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Found 558 hits Enz. Inhib. hit(s) with Target = 'Neuropilin-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropilin-1


(Homo sapiens)
BDBM50188994
PNG
(5-chloro-2-(3-fluorophenyl)-3-(phenethylamino)indo...)
Show SMILES Fc1cccc(c1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C23H17ClFN3/c24-21-11-5-10-20-19(15-26)22(17-8-4-9-18(25)14-17)23(28(20)21)27-13-12-16-6-2-1-3-7-16/h1-11,14,27H,12-13H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188970
PNG
(5-chloro-2-(4-chlorophenyl)-3-(phenethylamino)indo...)
Show SMILES Clc1ccc(cc1)-c1c(C#N)c2cccc(Cl)n2c1NCCc1ccccc1
Show InChI InChI=1S/C23H17Cl2N3/c24-18-11-9-17(10-12-18)22-19(15-26)20-7-4-8-21(25)28(20)23(22)27-14-13-16-5-2-1-3-6-16/h1-12,27H,13-14H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188968
PNG
(5-chloro-3-(phenethylamino)-2-phenylindolizine-1-c...)
Show SMILES Clc1cccc2c(C#N)c(c(NCCc3ccccc3)n12)-c1ccccc1
Show InChI InChI=1S/C23H18ClN3/c24-21-13-7-12-20-19(16-25)22(18-10-5-2-6-11-18)23(27(20)21)26-15-14-17-8-3-1-4-9-17/h1-13,26H,14-15H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188998
PNG
(5-chloro-2-(3-methoxyphenyl)-3-(phenethylamino)ind...)
Show SMILES COc1cccc(c1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H20ClN3O/c1-29-19-10-5-9-18(15-19)23-20(16-26)21-11-6-12-22(25)28(21)24(23)27-14-13-17-7-3-2-4-8-17/h2-12,15,27H,13-14H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50189004
PNG
(5-chloro-2-phenethyl-3-(phenethylamino)indolizine-...)
Show SMILES Clc1cccc2c(C#N)c(CCc3ccccc3)c(NCCc3ccccc3)n12
Show InChI InChI=1S/C25H22ClN3/c26-24-13-7-12-23-22(18-27)21(15-14-19-8-3-1-4-9-19)25(29(23)24)28-17-16-20-10-5-2-6-11-20/h1-13,28H,14-17H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188974
PNG
(5-chloro-3-(phenethylamino)-2-(pyridin-2-yl)indoli...)
Show SMILES Clc1cccc2c(C#N)c(c(NCCc3ccccc3)n12)-c1ccccn1
Show InChI InChI=1S/C22H17ClN4/c23-20-11-6-10-19-17(15-24)21(18-9-4-5-13-25-18)22(27(19)20)26-14-12-16-7-2-1-3-8-16/h1-11,13,26H,12,14H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188969
PNG
(5-chloro-2-(2-methoxyphenyl)-3-(phenethylamino)ind...)
Show SMILES COc1ccccc1-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H20ClN3O/c1-29-21-12-6-5-10-18(21)23-19(16-26)20-11-7-13-22(25)28(20)24(23)27-15-14-17-8-3-2-4-9-17/h2-13,27H,14-15H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188979
PNG
(3-(2-chlorophenethylamino)-5-chloro-2-phenylindoli...)
Show SMILES Clc1ccccc1CCNc1c(c(C#N)c2cccc(Cl)n12)-c1ccccc1
Show InChI InChI=1S/C23H17Cl2N3/c24-19-10-5-4-7-16(19)13-14-27-23-22(17-8-2-1-3-9-17)18(15-26)20-11-6-12-21(25)28(20)23/h1-12,27H,13-14H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188971
PNG
(5-chloro-2-(4-(methylthio)phenyl)-3-(phenethylamin...)
Show SMILES CSc1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H20ClN3S/c1-29-19-12-10-18(11-13-19)23-20(16-26)21-8-5-9-22(25)28(21)24(23)27-15-14-17-6-3-2-4-7-17/h2-13,27H,14-15H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313491
PNG
((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc2nsnc12)C(O)=O
Show InChI InChI=1S/C17H19N7O5S3/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20)/t11-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of biotinylated-VEGF-A125 from NRP1 b1 domain by cell-free assay


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188985
PNG
(5-chloro-2-(3-chlorophenyl)-3-(phenethylamino)indo...)
Show SMILES Clc1cccc(c1)-c1c(C#N)c2cccc(Cl)n2c1NCCc1ccccc1
Show InChI InChI=1S/C23H17Cl2N3/c24-18-9-4-8-17(14-18)22-19(15-26)20-10-5-11-21(25)28(20)23(22)27-13-12-16-6-2-1-3-7-16/h1-11,14,27H,12-13H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313491
PNG
((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc2nsnc12)C(O)=O
Show InChI InChI=1S/C17H19N7O5S3/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20)/t11-/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188967
PNG
(5-chloro-2-(2-chlorophenyl)-3-(phenethylamino)indo...)
Show SMILES Clc1ccccc1-c1c(C#N)c2cccc(Cl)n2c1NCCc1ccccc1
Show InChI InChI=1S/C23H17Cl2N3/c24-19-10-5-4-9-17(19)22-18(15-26)20-11-6-12-21(25)28(20)23(22)27-14-13-16-7-2-1-3-8-16/h1-12,27H,13-14H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188990
PNG
(5-chloro-2-(2-fluorophenyl)-3-(phenethylamino)indo...)
Show SMILES Fc1ccccc1-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C23H17ClFN3/c24-21-12-6-11-20-18(15-26)22(17-9-4-5-10-19(17)25)23(28(20)21)27-14-13-16-7-2-1-3-8-16/h1-12,27H,13-14H2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50189000
PNG
(3-(4-chlorophenethylamino)-5-chloro-2-phenylindoli...)
Show SMILES Clc1ccc(CCNc2c(c(C#N)c3cccc(Cl)n23)-c2ccccc2)cc1
Show InChI InChI=1S/C23H17Cl2N3/c24-18-11-9-16(10-12-18)13-14-27-23-22(17-5-2-1-3-6-17)19(15-26)20-7-4-8-21(25)28(20)23/h1-12,27H,13-14H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188983
PNG
(3-(2-(benzyl(methyl)amino)ethylamino)-5-chloro-2-p...)
Show SMILES CN(CCNc1c(c(C#N)c2cccc(Cl)n12)-c1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C25H23ClN4/c1-29(18-19-9-4-2-5-10-19)16-15-28-25-24(20-11-6-3-7-12-20)21(17-27)22-13-8-14-23(26)30(22)25/h2-14,28H,15-16,18H2,1H3
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n/an/a 4.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188982
PNG
(5-chloro-3-(phenethylamino)-2-(pyridin-3-yl)indoli...)
Show SMILES Clc1cccc2c(C#N)c(c(NCCc3ccccc3)n12)-c1cccnc1
Show InChI InChI=1S/C22H17ClN4/c23-20-10-4-9-19-18(14-24)21(17-8-5-12-25-15-17)22(27(19)20)26-13-11-16-6-2-1-3-7-16/h1-10,12,15,26H,11,13H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188999
PNG
(5-chloro-2-(4-fluoronaphthalen-1-yl)-3-(phenethyla...)
Show SMILES Fc1ccc(-c2c(NCCc3ccccc3)n3c(Cl)cccc3c2C#N)c2ccccc12
Show InChI InChI=1S/C27H19ClFN3/c28-25-12-6-11-24-22(17-30)26(21-13-14-23(29)20-10-5-4-9-19(20)21)27(32(24)25)31-16-15-18-7-2-1-3-8-18/h1-14,31H,15-16H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50189003
PNG
(5-chloro-3-(phenethylamino)-2-p-tolylindolizine-1-...)
Show SMILES Cc1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H20ClN3/c1-17-10-12-19(13-11-17)23-20(16-26)21-8-5-9-22(25)28(21)24(23)27-15-14-18-6-3-2-4-7-18/h2-13,27H,14-15H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188972
PNG
(5-chloro-2-(4-methoxyphenyl)-3-(phenethylamino)ind...)
Show SMILES COc1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H20ClN3O/c1-29-19-12-10-18(11-13-19)23-20(16-26)21-8-5-9-22(25)28(21)24(23)27-15-14-17-6-3-2-4-7-17/h2-13,27H,14-15H2,1H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188975
PNG
(5-chloro-2-(4-fluorophenyl)-3-(phenethylamino)indo...)
Show SMILES Fc1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C23H17ClFN3/c24-21-8-4-7-20-19(15-26)22(17-9-11-18(25)12-10-17)23(28(20)21)27-14-13-16-5-2-1-3-6-16/h1-12,27H,13-14H2
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n/an/a 5.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188997
PNG
(5-chloro-2-(2,5-dimethylphenyl)-3-(phenethylamino)...)
Show SMILES Cc1ccc(C)c(c1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C25H22ClN3/c1-17-11-12-18(2)20(15-17)24-21(16-27)22-9-6-10-23(26)29(22)25(24)28-14-13-19-7-4-3-5-8-19/h3-12,15,28H,13-14H2,1-2H3
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188992
PNG
(5-chloro-3-(phenethylamino)-2-(pyridin-4-yl)indoli...)
Show SMILES Clc1cccc2c(C#N)c(c(NCCc3ccccc3)n12)-c1ccncc1
Show InChI InChI=1S/C22H17ClN4/c23-20-8-4-7-19-18(15-24)21(17-10-12-25-13-11-17)22(27(19)20)26-14-9-16-5-2-1-3-6-16/h1-8,10-13,26H,9,14H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188984
PNG
(5-chloro-2-(3-mercaptophenyl)-3-(phenethylamino)in...)
Show SMILES Sc1cccc(c1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C23H18ClN3S/c24-21-11-5-10-20-19(15-25)22(17-8-4-9-18(28)14-17)23(27(20)21)26-13-12-16-6-2-1-3-7-16/h1-11,14,26,28H,12-13H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313494
PNG
((S)-2-[(3-{3-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-...)
Show SMILES Cc1nn(C)c(Cl)c1CNc1cccc(c1)S(=O)(=O)Nc1ccsc1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C23H29ClN8O5S2/c1-13-16(20(24)32(2)30-13)12-28-14-5-3-6-15(11-14)39(36,37)31-17-8-10-38-19(17)21(33)29-18(22(34)35)7-4-9-27-23(25)26/h3,5-6,8,10-11,18,28,31H,4,7,9,12H2,1-2H3,(H,29,33)(H,34,35)(H4,25,26,27)/t18-/m0/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313491
PNG
((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc2nsnc12)C(O)=O
Show InChI InChI=1S/C17H19N7O5S3/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20)/t11-/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313491
PNG
((S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc2nsnc12)C(O)=O
Show InChI InChI=1S/C17H19N7O5S3/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20)/t11-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188996
PNG
(5-chloro-3-(2-methoxyethylamino)-2-phenylindolizin...)
Show SMILES COCCNc1c(c(C#N)c2cccc(Cl)n12)-c1ccccc1
Show InChI InChI=1S/C18H16ClN3O/c1-23-11-10-21-18-17(13-6-3-2-4-7-13)14(12-20)15-8-5-9-16(19)22(15)18/h2-9,21H,10-11H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313489
PNG
((S)-2-{[3-(2-nitro-benzenesulfonylamino)-thiophene...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1ccccc1[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C17H20N6O7S2/c18-17(19)20-8-3-4-11(16(25)26)21-15(24)14-10(7-9-31-14)22-32(29,30)13-6-2-1-5-12(13)23(27)28/h1-2,5-7,9,11,22H,3-4,8H2,(H,21,24)(H,25,26)(H4,18,19,20)/t11-/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188986
PNG
(5-chloro-3-(phenethylamino)-2-o-tolylindolizine-1-...)
Show SMILES Cc1ccccc1-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H20ClN3/c1-17-8-5-6-11-19(17)23-20(16-26)21-12-7-13-22(25)28(21)24(23)27-15-14-18-9-3-2-4-10-18/h2-13,27H,14-15H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1


(Homo sapiens)
BDBM94385
PNG
((2-Allyloxy-3-ethoxy-benzyl)-(1H-[1,2,4]triazol-3-...)
Show SMILES CCOc1cccc(CNc2nnc[nH]2)c1OCC=C
Show InChI InChI=1S/C14H18N4O2/c1-3-8-20-13-11(6-5-7-12(13)19-4-2)9-15-14-16-10-17-18-14/h3,5-7,10H,1,4,8-9H2,2H3,(H2,15,16,17,18)
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n/an/a 9.90E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188966
PNG
(5-chloro-2-(2-mercaptophenyl)-3-(phenethylamino)in...)
Show SMILES Sc1ccccc1-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C23H18ClN3S/c24-21-12-6-10-19-18(15-25)22(17-9-4-5-11-20(17)28)23(27(19)21)26-14-13-16-7-2-1-3-8-16/h1-12,26,28H,13-14H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50189001
PNG
(5-chloro-2-(4-(3-(dimethylamino)propoxy)phenyl)-3-...)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C28H29ClN4O/c1-32(2)18-7-19-34-23-14-12-22(13-15-23)27-24(20-30)25-10-6-11-26(29)33(25)28(27)31-17-16-21-8-4-3-5-9-21/h3-6,8-15,31H,7,16-19H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313493
PNG
((S)-2-{[3-(1,2-Dimethyl-1H-imidazole-4-sulfonylami...)
Show SMILES Cc1nc(cn1C)S(=O)(=O)Nc1ccsc1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C16H23N7O5S2/c1-9-20-12(8-23(9)2)30(27,28)22-10-5-7-29-13(10)14(24)21-11(15(25)26)4-3-6-19-16(17)18/h5,7-8,11,22H,3-4,6H2,1-2H3,(H,21,24)(H,25,26)(H4,17,18,19)/t11-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313484
PNG
((S)-2-{[3-(4-Amino-benzenesulfonylamino)-thiophene...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1ccc(N)cc1)C(O)=O
Show InChI InChI=1S/C17H22N6O5S2/c18-10-3-5-11(6-4-10)30(27,28)23-12-7-9-29-14(12)15(24)22-13(16(25)26)2-1-8-21-17(19)20/h3-7,9,13,23H,1-2,8,18H2,(H,22,24)(H,25,26)(H4,19,20,21)/t13-/m0/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188965
PNG
(5-chloro-3-(phenethylamino)-2-(4-(trifluoromethoxy...)
Show SMILES FC(F)(F)Oc1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C24H17ClF3N3O/c25-21-8-4-7-20-19(15-29)22(17-9-11-18(12-10-17)32-24(26,27)28)23(31(20)21)30-14-13-16-5-2-1-3-6-16/h1-12,30H,13-14H2
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n/an/a 1.30E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188993
PNG
(5-chloro-2-(2-hydroxyethyl)-3-(phenethylamino)indo...)
Show SMILES OCCc1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C19H18ClN3O/c20-18-8-4-7-17-16(13-21)15(10-12-24)19(23(17)18)22-11-9-14-5-2-1-3-6-14/h1-8,22,24H,9-12H2
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n/an/a 1.30E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188991
PNG
(3-(3,4-dichlorobenzylamino)-5-chloro-2-phenylindol...)
Show SMILES Clc1ccc(CNc2c(c(C#N)c3cccc(Cl)n23)-c2ccccc2)cc1Cl
Show InChI InChI=1S/C22H14Cl3N3/c23-17-10-9-14(11-18(17)24)13-27-22-21(15-5-2-1-3-6-15)16(12-26)19-7-4-8-20(25)28(19)22/h1-11,27H,13H2
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n/an/a 1.30E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313483
PNG
(CHEMBL1091089 | H-KPPR-OH)
Show SMILES NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C22H40N8O5/c23-10-2-1-6-14(24)19(32)30-13-5-9-17(30)20(33)29-12-4-8-16(29)18(31)28-15(21(34)35)7-3-11-27-22(25)26/h14-17H,1-13,23-24H2,(H,28,31)(H,34,35)(H4,25,26,27)/t14-,15-,16-,17-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188989
PNG
(2-(4-tert-butylphenyl)-5-chloro-3-(phenethylamino)...)
Show SMILES CC(C)(C)c1ccc(cc1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C27H26ClN3/c1-27(2,3)21-14-12-20(13-15-21)25-22(18-29)23-10-7-11-24(28)31(23)26(25)30-17-16-19-8-5-4-6-9-19/h4-15,30H,16-17H2,1-3H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313485
PNG
((S)-2-{[3-(3-Amino-benzenesulfonylamino)-thiophene...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc(N)c1)C(O)=O
Show InChI InChI=1S/C17H22N6O5S2/c18-10-3-1-4-11(9-10)30(27,28)23-12-6-8-29-14(12)15(24)22-13(16(25)26)5-2-7-21-17(19)20/h1,3-4,6,8-9,13,23H,2,5,7,18H2,(H,22,24)(H,25,26)(H4,19,20,21)/t13-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313492
PNG
((S)-2-{[3-(Benzo[1,2,5]oxadiazole-4-sulfonylamino)...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1cccc2nonc12)C(O)=O
Show InChI InChI=1S/C17H19N7O6S2/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-31-14)24-32(28,29)12-5-1-3-9-13(12)23-30-22-9/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20)/t11-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313486
PNG
((S)-2-{[3-(2-Amino-benzenesulfonylamino)-thiophene...)
Show SMILES NC(N)=NCCC[C@H](NC(=O)c1sccc1NS(=O)(=O)c1ccccc1N)C(O)=O
Show InChI InChI=1S/C17H22N6O5S2/c18-10-4-1-2-6-13(10)30(27,28)23-11-7-9-29-14(11)15(24)22-12(16(25)26)5-3-8-21-17(19)20/h1-2,4,6-7,9,12,23H,3,5,8,18H2,(H,22,24)(H,25,26)(H4,19,20,21)/t12-/m0/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313481
PNG
((2S)-2-((2S)-2-((2S)-1-((6S,12S,15S)-6-acetamido-1...)
Show SMILES CCC(NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C36H64N14O11/c1-4-21(46-30(56)22(45-20(3)51)11-7-15-42-35(38)39)29(55)49-25(18-27(52)53)31(57)47-23(10-5-6-14-37)33(59)50-17-9-13-26(50)32(58)44-19(2)28(54)48-24(34(60)61)12-8-16-43-36(40)41/h19,21-26H,4-18,37H2,1-3H3,(H,44,58)(H,45,51)(H,46,56)(H,47,57)(H,48,54)(H,49,55)(H,52,53)(H,60,61)(H4,38,39,42)(H4,40,41,43)/t19-,21?,22-,23-,24-,25-,26-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50313487
PNG
((S)-2-{[3-(4-Acetylamino-benzenesulfonylamino)-thi...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccsc1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C19H24N6O6S2/c1-11(26)23-12-4-6-13(7-5-12)33(30,31)25-14-8-10-32-16(14)17(27)24-15(18(28)29)3-2-9-22-19(20)21/h4-8,10,15,25H,2-3,9H2,1H3,(H,23,26)(H,24,27)(H,28,29)(H4,20,21,22)/t15-/m0/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Domainex Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188976
PNG
(2-(5-chloro-1-cyano-2-phenylindolizin-3-ylamino)-N...)
Show SMILES Clc1cccc2c(C#N)c(c(NCC(=O)NCc3ccco3)n12)-c1ccccc1
Show InChI InChI=1S/C22H17ClN4O2/c23-19-10-4-9-18-17(12-24)21(15-6-2-1-3-7-15)22(27(18)19)26-14-20(28)25-13-16-8-5-11-29-16/h1-11,26H,13-14H2,(H,25,28)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50317441
PNG
(ATWLPPR | CHEMBL1095672)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
Show InChI InChI=1S/C40H61N11O9/c1-21(2)18-29(48-34(54)28(19-24-20-45-26-11-6-5-10-25(24)26)47-36(56)32(23(4)52)49-33(53)22(3)41)37(57)51-17-9-14-31(51)38(58)50-16-8-13-30(50)35(55)46-27(39(59)60)12-7-15-44-40(42)43/h5-6,10-11,20-23,27-32,45,52H,7-9,12-19,41H2,1-4H3,(H,46,55)(H,47,56)(H,48,54)(H,49,53)(H,59,60)(H4,42,43,44)/t22-,23+,27-,28-,29-,30-,31-,32-/m0/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Nancy Universit£-CNRS

Curated by ChEMBL


Assay Description
Inhibition of VEGF binding to NRP1 expressed in CHO cells


Citation and Details
More data for this
Ligand-Target Pair
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1


(Homo sapiens)
BDBM94103
PNG
(4-(4-methoxyphenoxy)-2-phenyl-5-pyrimidinecarboxyl...)
Show SMILES CCOC(=O)c1cnc(nc1Oc1ccc(OC)cc1)-c1ccccc1
Show InChI InChI=1S/C20H18N2O4/c1-3-25-20(23)17-13-21-18(14-7-5-4-6-8-14)22-19(17)26-16-11-9-15(24-2)10-12-16/h4-13H,3H2,1-2H3
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n/an/a 1.99E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1


(Homo sapiens)
BDBM94452
PNG
(2-(4-Hydroxy-5-methyl-6-oxo-1-p-tolyl-1,6-dihydro-...)
Show SMILES COc1cccc(NC(=O)CSc2nc(O)c(C)c(=O)n2-c2ccc(C)cc2)c1
Show InChI InChI=1S/C21H21N3O4S/c1-13-7-9-16(10-8-13)24-20(27)14(2)19(26)23-21(24)29-12-18(25)22-15-5-4-6-17(11-15)28-3/h4-11,26H,12H2,1-3H3,(H,22,25)
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n/an/a 2.01E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay




PubChem Bioassay (2012)

More data for this
Ligand-Target Pair
Neuropilin-1


(Homo sapiens)
BDBM50188981
PNG
(5-chloro-2-(5-methylthiazol-2-yl)-3-(phenethylamin...)
Show SMILES Cc1cnc(s1)-c1c(NCCc2ccccc2)n2c(Cl)cccc2c1C#N
Show InChI InChI=1S/C21H17ClN4S/c1-14-13-25-21(27-14)19-16(12-23)17-8-5-9-18(22)26(17)20(19)24-11-10-15-6-3-2-4-7-15/h2-9,13,24H,10-11H2,1H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



Pierre Fabre Urologie

Curated by ChEMBL


Assay Description
Inhibition of VEGF165-NRP1 interaction by ELISA


Citation and Details
More data for this
Ligand-Target Pair
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