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Found 9 hits Enz. Inhib. hit(s) with Target = 'Nicotinamidase (BbNic)' AND taxid = 224326   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM50026863
PNG
(CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...)
Show SMILES O=Cc1cccnc1
Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H
KEGG

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PubMed
110n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92852
PNG
(Nicotinamidase Inhibitor, 19)
Show SMILES Cc1cncc(C=O)c1
Show InChI InChI=1S/C7H7NO/c1-6-2-7(5-9)4-8-3-6/h2-5H,1H3
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190n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92851
PNG
(Nicotinamidase Inhibitor, 18)
Show SMILES COc1cncc(C=O)c1
Show InChI InChI=1S/C7H7NO2/c1-10-7-2-6(5-9)3-8-4-7/h2-5H,1H3
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850n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92850
PNG
(Nicotinamidase Inhibitor, 17)
Show SMILES Brc1cncc(C=O)c1
Show InChI InChI=1S/C6H4BrNO/c7-6-1-5(4-9)2-8-3-6/h1-4H
KEGG

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1.30E+3n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92854
PNG
(Nicotinamidase Inhibitor, 21)
Show SMILES Fc1ccc(C=O)cn1
Show InChI InChI=1S/C6H4FNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
KEGG

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PubMed
1.80E+4n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92855
PNG
(Nicotinamidase Inhibitor, 22)
Show SMILES COc1ccncc1C=O
Show InChI InChI=1S/C7H7NO2/c1-10-7-2-3-8-4-6(7)5-9/h2-5H,1H3
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PubMed
1.53E+5n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92857
PNG
(Nicotinamidase Inhibitor, 24)
Show SMILES CC(=O)c1cccnc1
Show InChI InChI=1S/C7H7NO/c1-6(9)7-3-2-4-8-5-7/h2-5H,1H3
KEGG

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PubMed
3.42E+5n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92853
PNG
(Nicotinamidase Inhibitor, 20)
Show SMILES Clc1ncccc1C=O
Show InChI InChI=1S/C6H4ClNO/c7-6-5(4-9)2-1-3-8-6/h1-4H
KEGG

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PubMed
3.70E+5n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92856
PNG
(Nicotinamidase Inhibitor, 23 | PncA Inhibitor, 5)
Show SMILES N#Cc1cccnc1
Show InChI InChI=1S/C6H4N2/c7-4-6-2-1-3-8-5-6/h1-3,5H
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PubMed
2.00E+6n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Biochemistry 49: 10421-39 (2010)

More data for this
Ligand-Target Pair