BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with Target = 'Norepinephrine transporter' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Norepinephrine transporter


(MOUSE)
BDBM50014245
PNG
(6-Phenyl-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]iso...)
Show SMILES C1C[C@H]2N(C1)CC(c1ccccc1)c1ccccc21
Show InChI InChI=1S/C18H19N/c1-2-7-14(8-3-1)17-13-19-12-6-11-18(19)16-10-5-4-9-15(16)17/h1-5,7-10,17-18H,6,11-13H2/t17?,18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
0.600n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50021879
PNG
(6-(4-Chloro-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrol...)
Show SMILES Clc1ccc(cc1)[C@@H]1CN2CCC[C@@H]2c2ccccc12
Show InChI InChI=1S/C18H18ClN/c19-14-9-7-13(8-10-14)17-12-20-11-3-6-18(20)16-5-2-1-4-15(16)17/h1-2,4-5,7-10,17-18H,3,6,11-12H2/t17-,18+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
0.680n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014232
PNG
(6-(4-Ethynyl-phenyl)-1,2,3,5,6,10b-hexahydro-pyrro...)
Show SMILES C#Cc1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C20H19N/c1-2-15-9-11-16(12-10-15)19-14-21-13-5-8-20(21)18-7-4-3-6-17(18)19/h1,3-4,6-7,9-12,19-20H,5,8,13-14H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
0.940n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50322698
PNG
(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Show SMILES COC[C@]12C[C@]1(CCNC2)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H17Cl2NO/c1-18-9-13-7-14(13,4-5-17-8-13)10-2-3-11(15)12(16)6-10/h2-3,6,17H,4-5,7-9H2,1H3/t13-,14-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.58n/an/an/an/an/an/an/an/a



GlaxoSmithKline Medicines Research Centre

Curated by ChEMBL


Assay Description
Displacement of [3H]nisoxetine from NET in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014233
PNG
(6-(2-Chloro-phenyl)-1,2,3,5,6,10b-hexahydro-pyrrol...)
Show SMILES Clc1ccccc1C1CN2CCC[C@@H]2c2ccccc12
Show InChI InChI=1S/C18H18ClN/c19-17-9-4-3-7-14(17)16-12-20-11-5-10-18(20)15-8-2-1-6-13(15)16/h1-4,6-9,16,18H,5,10-12H2/t16?,18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
1.60n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014234
PNG
(9-Chloro-6-(4-chloro-phenyl)-1,2,3,5,6,10b-hexahyd...)
Show SMILES Clc1ccc(cc1)C1CN2CCCC2c2cc(Cl)ccc12
Show InChI InChI=1S/C18H17Cl2N/c19-13-5-3-12(4-6-13)17-11-21-9-1-2-18(21)16-10-14(20)7-8-15(16)17/h3-8,10,17-18H,1-2,9,11H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
3.20n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014242
PNG
(6-(2-Methoxy-phenyl)-1,2,3,5,6,10b-hexahydro-pyrro...)
Show SMILES COc1ccccc1C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H21NO/c1-21-19-11-5-4-9-16(19)17-13-20-12-6-10-18(20)15-8-3-2-7-14(15)17/h2-5,7-9,11,17-18H,6,10,12-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
3.30n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014240
PNG
(6-(2-Methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydr...)
Show SMILES CSc1ccccc1C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H21NS/c1-21-19-11-5-4-9-16(19)17-13-20-12-6-10-18(20)15-8-3-2-7-14(15)17/h2-5,7-9,11,17-18H,6,10,12-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
4.5n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014236
PNG
(6-(4-Ethylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydro...)
Show SMILES CCSc1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C20H23NS/c1-2-22-16-11-9-15(10-12-16)19-14-21-13-5-8-20(21)18-7-4-3-6-17(18)19/h3-4,6-7,9-12,19-20H,2,5,8,13-14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
6n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014241
PNG
(6-(4-Trifluoromethyl-phenyl)-1,2,3,5,6,10b-hexahyd...)
Show SMILES FC(F)(F)c1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H18F3N/c20-19(21,22)14-9-7-13(8-10-14)17-12-23-11-3-6-18(23)16-5-2-1-4-15(16)17/h1-2,4-5,7-10,17-18H,3,6,11-12H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
11n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014244
PNG
(10-Methyl-6-(4-methylsulfanyl-phenyl)-1,2,3,5,6,10...)
Show SMILES CSc1ccc(cc1)C1CN2CCCC2c2c(C)cccc12
Show InChI InChI=1S/C20H23NS/c1-14-5-3-6-17-18(15-8-10-16(22-2)11-9-15)13-21-12-4-7-19(21)20(14)17/h3,5-6,8-11,18-19H,4,7,12-13H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
12n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
12n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014239
PNG
(4-(1,2,3,5,6,10b-Hexahydro-pyrrolo[2,1-a]isoquinol...)
Show SMILES N#Cc1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H18N2/c20-12-14-7-9-15(10-8-14)18-13-21-11-3-6-19(21)17-5-2-1-4-16(17)18/h1-2,4-5,7-10,18-19H,3,6,11,13H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
14n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014224
PNG
(8-Chloro-6-(4-methylsulfanyl-phenyl)-1,2,3,5,6,10b...)
Show SMILES CSc1ccc(cc1)C1CN2CCCC2c2ccc(Cl)cc12
Show InChI InChI=1S/C19H20ClNS/c1-22-15-7-4-13(5-8-15)18-12-21-10-2-3-19(21)16-9-6-14(20)11-17(16)18/h4-9,11,18-19H,2-3,10,12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
16n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50010859
PNG
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
16n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells


Bioorg Med Chem Lett 11: 655-8 (2001)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014231
PNG
(6-(2,4-Dichloro-phenyl)-1,2,3,5,6,10b-hexahydro-py...)
Show SMILES Clc1ccc(C2CN3CCCC3c3ccccc23)c(Cl)c1
Show InChI InChI=1S/C18H17Cl2N/c19-12-7-8-14(17(20)10-12)16-11-21-9-3-6-18(21)15-5-2-1-4-13(15)16/h1-2,4-5,7-8,10,16,18H,3,6,9,11H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
17n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM22416
PNG
((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Show SMILES Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
Show InChI InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
20n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014226
PNG
(10-Chloro-6-(4-methylsulfanyl-phenyl)-1,2,3,5,6,10...)
Show SMILES CSc1ccc(cc1)C1CN2CCC[C@@H]2c2c(Cl)cccc12
Show InChI InChI=1S/C19H20ClNS/c1-22-14-9-7-13(8-10-14)16-12-21-11-3-6-18(21)19-15(16)4-2-5-17(19)20/h2,4-5,7-10,16,18H,3,6,11-12H2,1H3/t16?,18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
23n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014243
PNG
(CHEMBL95153 | N-[4-(1,2,3,5,6,10b-Hexahydro-pyrrol...)
Show SMILES CC(=O)Nc1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C20H22N2O/c1-14(23)21-16-10-8-15(9-11-16)19-13-22-12-4-7-20(22)18-6-3-2-5-17(18)19/h2-3,5-6,8-11,19-20H,4,7,12-13H2,1H3,(H,21,23)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
59n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014230
PNG
(6-(4-Methanesulfonyl-phenyl)-1,2,3,5,6,10b-hexahyd...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H21NO2S/c1-23(21,22)15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
79n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM30130
PNG
(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Show SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
85n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014225
PNG
(4-(1,2,3,5,6,10b-Hexahydro-pyrrolo[2,1-a]isoquinol...)
Show SMILES NC(=O)c1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H20N2O/c20-19(22)14-9-7-13(8-10-14)17-12-21-11-3-6-18(21)16-5-2-1-4-15(16)17/h1-2,4-5,7-10,17-18H,3,6,11-12H2,(H2,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
90n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014228
PNG
(10-Bromo-6-(4-methylsulfanyl-phenyl)-1,2,3,5,6,10b...)
Show SMILES CSc1ccc(cc1)C1CN2CCCC2c2c(Br)cccc12
Show InChI InChI=1S/C19H20BrNS/c1-22-14-9-7-13(8-10-14)16-12-21-11-3-6-18(21)19-15(16)4-2-5-17(19)20/h2,4-5,7-10,16,18H,3,6,11-12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
94n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014247
PNG
((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Show SMILES COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1
Show InChI InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3/t17-,20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
120n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014246
PNG
(6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydr...)
Show SMILES CSc1ccc(cc1)C1CN2CCC[C@H]2c2ccccc12
Show InChI InChI=1S/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18?,19-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
127n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014237
PNG
(6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydr...)
Show SMILES CSc1ccc(cc1)C1CN2CCC[C@@H]2c2ccccc12
Show InChI InChI=1S/C19H21NS/c1-21-15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3/t18?,19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
280n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50017721
PNG
(1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)pipe...)
Show SMILES CN1CCC(CC1)=C1c2ccccc2C=Cc2ccccc12
Show InChI InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
290n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells


Bioorg Med Chem Lett 11: 655-8 (2001)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014229
PNG
(6-(4-Methylsulfanyl-phenyl)-1,2,3,5,6,10b-hexahydr...)
Show SMILES CSc1ccc(cc1)C1CN2CCCC2c2c(cccc12)C#N
Show InChI InChI=1S/C20H20N2S/c1-23-16-9-7-14(8-10-16)18-13-22-11-3-6-19(22)20-15(12-21)4-2-5-17(18)20/h2,4-5,7-10,18-19H,3,6,11,13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
390n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50014227
PNG
(6-(4-Methanesulfinyl-phenyl)-1,2,3,5,6,10b-hexahyd...)
Show SMILES CS(=O)c1ccc(cc1)C1CN2CCCC2c2ccccc12
Show InChI InChI=1S/C19H21NOS/c1-22(21)15-10-8-14(9-11-15)18-13-20-12-4-7-19(20)17-6-3-2-5-16(17)18/h2-3,5-6,8-11,18-19H,4,7,12-13H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
723n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM25870
PNG
(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Show SMILES CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical

Curated by ChEMBL


Assay Description
Tested in vitro for norepinephrine (NE) neuronal uptake inhibition


J Med Chem 33: 2793-7 (1990)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM22417
PNG
(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)
Show SMILES CNCCC(Oc1ccccc1OC)c1ccccc1
Show InChI InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
7.05E+3n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM35229
PNG
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Show SMILES CNCCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
8.11E+3n/an/an/an/an/an/an/an/a



National Institutes of Health

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM35920
PNG
(9,10-dihydroanthracene(DHA), 1a | 9-(Aminomethyl)-...)
Show SMILES NCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C15H15N/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-8,15H,9-10,16H2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity to Norepinephrine transporter using [3H]-nisoxatine as radioligand in stably transfected NIH3T3 cells


Bioorg Med Chem Lett 11: 655-8 (2001)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50010307
PNG
(CHEMBL3251303)
Show SMILES Cl.CN(C)C1CC(C1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C18H21N.ClH/c1-19(2)17-13-18(14-17,15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 mins


J Med Chem 21: 78-82 (1978)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50010306
PNG
(CHEMBL3251302)
Show SMILES Cl.CNC1CC(C1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H19N.ClH/c1-18-16-12-17(13-16,14-8-4-2-5-9-14)15-10-6-3-7-11-15;/h2-11,16,18H,12-13H2,1H3;1H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 800n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 mins


J Med Chem 21: 78-82 (1978)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM77970
PNG
(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Show SMILES CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
Show InChI InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
PubMed
n/an/a 900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 mins


J Med Chem 21: 78-82 (1978)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50005246
PNG
(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)
Show SMILES CC(N)Cc1ccccc1
Show InChI InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 mins


J Med Chem 21: 78-82 (1978)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM35229
PNG
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Show SMILES CNCCCN1c2ccccc2CCc2ccccc12
Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 mins


J Med Chem 21: 78-82 (1978)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50010305
PNG
(CHEMBL3251301)
Show SMILES Cl.NC1CC(C1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H17N.ClH/c17-15-11-16(12-15,13-7-3-1-4-8-13)14-9-5-2-6-10-14;/h1-10,15H,11-12,17H2;1H
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 mins


J Med Chem 21: 78-82 (1978)

More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50063500
PNG
(CHEMBL3398506)
Show SMILES OC(=O)C(F)(F)F.Cc1ccsc1C(=CCCN1CCC[C@@H]1[C@@H](N)C(O)=O)c1sccc1C
Show InChI InChI=1/C20H26N2O2S2/c1-13-7-11-25-18(13)15(19-14(2)8-12-26-19)5-3-9-22-10-4-6-16(22)17(21)20(23)24/h5,7-8,11-12,16-17H,3-4,6,9-10,21H2,1-2H3,(H,23,24)/t16-,17-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.27E+4n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50063507
PNG
(CHEMBL3398507)
Show SMILES OC(=O)C(F)(F)F.Cc1ccsc1C(=CCCN1CCC[C@@H]1[C@H](N)C(O)=O)c1sccc1C
Show InChI InChI=1/C20H26N2O2S2/c1-13-7-11-25-18(13)15(19-14(2)8-12-26-19)5-3-9-22-10-4-6-16(22)17(21)20(23)24/h5,7-8,11-12,16-17H,3-4,6,9-10,21H2,1-2H3,(H,23,24)/t16-,17+/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+5n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50063513
PNG
(CHEMBL3398496)
Show SMILES OC(=O)C(F)(F)F.N[C@H]([C@H]1CCCN1)C(O)=O
Show InChI InChI=1/C6H12N2O2/c7-5(6(9)10)4-2-1-3-8-4/h4-5,8H,1-3,7H2,(H,9,10)/t4-,5-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.58E+5n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assay


Citation and Details
More data for this
Ligand-Target Pair
Norepinephrine transporter


(MOUSE)
BDBM50063510
PNG
(CHEMBL3398494)
Show SMILES O[C@H]([C@H]1CCCN1)C(O)=O
Show InChI InChI=1/C6H11NO3/c8-5(6(9)10)4-2-1-3-7-4/h4-5,7-8H,1-3H2,(H,9,10)/t4-,5-/s2
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.70E+5n/an/an/an/an/an/a



Ludwig-Maximilians-Universit£t M£nchen

Curated by ChEMBL


Assay Description
Inhibition of mouse GAT2 expressed in HEK293 cells by [3H]GABA uptake assay


Citation and Details
More data for this
Ligand-Target Pair