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Found 62 hits Enz. Inhib. hit(s) with Target = 'Neuropeptide Y receptor type 5' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50354072
PNG
(CHEMBL1836317)
Show SMILES CS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc-2c(CCSc3ccccc-23)s1
Show InChI InChI=1S/C19H25N3O2S3/c1-27(23,24)20-12-13-6-8-14(9-7-13)21-19-22-18-15-4-2-3-5-16(15)25-11-10-17(18)26-19/h2-5,13-14,20H,6-12H2,1H3,(H,21,22)/t13-,14-
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PubMed
1.40n/an/an/an/an/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat NPY5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50123737
PNG
(3-{2-[6-(2-tert-Butoxy-ethoxy)-pyridin-3-yl]-3H-im...)
Show SMILES CC(C)(C)OCCOc1ccc(cn1)-c1nc(c[nH]1)-c1cccc(c1)C#N
Show InChI InChI=1S/C21H22N4O2/c1-21(2,3)27-10-9-26-19-8-7-17(13-23-19)20-24-14-18(25-20)16-6-4-5-15(11-16)12-22/h4-8,11,13-14H,9-10H2,1-3H3,(H,24,25)
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1.70n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Binding affinity of the compound to the rat Neuropeptide Y receptor type 5 was determined using [125I]- [Leu31,Pro34]PYY as radioligand


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50355852
PNG
(CHEMBL1909725)
Show SMILES CN(C)S(=O)(=O)NCCCCCNc1nc(cs1)-c1ccccn1
Show InChI InChI=1S/C15H23N5O2S2/c1-20(2)24(21,22)18-11-6-3-5-10-17-15-19-14(12-23-15)13-8-4-7-9-16-13/h4,7-9,12,18H,3,5-6,10-11H2,1-2H3,(H,17,19)
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5.40n/an/an/an/an/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50114974
PNG
(2-Nitro-N-(4-{[(1,2,3,4-tetrahydro-naphthalen-2-yl...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1
Show InChI InChI=1S/C25H33N3O4S/c29-28(30)24-7-3-4-8-25(24)33(31,32)27-18-20-11-9-19(10-12-20)16-26-17-21-13-14-22-5-1-2-6-23(22)15-21/h1-8,19-21,26-27H,9-18H2/t19-,20-,21?
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18n/an/an/an/an/an/an/an/a



Lundbeck Research USA, Inc.

Curated by ChEMBL


Assay Description
Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with rat Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 12: 1767-9 (2002)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50268532
PNG
(3-oxo-N-(5-phenylpyrimidin-2-yl)-3H-spiro[isobenzo...)
Show SMILES O=C(Nc1ncc(cn1)-c1ccccc1)N1CCC2(CC1)OC(=O)c1ccccc21
Show InChI InChI=1S/C23H20N4O3/c28-20-18-8-4-5-9-19(18)23(30-20)10-12-27(13-11-23)22(29)26-21-24-14-17(15-25-21)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,24,25,26,29)
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n/an/a 0.670n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from rat NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50268739
PNG
(CHEMBL524085 | N-(3-(4-chlorophenyl)isoxazol-5-yl)...)
Show SMILES Clc1ccc(cc1)-c1cc(NC(=O)N2CCC3(CC2)OC(=O)c2ccccc32)on1
Show InChI InChI=1S/C22H18ClN3O4/c23-15-7-5-14(6-8-15)18-13-19(30-25-18)24-21(28)26-11-9-22(10-12-26)17-4-2-1-3-16(17)20(27)29-22/h1-8,13H,9-12H2,(H,24,28)
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n/an/a 1.30n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from rat NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50089038
PNG
(CGP 71683 | CGP-71683A | CHEMBL17645 | N-{[(1r,4r)...)
Show SMILES Nc1nc(NC[C@H]2CC[C@H](CNS(=O)(=O)c3cccc4ccccc34)CC2)nc2ccccc12
Show InChI InChI=1S/C26H29N5O2S/c27-25-22-9-3-4-10-23(22)30-26(31-25)28-16-18-12-14-19(15-13-18)17-29-34(32,33)24-11-5-7-20-6-1-2-8-21(20)24/h1-11,18-19,29H,12-17H2,(H3,27,28,30,31)/t18-,19-
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n/an/a 1.40n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Compound was tested for rat Neuropeptide Y receptor type 5


Bioorg Med Chem Lett 10: 1175-9 (2000)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50304297
PNG
(CHEMBL594163 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Show SMILES O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21
Show InChI InChI=1S/C22H20N4O3/c27-20(24-18-10-14-26(25-18)16-5-2-1-3-6-16)15-8-11-22(12-9-15)17-7-4-13-23-19(17)21(28)29-22/h1-7,10,13-15H,8-9,11-12H2,(H,24,25,27)/t15-,22-
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n/an/a 1.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50249869
PNG
(3-oxo-N-(5-phenylpyrazin-2-yl)-3H-spiro[isobenzofu...)
Show SMILES O=C(Nc1cnc(cn1)-c1ccccc1)N1CCC2(CC1)OC(=O)c1ccccc21
Show InChI InChI=1S/C23H20N4O3/c28-21-17-8-4-5-9-18(17)23(30-21)10-12-27(13-11-23)22(29)26-20-15-24-19(14-25-20)16-6-2-1-3-7-16/h1-9,14-15H,10-13H2,(H,25,26,29)
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n/an/a 1.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]PYY from rat NPY Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50304301
PNG
(CHEMBL595790 | trans-N-[1-(3-Fluorophenyl)-1H-pyra...)
Show SMILES Fc1ccc(cc1)-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1
Show InChI InChI=1S/C22H19FN4O3/c23-15-1-3-16(4-2-15)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)18-13-24-11-7-17(18)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)/t14-,22-
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n/an/a 2.10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50304300
PNG
(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)
Show SMILES Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@@]3(CC2)OC(=O)c2ccncc32)n1
Show InChI InChI=1S/C22H19FN4O3/c23-17-3-1-2-4-18(17)27-12-8-19(26-27)25-20(28)14-5-9-22(10-6-14)16-13-24-11-7-15(16)21(29)30-22/h1-4,7-8,11-14H,5-6,9-10H2,(H,25,26,28)/t14-,22-
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n/an/a 2.10n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50304299
PNG
(CHEMBL595560 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Show SMILES O=C(Nc1ccn(n1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccncc21
Show InChI InChI=1S/C22H20N4O3/c27-20(24-19-9-13-26(25-19)16-4-2-1-3-5-16)15-6-10-22(11-7-15)18-14-23-12-8-17(18)21(28)29-22/h1-5,8-9,12-15H,6-7,10-11H2,(H,24,25,27)/t15-,22-
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n/an/a 2.20n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50073051
PNG
(CHEMBL60319 | N-[5-(3,4-Dimethoxy-phenyl)-1H-pyraz...)
Show SMILES COc1ccc(cc1OC)-c1cc(NC(=O)CC23CCCC2Cc2ccccc2C3)[nH]n1
Show InChI InChI=1S/C26H29N3O3/c1-31-22-10-9-18(13-23(22)32-2)21-14-24(29-28-21)27-25(30)16-26-11-5-8-20(26)12-17-6-3-4-7-19(17)15-26/h3-4,6-7,9-10,13-14,20H,5,8,11-12,15-16H2,1-2H3,(H2,27,28,29,30)
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n/an/a 2.30n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for the binding affinity against Neuropeptide Y receptor type 5 in rat


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50304302
PNG
(3'-oxo-N-(5-phenylpyrazin-2-yl)-3'H-spiro[cyclohex...)
Show InChI InChI=1S/C24H21N3O3/c28-22(27-21-15-25-20(14-26-21)16-6-2-1-3-7-16)17-10-12-24(13-11-17)19-9-5-4-8-18(19)23(29)30-24/h1-9,14-15,17H,10-13H2,(H,26,27,28)
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n/an/a 2.5n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50145232
PNG
(CHEMBL311229 | {4-[(9-Methyl-4,5-dihydro-6-oxa-3-t...)
Show SMILES Cc1ccc2OCCc3sc(NCC4CCN(CC4)C(=O)[C@H]4CCCO4)nc3-c2c1
Show InChI InChI=1S/C23H29N3O3S/c1-15-4-5-18-17(13-15)21-20(8-12-29-18)30-23(25-21)24-14-16-6-9-26(10-7-16)22(27)19-3-2-11-28-19/h4-5,13,16,19H,2-3,6-12,14H2,1H3,(H,24,25)/t19-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound against rat neuropeptide Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50073055
PNG
(2-Methyl-4-pyrrolidin-1-yl-6-[(E)-2-(3-trifluorome...)
Show SMILES Cc1cc(cc(\C=C\c2cccc(c2)C(F)(F)F)n1)N1CCCC1
Show InChI InChI=1S/C19H19F3N2/c1-14-11-18(24-9-2-3-10-24)13-17(23-14)8-7-15-5-4-6-16(12-15)19(20,21)22/h4-8,11-13H,2-3,9-10H2,1H3/b8-7+
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n/an/a 4.10n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for the binding affinity against Neuropeptide Y receptor type 5 in rat


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50304298
PNG
(CHEMBL595120 | trans-3-Oxo-N-(1-phenyl-1H-pyrazol-...)
Show SMILES O=C(Nc1cnn(c1)-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ncccc21
Show InChI InChI=1S/C22H20N4O3/c27-20(25-16-13-24-26(14-16)17-5-2-1-3-6-17)15-8-10-22(11-9-15)18-7-4-12-23-19(18)21(28)29-22/h1-7,12-15H,8-11H2,(H,25,27)/t15-,22-
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n/an/a 4.70n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50145236
PNG
(1-{4-[(9-Fluoro-4,5-dihydro-6-oxa-3-thia-1-aza-ben...)
Show SMILES CCCCC(=O)N1CCC(CNc2nc-3c(CCOc4ccc(F)cc-34)s2)CC1
Show InChI InChI=1S/C22H28FN3O2S/c1-2-3-4-20(27)26-10-7-15(8-11-26)14-24-22-25-21-17-13-16(23)5-6-18(17)28-12-9-19(21)29-22/h5-6,13,15H,2-4,7-12,14H2,1H3,(H,24,25)
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n/an/a 6n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound against rat neuropeptide Y5 receptor


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50116600
PNG
(CHEMBL325475 | N-(9-Ethyl-9H-carbazol-3-yl)-3-pyri...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CCc3ccncc3)ccc12
Show InChI InChI=1S/C22H21N3O/c1-2-25-20-6-4-3-5-18(20)19-15-17(8-9-21(19)25)24-22(26)10-7-16-11-13-23-14-12-16/h3-6,8-9,11-15H,2,7,10H2,1H3,(H,24,26)
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n/an/a 7n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity against rat Neuropeptide Y receptor Y5


J Med Chem 45: 3509-23 (2002)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163525
PNG
(CHEMBL179972 | N-(4-Benzoyl-phenyl)-2-[4-(2-oxo-4H...)
Show SMILES O=C(CN1CCC(CC1)N1C(=O)OCc2ccccc12)Nc1ccc(cc1)C(=O)c1ccccc1
Show InChI InChI=1S/C28H27N3O4/c32-26(29-23-12-10-21(11-13-23)27(33)20-6-2-1-3-7-20)18-30-16-14-24(15-17-30)31-25-9-5-4-8-22(25)19-35-28(31)34/h1-13,24H,14-19H2,(H,29,32)
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n/an/a 7.60n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163516
PNG
(2-[4-(6-Fluoro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Fc1ccc2N(C3CCN(CC(=O)Nc4ccc5ncccc5c4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C24H23FN4O3/c25-18-3-6-22-17(12-18)15-32-24(31)29(22)20-7-10-28(11-8-20)14-23(30)27-19-4-5-21-16(13-19)2-1-9-26-21/h1-6,9,12-13,20H,7-8,10-11,14-15H2,(H,27,30)
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n/an/a 7.70n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163541
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES OC1c2ccccc2-c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4cc(Cl)ccc34)ccc12
Show InChI InChI=1S/C28H26ClN3O4/c29-18-5-8-25-17(13-18)16-36-28(35)32(25)20-9-11-31(12-10-20)15-26(33)30-19-6-7-23-24(14-19)21-3-1-2-4-22(21)27(23)34/h1-8,13-14,20,27,34H,9-12,15-16H2,(H,30,33)
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n/an/a 8n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50073047
PNG
(CHEMBL291666 | N-[5-(3,4-Dimethoxy-phenyl)-1H-pyra...)
Show SMILES COc1ccc(cc1OC)-c1cc(NC(=O)Cc2ccc3ccccc3c2)[nH]n1
Show InChI InChI=1S/C23H21N3O3/c1-28-20-10-9-18(13-21(20)29-2)19-14-22(26-25-19)24-23(27)12-15-7-8-16-5-3-4-6-17(16)11-15/h3-11,13-14H,12H2,1-2H3,(H2,24,25,26,27)
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n/an/a 8.30n/an/an/an/an/an/a



The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for the binding affinity against Neuropeptide Y receptor type 5 in rat


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163539
PNG
(CHEMBL557802 | N-(9-Hydroxy-9H-fluoren-3-yl)-2-[4-...)
Show SMILES OC1c2ccccc2-c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4ccccc34)ccc12
Show InChI InChI=1S/C28H27N3O4/c32-26(29-19-9-10-23-24(15-19)21-6-2-3-7-22(21)27(23)33)16-30-13-11-20(12-14-30)31-25-8-4-1-5-18(25)17-35-28(31)34/h1-10,15,20,27,33H,11-14,16-17H2,(H,29,32)
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n/an/a 8.70n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163552
PNG
(CHEMBL557540 | N-(9-Methyl-9H-carbazol-3-yl)-2-[4-...)
Show SMILES Cn1c2ccccc2c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4ccccc34)ccc12
Show InChI InChI=1S/C28H28N4O3/c1-30-25-9-5-3-7-22(25)23-16-20(10-11-26(23)30)29-27(33)17-31-14-12-21(13-15-31)32-24-8-4-2-6-19(24)18-35-28(32)34/h2-11,16,21H,12-15,17-18H2,1H3,(H,29,33)
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n/an/a 9.60n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163513
PNG
(CHEMBL541121 | N-(4-Benzoyl-phenyl)-2-[4-(6-chloro...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc(cc4)C(=O)c4ccccc4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C28H26ClN3O4/c29-22-8-11-25-21(16-22)18-36-28(35)32(25)24-12-14-31(15-13-24)17-26(33)30-23-9-6-20(7-10-23)27(34)19-4-2-1-3-5-19/h1-11,16,24H,12-15,17-18H2,(H,30,33)
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n/an/a 11.2n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163545
PNG
(CHEMBL537412 | N-(4-Acetyl-phenyl)-2-[4-(2-oxo-4H-...)
Show SMILES CC(=O)c1ccc(NC(=O)CN2CCC(CC2)N2C(=O)OCc3ccccc23)cc1
Show InChI InChI=1S/C23H25N3O4/c1-16(27)17-6-8-19(9-7-17)24-22(28)14-25-12-10-20(11-13-25)26-21-5-3-2-4-18(21)15-30-23(26)29/h2-9,20H,10-15H2,1H3,(H,24,28)
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n/an/a 17.3n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163535
PNG
(2-[4-(2-Oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin...)
Show SMILES O=C(CN1CCC(CC1)N1C(=O)OCc2ccccc12)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H27N3O4/c31-26(28-21-10-12-24(13-11-21)34-23-7-2-1-3-8-23)18-29-16-14-22(15-17-29)30-25-9-5-4-6-20(25)19-33-27(30)32/h1-13,22H,14-19H2,(H,28,31)
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n/an/a 20n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163526
PNG
(CHEMBL537191 | N-(4-Acetyl-phenyl)-2-[4-(6-chloro-...)
Show SMILES CC(=O)c1ccc(NC(=O)CN2CCC(CC2)N2C(=O)OCc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C23H24ClN3O4/c1-15(28)16-2-5-19(6-3-16)25-22(29)13-26-10-8-20(9-11-26)27-21-7-4-18(24)12-17(21)14-31-23(27)30/h2-7,12,20H,8-11,13-14H2,1H3,(H,25,29)
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n/an/a 21n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163512
PNG
(2-[4-(2-Oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin...)
Show SMILES O=C(CN1CCC(CC1)N1C(=O)OCc2ccccc12)Nc1ccc2C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C28H25N3O4/c32-26(29-19-9-10-23-24(15-19)21-6-2-3-7-22(21)27(23)33)16-30-13-11-20(12-14-30)31-25-8-4-1-5-18(25)17-35-28(31)34/h1-10,15,20H,11-14,16-17H2,(H,29,32)
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n/an/a 23.3n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163538
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc5C(=O)c6ccccc6-c5c4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C28H24ClN3O4/c29-18-5-8-25-17(13-18)16-36-28(35)32(25)20-9-11-31(12-10-20)15-26(33)30-19-6-7-23-24(14-19)21-3-1-2-4-22(21)27(23)34/h1-8,13-14,20H,9-12,15-16H2,(H,30,33)
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n/an/a 25n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163548
PNG
(CHEMBL537187 | N-(4-Acetyl-phenyl)-2-[4-(6-methyl-...)
Show SMILES CC(=O)c1ccc(NC(=O)CN2CCC(CC2)N2C(=O)OCc3cc(C)ccc23)cc1
Show InChI InChI=1S/C24H27N3O4/c1-16-3-8-22-19(13-16)15-31-24(30)27(22)21-9-11-26(12-10-21)14-23(29)25-20-6-4-18(5-7-20)17(2)28/h3-8,13,21H,9-12,14-15H2,1-2H3,(H,25,29)
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n/an/a 26n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163529
PNG
(CHEMBL535824 | N-(9-Hydroxy-9H-fluoren-3-yl)-2-[4-...)
Show SMILES Cc1cccc2COC(=O)N(C3CCN(CC(=O)Nc4ccc5C(O)c6ccccc6-c5c4)CC3)c12
Show InChI InChI=1S/C29H29N3O4/c1-18-5-4-6-19-17-36-29(35)32(27(18)19)21-11-13-31(14-12-21)16-26(33)30-20-9-10-24-25(15-20)22-7-2-3-8-23(22)28(24)34/h2-10,15,21,28,34H,11-14,16-17H2,1H3,(H,30,33)
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n/an/a 30n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163511
PNG
(CHEMBL536276 | N-(4-Benzoyl-phenyl)-2-[4-(8-methyl...)
Show SMILES Cc1cccc2COC(=O)N(C3CCN(CC(=O)Nc4ccc(cc4)C(=O)c4ccccc4)CC3)c12
Show InChI InChI=1S/C29H29N3O4/c1-20-6-5-9-23-19-36-29(35)32(27(20)23)25-14-16-31(17-15-25)18-26(33)30-24-12-10-22(11-13-24)28(34)21-7-3-2-4-8-21/h2-13,25H,14-19H2,1H3,(H,30,33)
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n/an/a 39.6n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163514
PNG
(CHEMBL540365 | N-(9-Ethyl-9H-carbazol-3-yl)-2-[4-(...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4cccc(C)c34)ccc12
Show InChI InChI=1S/C30H32N4O3/c1-3-33-26-10-5-4-9-24(26)25-17-22(11-12-27(25)33)31-28(35)18-32-15-13-23(14-16-32)34-29-20(2)7-6-8-21(29)19-37-30(34)36/h4-12,17,23H,3,13-16,18-19H2,1-2H3,(H,31,35)
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n/an/a 50n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163521
PNG
(2-[4-(8-Methyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Cc1cccc2COC(=O)N(C3CCN(CC(=O)Nc4ccc5C(=O)c6ccccc6-c5c4)CC3)c12
Show InChI InChI=1S/C29H27N3O4/c1-18-5-4-6-19-17-36-29(35)32(27(18)19)21-11-13-31(14-12-21)16-26(33)30-20-9-10-24-25(15-20)22-7-2-3-8-23(22)28(24)34/h2-10,15,21H,11-14,16-17H2,1H3,(H,30,33)
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n/an/a 50n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163531
PNG
(CHEMBL557817 | N-(9-Ethyl-9H-carbazol-3-yl)-2-[4-(...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4c(Cl)cccc34)ccc12
Show InChI InChI=1S/C29H29ClN4O3/c1-2-33-25-8-4-3-6-21(25)22-16-19(10-11-26(22)33)31-28(35)17-32-14-12-20(13-15-32)34-27-9-5-7-24(30)23(27)18-37-29(34)36/h3-11,16,20H,2,12-15,17-18H2,1H3,(H,31,35)
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n/an/a 54.6n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163540
PNG
(CHEMBL365777 | N-Dibenzofuran-2-yl-2-[4-(8-methoxy...)
Show SMILES COc1cccc2COC(=O)N(C3CCN(CC(=O)Nc4ccc5oc6ccccc6c5c4)CC3)c12
Show InChI InChI=1S/C28H27N3O5/c1-34-25-8-4-5-18-17-35-28(33)31(27(18)25)20-11-13-30(14-12-20)16-26(32)29-19-9-10-24-22(15-19)21-6-2-3-7-23(21)36-24/h2-10,15,20H,11-14,16-17H2,1H3,(H,29,32)
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n/an/a 55.7n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163550
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C27H26ClN3O4/c28-20-6-11-25-19(16-20)18-34-27(33)31(25)22-12-14-30(15-13-22)17-26(32)29-21-7-9-24(10-8-21)35-23-4-2-1-3-5-23/h1-11,16,22H,12-15,17-18H2,(H,29,32)
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n/an/a 60.7n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163530
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc5-c6ccccc6C(=O)c5c4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C28H24ClN3O4/c29-18-5-8-25-17(13-18)16-36-28(35)32(25)20-9-11-31(12-10-20)15-26(33)30-19-6-7-22-21-3-1-2-4-23(21)27(34)24(22)14-19/h1-8,13-14,20H,9-12,15-16H2,(H,30,33)
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n/an/a 69n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163533
PNG
(2-[4-(6-Methyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Cc1ccc2N(C3CCN(CC(=O)Nc4ccc5-c6ccccc6C(=O)c5c4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C29H27N3O4/c1-18-6-9-26-19(14-18)17-36-29(35)32(26)21-10-12-31(13-11-21)16-27(33)30-20-7-8-23-22-4-2-3-5-24(22)28(34)25(23)15-20/h2-9,14-15,21H,10-13,16-17H2,1H3,(H,30,33)
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n/an/a 86.7n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163524
PNG
(2-[4-(5-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4cc(Cl)ccc34)ccc12
Show InChI InChI=1S/C29H29ClN4O3/c1-2-33-26-6-4-3-5-23(26)24-16-21(8-10-27(24)33)31-28(35)17-32-13-11-22(12-14-32)34-25-9-7-20(30)15-19(25)18-37-29(34)36/h3-10,15-16,22H,2,11-14,17-18H2,1H3,(H,31,35)
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n/an/a 100n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163519
PNG
(2-[4-(6-Methyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Cc1ccc2N(C3CCN(CC(=O)Nc4ccc(Oc5ccccc5)cc4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C28H29N3O4/c1-20-7-12-26-21(17-20)19-34-28(33)31(26)23-13-15-30(16-14-23)18-27(32)29-22-8-10-25(11-9-22)35-24-5-3-2-4-6-24/h2-12,17,23H,13-16,18-19H2,1H3,(H,29,32)
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n/an/a 104n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163522
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc(cc4)C4CCCCC4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C27H32ClN3O3/c28-22-8-11-25-21(16-22)18-34-27(33)31(25)24-12-14-30(15-13-24)17-26(32)29-23-9-6-20(7-10-23)19-4-2-1-3-5-19/h6-11,16,19,24H,1-5,12-15,17-18H2,(H,29,32)
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n/an/a 112n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163549
PNG
(CHEMBL556999 | N-(4-Cyano-phenyl)-2-[4-(2-oxo-4H-b...)
Show SMILES O=C(CN1CCC(CC1)N1C(=O)OCc2ccccc12)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C22H22N4O3/c23-13-16-5-7-18(8-6-16)24-21(27)14-25-11-9-19(10-12-25)26-20-4-2-1-3-17(20)15-29-22(26)28/h1-8,19H,9-12,14-15H2,(H,24,27)
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n/an/a 132n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163520
PNG
(2-[4-(2-Oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidin...)
Show SMILES O=C(CN1CCC(CC1)N1C(=O)OCc2ccccc12)Nc1cccc2C(=O)c3ccccc3-c12
Show InChI InChI=1S/C28H25N3O4/c32-25(29-23-10-5-9-22-26(23)20-7-2-3-8-21(20)27(22)33)16-30-14-12-19(13-15-30)31-24-11-4-1-6-18(24)17-35-28(31)34/h1-11,19H,12-17H2,(H,29,32)
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n/an/a 138n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163547
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc5ncccc5c4)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C24H23ClN4O3/c25-18-3-6-22-17(12-18)15-32-24(31)29(22)20-7-10-28(11-8-20)14-23(30)27-19-4-5-21-16(13-19)2-1-9-26-21/h1-6,9,12-13,20H,7-8,10-11,14-15H2,(H,27,30)
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n/an/a 148n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163532
PNG
(2-[4-(6-Chloro-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-...)
Show SMILES Clc1ccc2N(C3CCN(CC(=O)Nc4ccc(cc4)C#N)CC3)C(=O)OCc2c1
Show InChI InChI=1S/C22H21ClN4O3/c23-17-3-6-20-16(11-17)14-30-22(29)27(20)19-7-9-26(10-8-19)13-21(28)25-18-4-1-15(12-24)2-5-18/h1-6,11,19H,7-10,13-14H2,(H,25,28)
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n/an/a 199n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163528
PNG
(CHEMBL558393 | N-(4-Chloro-phenyl)-2-[4-(2-oxo-4H-...)
Show SMILES Clc1ccc(NC(=O)CN2CCC(CC2)N2C(=O)OCc3ccccc23)cc1
Show InChI InChI=1S/C21H22ClN3O3/c22-16-5-7-17(8-6-16)23-20(26)13-24-11-9-18(10-12-24)25-19-4-2-1-3-15(19)14-28-21(25)27/h1-8,18H,9-14H2,(H,23,26)
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n/an/a 300n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 5


(Rattus norvegicus)
BDBM50163542
PNG
(CHEMBL538569 | N-(9-Ethyl-9H-carbazol-3-yl)-2-[4-(...)
Show SMILES CCn1c2ccccc2c2cc(NC(=O)CN3CCC(CC3)N3C(=O)OCc4cccc(OC)c34)ccc12
Show InChI InChI=1S/C30H32N4O4/c1-3-33-25-9-5-4-8-23(25)24-17-21(11-12-26(24)33)31-28(35)18-32-15-13-22(14-16-32)34-29-20(19-38-30(34)36)7-6-10-27(29)37-2/h4-12,17,22H,3,13-16,18-19H2,1-2H3,(H,31,35)
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n/an/a 765n/an/an/an/an/an/a



Laboratorios Dr. Esteve, S.A.

Curated by ChEMBL


Assay Description
Inhibition of [125I]PYY binding to the rat NPY Y5 receptor in C6 cells


Citation and Details
More data for this
Ligand-Target Pair
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