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Found 9 hits Enz. Inhib. hit(s) with Target = 'Nicotinamidase (BbNic)' AND taxid = 224326   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM50026863
PNG
(CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...)
Show SMILES O=Cc1cccnc1
Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H
KEGG

UniProtKB/TrEMBL

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Article
PubMed
110n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


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More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92852
PNG
(Nicotinamidase Inhibitor, 19)
Show SMILES Cc1cncc(C=O)c1
Show InChI InChI=1S/C7H7NO/c1-6-2-7(5-9)4-8-3-6/h2-5H,1H3
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190n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92851
PNG
(Nicotinamidase Inhibitor, 18)
Show SMILES COc1cncc(C=O)c1
Show InChI InChI=1S/C7H7NO2/c1-10-7-2-6(5-9)3-8-4-7/h2-5H,1H3
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UniChem
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PubMed
850n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92850
PNG
(Nicotinamidase Inhibitor, 17)
Show SMILES Brc1cncc(C=O)c1
Show InChI InChI=1S/C6H4BrNO/c7-6-1-5(4-9)2-8-3-6/h1-4H
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PubMed
1.30E+3n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92854
PNG
(Nicotinamidase Inhibitor, 21)
Show SMILES Fc1ccc(C=O)cn1
Show InChI InChI=1S/C6H4FNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
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PubMed
1.80E+4n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92855
PNG
(Nicotinamidase Inhibitor, 22)
Show SMILES COc1ccncc1C=O
Show InChI InChI=1S/C7H7NO2/c1-10-7-2-3-8-4-6(7)5-9/h2-5H,1H3
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PubMed
1.53E+5n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92857
PNG
(Nicotinamidase Inhibitor, 24)
Show SMILES CC(=O)c1cccnc1
Show InChI InChI=1S/C7H7NO/c1-6(9)7-3-2-4-8-5-7/h2-5H,1H3
KEGG

UniProtKB/TrEMBL

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UniChem
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Article
PubMed
3.42E+5n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92853
PNG
(Nicotinamidase Inhibitor, 20)
Show SMILES Clc1ncccc1C=O
Show InChI InChI=1S/C6H4ClNO/c7-6-5(4-9)2-1-3-8-6/h1-4H
KEGG

UniProtKB/TrEMBL

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UniChem
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Article
PubMed
3.70E+5n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair
Nicotinamidase (BbNic)


(Borrelia burgdorferi)
BDBM92856
PNG
(Nicotinamidase Inhibitor, 23 | PncA Inhibitor, 5)
Show SMILES N#Cc1cccnc1
Show InChI InChI=1S/C6H4N2/c7-4-6-2-1-3-8-5-6/h1-3,5H
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UniChem
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Article
PubMed
2.00E+6n/an/an/an/an/an/an/an/a



Cornell University



Assay Description
Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...


Citation and Details
More data for this
Ligand-Target Pair