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Compile Data Set for Download or QSAR

Found 79 hits Enz. Inhib. hit(s) with Target = 'Neurotensin receptor 1' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50130880
PNG
(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM85050
PNG
(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccc(cc1C(C)C)C(=O)N(C)CCCN(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O
Show InChI InChI=1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48)
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1.40n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50130880
PNG
(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
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1.70n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM85050
PNG
(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccc(cc1C(C)C)C(=O)N(C)CCCN(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O
Show InChI InChI=1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48)
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2n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50248034
PNG
(2-{[1-(7-Chloro-quinolin-4-yl)-5-(2,6-dimethoxy-ph...)
Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O
Show InChI InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)
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2.60n/an/an/an/an/an/an/an/a



Durham University

Curated by ChEMBL


Assay Description
Displacement of [125I]NT from rat NTR1 transfected in mouse LTK cells


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50041429
PNG
(CHEMBL3356854)
Show SMILES COc1cccc(OC)c1-c1nc(nc2ccc(Cl)cc12)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1/C23H24ClN3O5/c1-12(2)10-16(23(29)30)26-22(28)21-25-15-9-8-13(24)11-14(15)20(27-21)19-17(31-3)6-5-7-18(19)32-4/h5-9,11-12,16H,10H2,1-4H3,(H,26,28)(H,29,30)/t16-/s2
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>25n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50041427
PNG
(CHEMBL3356853)
Show SMILES COc1cccc(OC)c1-c1nc(nc2ccc(Cl)cc12)C(=O)NC1(CCCCC1)C(O)=O
Show InChI InChI=1S/C24H24ClN3O5/c1-32-17-7-6-8-18(33-2)19(17)20-15-13-14(25)9-10-16(15)26-21(27-20)22(29)28-24(23(30)31)11-4-3-5-12-24/h6-10,13H,3-5,11-12H2,1-2H3,(H,28,29)(H,30,31)
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>25n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50041428
PNG
(CHEMBL3356855)
Show SMILES COc1cccc(OC)c1-c1nc(nc2ccc(Cl)cc12)C(=O)N[C@@H](C1CCCCC1)C(O)=O
Show InChI InChI=1/C25H26ClN3O5/c1-33-18-9-6-10-19(34-2)20(18)22-16-13-15(26)11-12-17(16)27-23(28-22)24(30)29-21(25(31)32)14-7-4-3-5-8-14/h6,9-14,21H,3-5,7-8H2,1-2H3,(H,29,30)(H,31,32)/t21-/s2
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>25n/an/an/an/an/an/an/an/a



Research Triangle Institute

Curated by ChEMBL


Assay Description
Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366375
PNG
(CHEMBL1794002)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C38H57N5O8/c1-8-24(4)32(35(47)41-31(36(48)49)20-23(2)3)43-33(45)29(21-25-15-17-28(44)18-16-25)26-12-11-13-27(22-26)40-34(46)30(14-9-10-19-39)42-37(50)51-38(5,6)7/h11-13,15-18,22-24,29-32,44H,8-10,14,19-21,39H2,1-7H3,(H,40,46)(H,41,47)(H,42,50)(H,43,45)(H,48,49)/t24-,29+,30-,31-,32-/m0/s1
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29n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for binding affinity against Neurotensin receptor


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281809
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-6-Amino-2-ter...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H60N6O9/c1-8-23(4)30(33(47)40-28(35(49)50)20-22(2)3)42-31(45)27(21-24-14-16-25(44)17-15-24)39-32(46)29-13-11-19-43(29)34(48)26(12-9-10-18-38)41-36(51)52-37(5,6)7/h14-17,22-23,26-30,44H,8-13,18-21,38H2,1-7H3,(H,39,46)(H,40,47)(H,41,51)(H,42,45)(H,49,50)/t23-,26-,27-,28-,29-,30-/m0/s1
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63n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281809
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-6-Amino-2-ter...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H60N6O9/c1-8-23(4)30(33(47)40-28(35(49)50)20-22(2)3)42-31(45)27(21-24-14-16-25(44)17-15-24)39-32(46)29-13-11-19-43(29)34(48)26(12-9-10-18-38)41-36(51)52-37(5,6)7/h14-17,22-23,26-30,44H,8-13,18-21,38H2,1-7H3,(H,39,46)(H,40,47)(H,41,51)(H,42,45)(H,49,50)/t23-,26-,27-,28-,29-,30-/m0/s1
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TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281812
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-5-Amino-2-ter...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C36H58N6O9/c1-8-22(4)29(32(46)39-27(34(48)49)19-21(2)3)41-30(44)26(20-23-13-15-24(43)16-14-23)38-31(45)28-12-10-18-42(28)33(47)25(11-9-17-37)40-35(50)51-36(5,6)7/h13-16,21-22,25-29,43H,8-12,17-20,37H2,1-7H3,(H,38,45)(H,39,46)(H,40,50)(H,41,44)(H,48,49)/t22-,25-,26-,27-,28-,29-/m0/s1
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82n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281812
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-5-Amino-2-ter...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C36H58N6O9/c1-8-22(4)29(32(46)39-27(34(48)49)19-21(2)3)41-30(44)26(20-23-13-15-24(43)16-14-23)38-31(45)28-12-10-18-42(28)33(47)25(11-9-17-37)40-35(50)51-36(5,6)7/h13-16,21-22,25-29,43H,8-12,17-20,37H2,1-7H3,(H,38,45)(H,39,46)(H,40,50)(H,41,44)(H,48,49)/t22-,25-,26-,27-,28-,29-/m0/s1
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82n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366303
PNG
(CHEMBL1790460)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C39H56N6O8/c1-5-25(4)33(37(50)43-31(39(52)53)22-24(2)3)44-35(48)30(23-26-16-18-28(46)19-17-26)42-36(49)32-15-11-21-45(32)38(51)29(14-9-10-20-40)41-34(47)27-12-7-6-8-13-27/h6-8,12-13,16-19,24-25,29-33,46H,5,9-11,14-15,20-23,40H2,1-4H3,(H,41,47)(H,42,49)(H,43,50)(H,44,48)(H,52,53)/t25-,29+,30+,31+,32+,33+/m1/s1
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100n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281811
PNG
((S)-2-{(2S,3S)-2-[(S)-2-[((S)-1-{(S)-2-[(Adamantan...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C43H66N6O8/c1-5-26(4)36(39(53)46-34(41(55)56)17-25(2)3)48-37(51)33(21-27-11-13-31(50)14-12-27)45-38(52)35-10-8-16-49(35)40(54)32(9-6-7-15-44)47-42(57)43-22-28-18-29(23-43)20-30(19-28)24-43/h11-14,25-26,28-30,32-36,50H,5-10,15-24,44H2,1-4H3,(H,45,52)(H,46,53)(H,47,57)(H,48,51)(H,55,56)/t26-,28?,29?,30?,32-,33-,34-,35-,36-,43?/m0/s1
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117n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281811
PNG
((S)-2-{(2S,3S)-2-[(S)-2-[((S)-1-{(S)-2-[(Adamantan...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C43H66N6O8/c1-5-26(4)36(39(53)46-34(41(55)56)17-25(2)3)48-37(51)33(21-27-11-13-31(50)14-12-27)45-38(52)35-10-8-16-49(35)40(54)32(9-6-7-15-44)47-42(57)43-22-28-18-29(23-43)20-30(19-28)24-43/h11-14,25-26,28-30,32-36,50H,5-10,15-24,44H2,1-4H3,(H,45,52)(H,46,53)(H,47,57)(H,48,51)(H,55,56)/t26-,28?,29?,30?,32-,33-,34-,35-,36-,43?/m0/s1
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120n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50019412
PNG
(CHEMBL3290096)
Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccnc2cc(Cl)ccc12)C(=O)NC1(CCCCC1)C(O)=O
Show InChI InChI=1S/C28H27ClN4O5/c1-37-23-7-6-8-24(38-2)25(23)22-16-20(26(34)31-28(27(35)36)12-4-3-5-13-28)32-33(22)21-11-14-30-19-15-17(29)9-10-18(19)21/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,31,34)(H,35,36)
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177n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366296
PNG
(CHEMBL1790463)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)C12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C42H64N6O8/c1-5-25(4)35(38(52)45-33(40(54)55)16-24(2)3)47-36(50)32(20-26-10-12-30(49)13-11-26)44-37(51)34-9-7-15-48(34)39(53)31(8-6-14-43)46-41(56)42-21-27-17-28(22-42)19-29(18-27)23-42/h10-13,24-25,27-29,31-35,49H,5-9,14-23,43H2,1-4H3,(H,44,51)(H,45,52)(H,46,56)(H,47,50)(H,54,55)/t25-,27?,28?,29?,31+,32+,33+,34+,35+,42?/m1/s1
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180n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366308
PNG
(CHEMBL1790472)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H60N6O8/c1-8-23(4)30(33(47)40-28(35(49)50)20-22(2)3)42-31(45)27(21-24-14-16-25(44)17-15-24)39-32(46)29-13-11-19-43(29)34(48)26(12-9-10-18-38)41-36(51)37(5,6)7/h14-17,22-23,26-30,44H,8-13,18-21,38H2,1-7H3,(H,39,46)(H,40,47)(H,41,51)(H,42,45)(H,49,50)/t23-,26+,27+,28+,29+,30+/m1/s1
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190n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366299
PNG
(CHEMBL1790467)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C43H64N6O8/c1-8-27(4)36(40(54)47-34(42(56)57)24-26(2)3)48-38(52)33(25-28-14-20-31(50)21-15-28)46-39(53)35-13-11-23-49(35)41(55)32(12-9-10-22-44)45-37(51)29-16-18-30(19-17-29)43(5,6)7/h14-21,26-27,32-36,50H,8-13,22-25,44H2,1-7H3,(H,45,51)(H,46,53)(H,47,54)(H,48,52)(H,56,57)/t27-,32+,33+,34+,35+,36+/m1/s1
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220n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366307
PNG
(CHEMBL1790457)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CCCCC1SCC2NC(=O)NC12)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C42H66N8O9S/c1-5-25(4)35(39(55)46-30(41(57)58)21-24(2)3)48-37(53)29(22-26-15-17-27(51)18-16-26)45-38(54)32-12-10-20-50(32)40(56)28(11-8-9-19-43)44-34(52)14-7-6-13-33-36-31(23-60-33)47-42(59)49-36/h15-18,24-25,28-33,35-36,51H,5-14,19-23,43H2,1-4H3,(H,44,52)(H,45,54)(H,46,55)(H,48,53)(H,57,58)(H2,47,49,59)/t25-,28+,29+,30+,31?,32+,33?,35+,36?/m1/s1
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290n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366298
PNG
(CHEMBL1790466)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1cccnc1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C38H55N7O8/c1-5-24(4)32(36(50)43-30(38(52)53)20-23(2)3)44-34(48)29(21-25-13-15-27(46)16-14-25)42-35(49)31-12-9-19-45(31)37(51)28(11-6-7-17-39)41-33(47)26-10-8-18-40-22-26/h8,10,13-16,18,22-24,28-32,46H,5-7,9,11-12,17,19-21,39H2,1-4H3,(H,41,47)(H,42,49)(H,43,50)(H,44,48)(H,52,53)/t24-,28+,29+,30+,31+,32+/m1/s1
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420n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366311
PNG
(CHEMBL1790470)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C31H50N6O7/c1-5-19(4)26(29(41)35-24(31(43)44)16-18(2)3)36-27(39)23(17-20-10-12-21(38)13-11-20)34-28(40)25-9-7-15-37(25)30(42)22(33)8-6-14-32/h10-13,18-19,22-26,38H,5-9,14-17,32-33H2,1-4H3,(H,34,40)(H,35,41)(H,36,39)(H,43,44)/t19-,22+,23+,24+,25+,26+/m1/s1
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520n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366302
PNG
(CHEMBL2369587)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC1CCC2CCCC12)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C42H66N6O8/c1-5-26(4)37(40(53)46-34(42(55)56)22-25(2)3)47-38(51)33(23-27-14-18-30(49)19-15-27)45-39(52)35-13-9-21-48(35)41(54)32(12-6-7-20-43)44-36(50)24-29-17-16-28-10-8-11-31(28)29/h14-15,18-19,25-26,28-29,31-35,37,49H,5-13,16-17,20-24,43H2,1-4H3,(H,44,50)(H,45,52)(H,46,53)(H,47,51)(H,55,56)/t26-,28?,29?,31?,32-,33-,34-,35-,37-/m0/s1
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540n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366310
PNG
(CHEMBL1790461)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C38H62N6O8/c1-8-24(4)32(35(49)42-29(37(51)52)20-23(2)3)43-33(47)28(21-25-14-16-26(45)17-15-25)41-34(48)30-13-11-19-44(30)36(50)27(12-9-10-18-39)40-31(46)22-38(5,6)7/h14-17,23-24,27-30,32,45H,8-13,18-22,39H2,1-7H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47)(H,51,52)/t24-,27+,28+,29+,30+,32+/m1/s1
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680n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281807
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-2,6-Diamino-h...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C32H52N6O7/c1-5-20(4)27(30(42)36-25(32(44)45)17-19(2)3)37-28(40)24(18-21-11-13-22(39)14-12-21)35-29(41)26-10-8-16-38(26)31(43)23(34)9-6-7-15-33/h11-14,19-20,23-27,39H,5-10,15-18,33-34H2,1-4H3,(H,35,41)(H,36,42)(H,37,40)(H,44,45)/t20-,23-,24-,25-,26-,27-/m0/s1
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688n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281807
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{[(S)-1-((S)-2,6-Diamino-h...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C32H52N6O7/c1-5-20(4)27(30(42)36-25(32(44)45)17-19(2)3)37-28(40)24(18-21-11-13-22(39)14-12-21)35-29(41)26-10-8-16-38(26)31(43)23(34)9-6-7-15-33/h11-14,19-20,23-27,39H,5-10,15-18,33-34H2,1-4H3,(H,35,41)(H,36,42)(H,37,40)(H,44,45)/t20-,23-,24-,25-,26-,27-/m0/s1
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690n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366371
PNG
(CHEMBL1793833)
Show SMILES CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H58N6O7/c1-8-25(4)32(33(45)41-31(34(46)47)20-24(2)3)42-35(48)43(23-26-15-17-30(44)18-16-26)29-14-11-13-27(21-29)39-22-28(12-9-10-19-38)40-36(49)50-37(5,6)7/h11,13-18,21,24-25,28,31-32,39,44H,8-10,12,19-20,22-23,38H2,1-7H3,(H,40,49)(H,41,45)(H,42,48)(H,46,47)/t25-,28-,31-,32-/m0/s1
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730n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for binding affinity against Neurotensin receptor


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366300
PNG
(CHEMBL1790465)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)c1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C45H60N6O8/c1-5-29(4)39(43(56)49-37(45(58)59)26-28(2)3)50-41(54)36(27-30-16-22-34(52)23-17-30)48-42(55)38-15-11-25-51(38)44(57)35(14-9-10-24-46)47-40(53)33-20-18-32(19-21-33)31-12-7-6-8-13-31/h6-8,12-13,16-23,28-29,35-39,52H,5,9-11,14-15,24-27,46H2,1-4H3,(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H,58,59)/t29-,35+,36+,37+,38+,39+/m1/s1
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880n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366374
PNG
(CHEMBL1793999)
Show SMILES CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(F)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H55FN6O7/c1-8-24(4)31(33(46)41-30(34(47)48)20-23(2)3)43-35(49)44(22-25-15-17-26(38)18-16-25)28-13-11-12-27(21-28)40-32(45)29(14-9-10-19-39)42-36(50)51-37(5,6)7/h11-13,15-18,21,23-24,29-31H,8-10,14,19-20,22,39H2,1-7H3,(H,40,45)(H,41,46)(H,42,50)(H,43,49)(H,47,48)/t24-,29-,30-,31-/m0/s1
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890n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for binding affinity against Neurotensin receptor


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366304
PNG
(CHEMBL2369588)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CC1CC2CCC1C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C41H64N6O8/c1-5-25(4)36(39(52)45-33(41(54)55)19-24(2)3)46-37(50)32(22-26-12-15-30(48)16-13-26)44-38(51)34-10-8-18-47(34)40(53)31(9-6-7-17-42)43-35(49)23-29-21-27-11-14-28(29)20-27/h12-13,15-16,24-25,27-29,31-34,36,48H,5-11,14,17-23,42H2,1-4H3,(H,43,49)(H,44,51)(H,45,52)(H,46,50)(H,54,55)/t25-,27?,28?,29?,31-,32-,33-,34-,36-/m0/s1
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1.00E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50019417
PNG
(CHEMBL3290101)
Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1cccc2ccccc12)C(=O)NC1(CCCCC1)C(O)=O
Show InChI InChI=1S/C29H29N3O5/c1-36-24-14-9-15-25(37-2)26(24)23-18-21(27(33)30-29(28(34)35)16-6-3-7-17-29)31-32(23)22-13-8-11-19-10-4-5-12-20(19)22/h4-5,8-15,18H,3,6-7,16-17H2,1-2H3,(H,30,33)(H,34,35)
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1.21E+3n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366370
PNG
(CHEMBL1794003)
Show SMILES CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H56N6O8/c1-8-24(4)31(33(46)40-30(34(47)48)20-23(2)3)42-35(49)43(22-25-15-17-28(44)18-16-25)27-13-11-12-26(21-27)39-32(45)29(14-9-10-19-38)41-36(50)51-37(5,6)7/h11-13,15-18,21,23-24,29-31,44H,8-10,14,19-20,22,38H2,1-7H3,(H,39,45)(H,40,46)(H,41,50)(H,42,49)(H,47,48)/t24-,29-,30-,31-/m0/s1
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1.25E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for binding affinity against Neurotensin receptor


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281806
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{N'-[2-((S)-1-{(S)-2-[(Ada...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NNCC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C44H69N7O8/c1-5-27(4)38(40(55)47-35(42(57)58)17-26(2)3)49-39(54)34(21-28-11-13-32(52)14-12-28)50-46-25-37(53)36-10-8-16-51(36)41(56)33(9-6-7-15-45)48-43(59)44-22-29-18-30(23-44)20-31(19-29)24-44/h11-14,26-27,29-31,33-36,38,46,50,52H,5-10,15-25,45H2,1-4H3,(H,47,55)(H,48,59)(H,49,54)(H,57,58)/t27-,29-,30+,31-,33-,34-,35-,36-,38-,44?/m0/s1
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1.61E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281810
PNG
((S)-2-{(2S,3S)-2-[(S)-2-{(E)-3-[(S)-1-((S)-6-Amino...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)N=CCC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C39H62N6O9/c1-8-25(4)33(35(49)42-30(37(51)52)22-24(2)3)44-34(48)29(23-26-14-16-27(46)17-15-26)41-20-18-32(47)31-13-11-21-45(31)36(50)28(12-9-10-19-40)43-38(53)54-39(5,6)7/h14-17,20,24-25,28-31,33,46H,8-13,18-19,21-23,40H2,1-7H3,(H,42,49)(H,43,53)(H,44,48)(H,51,52)/t25-,28-,29-,30-,31-,33-/m0/s1
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1.63E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366306
PNG
(CHEMBL1790473)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C34H54N6O8/c1-6-21(4)29(32(45)38-27(34(47)48)18-20(2)3)39-30(43)26(19-23-12-14-24(42)15-13-23)37-31(44)28-11-9-17-40(28)33(46)25(36-22(5)41)10-7-8-16-35/h12-15,20-21,25-29,42H,6-11,16-19,35H2,1-5H3,(H,36,41)(H,37,44)(H,38,45)(H,39,43)(H,47,48)/t21-,25+,26+,27+,28+,29+/m1/s1
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2.10E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366301
PNG
(CHEMBL1790469)
Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C40H51F15N6O8/c1-5-20(4)27(30(65)58-25(32(67)68)17-19(2)3)60-28(63)24(18-21-11-13-22(62)14-12-21)57-29(64)26-10-8-16-61(26)31(66)23(9-6-7-15-56)59-33(69)34(41,42)35(43,44)36(45,46)37(47,48)38(49,50)39(51,52)40(53,54)55/h11-14,19-20,23-27,62H,5-10,15-18,56H2,1-4H3,(H,57,64)(H,58,65)(H,59,69)(H,60,63)(H,67,68)/t20-,23+,24+,25+,26+,27+/m1/s1
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2.10E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366373
PNG
(CHEMBL1794000)
Show SMILES CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1cccc(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1F)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H55FN6O8/c1-8-23(4)31(33(47)41-28(34(48)49)20-22(2)3)43-35(50)44(21-24-15-17-25(45)18-16-24)29-14-11-13-26(30(29)38)40-32(46)27(12-9-10-19-39)42-36(51)52-37(5,6)7/h11,13-18,22-23,27-28,31,45H,8-10,12,19-21,39H2,1-7H3,(H,40,46)(H,41,47)(H,42,51)(H,43,50)(H,48,49)/t23-,27-,28-,31-/m0/s1
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2.20E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for binding affinity against Neurotensin receptor


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281804
PNG
((S)-2-{(2S,3S)-2-[(S)-2-(N'-{2-[(S)-1-((S)-5-Amino...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NNCC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H61N7O9/c1-8-23(4)31(33(48)40-28(35(50)51)19-22(2)3)42-32(47)27(20-24-13-15-25(45)16-14-24)43-39-21-30(46)29-12-10-18-44(29)34(49)26(11-9-17-38)41-36(52)53-37(5,6)7/h13-16,22-23,26-29,31,39,43,45H,8-12,17-21,38H2,1-7H3,(H,40,48)(H,41,52)(H,42,47)(H,50,51)/t23-,26-,27-,28-,29-,31-/m0/s1
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2.99E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50019423
PNG
(CHEMBL3290105)
Show SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccc(F)cc1)C(=O)NC1(CCCCC1)C(O)=O
Show InChI InChI=1S/C25H26FN3O5/c1-33-20-7-6-8-21(34-2)22(20)19-15-18(28-29(19)17-11-9-16(26)10-12-17)23(30)27-25(24(31)32)13-4-3-5-14-25/h6-12,15H,3-5,13-14H2,1-2H3,(H,27,30)(H,31,32)
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3.21E+3n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281813
PNG
((S)-2-((2S,3S)-2-{N'-[(S)-3-[((S)-1-{(S)-3-[(Adama...)
Show SMILES CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1NCC(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C45H72N8O8/c1-5-28(4)40(42(58)50-36(43(59)60)17-27(2)3)52-47-25-38(55)35(21-29-11-13-33(54)14-12-29)49-41(57)37-10-8-16-53(37)48-26-39(56)34(9-6-7-15-46)51-44(61)45-22-30-18-31(23-45)20-32(19-30)24-45/h11-14,27-28,30-32,34-37,40,47-48,52,54H,5-10,15-26,46H2,1-4H3,(H,49,57)(H,50,58)(H,51,61)(H,59,60)/t28-,30-,31+,32-,34-,35-,36-,37-,40-,45?/m0/s1
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3.86E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281805
PNG
((S)-2-((2S,3S)-2-{N'-[(S)-3-[((S)-1-{(S)-2-[(Adama...)
Show SMILES CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C44H69N7O8/c1-5-27(4)38(40(55)48-35(42(57)58)17-26(2)3)50-46-25-37(53)34(21-28-11-13-32(52)14-12-28)47-39(54)36-10-8-16-51(36)41(56)33(9-6-7-15-45)49-43(59)44-22-29-18-30(23-44)20-31(19-29)24-44/h11-14,26-27,29-31,33-36,38,46,50,52H,5-10,15-25,45H2,1-4H3,(H,47,54)(H,48,55)(H,49,59)(H,57,58)/t27-,29-,30+,31-,33-,34-,35-,36-,38-,44?/m0/s1
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5.96E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50069089
PNG
(CHEMBL3403505)
Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1S/C28H27ClN4O5/c1-37-22-7-6-8-23(38-2)25(22)21-16-24(31-26(34)28(27(35)36)12-4-3-5-13-28)32-33(21)20-11-14-30-19-15-17(29)9-10-18(19)20/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,35,36)(H,31,32,34)
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7.18E+3n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366372
PNG
(CHEMBL1793998)
Show SMILES CC[C@H](C)[C@H](NC(=O)N(Cc1ccc(O)cc1)c1ccc(F)c(NC(=O)[C@H](CCCCN)NC(=O)OC(C)(C)C)c1)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H55FN6O8/c1-8-23(4)31(33(47)41-30(34(48)49)19-22(2)3)43-35(50)44(21-24-12-15-26(45)16-13-24)25-14-17-27(38)29(20-25)40-32(46)28(11-9-10-18-39)42-36(51)52-37(5,6)7/h12-17,20,22-23,28,30-31,45H,8-11,18-19,21,39H2,1-7H3,(H,40,46)(H,41,47)(H,42,51)(H,43,50)(H,48,49)/t23-,28-,30-,31-/m0/s1
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>1.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for binding affinity against Neurotensin receptor


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50281808
PNG
((S)-2-((2S,3S)-2-{N'-[(S)-3-{[(S)-1-((S)-5-Amino-2...)
Show SMILES CC[C@H](C)[C@H](NNCC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C37H61N7O9/c1-8-23(4)31(33(48)41-28(35(50)51)19-22(2)3)43-39-21-30(46)27(20-24-13-15-25(45)16-14-24)40-32(47)29-12-10-18-44(29)34(49)26(11-9-17-38)42-36(52)53-37(5,6)7/h13-16,22-23,26-29,31,39,43,45H,8-12,17-21,38H2,1-7H3,(H,40,47)(H,41,48)(H,42,52)(H,50,51)/t23-,26-,27-,28-,29-,31-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Neurotensin receptor binding affinity by displacement of [3H]- neurotensin


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50366312
PNG
(CHEMBL1790476)
Show SMILES CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O
Show InChI InChI=1S/C50H86N6O8/c1-6-8-9-10-11-12-13-14-15-16-17-18-19-20-21-27-44(58)52-40(25-22-23-32-51)49(62)56-33-24-26-43(56)47(60)53-41(35-38-28-30-39(57)31-29-38)46(59)55-45(37(5)7-2)48(61)54-42(50(63)64)34-36(3)4/h28-31,36-37,40-43,45,57H,6-27,32-35,51H2,1-5H3,(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,63,64)/t37-,40+,41+,42+,43+,45+/m1/s1
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TBA

Assay Description
Binding affinity against rat neurotensin receptor.


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50069088
PNG
(CHEMBL3403504)
Show SMILES COc1cccc(OC)c1-c1cc(CN[C@@H](C2CCCCC2)C(O)=O)nn1-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1/C29H31ClN4O4/c1-37-25-9-6-10-26(38-2)27(25)24-16-20(17-32-28(29(35)36)18-7-4-3-5-8-18)33-34(24)23-13-14-31-22-15-19(30)11-12-21(22)23/h6,9-16,18,28,32H,3-5,7-8,17H2,1-2H3,(H,35,36)/t28-/s2
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>1.00E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50069090
PNG
(CHEMBL3403506)
Show SMILES COc1cccc(OC)c1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1cccc2ccccc12
Show InChI InChI=1S/C29H29N3O5/c1-36-23-14-9-15-24(37-2)26(23)22-18-25(30-27(33)29(28(34)35)16-6-3-7-17-29)31-32(22)21-13-8-11-19-10-4-5-12-20(19)21/h4-5,8-15,18H,3,6-7,16-17H2,1-2H3,(H,34,35)(H,30,31,33)
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1.02E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50019424
PNG
(CHEMBL3290106)
Show SMILES COc1ccccc1-c1cc(nn1-c1ccc(F)cc1)C(=O)NC1(CCCCC1)C(O)=O
Show InChI InChI=1S/C24H24FN3O4/c1-32-21-8-4-3-7-18(21)20-15-19(27-28(20)17-11-9-16(25)10-12-17)22(29)26-24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,26,29)(H,30,31)
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>2.50E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


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Ligand-Target Pair
Neurotensin receptor 1


(Rattus norvegicus)
BDBM50069092
PNG
(CHEMBL3403508)
Show SMILES COc1ccccc1-c1cc(NC(=O)C2(CCCCC2)C(O)=O)nn1-c1ccc(F)cc1
Show InChI InChI=1S/C24H24FN3O4/c1-32-20-8-4-3-7-18(20)19-15-21(27-28(19)17-11-9-16(25)10-12-17)26-22(29)24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,30,31)(H,26,27,29)
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PubMed
>2.50E+4n/an/an/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Displacement of [I125]neurotensin from rat NTS1 overexpressed in CHO-k1 cells by competitive binding Assay


Citation and Details
More data for this
Ligand-Target Pair
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