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Found 22 hits Enz. Inhib. hit(s) with Target = 'Nitric-oxide synthase, brain' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138191
PNG
((1S,5S,6R,7R)-7-Chloro-5-methyl-2-aza-bicyclo[4.1....)
Show SMILES C[C@H]1CC(N)=N[C@@H]2[C@H](Cl)[C@H]12
Show InChI InChI=1S/C7H11ClN2/c1-3-2-4(9)10-7-5(3)6(7)8/h3,5-7H,2H2,1H3,(H2,9,10)/t3-,5?,6+,7-/m0/s1
PDB
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n/an/a 15n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138186
PNG
(5-Bromomethyl-oxazolidin-(2Z)-ylideneamine | CHEMB...)
Show SMILES NC1=NCC(CBr)O1
Show InChI InChI=1S/C4H7BrN2O/c5-1-3-2-7-4(6)8-3/h3H,1-2H2,(H2,6,7)
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n/an/a 400n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50225106
PNG
((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Show SMILES N[C@@H](CCCNC(N)=N[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138190
PNG
((4S,5S)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...)
Show SMILES CCC[C@@H]1N=C(N)O[C@H]1C
Show InChI InChI=1S/C7H14N2O/c1-3-4-6-5(2)10-7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6-/m0/s1
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n/an/a 570n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138192
PNG
((4S,5R)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...)
Show SMILES CC[C@@H]1N=C(N)O[C@@H]1C
Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)9-6(7)8-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5+/m1/s1
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n/an/a 680n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138200
PNG
((4S,5S)-5-Methyl-4-pentyl-oxazolidin-(2Z)-ylidenea...)
Show SMILES CCCCC[C@@H]1N=C(N)O[C@H]1C
Show InChI InChI=1S/C9H18N2O/c1-3-4-5-6-8-7(2)12-9(10)11-8/h7-8H,3-6H2,1-2H3,(H2,10,11)/t7-,8-/m0/s1
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n/an/a 790n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138185
PNG
((4S,5R)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...)
Show SMILES CC[C@H]1OC(N)=N[C@H]1C
Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)8-6(7)9-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5+/m0/s1
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n/an/a 850n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138189
PNG
((4S,5R)-5-Methyl-4-propyl-oxazolidin-(2Z)-ylidenea...)
Show SMILES CCC[C@@H]1N=C(N)O[C@@H]1C
Show InChI InChI=1S/C7H14N2O/c1-3-4-6-5(2)10-7(8)9-6/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6+/m1/s1
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n/an/a 920n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138198
PNG
((4S,5R)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...)
Show SMILES CC[C@H]1OC(N)=N[C@H]1CC
Show InChI InChI=1S/C7H14N2O/c1-3-5-6(4-2)10-7(8)9-5/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6+/m0/s1
PDB
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n/an/a 1.20E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138201
PNG
(5-Methyl-oxazolidin-(2Z)-ylideneamine | CHEMBL1074...)
Show SMILES CC1CN=C(N)O1
Show InChI InChI=1S/C4H8N2O/c1-3-2-6-4(5)7-3/h3H,2H2,1H3,(H2,5,6)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138184
PNG
((4S,5R)-4,5-Dimethyl-oxazolidin-(2Z)-ylideneamine ...)
Show SMILES C[C@H]1OC(N)=N[C@H]1C
Show InChI InChI=1S/C5H10N2O/c1-3-4(2)8-5(6)7-3/h3-4H,1-2H3,(H2,6,7)/t3-,4+/m0/s1
PDB
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n/an/a 1.60E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138194
PNG
((4S,5S)-5-Ethyl-4-methyl-oxazolidin-(2Z)-ylideneam...)
Show SMILES CC[C@@H]1OC(N)=N[C@H]1C
Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)8-6(7)9-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138193
PNG
(5-Ethyl-oxazolidin-(2Z)-ylideneamine | CHEMBL10835...)
Show SMILES CCC1CN=C(N)O1
Show InChI InChI=1S/C5H10N2O/c1-2-4-3-7-5(6)8-4/h4H,2-3H2,1H3,(H2,6,7)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138187
PNG
((4S,5S)-4-Ethyl-5-methyl-oxazolidin-(2Z)-ylideneam...)
Show SMILES CC[C@@H]1N=C(N)O[C@H]1C
Show InChI InChI=1S/C6H12N2O/c1-3-5-4(2)9-6(7)8-5/h4-5H,3H2,1-2H3,(H2,7,8)/t4-,5-/m0/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138195
PNG
((4S,5S)-4,5-Diethyl-oxazolidin-(2Z)-ylideneamine |...)
Show SMILES CC[C@@H]1OC(N)=N[C@H]1CC
Show InChI InChI=1S/C7H14N2O/c1-3-5-6(4-2)10-7(8)9-5/h5-6H,3-4H2,1-2H3,(H2,8,9)/t5-,6-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138188
PNG
(4-Ethyl-oxazolidin-(2Z)-ylideneamine | CHEMBL10878...)
Show SMILES CCC1COC(N)=N1
Show InChI InChI=1S/C5H10N2O/c1-2-4-3-8-5(6)7-4/h4H,2-3H2,1H3,(H2,6,7)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138196
PNG
((4S,5R)-5-Methyl-4-pentyl-oxazolidin-(2Z)-ylidenea...)
Show SMILES CCCCC[C@@H]1N=C(N)O[C@@H]1C
Show InChI InChI=1S/C9H18N2O/c1-3-4-5-6-8-7(2)12-9(10)11-8/h7-8H,3-6H2,1-2H3,(H2,10,11)/t7-,8+/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50230993
PNG
((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...)
Show SMILES CNC(N)=NCCC[C@H](N)C(O)=O
Show InChI InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)/t5-/m0/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138202
PNG
(4-Methyl-oxazolidin-(2Z)-ylideneamine | CHEMBL1058...)
Show SMILES CC1COC(N)=N1
Show InChI InChI=1S/C4H8N2O/c1-3-2-7-4(5)6-3/h3H,2H2,1H3,(H2,5,6)
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n/an/a 9.80E+3n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50078037
PNG
(CHEMBL69446 | Oxazolidin-(2Z)-ylideneamine)
Show SMILES NC1=NCCO1
Show InChI InChI=1S/C3H6N2O/c4-3-5-1-2-6-3/h1-2H2,(H2,4,5)
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n/an/a 3.40E+4n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138197
PNG
((4S,5R)-4,5-Dipropyl-oxazolidin-(2Z)-ylideneamine ...)
Show SMILES CCC[C@H]1OC(N)=N[C@H]1CCC
Show InChI InChI=1S/C9H18N2O/c1-3-5-7-8(6-4-2)12-9(10)11-7/h7-8H,3-6H2,1-2H3,(H2,10,11)/t7-,8+/m0/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair
Nitric-oxide synthase, brain


(Mus musculus)
BDBM50138199
PNG
((4S,5S)-4,5-Dipropyl-oxazolidin-(2Z)-ylideneamine ...)
Show SMILES CCC[C@@H]1OC(N)=N[C@H]1CCC
Show InChI InChI=1S/C9H18N2O/c1-3-5-7-8(6-4-2)12-9(10)11-7/h7-8H,3-6H2,1-2H3,(H2,10,11)/t7-,8-/m0/s1
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n/an/a 7.30E+4n/an/an/an/an/an/a



Dainippon Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of neuronal nitric oxide synthase (nNOS) in mice


Bioorg Med Chem Lett 14: 313-6 (2003)

More data for this
Ligand-Target Pair