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Compile Data Set for Download or QSAR

Found 23 hits Enz. Inhib. hit(s) with Target = 'Nociceptin receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Mus musculus)
BDBM50333103
PNG
(CHEMBL1631931 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H143FN32O25/c1-48(125)73(123-86(146)61(39-49-26-28-51(91)29-27-49)111-71(132)45-107-69(130)43-106-70(131)44-108-75(135)50-17-3-2-4-18-50)88(148)109-46-72(133)110-52-22-8-13-36-103-68(129)42-63(121-87(147)64(47-124)122-82(142)55(21-7-12-34-94)114-79(139)57(116-76(52)136)24-15-37-104-89(98)99)85(145)117-58(25-16-38-105-90(100)101)80(140)112-53(19-5-10-32-92)77(137)115-56-23-9-14-35-102-67(128)41-60(74(97)134)119-83(143)59(30-31-65(95)126)118-84(144)62(40-66(96)127)120-81(141)54(113-78(56)138)20-6-11-33-93/h2-4,17-18,26-29,48,52-64,73,124-125H,5-16,19-25,30-47,92-94H2,1H3,(H2,95,126)(H2,96,127)(H2,97,134)(H,102,128)(H,103,129)(H,106,131)(H,107,130)(H,108,135)(H,109,148)(H,110,133)(H,111,132)(H,112,140)(H,113,138)(H,114,139)(H,115,137)(H,116,136)(H,117,145)(H,118,144)(H,119,143)(H,120,141)(H,121,147)(H,122,142)(H,123,146)(H4,98,99,104)(H4,100,101,105)/t48-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,73+/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333102
PNG
(CHEMBL1631930 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H144N32O25/c1-49(124)73(122-86(145)61(40-50-20-4-2-5-21-50)110-71(131)46-106-69(129)44-105-70(130)45-107-75(134)51-22-6-3-7-23-51)88(147)108-47-72(132)109-52-27-11-16-37-102-68(128)43-63(120-87(146)64(48-123)121-82(141)55(26-10-15-35-93)113-79(138)57(115-76(52)135)29-18-38-103-89(97)98)85(144)116-58(30-19-39-104-90(99)100)80(139)111-53(24-8-13-33-91)77(136)114-56-28-12-17-36-101-67(127)42-60(74(96)133)118-83(142)59(31-32-65(94)125)117-84(143)62(41-66(95)126)119-81(140)54(112-78(56)137)25-9-14-34-92/h2-7,20-23,49,52-64,73,123-124H,8-19,24-48,91-93H2,1H3,(H2,94,125)(H2,95,126)(H2,96,133)(H,101,127)(H,102,128)(H,105,130)(H,106,129)(H,107,134)(H,108,147)(H,109,132)(H,110,131)(H,111,139)(H,112,137)(H,113,138)(H,114,136)(H,115,135)(H,116,144)(H,117,143)(H,118,142)(H,119,140)(H,120,146)(H,121,141)(H,122,145)(H4,97,98,103)(H4,99,100,104)/t49-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,73+/m1/s1
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n/an/a 12n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333100
PNG
(BzLGlyGGF(4-F)TGARKSARKLKNQ-NH2 | CHEMBL1631928)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C82H134FN29O22/c1-43(2)35-56(76(130)108-52(20-10-13-31-85)74(128)110-58(37-61(88)116)77(131)103-50(67(89)121)28-29-60(87)115)109-73(127)51(19-9-12-30-84)106-72(126)55(23-16-34-95-82(92)93)105-69(123)45(4)101-79(133)59(42-113)111-75(129)53(21-11-14-32-86)107-71(125)54(22-15-33-94-81(90)91)104-68(122)44(3)100-64(119)41-99-80(134)66(46(5)114)112-78(132)57(36-47-24-26-49(83)27-25-47)102-65(120)40-97-62(117)38-96-63(118)39-98-70(124)48-17-7-6-8-18-48/h6-8,17-18,24-27,43-46,50-59,66,113-114H,9-16,19-23,28-42,84-86H2,1-5H3,(H2,87,115)(H2,88,116)(H2,89,121)(H,96,118)(H,97,117)(H,98,124)(H,99,134)(H,100,119)(H,101,133)(H,102,120)(H,103,131)(H,104,122)(H,105,123)(H,106,126)(H,107,125)(H,108,130)(H,109,127)(H,110,128)(H,111,129)(H,112,132)(H4,90,91,94)(H4,92,93,95)/t44-,45-,46+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,66-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333099
PNG
(BzLGlyGGFTGARKSARKLKNQ-NH2 | CHEMBL1631927)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C82H135N29O22/c1-44(2)36-56(76(129)107-52(25-13-16-32-84)74(127)109-58(38-61(87)115)77(130)102-50(67(88)120)29-30-60(86)114)108-73(126)51(24-12-15-31-83)105-72(125)55(28-19-35-94-82(91)92)104-69(122)46(4)100-79(132)59(43-112)110-75(128)53(26-14-17-33-85)106-71(124)54(27-18-34-93-81(89)90)103-68(121)45(3)99-64(118)42-98-80(133)66(47(5)113)111-78(131)57(37-48-20-8-6-9-21-48)101-65(119)41-96-62(116)39-95-63(117)40-97-70(123)49-22-10-7-11-23-49/h6-11,20-23,44-47,50-59,66,112-113H,12-19,24-43,83-85H2,1-5H3,(H2,86,114)(H2,87,115)(H2,88,120)(H,95,117)(H,96,116)(H,97,123)(H,98,133)(H,99,118)(H,100,132)(H,101,119)(H,102,130)(H,103,121)(H,104,122)(H,105,125)(H,106,124)(H,107,129)(H,108,126)(H,109,127)(H,110,128)(H,111,131)(H4,89,90,93)(H4,91,92,94)/t45-,46-,47+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,66-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50417551
PNG
(CHEMBL1631932)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1
Show InChI InChI=1S/C59H106N22O15/c1-31(2)28-42-55(94)79-41(47(62)86)29-44(84)67-24-13-9-19-38(50(89)76-40(21-15-27-70-59(65)66)52(91)75-36(53(92)80-42)16-6-10-22-60)77-56(95)43-30-45(85)68-25-12-8-18-35(78-57(96)46(33(4)82)72-34(5)83)49(88)71-32(3)48(87)73-39(20-14-26-69-58(63)64)51(90)74-37(54(93)81-43)17-7-11-23-61/h31-33,35-43,46,82H,6-30,60-61H2,1-5H3,(H2,62,86)(H,67,84)(H,68,85)(H,71,88)(H,72,83)(H,73,87)(H,74,90)(H,75,91)(H,76,89)(H,77,95)(H,78,96)(H,79,94)(H,80,92)(H,81,93)(H4,63,64,69)(H4,65,66,70)/t32-,33+,35-,36-,37-,38-,39-,40-,41-,42-,43-,46-/m0/s1
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n/an/a>100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50417552
PNG
(CHEMBL1631934)
Show SMILES C[C@@H](O)[C@H](N)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C68H122N28O20/c1-35(98)53(74)66(116)84-33-52(103)85-36-17-5-10-27-81-51(102)32-46(95-65(115)47(34-97)96-61(111)39(16-4-9-25-71)88-58(108)41(90-55(36)105)19-12-28-82-67(76)77)64(114)91-42(20-13-29-83-68(78)79)59(109)86-37(14-2-7-23-69)56(106)89-40-18-6-11-26-80-50(101)31-44(54(75)104)93-62(112)43(21-22-48(72)99)92-63(113)45(30-49(73)100)94-60(110)38(87-57(40)107)15-3-8-24-70/h35-47,53,97-98H,2-34,69-71,74H2,1H3,(H2,72,99)(H2,73,100)(H2,75,104)(H,80,101)(H,81,102)(H,84,116)(H,85,103)(H,86,109)(H,87,107)(H,88,108)(H,89,106)(H,90,105)(H,91,114)(H,92,113)(H,93,112)(H,94,110)(H,95,115)(H,96,111)(H4,76,77,82)(H4,78,79,83)/t35-,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,53+/m1/s1
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n/an/a>100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50417553
PNG
(CHEMBL1631933)
Show SMILES CC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C64H114N26O18/c1-34(92)79-35-17-5-10-27-76-50(96)32-45(89-62(108)46(33-91)90-58(104)38(16-4-9-25-67)82-55(101)40(84-52(35)98)19-12-28-77-63(71)72)61(107)85-41(20-13-29-78-64(73)74)56(102)80-36(14-2-7-23-65)53(99)83-39-18-6-11-26-75-49(95)31-43(51(70)97)87-59(105)42(21-22-47(68)93)86-60(106)44(30-48(69)94)88-57(103)37(81-54(39)100)15-3-8-24-66/h35-46,91H,2-33,65-67H2,1H3,(H2,68,93)(H2,69,94)(H2,70,97)(H,75,95)(H,76,96)(H,79,92)(H,80,102)(H,81,100)(H,82,101)(H,83,99)(H,84,98)(H,85,107)(H,86,106)(H,87,105)(H,88,103)(H,89,108)(H,90,104)(H4,71,72,77)(H4,73,74,78)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50417550
PNG
(CHEMBL1631919)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)CNC(=O)CNC(=O)c2ccccc2)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1
Show InChI InChI=1S/C79H126N26O19/c1-44(2)37-56-74(121)102-55(65(82)112)39-59(107)87-33-18-14-28-52(69(116)99-54(30-20-36-90-79(85)86)71(118)98-50(72(119)103-56)25-11-15-31-80)100-75(122)58-40-60(108)88-34-17-13-27-49(68(115)94-45(3)66(113)96-53(29-19-35-89-78(83)84)70(117)97-51(73(120)104-58)26-12-16-32-81)101-77(124)64(46(4)106)105-76(123)57(38-47-21-7-5-8-22-47)95-63(111)43-92-61(109)41-91-62(110)42-93-67(114)48-23-9-6-10-24-48/h5-10,21-24,44-46,49-58,64,106H,11-20,25-43,80-81H2,1-4H3,(H2,82,112)(H,87,107)(H,88,108)(H,91,110)(H,92,109)(H,93,114)(H,94,115)(H,95,111)(H,96,113)(H,97,117)(H,98,118)(H,99,116)(H,100,122)(H,101,124)(H,102,121)(H,103,119)(H,104,120)(H,105,123)(H4,83,84,89)(H4,85,86,90)/t45-,46+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,64-/m0/s1
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n/an/a>100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333101
PNG
(BzLGlyGGFTGARKSARK-NH2 | CHEMBL1631929)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C61H98N22O16/c1-34(75-47(88)32-74-59(99)49(36(3)85)83-57(97)43(28-37-16-6-4-7-17-37)77-48(89)31-72-45(86)29-71-46(87)30-73-53(93)38-18-8-5-9-19-38)51(91)79-42(23-15-27-70-61(67)68)55(95)81-40(21-11-13-25-63)56(96)82-44(33-84)58(98)76-35(2)52(92)80-41(22-14-26-69-60(65)66)54(94)78-39(50(64)90)20-10-12-24-62/h4-9,16-19,34-36,39-44,49,84-85H,10-15,20-33,62-63H2,1-3H3,(H2,64,90)(H,71,87)(H,72,86)(H,73,93)(H,74,99)(H,75,88)(H,76,98)(H,77,89)(H,78,94)(H,79,91)(H,80,92)(H,81,95)(H,82,96)(H,83,97)(H4,65,66,69)(H4,67,68,70)/t34-,35-,36+,39-,40-,41-,42-,43-,44-,49-/m0/s1
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n/an/a 755n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333107
PNG
(CHEMBL1631921 | H-FGGFTGARKSARKAANQA-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C79H129N29O22/c1-40(63(85)116)96-70(123)53(27-28-57(83)111)105-74(127)55(35-58(84)112)106-67(120)43(4)97-64(117)42(3)98-69(122)49(23-13-15-29-80)103-71(124)52(26-18-32-91-79(88)89)102-66(119)44(5)99-76(129)56(39-109)107-73(126)50(24-14-16-30-81)104-72(125)51(25-17-31-90-78(86)87)101-65(118)41(2)95-60(114)38-94-77(130)62(45(6)110)108-75(128)54(34-47-21-11-8-12-22-47)100-61(115)37-92-59(113)36-93-68(121)48(82)33-46-19-9-7-10-20-46/h7-12,19-22,40-45,48-56,62,109-110H,13-18,23-39,80-82H2,1-6H3,(H2,83,111)(H2,84,112)(H2,85,116)(H,92,113)(H,93,121)(H,94,130)(H,95,114)(H,96,123)(H,97,117)(H,98,122)(H,99,129)(H,100,115)(H,101,118)(H,102,119)(H,103,124)(H,104,125)(H,105,127)(H,106,120)(H,107,126)(H,108,128)(H4,86,87,90)(H4,88,89,91)/t40-,41-,42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,62-/m0/s1
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n/an/an/an/a 3.80n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333108
PNG
(CHEMBL1631922 | NA)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCNC(=O)C[C@H](NC1=O)C(N)=O)NC(=O)[C@@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccccc2)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N1
Show InChI InChI=1S/C79H128N26O18/c1-44(2)37-57-74(120)102-56(65(83)111)40-60(107)88-33-18-14-28-53(69(115)99-55(30-20-36-91-79(86)87)71(117)98-51(72(118)103-57)25-11-15-31-80)100-75(121)59-41-61(108)89-34-17-13-27-50(68(114)94-45(3)66(112)96-54(29-19-35-90-78(84)85)70(116)97-52(73(119)104-59)26-12-16-32-81)101-77(123)64(46(4)106)105-76(122)58(39-48-23-9-6-10-24-48)95-63(110)43-92-62(109)42-93-67(113)49(82)38-47-21-7-5-8-22-47/h5-10,21-24,44-46,49-59,64,106H,11-20,25-43,80-82H2,1-4H3,(H2,83,111)(H,88,107)(H,89,108)(H,92,109)(H,93,113)(H,94,114)(H,95,110)(H,96,112)(H,97,116)(H,98,117)(H,99,115)(H,100,121)(H,101,123)(H,102,120)(H,103,118)(H,104,119)(H,105,122)(H4,84,85,90)(H4,86,87,91)/t45-,46+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,64-/m0/s1
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n/an/an/an/a 3.10n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333103
PNG
(CHEMBL1631931 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)CNC(=O)c1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H143FN32O25/c1-48(125)73(123-86(146)61(39-49-26-28-51(91)29-27-49)111-71(132)45-107-69(130)43-106-70(131)44-108-75(135)50-17-3-2-4-18-50)88(148)109-46-72(133)110-52-22-8-13-36-103-68(129)42-63(121-87(147)64(47-124)122-82(142)55(21-7-12-34-94)114-79(139)57(116-76(52)136)24-15-37-104-89(98)99)85(145)117-58(25-16-38-105-90(100)101)80(140)112-53(19-5-10-32-92)77(137)115-56-23-9-14-35-102-67(128)41-60(74(97)134)119-83(143)59(30-31-65(95)126)118-84(144)62(40-66(96)127)120-81(141)54(113-78(56)138)20-6-11-33-93/h2-4,17-18,26-29,48,52-64,73,124-125H,5-16,19-25,30-47,92-94H2,1H3,(H2,95,126)(H2,96,127)(H2,97,134)(H,102,128)(H,103,129)(H,106,131)(H,107,130)(H,108,135)(H,109,148)(H,110,133)(H,111,132)(H,112,140)(H,113,138)(H,114,139)(H,115,137)(H,116,136)(H,117,145)(H,118,144)(H,119,143)(H,120,141)(H,121,147)(H,122,142)(H,123,146)(H4,98,99,104)(H4,100,101,105)/t48-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,73+/m1/s1
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n/an/an/a 1.95n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50411362
PNG
(CHEMBL437744)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)C(CN)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)NC(C)(C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C84H142FN33O21/c1-44(67(126)108-54(22-14-34-100-81(94)95)71(130)109-51(19-8-11-31-86)70(129)112-55(23-15-35-101-82(96)97)72(131)110-52(20-9-12-32-87)73(132)113-58(39-62(92)122)76(135)107-50(66(93)125)29-30-61(91)121)105-78(137)60(43-119)115-74(133)53(21-10-13-33-88)111-75(134)56(24-16-36-102-83(98)99)116-80(139)84(3,4)118-64(124)42-104-79(138)65(45(2)120)117-77(136)57(38-47-25-27-48(85)28-26-47)106-63(123)41-103-69(128)59(40-89)114-68(127)49(90)37-46-17-6-5-7-18-46/h5-7,17-18,25-28,44-45,49-60,65,119-120H,8-16,19-24,29-43,86-90H2,1-4H3,(H2,91,121)(H2,92,122)(H2,93,125)(H,103,128)(H,104,138)(H,105,137)(H,106,123)(H,107,135)(H,108,126)(H,109,130)(H,110,131)(H,111,134)(H,112,129)(H,113,132)(H,114,127)(H,115,133)(H,116,139)(H,117,136)(H,118,124)(H4,94,95,100)(H4,96,97,101)(H4,98,99,102)/t44-,45+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59?,60-,65-/m0/s1
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n/an/an/a 0.794n/an/an/an/an/a



University of Ferrara

Curated by ChEMBL


Assay Description
Antagonist activity at NOP receptor in Swiss mouse vas deferens by [35S]GTP-gamma-S binding assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333106
PNG
(CHEMBL1631920 | H-FGGFTGK(Ac)RKSNRKK(Ac)ANQN-NH2)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C91H149N33O26/c1-48(76(137)121-64(42-69(97)131)85(146)119-61(31-32-67(95)129)84(145)120-62(75(99)136)41-68(96)130)111-78(139)56(28-14-18-36-105-51(4)128)114-80(141)57(25-11-15-33-92)115-82(143)60(30-20-38-107-91(102)103)118-86(147)65(43-70(98)132)122-88(149)66(47-125)123-83(144)58(26-12-16-34-93)116-81(142)59(29-19-37-106-90(100)101)117-79(140)55(27-13-17-35-104-50(3)127)112-73(135)46-110-89(150)74(49(2)126)124-87(148)63(40-53-23-9-6-10-24-53)113-72(134)45-108-71(133)44-109-77(138)54(94)39-52-21-7-5-8-22-52/h5-10,21-24,48-49,54-66,74,125-126H,11-20,25-47,92-94H2,1-4H3,(H2,95,129)(H2,96,130)(H2,97,131)(H2,98,132)(H2,99,136)(H,104,127)(H,105,128)(H,108,133)(H,109,138)(H,110,150)(H,111,139)(H,112,135)(H,113,134)(H,114,141)(H,115,143)(H,116,142)(H,117,140)(H,118,147)(H,119,146)(H,120,145)(H,121,137)(H,122,149)(H,123,144)(H,124,148)(H4,100,101,106)(H4,102,103,107)/t48-,49+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,74-/m0/s1
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n/an/an/an/a 355n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333105
PNG
(CHEMBL1631909 | H-FGGF(4-F)TGARKSARKLKNQ-NH2)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C82H136FN29O21/c1-43(2)35-57(76(129)108-53(20-10-13-31-85)74(127)110-59(38-62(89)116)77(130)103-51(67(90)120)28-29-61(88)115)109-73(126)52(19-9-12-30-84)106-72(125)56(23-16-34-96-82(93)94)105-69(122)45(4)101-79(132)60(42-113)111-75(128)54(21-11-14-32-86)107-71(124)55(22-15-33-95-81(91)92)104-68(121)44(3)100-64(118)41-99-80(133)66(46(5)114)112-78(131)58(37-48-24-26-49(83)27-25-48)102-65(119)40-97-63(117)39-98-70(123)50(87)36-47-17-7-6-8-18-47/h6-8,17-18,24-27,43-46,50-60,66,113-114H,9-16,19-23,28-42,84-87H2,1-5H3,(H2,88,115)(H2,89,116)(H2,90,120)(H,97,117)(H,98,123)(H,99,133)(H,100,118)(H,101,132)(H,102,119)(H,103,130)(H,104,121)(H,105,122)(H,106,125)(H,107,124)(H,108,129)(H,109,126)(H,110,127)(H,111,128)(H,112,131)(H4,91,92,95)(H4,93,94,96)/t44-,45-,46+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,66-/m0/s1
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n/an/an/an/a 0.360n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50106479
PNG
(CHEMBL384755 | FGGFTGARKSARK | H-FGGFTGARKSARK-NH2...)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C61H100N22O15/c1-34(75-47(87)32-74-59(98)49(36(3)85)83-57(96)44(29-38-18-8-5-9-19-38)77-48(88)31-72-46(86)30-73-53(92)39(64)28-37-16-6-4-7-17-37)51(90)79-43(23-15-27-71-61(68)69)55(94)81-41(21-11-13-25-63)56(95)82-45(33-84)58(97)76-35(2)52(91)80-42(22-14-26-70-60(66)67)54(93)78-40(50(65)89)20-10-12-24-62/h4-9,16-19,34-36,39-45,49,84-85H,10-15,20-33,62-64H2,1-3H3,(H2,65,89)(H,72,86)(H,73,92)(H,74,98)(H,75,87)(H,76,97)(H,77,88)(H,78,93)(H,79,90)(H,80,91)(H,81,94)(H,82,95)(H,83,96)(H4,66,67,70)(H4,68,69,71)/t34-,35-,36+,39-,40-,41-,42-,43-,44-,45-,49-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333104
PNG
(CHEMBL389521 | H-FGGFTGARKSARKLANQ-NH2 | N/OFQ-NH2...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C79H130N28O21/c1-41(2)33-54(73(124)96-44(5)67(118)104-56(36-59(84)111)74(125)99-49(64(85)115)27-28-58(83)110)105-71(122)50(23-13-15-29-80)102-70(121)53(26-18-32-91-79(88)89)101-66(117)43(4)97-76(127)57(40-108)106-72(123)51(24-14-16-30-81)103-69(120)52(25-17-31-90-78(86)87)100-65(116)42(3)95-61(113)39-94-77(128)63(45(6)109)107-75(126)55(35-47-21-11-8-12-22-47)98-62(114)38-92-60(112)37-93-68(119)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,108-109H,13-18,23-40,80-82H2,1-6H3,(H2,83,110)(H2,84,111)(H2,85,115)(H,92,112)(H,93,119)(H,94,128)(H,95,113)(H,96,124)(H,97,127)(H,98,114)(H,99,125)(H,100,116)(H,101,117)(H,102,121)(H,103,120)(H,104,118)(H,105,122)(H,106,123)(H,107,126)(H4,86,87,90)(H4,88,89,91)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333098
PNG
(CHEMBL1631926 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H145FN32O24/c1-48(125)73(123-86(145)62(40-50-26-28-51(91)29-27-50)111-71(131)45-107-70(130)44-108-75(134)52(95)39-49-17-3-2-4-18-49)88(147)109-46-72(132)110-53-22-8-13-36-104-69(129)43-64(121-87(146)65(47-124)122-82(141)56(21-7-12-34-94)114-79(138)58(116-76(53)135)24-15-37-105-89(99)100)85(144)117-59(25-16-38-106-90(101)102)80(139)112-54(19-5-10-32-92)77(136)115-57-23-9-14-35-103-68(128)42-61(74(98)133)119-83(142)60(30-31-66(96)126)118-84(143)63(41-67(97)127)120-81(140)55(113-78(57)137)20-6-11-33-93/h2-4,17-18,26-29,48,52-65,73,124-125H,5-16,19-25,30-47,92-95H2,1H3,(H2,96,126)(H2,97,127)(H2,98,133)(H,103,128)(H,104,129)(H,107,130)(H,108,134)(H,109,147)(H,110,132)(H,111,131)(H,112,139)(H,113,137)(H,114,138)(H,115,136)(H,116,135)(H,117,144)(H,118,143)(H,119,142)(H,120,140)(H,121,146)(H,122,141)(H,123,145)(H4,99,100,105)(H4,101,102,106)/t48-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
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n/an/an/an/a 1n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose in presence of compound 14 by ...


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333098
PNG
(CHEMBL1631926 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C90H145FN32O24/c1-48(125)73(123-86(145)62(40-50-26-28-51(91)29-27-50)111-71(131)45-107-70(130)44-108-75(134)52(95)39-49-17-3-2-4-18-49)88(147)109-46-72(132)110-53-22-8-13-36-104-69(129)43-64(121-87(146)65(47-124)122-82(141)56(21-7-12-34-94)114-79(138)58(116-76(53)135)24-15-37-105-89(99)100)85(144)117-59(25-16-38-106-90(101)102)80(139)112-54(19-5-10-32-92)77(136)115-57-23-9-14-35-103-68(128)42-61(74(98)133)119-83(142)60(30-31-66(96)126)118-84(143)63(41-67(97)127)120-81(140)55(113-78(57)137)20-6-11-33-93/h2-4,17-18,26-29,48,52-65,73,124-125H,5-16,19-25,30-47,92-95H2,1H3,(H2,96,126)(H2,97,127)(H2,98,133)(H,103,128)(H,104,129)(H,107,130)(H,108,134)(H,109,147)(H,110,132)(H,111,131)(H,112,139)(H,113,137)(H,114,138)(H,115,136)(H,116,135)(H,117,144)(H,118,143)(H,119,142)(H,120,140)(H,121,146)(H,122,141)(H,123,145)(H4,99,100,105)(H4,101,102,106)/t48-,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,64+,65+,73+/m1/s1
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n/an/an/an/a 0.0400n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333097
PNG
(CHEMBL1631925 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C65H105N23O16/c1-37(90)53(88-61(102)46(31-39-18-6-3-7-19-39)81-51(93)34-77-50(92)33-78-55(96)40(68)30-38-16-4-2-5-17-38)63(104)79-35-52(94)80-42-22-10-13-27-74-49(91)32-47(60(101)85-44(23-14-28-75-64(70)71)57(98)82-41(54(69)95)20-8-11-25-66)86-62(103)48(36-89)87-59(100)43(21-9-12-26-67)83-58(99)45(84-56(42)97)24-15-29-76-65(72)73/h2-7,16-19,37,40-48,53,89-90H,8-15,20-36,66-68H2,1H3,(H2,69,95)(H,74,91)(H,77,92)(H,78,96)(H,79,104)(H,80,94)(H,81,93)(H,82,98)(H,83,99)(H,84,97)(H,85,101)(H,86,103)(H,87,100)(H,88,102)(H4,70,71,75)(H4,72,73,76)/t37-,40+,41+,42+,43+,44+,45+,46+,47+,48+,53+/m1/s1
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n/an/an/an/a 30n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50411363
PNG
(CHEMBL269068 | UFP-111)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)NC(C)(C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C83H140N32O21/c1-45(67(124)106-54(27-17-35-97-80(91)92)70(127)107-51(24-11-14-32-84)69(126)110-55(28-18-36-98-81(93)94)71(128)108-52(25-12-15-33-85)72(129)111-58(40-61(89)119)75(132)105-50(66(90)123)30-31-60(88)118)103-77(134)59(44-116)112-73(130)53(26-13-16-34-86)109-74(131)56(29-19-37-99-82(95)96)113-79(136)83(3,4)115-64(122)43-102-78(135)65(46(2)117)114-76(133)57(39-48-22-9-6-10-23-48)104-63(121)42-100-62(120)41-101-68(125)49(87)38-47-20-7-5-8-21-47/h5-10,20-23,45-46,49-59,65,116-117H,11-19,24-44,84-87H2,1-4H3,(H2,88,118)(H2,89,119)(H2,90,123)(H,100,120)(H,101,125)(H,102,135)(H,103,134)(H,104,121)(H,105,132)(H,106,124)(H,107,127)(H,108,128)(H,109,131)(H,110,126)(H,111,129)(H,112,130)(H,113,136)(H,114,133)(H,115,122)(H4,91,92,97)(H4,93,94,98)(H4,95,96,99)/t45-,46+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,65-/m0/s1
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n/an/an/a 34.7n/an/an/an/an/a



University of Ferrara

Curated by ChEMBL


Assay Description
Antagonist activity at NOP receptor in Swiss mouse vas deferens by [35S]GTP-gamma-S binding assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333095
PNG
(CHEMBL1631923 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC1=O)C(N)=O
Show InChI InChI=1S/C87H139N31O24/c1-46-72(129)115-60(39-64(92)122)81(138)113-57(29-30-63(91)121)80(137)114-58(71(93)128)40-65(123)98-33-16-12-26-52(74(131)105-46)108-76(133)53(23-9-13-31-88)109-78(135)56(28-18-36-101-87(96)97)112-82(139)61-41-66(124)99-34-15-11-25-51(75(132)111-55(27-17-35-100-86(94)95)77(134)110-54(24-10-14-32-89)79(136)117-62(45-119)84(141)116-61)106-69(127)44-104-85(142)70(47(2)120)118-83(140)59(38-49-21-7-4-8-22-49)107-68(126)43-102-67(125)42-103-73(130)50(90)37-48-19-5-3-6-20-48/h3-8,19-22,46-47,50-62,70,119-120H,9-18,23-45,88-90H2,1-2H3,(H2,91,121)(H2,92,122)(H2,93,128)(H,98,123)(H,99,124)(H,102,125)(H,103,130)(H,104,142)(H,105,131)(H,106,127)(H,107,126)(H,108,133)(H,109,135)(H,110,134)(H,111,132)(H,112,139)(H,113,138)(H,114,137)(H,115,129)(H,116,141)(H,117,136)(H,118,140)(H4,94,95,100)(H4,96,97,101)/t46-,47+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,70-/m0/s1
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n/an/an/an/a 0.610n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair
Nociceptin receptor


(Mus musculus)
BDBM50333096
PNG
(CHEMBL1631924 | NA)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CC(=O)NCCCC[C@@H](CC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N2)C(N)=O
Show InChI InChI=1S/C73H116N24O17/c1-42(98)61(97-70(113)53(35-44-20-6-3-7-21-44)90-59(103)40-86-58(102)39-87-64(107)46(76)34-43-18-4-2-5-19-43)71(114)88-41-60(104)89-48-25-11-15-31-82-56(100)37-52(62(77)105)95-68(111)49(24-9-13-29-75)92-67(110)51(27-17-33-85-73(80)81)94-69(112)54-38-57(101)83-30-14-10-22-45(63(106)96-54)36-55(99)47(23-8-12-28-74)91-66(109)50(93-65(48)108)26-16-32-84-72(78)79/h2-7,18-21,42,45-54,61,98H,8-17,22-41,74-76H2,1H3,(H2,77,105)(H,82,100)(H,83,101)(H,86,102)(H,87,107)(H,88,114)(H,89,104)(H,90,103)(H,91,109)(H,92,110)(H,93,108)(H,94,112)(H,95,111)(H,96,106)(H,97,113)(H4,78,79,84)(H4,80,81,85)/t42-,45+,46+,47+,48+,49+,50+,51+,52+,53+,54+,61+/m1/s1
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n/an/an/an/a 14n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assay


Citation and Details
More data for this
Ligand-Target Pair