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Compile Data Set for Download or QSAR

Found 52 hits Enz. Inhib. hit(s) with Target = 'Neuronal proto-oncogene tyrosine-protein kinase Src'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50318870
PNG
(((4-(2-(cis-4-aminocyclohexyl)-9-ethyl-9H-purin-6-...)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(nc12)[C@H]1CC[C@H](N)CC1
Show InChI InChI=1S/C20H28N6O5P2/c1-2-26-11-22-17-19(24-18(25-20(17)26)13-3-5-14(21)6-4-13)23-15-7-9-16(10-8-15)32(27,28)12-33(29,30)31/h7-11,13-14H,2-6,12,21H2,1H3,(H,27,28)(H,23,24,25)(H2,29,30,31)/t13-,14-
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n/an/a 68n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81725
PNG
(2,6,9-Trisubstituted Purine, AP23517)
Show SMILES CCn1cnc2c(Nc3ccccc3)nc(nc12)[C@H]1CC[C@H](N)CC1
Show InChI InChI=1S/C19H24N6/c1-2-25-12-21-16-18(22-15-6-4-3-5-7-15)23-17(24-19(16)25)13-8-10-14(20)11-9-13/h3-7,12-14H,2,8-11,20H2,1H3,(H,22,23,24)/t13-,14-
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n/an/a 73n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81723
PNG
(2,6,9-Trisubstituted Purine, 10)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(C[C@@H]3CC[C@H](N)CC3)nc12
Show InChI InChI=1S/C21H30N6O5P2/c1-2-27-12-23-19-20(25-18(26-21(19)27)11-14-3-5-15(22)6-4-14)24-16-7-9-17(10-8-16)33(28,29)13-34(30,31)32/h7-10,12,14-15H,2-6,11,13,22H2,1H3,(H,28,29)(H,24,25,26)(H2,30,31,32)/t14-,15+
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n/an/a 101n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81722
PNG
(2,6,9-Trisubstituted Purine, 9)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(C[C@H]3CC[C@H](N)CC3)nc12
Show InChI InChI=1S/C21H30N6O5P2/c1-2-27-12-23-19-20(25-18(26-21(19)27)11-14-3-5-15(22)6-4-14)24-16-7-9-17(10-8-16)33(28,29)13-34(30,31)32/h7-10,12,14-15H,2-6,11,13,22H2,1H3,(H,28,29)(H,24,25,26)(H2,30,31,32)/t14-,15-
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n/an/a 205n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50318870
PNG
(((4-(2-(cis-4-aminocyclohexyl)-9-ethyl-9H-purin-6-...)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(nc12)[C@H]1CC[C@H](N)CC1
Show InChI InChI=1S/C20H28N6O5P2/c1-2-26-11-22-17-19(24-18(25-20(17)26)13-3-5-14(21)6-4-13)23-15-7-9-16(10-8-15)32(27,28)12-33(29,30)31/h7-11,13-14H,2-6,12,21H2,1H3,(H,27,28)(H,23,24,25)(H2,29,30,31)/t13-,14-
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n/an/a 273n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81718
PNG
(2,6,9-Trisubstituted Purine, 4)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(nc12)C1CCNCC1
Show InChI InChI=1S/C19H26N6O5P2/c1-2-25-11-21-16-18(23-17(24-19(16)25)13-7-9-20-10-8-13)22-14-3-5-15(6-4-14)31(26,27)12-32(28,29)30/h3-6,11,13,20H,2,7-10,12H2,1H3,(H,26,27)(H,22,23,24)(H2,28,29,30)
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n/an/a 665n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81720
PNG
(2,6,9-Trisubstituted Purine, 6)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(CCC3CCNCC3)nc12
Show InChI InChI=1S/C21H30N6O5P2/c1-2-27-13-23-19-20(25-18(26-21(19)27)8-3-15-9-11-22-12-10-15)24-16-4-6-17(7-5-16)33(28,29)14-34(30,31)32/h4-7,13,15,22H,2-3,8-12,14H2,1H3,(H,28,29)(H,24,25,26)(H2,30,31,32)
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n/an/a 1.01E+3n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81724
PNG
(2,6,9-Trisubstituted Purine, 11)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(CCCCN)nc12
Show InChI InChI=1S/C18H26N6O5P2/c1-2-24-11-20-16-17(22-15(23-18(16)24)5-3-4-10-19)21-13-6-8-14(9-7-13)30(25,26)12-31(27,28)29/h6-9,11H,2-5,10,12,19H2,1H3,(H,25,26)(H,21,22,23)(H2,27,28,29)
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n/an/a 2.11E+3n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50140172
PNG
(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Show SMILES COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
Show InChI InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
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n/an/a 2.20E+3n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81721
PNG
(2,6,9-Trisubstituted Purine, 7)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(CC3CCCNC3)nc12
Show InChI InChI=1S/C20H28N6O5P2/c1-2-26-12-22-18-19(24-17(25-20(18)26)10-14-4-3-9-21-11-14)23-15-5-7-16(8-6-15)32(27,28)13-33(29,30)31/h5-8,12,14,21H,2-4,9-11,13H2,1H3,(H,27,28)(H,23,24,25)(H2,29,30,31)
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n/an/a 2.30E+3n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM81719
PNG
(2,6,9-Trisubstituted Purine, 5)
Show SMILES CCn1cnc2c(Nc3ccc(cc3)P(O)(=O)CP(O)(O)=O)nc(CC3CCNCC3)nc12
Show InChI InChI=1S/C20H28N6O5P2/c1-2-26-12-22-18-19(24-17(25-20(18)26)11-14-7-9-21-10-8-14)23-15-3-5-16(6-4-15)32(27,28)13-33(29,30)31/h3-6,12,14,21H,2,7-11,13H2,1H3,(H,27,28)(H,23,24,25)(H2,29,30,31)
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n/an/a 2.31E+3n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.



Assay Description
2,6,9-Trisubstituted purines were evaluated for their src kinase inhibitory activities using an ELISA assay.


Chem Biol Drug Des 71: 97-105 (2008)


Article DOI: 10.1111/j.1747-0285.2007.00615.x
BindingDB Entry DOI: 10.7270/Q2FF3QTQ
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384721
PNG
(CHEMBL2037224)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1
Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14-
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384734
PNG
(CHEMBL2037211)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C32H29F3N6O2/c1-40-10-12-41(13-11-40)26-15-20(14-21(16-26)32(33,34)35)30(42)38-24-5-2-4-23(17-24)37-25-7-8-27-28(18-22-6-3-9-36-22)31(43)39-29(27)19-25/h2-9,14-19,36-37H,10-13H2,1H3,(H,38,42)(H,39,43)/b28-18-
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n/an/a 5.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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n/an/a 5.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384725
PNG
(CHEMBL2037209)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14-
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n/an/a 5.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196888
PNG
(CHEMBL3915949)
Show SMILES COc1cc(O)cc(O)c1C(=O)CC(C)C
Show InChI InChI=1S/C12H16O4/c1-7(2)4-9(14)12-10(15)5-8(13)6-11(12)16-3/h5-7,13,15H,4H2,1-3H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196887
PNG
(CHEMBL3908316)
Show SMILES COc1cc(OC)c(CN[C@@H](CO)C(O)=O)c(OC)c1
Show InChI InChI=1S/C13H19NO6/c1-18-8-4-11(19-2)9(12(5-8)20-3)6-14-10(7-15)13(16)17/h4-5,10,14-15H,6-7H2,1-3H3,(H,16,17)/t10-/m0/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384727
PNG
(CHEMBL2037226)
Show SMILES Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1
Show InChI InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
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n/an/a 7.30E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196880
PNG
(CHEMBL3899270)
Show SMILES COc1cc(OC)c(CN[C@@H](CCC(O)=O)C(O)=O)c(OC)c1
Show InChI InChI=1S/C15H21NO7/c1-21-9-6-12(22-2)10(13(7-9)23-3)8-16-11(15(19)20)4-5-14(17)18/h6-7,11,16H,4-5,8H2,1-3H3,(H,17,18)(H,19,20)/t11-/m0/s1
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n/an/a 8.40E+3n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196892
PNG
(CHEMBL3984647)
Show SMILES CC(C)CC(=O)c1c(O)cc(O)cc1OCc1c(no[n+]1[O-])-c1ccccc1
Show InChI InChI=1S/C20H20N2O6/c1-12(2)8-16(24)19-17(25)9-14(23)10-18(19)27-11-15-20(21-28-22(15)26)13-6-4-3-5-7-13/h3-7,9-10,12,23,25H,8,11H2,1-2H3
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n/an/a 8.50E+3n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50384720
PNG
(CHEMBL2037220)
Show SMILES CN1CCN(CC1)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4cc(c[nH]4)C(O)=O)C(=O)Nc3c2)c1
Show InChI InChI=1S/C33H29F3N6O4/c1-41-7-9-42(10-8-41)26-13-19(11-21(14-26)33(34,35)36)30(43)39-23-4-2-3-22(15-23)38-24-5-6-27-28(31(44)40-29(27)17-24)16-25-12-20(18-37-25)32(45)46/h2-6,11-18,37-38H,7-10H2,1H3,(H,39,43)(H,40,44)(H,45,46)/b28-16-
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Tel-fused SRC in mouse BA/F3 cells


ACS Med Chem Lett 3: 140-145 (2012)


Article DOI: 10.1021/ml200261d
BindingDB Entry DOI: 10.7270/Q2SJ1MNM
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196872
PNG
(CHEMBL3924943)
Show SMILES COc1cc(OC)c(C(=O)CC(C)C)c(OC)c1
Show InChI InChI=1S/C14H20O4/c1-9(2)6-11(15)14-12(17-4)7-10(16-3)8-13(14)18-5/h7-9H,6H2,1-5H3
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n/an/a 1.11E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196896
PNG
(CHEMBL3946100)
Show SMILES CCCCC(=O)c1c(O)cc(O)cc1O
Show InChI InChI=1S/C11H14O4/c1-2-3-4-8(13)11-9(14)5-7(12)6-10(11)15/h5-6,12,14-15H,2-4H2,1H3
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n/an/a 1.12E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196882
PNG
(CHEMBL3919374)
Show SMILES Cl.COc1cc(OC)c(C(=O)CC(C)C)c(OC[C@@H](O)CNC(C)(C)C)c1
Show InChI InChI=1S/C20H33NO5.ClH/c1-13(2)8-16(23)19-17(25-7)9-15(24-6)10-18(19)26-12-14(22)11-21-20(3,4)5;/h9-10,13-14,21-22H,8,11-12H2,1-7H3;1H/t14-;/m0./s1
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n/an/a 1.12E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196853
PNG
(CHEMBL3970451)
Show SMILES COc1cc(OC)c(CN[C@@H](CC(O)=O)C(O)=O)c(OC)c1
Show InChI InChI=1S/C14H19NO7/c1-20-8-4-11(21-2)9(12(5-8)22-3)7-15-10(14(18)19)6-13(16)17/h4-5,10,15H,6-7H2,1-3H3,(H,16,17)(H,18,19)/t10-/m0/s1
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n/an/a 1.44E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196854
PNG
(CHEMBL3945092)
Show SMILES Cl.CC(C)CC(=O)c1c(O)cc(O)cc1OCC(O)CNC(C)(C)C
Show InChI InChI=1S/C18H29NO5.ClH/c1-11(2)6-14(22)17-15(23)7-12(20)8-16(17)24-10-13(21)9-19-18(3,4)5;/h7-8,11,13,19-21,23H,6,9-10H2,1-5H3;1H
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n/an/a 2.17E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196878
PNG
(CHEMBL3938320)
Show SMILES CCN1CCN(CC(=O)c2c(OC)cc(OC)cc2OC)CC1
Show InChI InChI=1S/C17H26N2O4/c1-5-18-6-8-19(9-7-18)12-14(20)17-15(22-3)10-13(21-2)11-16(17)23-4/h10-11H,5-9,12H2,1-4H3
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n/an/a 2.27E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196885
PNG
(CHEMBL3939629)
Show SMILES Cl.CC(C)CC(=O)c1c(O)cc(O)cc1OC[C@@H](O)CNC(C)(C)C
Show InChI InChI=1S/C18H29NO5.ClH/c1-11(2)6-14(22)17-15(23)7-12(20)8-16(17)24-10-13(21)9-19-18(3,4)5;/h7-8,11,13,19-21,23H,6,9-10H2,1-5H3;1H/t13-;/m0./s1
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n/an/a 2.41E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196877
PNG
(CHEMBL3928223)
Show SMILES COc1cc(OC)c(C(=O)CN2CCCCC2)c(OC)c1
Show InChI InChI=1S/C16H23NO4/c1-19-12-9-14(20-2)16(15(10-12)21-3)13(18)11-17-7-5-4-6-8-17/h9-10H,4-8,11H2,1-3H3
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n/an/a 2.49E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196883
PNG
(CHEMBL3926408)
Show SMILES Cl.COc1ccc(C(=O)CC(C)C)c(OC[C@@H](O)CNC(C)C)c1
Show InChI InChI=1S/C18H29NO4.ClH/c1-12(2)8-17(21)16-7-6-15(22-5)9-18(16)23-11-14(20)10-19-13(3)4;/h6-7,9,12-14,19-20H,8,10-11H2,1-5H3;1H/t14-;/m0./s1
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n/an/a 2.56E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196884
PNG
(CHEMBL3985713)
Show SMILES Cl.COc1ccc(C(=O)CC(C)C)c(OC[C@H](O)CNC(C)(C)C)c1
Show InChI InChI=1S/C19H31NO4.ClH/c1-13(2)9-17(22)16-8-7-15(23-6)10-18(16)24-12-14(21)11-20-19(3,4)5;/h7-8,10,13-14,20-21H,9,11-12H2,1-6H3;1H/t14-;/m1./s1
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n/an/a 2.82E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196897
PNG
(CHEMBL3947110)
Show SMILES COc1cc(OC)c(C(=O)CN2CCOCC2)c(OC)c1
Show InChI InChI=1S/C15H21NO5/c1-18-11-8-13(19-2)15(14(9-11)20-3)12(17)10-16-4-6-21-7-5-16/h8-9H,4-7,10H2,1-3H3
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n/an/a 3.24E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196876
PNG
(CHEMBL3955840)
Show SMILES CCCCNC(=O)c1c(O)cc(O)cc1O
Show InChI InChI=1S/C11H15NO4/c1-2-3-4-12-11(16)10-8(14)5-7(13)6-9(10)15/h5-6,13-15H,2-4H2,1H3,(H,12,16)
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n/an/a 3.71E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196886
PNG
(CHEMBL3969544)
Show SMILES Cl.CC(C)CC(=O)c1c(O)cc(O)cc1OC[C@H](O)CNC(C)(C)C
Show InChI InChI=1S/C18H29NO5.ClH/c1-11(2)6-14(22)17-15(23)7-12(20)8-16(17)24-10-13(21)9-19-18(3,4)5;/h7-8,11,13,19-21,23H,6,9-10H2,1-5H3;1H/t13-;/m1./s1
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n/an/a 3.73E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196879
PNG
(CHEMBL3978735)
Show SMILES COc1cc(OC)c(CN[C@@H](C)C(O)=O)c(OC)c1
Show InChI InChI=1S/C13H19NO5/c1-8(13(15)16)14-7-10-11(18-3)5-9(17-2)6-12(10)19-4/h5-6,8,14H,7H2,1-4H3,(H,15,16)/t8-/m0/s1
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n/an/a 3.91E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196873
PNG
(CHEMBL3924218)
Show SMILES Cl.COc1ccc(C(=O)CC(C)C)c(OC[C@H](O)CNC(C)C)c1
Show InChI InChI=1S/C18H29NO4.ClH/c1-12(2)8-17(21)16-7-6-15(22-5)9-18(16)23-11-14(20)10-19-13(3)4;/h6-7,9,12-14,19-20H,8,10-11H2,1-5H3;1H/t14-;/m1./s1
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n/an/a 4.09E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196894
PNG
(CHEMBL3953825)
Show SMILES Cl.COc1cc(OC)c(C(=O)CC(C)C)c(OC[C@H](O)CNC(C)C)c1
Show InChI InChI=1S/C19H31NO5.ClH/c1-12(2)7-16(22)19-17(24-6)8-15(23-5)9-18(19)25-11-14(21)10-20-13(3)4;/h8-9,12-14,20-21H,7,10-11H2,1-6H3;1H/t14-;/m1./s1
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n/an/a 4.13E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196895
PNG
(CHEBI:15951 | CHEMBL19948)
Show SMILES CC(C)CC(=O)c1c(O)cc(O)cc1O
Show InChI InChI=1S/C11H14O4/c1-6(2)3-8(13)11-9(14)4-7(12)5-10(11)15/h4-6,12,14-15H,3H2,1-2H3
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n/an/a 5.06E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196870
PNG
(CHEMBL3943902)
Show SMILES COc1cc(O)c(C(=O)CC(C)C)c(OC)c1
Show InChI InChI=1S/C13H18O4/c1-8(2)5-10(14)13-11(15)6-9(16-3)7-12(13)17-4/h6-8,15H,5H2,1-4H3
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n/an/a 5.15E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196874
PNG
(CHEMBL3907638)
Show SMILES Cl.COc1ccc(C(=O)CC(C)C)c(OC[C@@H](O)CNC(C)(C)C)c1
Show InChI InChI=1S/C19H31NO4.ClH/c1-13(2)9-17(22)16-8-7-15(23-6)10-18(16)24-12-14(21)11-20-19(3,4)5;/h7-8,10,13-14,20-21H,9,11-12H2,1-6H3;1H/t14-;/m0./s1
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n/an/a 5.38E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196875
PNG
(CHEMBL3959386)
Show SMILES Cl.CN(CCCC(=O)c1c(O)cc(O)cc1O)C1CCCCC1
Show InChI InChI=1S/C17H25NO4.ClH/c1-18(12-6-3-2-4-7-12)9-5-8-14(20)17-15(21)10-13(19)11-16(17)22;/h10-12,19,21-22H,2-9H2,1H3;1H
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n/an/a 5.48E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196889
PNG
(CHEMBL3974513)
Show SMILES Cl.CC(C)CC(=O)c1c(O)cc(O)cc1OCC(O)CNC(C)C
Show InChI InChI=1S/C17H27NO5.ClH/c1-10(2)5-14(21)17-15(22)6-12(19)7-16(17)23-9-13(20)8-18-11(3)4;/h6-7,10-11,13,18-20,22H,5,8-9H2,1-4H3;1H
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n/an/a 7.40E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196899
PNG
(CHEMBL3920958)
Show SMILES Cl.COc1cc(OC)c(C(=O)CC(C)C)c(OCC(O)CNC(C)(C)C)c1
Show InChI InChI=1S/C20H33NO5.ClH/c1-13(2)8-16(23)19-17(25-7)9-15(24-6)10-18(19)26-12-14(22)11-21-20(3,4)5;/h9-10,13-14,21-22H,8,11-12H2,1-7H3;1H
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n/an/a 7.50E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196871
PNG
(CHEMBL3954859)
Show SMILES Cl.COc1cc(OC)c(C(=O)CC(C)C)c(OCC(O)CNC(C)C)c1
Show InChI InChI=1S/C19H31NO5.ClH/c1-12(2)7-16(22)19-17(24-6)8-15(23-5)9-18(19)25-11-14(21)10-20-13(3)4;/h8-9,12-14,20-21H,7,10-11H2,1-6H3;1H
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n/an/a 8.48E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196893
PNG
(CHEMBL3975436)
Show SMILES CC(C)CC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C11H14O2/c1-8(2)7-11(13)9-3-5-10(12)6-4-9/h3-6,8,12H,7H2,1-2H3
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n/an/a 9.07E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196890
PNG
(CHEMBL3937206)
Show SMILES CC(C)NC(=O)c1c(O)cc(O)cc1O
Show InChI InChI=1S/C10H13NO4/c1-5(2)11-10(15)9-7(13)3-6(12)4-8(9)14/h3-5,12-14H,1-2H3,(H,11,15)
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n/an/a 9.26E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196852
PNG
(CHEMBL3919319)
Show SMILES COc1cc(OC)c(C(=O)CN2CCN(C)CC2)c(OC)c1
Show InChI InChI=1S/C16H24N2O4/c1-17-5-7-18(8-6-17)11-13(19)16-14(21-3)9-12(20-2)10-15(16)22-4/h9-10H,5-8,11H2,1-4H3
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n/an/a 9.53E+4n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196851
PNG
(CHEMBL3952652)
Show SMILES COc1ccc(C(=O)CC(C)C)c(O)c1
Show InChI InChI=1S/C12H16O3/c1-8(2)6-11(13)10-5-4-9(15-3)7-12(10)14/h4-5,7-8,14H,6H2,1-3H3
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n/an/a 1.13E+5n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196881
PNG
(CHEMBL3936167)
Show SMILES Cl.COc1ccc(C(=O)CC(C)C)c(OCC(O)CNC(C)(C)C)c1
Show InChI InChI=1S/C19H31NO4.ClH/c1-13(2)9-17(22)16-8-7-15(23-6)10-18(16)24-12-14(21)11-20-19(3,4)5;/h7-8,10,13-14,20-21H,9,11-12H2,1-6H3;1H
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n/an/a 1.38E+5n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
Neuronal proto-oncogene tyrosine-protein kinase Src


(Mus musculus (Mouse))
BDBM50196900
PNG
(CHEMBL3982525)
Show SMILES Cl.COc1cc(OC)c(C(=O)CC(C)C)c(OC[C@@H](O)CNC(C)C)c1
Show InChI InChI=1S/C19H31NO5.ClH/c1-12(2)7-16(22)19-17(24-6)8-15(23-5)9-18(19)25-11-14(21)10-20-13(3)4;/h8-9,12-14,20-21H,7,10-11H2,1-6H3;1H/t14-;/m0./s1
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n/an/a 1.38E+5n/an/an/an/an/an/a



Chinese Academy of Medical Sciences and Peking Union Medical College

Curated by ChEMBL


Assay Description
Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after ...


J Med Chem 59: 9062-9079 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00976
BindingDB Entry DOI: 10.7270/Q2B56MP4
More data for this
Ligand-Target Pair
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