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Compile Data Set for Download or QSAR

Found 1705 hits Enz. Inhib. hit(s) with Target = 'Neprilysin'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50044866
PNG
(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Show SMILES OC(=O)[C@H]1CCCC2N1C(=O)C(Cc1ccccc21)NC(=O)C(S)Cc1ccccc1
Show InChI InChI=1S/C24H26N2O4S/c27-22(21(31)13-15-7-2-1-3-8-15)25-18-14-16-9-4-5-10-17(16)19-11-6-12-20(24(29)30)26(19)23(18)28/h1-5,7-10,18-21,31H,6,11-14H2,(H,25,27)(H,29,30)/t18?,19?,20-,21?/m1/s1
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0.0700n/an/an/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determined


J Med Chem 36: 2420-3 (1993)


Article DOI: 10.1021/jm00068a022
BindingDB Entry DOI: 10.7270/Q22N51C1
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50175518
PNG
((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Show SMILES OC(=O)[C@H]1CCCC2N1C(=O)[C@H](Cc1ccccc21)NC(=O)[C@H](S)Cc1ccccc1
Show InChI InChI=1S/C24H26N2O4S/c27-22(21(31)13-15-7-2-1-3-8-15)25-18-14-16-9-4-5-10-17(16)19-11-6-12-20(24(29)30)26(19)23(18)28/h1-5,7-10,18-21,31H,6,11-14H2,(H,25,27)(H,29,30)/t18-,19?,20+,21+/m0/s1
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0.0700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of neutral endopeptidase (NEP).


Bioorg Med Chem Lett 6: 957-962 (1996)


Article DOI: 10.1016/0960-894X(96)00149-7
BindingDB Entry DOI: 10.7270/Q2BV7GMV
More data for this
Ligand-Target Pair
Neprilysin


(Rattus norvegicus (Rat))
BDBM50044866
PNG
(7-(2-Mercapto-3-phenyl-propionylamino)-6-oxo-1,2,3...)
Show SMILES OC(=O)[C@H]1CCCC2N1C(=O)C(Cc1ccccc21)NC(=O)C(S)Cc1ccccc1
Show InChI InChI=1S/C24H26N2O4S/c27-22(21(31)13-15-7-2-1-3-8-15)25-18-14-16-9-4-5-10-17(16)19-11-6-12-20(24(29)30)26(19)23(18)28/h1-5,7-10,18-21,31H,6,11-14H2,(H,25,27)(H,29,30)/t18?,19?,20-,21?/m1/s1
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0.0800n/an/an/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
Binding affinity of compound against rat kidney neutral endopeptidase (NEP) was determined


J Med Chem 36: 2420-3 (1993)


Article DOI: 10.1021/jm00068a022
BindingDB Entry DOI: 10.7270/Q22N51C1
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50287694
PNG
(3-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Show SMILES COC(=O)CCNC(=O)C1(CS)CCc2ccccc2C1
Show InChI InChI=1S/C16H21NO3S/c1-20-14(18)7-9-17-15(19)16(11-21)8-6-12-4-2-3-5-13(12)10-16/h2-5,21H,6-11H2,1H3,(H,17,19)
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0.200n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase(NEP).


Bioorg Med Chem Lett 6: 2053-2058 (1996)


Article DOI: 10.1016/0960-894X(96)00367-8
BindingDB Entry DOI: 10.7270/Q29G5MSW
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50411736
PNG
(CHEMBL271225)
Show SMILES CC(C)C[C@H](S)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H25NO3S/c1-14(2)12-19(26)20(23)22-18(21(24)25)13-15-8-10-17(11-9-15)16-6-4-3-5-7-16/h3-11,14,18-19,26H,12-13H2,1-2H3,(H,22,23)(H,24,25)/t18-,19-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NEP by fluorescence assay


Bioorg Med Chem Lett 18: 732-7 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.048
BindingDB Entry DOI: 10.7270/Q2GT5PCB
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50287702
PNG
((S)-2-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphth...)
Show SMILES C[C@H](NC(=O)C1(CS)CCc2ccccc2C1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C22H25NO3S/c1-16(20(24)26-14-17-7-3-2-4-8-17)23-21(25)22(15-27)12-11-18-9-5-6-10-19(18)13-22/h2-10,16,27H,11-15H2,1H3,(H,23,25)/t16-,22?/m0/s1
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0.300n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase(NEP).


Bioorg Med Chem Lett 6: 2053-2058 (1996)


Article DOI: 10.1016/0960-894X(96)00367-8
BindingDB Entry DOI: 10.7270/Q29G5MSW
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50289194
PNG
((S)-2-[(S)-4-((R)-2-Mercapto-3-phenyl-propionylami...)
Show SMILES CC(C)C[C@H](N1Cc2ccccc2C[C@H](NC(=O)[C@H](S)Cc2ccccc2)C1=O)C(O)=O
Show InChI InChI=1S/C25H30N2O4S/c1-16(2)12-21(25(30)31)27-15-19-11-7-6-10-18(19)14-20(24(27)29)26-23(28)22(32)13-17-8-4-3-5-9-17/h3-11,16,20-22,32H,12-15H2,1-2H3,(H,26,28)(H,30,31)/t20-,21-,22+/m0/s1
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0.400n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of neutral endopeptidase (NEP).


Bioorg Med Chem Lett 6: 957-962 (1996)


Article DOI: 10.1016/0960-894X(96)00149-7
BindingDB Entry DOI: 10.7270/Q2BV7GMV
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50287689
PNG
(CHEMBL304233 | [(2-Mercaptomethyl-1,2,3,4-tetrahyd...)
Show SMILES SCC1(CCc2ccccc2C1)C(=O)NCC(=O)OCc1ccccc1
Show InChI InChI=1S/C21H23NO3S/c23-19(25-14-16-6-2-1-3-7-16)13-22-20(24)21(15-26)11-10-17-8-4-5-9-18(17)12-21/h1-9,26H,10-15H2,(H,22,24)
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0.400n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase(NEP).


Bioorg Med Chem Lett 6: 2053-2058 (1996)


Article DOI: 10.1016/0960-894X(96)00367-8
BindingDB Entry DOI: 10.7270/Q29G5MSW
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50287700
PNG
((S)-3-(4-Hydroxy-phenyl)-2-[(2-mercaptomethyl-1,2,...)
Show SMILES Oc1ccc(C[C@H](NC(=O)C2(CS)CCc3ccccc3C2)C(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C28H29NO4S/c30-24-12-10-20(11-13-24)16-25(26(31)33-18-21-6-2-1-3-7-21)29-27(32)28(19-34)15-14-22-8-4-5-9-23(22)17-28/h1-13,25,30,34H,14-19H2,(H,29,32)/t25-,28?/m0/s1
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0.5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase(NEP).


Bioorg Med Chem Lett 6: 2053-2058 (1996)


Article DOI: 10.1016/0960-894X(96)00367-8
BindingDB Entry DOI: 10.7270/Q29G5MSW
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50287699
PNG
(4-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Show SMILES OC(=O)C1CCC(CC1)NC(=O)C1(CS)CCc2ccccc2C1
Show InChI InChI=1S/C19H25NO3S/c21-17(22)14-5-7-16(8-6-14)20-18(23)19(12-24)10-9-13-3-1-2-4-15(13)11-19/h1-4,14,16,24H,5-12H2,(H,20,23)(H,21,22)
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0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase(NEP).


Bioorg Med Chem Lett 6: 2053-2058 (1996)


Article DOI: 10.1016/0960-894X(96)00367-8
BindingDB Entry DOI: 10.7270/Q29G5MSW
More data for this
Ligand-Target Pair
Neutral Endopeptidase (NEP)


(Rattus norvegicus (Rat))
BDBM50287690
PNG
(7-[(2-Mercaptomethyl-1,2,3,4-tetrahydro-naphthalen...)
Show SMILES OC(=O)CCCCCCNC(=O)C1(CS)CCc2ccccc2C1
Show InChI InChI=1S/C19H27NO3S/c21-17(22)9-3-1-2-6-12-20-18(23)19(14-24)11-10-15-7-4-5-8-16(15)13-19/h4-5,7-8,24H,1-3,6,9-14H2,(H,20,23)(H,21,22)
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0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of neutral endopeptidase(NEP).


Bioorg Med Chem Lett 6: 2053-2058 (1996)


Article DOI: 10.1016/0960-894X(96)00367-8
BindingDB Entry DOI: 10.7270/Q29G5MSW
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50024101
PNG
((S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamin...)
Show SMILES C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C13H17NO3S/c1-9(13(16)17)14-12(15)11(8-18)7-10-5-3-2-4-6-10/h2-6,9,11,18H,7-8H2,1H3,(H,14,15)(H,16,17)/t9-,11+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Pharmaleads , Paris BioPark, 11 Rue Watt, 75013 Paris, France.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NEP using Suc-Ala-Ala-Phe-AMC as substrate after 30 mins by fluorimetry


J Med Chem 57: 5748-63 (2014)


Article DOI: 10.1021/jm500602h
BindingDB Entry DOI: 10.7270/Q2Q241TH
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM21653
PNG
((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Show SMILES OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)[C@H]1CCc2ccccc12
Show InChI InChI=1S/C23H24N2O3S/c26-22(19(13-29)18-10-9-14-5-1-2-6-16(14)18)25-21(23(27)28)11-15-12-24-20-8-4-3-7-17(15)20/h1-8,12,18-19,21,24,29H,9-11,13H2,(H,25,26)(H,27,28)/t18-,19+,21-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
In vitro inhibition of Neutral endopeptidase.


Bioorg Med Chem Lett 12: 2001-5 (2002)


Article DOI: 10.1016/s0960-894x(02)00248-2
BindingDB Entry DOI: 10.7270/Q27080S4
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM21653
PNG
((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Show SMILES OC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CS)[C@H]1CCc2ccccc12
Show InChI InChI=1S/C23H24N2O3S/c26-22(19(13-29)18-10-9-14-5-1-2-6-16(14)18)25-21(23(27)28)11-15-12-24-20-8-4-3-7-17(15)20/h1-8,12,18-19,21,24,29H,9-11,13H2,(H,25,26)(H,27,28)/t18-,19+,21-/m0/s1
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0.700 -54.4n/an/an/an/an/a7.437



CNRS



Assay Description
NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...


J Med Chem 45: 1477-86 (2002)


Article DOI: 10.1021/jm0005454
BindingDB Entry DOI: 10.7270/Q2T72FQ1
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM50411731
PNG
(CHEMBL257726)
Show SMILES CC[C@H](S)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C19H21NO3S/c1-2-17(24)18(21)20-16(19(22)23)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11,16-17,24H,2,12H2,1H3,(H,20,21)(H,22,23)/t16-,17-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NEP by fluorescence assay


Bioorg Med Chem Lett 18: 732-7 (2008)


Article DOI: 10.1016/j.bmcl.2007.11.048
BindingDB Entry DOI: 10.7270/Q2GT5PCB
More data for this
Ligand-Target Pair
Neprilysin


(Oryctolagus cuniculus (rabbit))
BDBM50087104
PNG
(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Show SMILES [NH3+][C@H](c1ccccc1)P(O)(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)NCC(O)=O
Show InChI InChI=1S/C25H27N2O5P/c26-24(21-9-5-2-6-10-21)33(31,32)17-22(25(30)27-16-23(28)29)15-18-11-13-20(14-12-18)19-7-3-1-4-8-19/h1-14,22,24H,15-17,26H2,(H,27,30)(H,28,29)(H,31,32)/p+1/t22-,24+/m1/s1
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0.940n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.


J Med Chem 43: 1398-408 (2001)


Article DOI: 10.1021/jm990483l
BindingDB Entry DOI: 10.7270/Q2TQ627J
More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300257
PNG
(US9593110, 2-5)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C23H22ClFN2O6/c1-32-12-15(23(30)31)9-17(26-22(29)20-11-21(28)27-33-20)8-13-2-4-14(5-3-13)18-10-16(24)6-7-19(18)25/h2-7,10-11,15,17H,8-9,12H2,1H3,(H,26,29)(H,27,28)(H,30,31)/t15-,17+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300258
PNG
(US9593110, 18-3)
Show SMILES Cc1cnc(o1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H20Cl2FN3O4/c1-11-10-27-21(32-11)20(29)28-15(9-19(26)22(30)31)6-13-3-2-12(7-17(13)24)16-8-14(23)4-5-18(16)25/h2-5,7-8,10,15,19H,6,9,26H2,1H3,(H,28,29)(H,30,31)/t15-,19-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300260
PNG
(US9593110, 2-6)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(OC)no1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O6/c1-32-13-16(24(30)31)10-18(27-23(29)21-12-22(33-2)28-34-21)9-14-3-5-15(6-4-14)19-11-17(25)7-8-20(19)26/h3-8,11-12,16,18H,9-10,13H2,1-2H3,(H,27,29)(H,30,31)/t16-,18+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300262
PNG
(US9593110, 59)
Show SMILES OC(=O)[C@@H](CC(Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cnn[nH]1)C1CCNCC1
Show InChI InChI=1S/C25H27ClFN5O3/c26-18-5-6-22(27)20(12-18)16-3-1-15(2-4-16)11-19(30-24(33)23-14-29-32-31-23)13-21(25(34)35)17-7-9-28-10-8-17/h1-6,12,14,17,19,21,28H,7-11,13H2,(H,30,33)(H,34,35)(H,29,31,32)/t19?,21-/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300263
PNG
(US9593110, 2-7)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncco1)C(O)=O
Show InChI InChI=1S/C23H22ClFN2O5/c1-31-13-16(23(29)30)11-18(27-21(28)22-26-8-9-32-22)10-14-2-4-15(5-3-14)19-12-17(24)6-7-20(19)25/h2-9,12,16,18H,10-11,13H2,1H3,(H,27,28)(H,29,30)/t16-,18+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300266
PNG
(US9593110, 2-8)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cocn1)C(O)=O
Show InChI InChI=1S/C23H22ClFN2O5/c1-31-11-16(23(29)30)9-18(27-22(28)21-12-32-13-26-21)8-14-2-4-15(5-3-14)19-10-17(24)6-7-20(19)25/h2-7,10,12-13,16,18H,8-9,11H2,1H3,(H,27,28)(H,29,30)/t16-,18+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300267
PNG
(US9593110, 18-6)
Show SMILES CCc1cc(on1)C(=O)N[C@@H](C[C@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H22Cl2FN3O4/c1-2-15-11-21(33-29-15)22(30)28-16(10-20(27)23(31)32)7-13-4-3-12(8-18(13)25)17-9-14(24)5-6-19(17)26/h3-6,8-9,11,16,20H,2,7,10,27H2,1H3,(H,28,30)(H,31,32)/t16-,20+/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300268
PNG
(US9593110, 2-9)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1coc(n1)C1CC1)C(O)=O
Show InChI InChI=1S/C26H26ClFN2O5/c1-34-13-18(26(32)33)11-20(29-24(31)23-14-35-25(30-23)17-6-7-17)10-15-2-4-16(5-3-15)21-12-19(27)8-9-22(21)28/h2-5,8-9,12,14,17-18,20H,6-7,10-11,13H2,1H3,(H,29,31)(H,32,33)/t18-,20+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300278
PNG
(US9593110, 18-11)
Show SMILES COc1cnc(o1)C(=O)N[C@@H](C[C@@H](N)C(O)=O)Cc1ccc(cc1Cl)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C22H20Cl2FN3O5/c1-32-19-10-27-21(33-19)20(29)28-14(9-18(26)22(30)31)6-12-3-2-11(7-16(12)24)15-8-13(23)4-5-17(15)25/h2-5,7-8,10,14,18H,6,9,26H2,1H3,(H,28,29)(H,30,31)/t14-,18-/m1/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300279
PNG
(US9593110, 2-14)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ccc(cn1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C26H23ClF4N2O4/c1-37-14-17(25(35)36)11-20(33-24(34)23-9-6-18(13-32-23)26(29,30)31)10-15-2-4-16(5-3-15)21-12-19(27)7-8-22(21)28/h2-9,12-13,17,20H,10-11,14H2,1H3,(H,33,34)(H,35,36)/t17-,20+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300281
PNG
(US9593110, 2-15)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncc(C)o1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O5/c1-14-12-27-23(33-14)22(29)28-19(10-17(13-32-2)24(30)31)9-15-3-5-16(6-4-15)20-11-18(25)7-8-21(20)26/h3-8,11-12,17,19H,9-10,13H2,1-2H3,(H,28,29)(H,30,31)/t17-,19+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300282
PNG
(US9593110, 2-16)
Show SMILES CCOc1cc(n[nH]1)C(=O)N[C@@H](C[C@@H](COC)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C25H27ClFN3O5/c1-3-35-23-13-22(29-30-23)24(31)28-19(11-17(14-34-2)25(32)33)10-15-4-6-16(7-5-15)20-12-18(26)8-9-21(20)27/h4-9,12-13,17,19H,3,10-11,14H2,1-2H3,(H,28,31)(H,29,30)(H,32,33)/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300283
PNG
(US9593110, 21-1)
Show SMILES CCc1cc(on1)C(=O)N[C@@H](C[C@@H](CN)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C24H25ClFN3O4/c1-2-18-12-22(33-29-18)23(30)28-19(10-16(13-27)24(31)32)9-14-3-5-15(6-4-14)20-11-17(25)7-8-21(20)26/h3-8,11-12,16,19H,2,9-10,13,27H2,1H3,(H,28,30)(H,31,32)/t16-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300284
PNG
(US9593110, 4-1)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C23H22ClF3N4O4/c1-35-12-16(21(33)34)11-18(28-20(32)19-29-22(31-30-19)23(25,26)27)9-13-5-7-14(8-6-13)15-3-2-4-17(24)10-15/h2-8,10,16,18H,9,11-12H2,1H3,(H,28,32)(H,33,34)(H,29,30,31)/t16-,18+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300286
PNG
(US9593110, 4-2)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C23H23ClN2O6/c1-31-13-17(23(29)30)11-19(25-22(28)20-12-21(27)26-32-20)9-14-5-7-15(8-6-14)16-3-2-4-18(24)10-16/h2-8,10,12,17,19H,9,11,13H2,1H3,(H,25,28)(H,26,27)(H,29,30)/t17-,19+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300287
PNG
(US9593110, 21-3)
Show SMILES Cc1cnc(o1)C(=O)N[C@@H](C[C@@H](CN)C(O)=O)Cc1ccc(cc1)-c1cc(Cl)ccc1F
Show InChI InChI=1S/C23H23ClFN3O4/c1-13-12-27-22(32-13)21(29)28-18(9-16(11-26)23(30)31)8-14-2-4-15(5-3-14)19-10-17(24)6-7-20(19)25/h2-7,10,12,16,18H,8-9,11,26H2,1H3,(H,28,29)(H,30,31)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300288
PNG
(US9593110, 4-3)
Show SMILES COC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C22H22ClN3O6/c1-31-12-16(21(28)29)11-18(24-20(27)19-25-22(30)32-26-19)9-13-5-7-14(8-6-13)15-3-2-4-17(23)10-15/h2-8,10,16,18H,9,11-12H2,1H3,(H,24,27)(H,28,29)(H,25,26,30)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300292
PNG
(US9593110, 7-1)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C23H24ClFN4O4/c1-2-33-13-16(23(31)32)10-18(27-22(30)21-12-26-29-28-21)9-14-3-5-15(6-4-14)19-11-17(24)7-8-20(19)25/h3-8,11-12,16,18H,2,9-10,13H2,1H3,(H,27,30)(H,31,32)(H,26,28,29)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300294
PNG
(US9593110, 7-2)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1[nH]nc(C2CC2)c1F)C(O)=O
Show InChI InChI=1S/C27H28ClF2N3O4/c1-2-37-14-18(27(35)36)12-20(31-26(34)25-23(30)24(32-33-25)17-7-8-17)11-15-3-5-16(6-4-15)21-13-19(28)9-10-22(21)29/h3-6,9-10,13,17-18,20H,2,7-8,11-12,14H2,1H3,(H,31,34)(H,32,33)(H,35,36)/t18-,20+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300295
PNG
(US9593110, 7-3)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(n[nH]1)C(C)=O)C(O)=O
Show InChI InChI=1S/C26H27ClFN3O5/c1-3-36-14-18(26(34)35)11-20(29-25(33)24-13-23(15(2)32)30-31-24)10-16-4-6-17(7-5-16)21-12-19(27)8-9-22(21)28/h4-9,12-13,18,20H,3,10-11,14H2,1-2H3,(H,29,33)(H,30,31)(H,34,35)/t18-,20+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300296
PNG
(US9593110, 7-4)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(O)no1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O6/c1-2-33-13-16(24(31)32)10-18(27-23(30)21-12-22(29)28-34-21)9-14-3-5-15(6-4-14)19-11-17(25)7-8-20(19)26/h3-8,11-12,16,18H,2,9-10,13H2,1H3,(H,27,30)(H,28,29)(H,31,32)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300297
PNG
(US9593110, 7-5)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(CC)no1)C(O)=O
Show InChI InChI=1S/C26H28ClFN2O5/c1-3-20-14-24(35-30-20)25(31)29-21(12-18(26(32)33)15-34-4-2)11-16-5-7-17(8-6-16)22-13-19(27)9-10-23(22)28/h5-10,13-14,18,21H,3-4,11-12,15H2,1-2H3,(H,29,31)(H,32,33)/t18-,21+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300298
PNG
(US9593110, 7-6)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncco1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O5/c1-2-32-14-17(24(30)31)12-19(28-22(29)23-27-9-10-33-23)11-15-3-5-16(6-4-15)20-13-18(25)7-8-21(20)26/h3-10,13,17,19H,2,11-12,14H2,1H3,(H,28,29)(H,30,31)/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300303
PNG
(US9593110, 7-9)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]c(=O)o1)C(O)=O
Show InChI InChI=1S/C24H24ClFN2O6/c1-2-33-13-16(23(30)31)10-18(28-22(29)21-12-27-24(32)34-21)9-14-3-5-15(6-4-14)19-11-17(25)7-8-20(19)26/h3-8,11-12,16,18H,2,9-10,13H2,1H3,(H,27,32)(H,28,29)(H,30,31)/t16-,18+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300304
PNG
(US9593110, 7-10)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H23ClFN3O6/c1-2-33-12-15(22(30)31)10-17(26-21(29)20-27-23(32)34-28-20)9-13-3-5-14(6-4-13)18-11-16(24)7-8-19(18)25/h3-8,11,15,17H,2,9-10,12H2,1H3,(H,26,29)(H,30,31)(H,27,28,32)/t15-,17+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300305
PNG
(US9593110, 7-11)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncccn1)C(O)=O
Show InChI InChI=1S/C25H25ClFN3O4/c1-2-34-15-18(25(32)33)13-20(30-24(31)23-28-10-3-11-29-23)12-16-4-6-17(7-5-16)21-14-19(26)8-9-22(21)27/h3-11,14,18,20H,2,12-13,15H2,1H3,(H,30,31)(H,32,33)/t18-,20+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300307
PNG
(US9593110, 9-1)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C23H25ClN4O4/c1-2-32-14-18(23(30)31)12-20(26-22(29)21-13-25-28-27-21)10-15-6-8-16(9-7-15)17-4-3-5-19(24)11-17/h3-9,11,13,18,20H,2,10,12,14H2,1H3,(H,26,29)(H,30,31)(H,25,27,28)/t18-,20+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300308
PNG
(US9593110, 9-2)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc([nH]n1)C(C)=O)C(O)=O
Show InChI InChI=1S/C26H28ClN3O5/c1-3-35-15-20(26(33)34)13-22(28-25(32)24-14-23(16(2)31)29-30-24)11-17-7-9-18(10-8-17)19-5-4-6-21(27)12-19/h4-10,12,14,20,22H,3,11,13,15H2,1-2H3,(H,28,32)(H,29,30)(H,33,34)/t20-,22+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300309
PNG
(US9593110, 30-1)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1c[nH]nn1)C(O)=O
Show InChI InChI=1S/C22H21ClFN5O5/c1-34-22(33)27-18(21(31)32)10-15(26-20(30)19-11-25-29-28-19)8-12-2-4-13(5-3-12)16-9-14(23)6-7-17(16)24/h2-7,9,11,15,18H,8,10H2,1H3,(H,26,30)(H,27,33)(H,31,32)(H,25,28,29)/t15-,18-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300310
PNG
(US9593110, 9-3)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1n[nH]c(n1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C24H24ClF3N4O4/c1-2-36-13-17(22(34)35)12-19(29-21(33)20-30-23(32-31-20)24(26,27)28)10-14-6-8-15(9-7-14)16-4-3-5-18(25)11-16/h3-9,11,17,19H,2,10,12-13H2,1H3,(H,29,33)(H,34,35)(H,30,31,32)/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300311
PNG
(US9593110, 30-2)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1cc(n[nH]1)C(C)=O)C(O)=O
Show InChI InChI=1S/C25H24ClFN4O6/c1-13(32)20-12-21(31-30-20)23(33)28-17(11-22(24(34)35)29-25(36)37-2)9-14-3-5-15(6-4-14)18-10-16(26)7-8-19(18)27/h3-8,10,12,17,22H,9,11H2,1-2H3,(H,28,33)(H,29,36)(H,30,31)(H,34,35)/t17-,22-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300312
PNG
(US9593110, 9-4)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(OC)no1)C(O)=O
Show InChI InChI=1S/C25H27ClN2O6/c1-3-33-15-19(25(30)31)13-21(27-24(29)22-14-23(32-2)28-34-22)11-16-7-9-17(10-8-16)18-5-4-6-20(26)12-18/h4-10,12,14,19,21H,3,11,13,15H2,1-2H3,(H,27,29)(H,30,31)/t19-,21+/m0/s1
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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300313
PNG
(US9593110, 30-3)
Show SMILES COC(=O)N[C@H](C[C@@H](Cc1ccc(cc1)-c1cc(Cl)ccc1F)NC(=O)c1ncco1)C(O)=O
Show InChI InChI=1S/C23H21ClFN3O6/c1-33-23(32)28-19(22(30)31)12-16(27-20(29)21-26-8-9-34-21)10-13-2-4-14(5-3-13)17-11-15(24)6-7-18(17)25/h2-9,11,16,19H,10,12H2,1H3,(H,27,29)(H,28,32)(H,30,31)/t16-,19-/m1/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
Neprilysin


(Homo sapiens (Human))
BDBM300314
PNG
(US9593110, 9-5)
Show SMILES CCOC[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1noc(=O)[nH]1)C(O)=O
Show InChI InChI=1S/C23H24ClN3O6/c1-2-32-13-17(22(29)30)12-19(25-21(28)20-26-23(31)33-27-20)10-14-6-8-15(9-7-14)16-4-3-5-18(24)11-16/h3-9,11,17,19H,2,10,12-13H2,1H3,(H,25,28)(H,29,30)(H,26,27,31)/t17-,19+/m0/s1
PDB

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<1n/an/an/an/an/an/an/an/a



Theravence Biopharma R&D IP, LLC

US Patent


Assay Description
Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...


US Patent US9593110 (2017)

More data for this
Ligand-Target Pair
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