-8-19-33-21-11-23-35-30(39)27(36-29(38)26-14-5-2-6-15-26)16-9-22-34-28(37)24-25-12-3-1-4-13-25/h1,3-4,12-13,26-27,32-33H,2,5-11,14-24,31H2,(H,34,37)(H,35,39)(H,36,38)/t27-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.03E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity at NR1-1a/NR2A receptor expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at -60mV ...


J Med Chem 53: 7441-51 (2010)


Article DOI: 10.1021/jm100886h
BindingDB Entry DOI: 10.7270/Q2125SX4
More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50044140
PNG
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Show SMILES CNC1(CCCCC1=O)c1ccccc1Cl
Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PubMed
n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay


Bioorg Med Chem Lett 21: 2059-63 (2011)

More data for this
Ligand-Target Pair
NR1/NR2A


(Homo sapiens (Human))
BDBM50001000
PNG
(CHEBI:29133 | DEXTRORPHAN)
Show SMILES CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc1ccc(O)cc31
Show InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/a7.6n/a



Xavier University of Louisiana

Curated by ChEMBL


Assay Description
Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...


Bioorg Med Chem 22: 1983-92 (2014)


Article DOI: 10.1016/j.bmc.2014.02.049
BindingDB Entry DOI: 10.7270/Q2N29ZGG
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 195 total )  |  Next  |  Last  >>
Jump to: