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Found 57 hits Enz. Inhib. hit(s) with Target = 'Notch 1 intracellular domain (Notch 1)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074771
PNG
(CHEMBL3410153)
Show SMILES CCC(CC)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C28H33F3N4O3/c1-4-17(5-2)22(24(32)36)20(15-16-28(29,30)31)26(37)34-25-27(38)35(3)21-14-10-9-13-19(21)23(33-25)18-11-7-6-8-12-18/h6-14,17,20,22,25H,4-5,15-16H2,1-3H3,(H2,32,36)(H,34,37)/t20-,22+,25-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074796
PNG
(CHEMBL3410169)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2F)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-19(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)20(13-14-29(32,33)34)23(25(35)39)18-12-11-17(30)15-21(18)31/h2-12,15,20,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t20-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074818
PNG
(CHEMBL3410163)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(c2)C(F)(F)F)C1=O)c1ccccc1
Show InChI InChI=1/C30H26F6N4O3/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209895
PNG
(US9273014, 24)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O
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n/an/a 1.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209891
PNG
(US9273014, 20)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F
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n/an/a 1.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209896
PNG
(US9273014, 25)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(c2)C2CC2)c2cccc(Cl)c2NC1=O
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n/an/a 1.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209874
PNG
(US9273014, 3)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074784
PNG
(CHEMBL3410151)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C29H38N4O3/c1-6-19(7-2)24(26(30)34)22(17-18(3)4)28(35)32-27-29(36)33(5)23-16-12-11-15-21(23)25(31-27)20-13-9-8-10-14-20/h8-16,18-19,22,24,27H,6-7,17H2,1-5H3,(H2,30,34)(H,32,35)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074795
PNG
(CHEMBL3410170)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cc(F)cc(F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-20(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)21(11-12-29(32,33)34)23(25(35)39)17-13-18(30)15-19(31)14-17/h2-10,13-15,21,23,26H,11-12H2,1H3,(H2,35,39)(H,37,40)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074799
PNG
(CHEMBL3410167)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)cc2)C1=O)c1ccccc1
Show InChI InChI=1/C29H26F4N4O3/c1-37-22-10-6-5-9-20(22)24(18-7-3-2-4-8-18)35-26(28(37)40)36-27(39)21(15-16-29(31,32)33)23(25(34)38)17-11-13-19(30)14-12-17/h2-14,21,23,26H,15-16H2,1H3,(H2,34,38)(H,36,39)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074798
PNG
(CHEMBL3410168)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccc(F)c(F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C29H25F5N4O3/c1-38-22-10-6-5-9-18(22)24(16-7-3-2-4-8-16)36-26(28(38)41)37-27(40)19(13-14-29(32,33)34)23(25(35)39)17-11-12-20(30)21(31)15-17/h2-12,15,19,23,26H,13-14H2,1H3,(H2,35,39)(H,37,40)/t19-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209876
PNG
(US9273014, 5)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
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n/an/a 2.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209881
PNG
(US9273014, 10)
Show SMILES Cc1cc(C)cc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209902
PNG
(US9273014, 31)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209898
PNG
(US9273014, 27)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cc1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074777
PNG
(CHEMBL3410152)
Show SMILES CCC(CC)[C@@H]([C@@H](CC(C)(C)C)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C30H40N4O3/c1-7-19(8-2)24(26(31)35)22(18-30(3,4)5)28(36)33-27-29(37)34(6)23-17-13-12-16-21(23)25(32-27)20-14-10-9-11-15-20/h9-17,19,22,24,27H,7-8,18H2,1-6H3,(H2,31,35)(H,33,36)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074695
PNG
(CHEMBL3410160)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2conc2C)C1=O)c1ccccc1
Show InChI InChI=1/C27H26F3N5O4/c1-15-19(14-39-34-15)21(23(31)36)18(12-13-27(28,29)30)25(37)33-24-26(38)35(2)20-11-7-6-10-17(20)22(32-24)16-8-4-3-5-9-16/h3-11,14,18,21,24H,12-13H2,1-2H3,(H2,31,36)(H,33,37)/t18-,21-,24-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074693
PNG
(CHEMBL3410162)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(C)c2)C1=O)c1ccccc1
Show InChI InChI=1/C30H29F3N4O3/c1-18-9-8-12-20(17-18)24(26(34)38)22(15-16-30(31,32)33)28(39)36-27-29(40)37(2)23-14-7-6-13-21(23)25(35-27)19-10-4-3-5-11-19/h3-14,17,22,24,27H,15-16H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074813
PNG
(CHEMBL3410164)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2cccc(OC(F)(F)F)c2)C1=O)c1ccccc1
Show InChI InChI=1/C30H26F6N4O4/c1-40-22-13-6-5-12-20(22)24(17-8-3-2-4-9-17)38-26(28(40)43)39-27(42)21(14-15-29(31,32)33)23(25(37)41)18-10-7-11-19(16-18)44-30(34,35)36/h2-13,16,21,23,26H,14-15H2,1H3,(H2,37,41)(H,39,42)/t21-,23+,26-/s2
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Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209883
PNG
(US9273014, 12)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209893
PNG
(US9273014, 22)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(F)cc1
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n/an/a 3.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209892
PNG
(US9273014, 21)
Show SMILES Cc1ccccc1C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
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n/an/a 3.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209884
PNG
(US9273014, 13)
Show SMILES CC(C)c1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209897
PNG
(US9273014, 26)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
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n/an/a 3.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209900
PNG
(US9273014, 29)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1
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n/an/a 3.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074694
PNG
(CHEMBL3410161)
Show SMILES CN1c2ccccc2C(=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)C1=O)c1ccccc1
Show InChI InChI=1/C29H27F3N4O3/c1-36-22-15-9-8-14-20(22)24(19-12-6-3-7-13-19)34-26(28(36)39)35-27(38)21(16-17-29(30,31)32)23(25(33)37)18-10-4-2-5-11-18/h2-15,21,23,26H,16-17H2,1H3,(H2,33,37)(H,35,38)/t21-,23+,26-/s2
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n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209904
PNG
(US9273014, 33)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(cn1)C(F)(F)F
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n/an/a 4.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O
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n/an/a 4.30n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209878
PNG
(US9273014, 7)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
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n/an/a 4.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209886
PNG
(US9273014, 15)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12
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n/an/a 4.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209889
PNG
(US9273014, 18)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(c1)C(F)(F)F
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n/an/a 4.60n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209894
PNG
(US9273014, 23)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccccc1
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n/an/a 4.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209905
PNG
(US9273014, 34)
Show SMILES COc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1ccc(Cl)cn1
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n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209890
PNG
(US9273014, 19)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O
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n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209901
PNG
(US9273014, 30 | US9273014, 35)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccc(CO)cc2)c2ccccc2NC1=O
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n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209899
PNG
(US9273014, 28)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
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n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209871
PNG
(US9273014, 2)
Show SMILES CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
UniProtKB/SwissProt

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n/an/a 4.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209888
PNG
(US9273014, 17)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
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n/an/a 5.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209887
PNG
(US9273014, 16)
Show SMILES NC(=O)[C@@H](CCCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(OC3CC3)c2NC1=O
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n/an/a 5.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209879
PNG
(US9273014, 8)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)N=C2c1cccc(Cl)c1
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n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209908
PNG
(US9273014, 37)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2cccc(F)c2)c2cccc(CO)c2NC1=O
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n/an/a 6.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209903
PNG
(US9273014, 32)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12
UniProtKB/SwissProt

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n/an/a 6.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209877
PNG
(US9273014, 6)
Show SMILES CCc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(C)c1
UniProtKB/SwissProt

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n/an/a 7.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209885
PNG
(US9273014, 14)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(OC3CC3)cccc12
UniProtKB/SwissProt

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n/an/a 7.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209870
PNG
(US9273014, 1)
Show SMILES Cc1cccc2c1NC(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)N=C2c1cccc(F)c1
UniProtKB/SwissProt

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n/an/a 7.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209880
PNG
(US9273014, 11 | US9273014, 9)
Show SMILES Cc1cccc(c1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2c1cccc2C(F)(F)F
UniProtKB/SwissProt

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n/an/a 8.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209875
PNG
(US9273014, 4)
Show SMILES Cc1ccc(cc1C)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCCC(F)(F)F)C(N)=O)C(=O)Nc2c(Cl)cccc12
UniProtKB/SwissProt

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n/an/a 8.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM50074804
PNG
(CHEMBL3410166)
Show SMILES COc1ccc(cc1)[C@@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2ccccc2N(C)C1=O)C(N)=O
Show InChI InChI=1/C30H29F3N4O4/c1-37-23-11-7-6-10-21(23)25(19-8-4-3-5-9-19)35-27(29(37)40)36-28(39)22(16-17-30(31,32)33)24(26(34)38)18-12-14-20(41-2)15-13-18/h3-15,22,24,27H,16-17H2,1-2H3,(H2,34,38)(H,36,39)/t22-,24+,27-/s2
UniProtKB/SwissProt

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n/an/a 9n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...


Citation and Details
More data for this
Ligand-Target Pair
Notch 1 intracellular domain (Notch 1)


(Homo sapiens (Human))
BDBM209907
PNG
(US9273014, 36)
Show SMILES Cc1ccc(cc1)C1=N[C@H](NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(N)=O)C(=O)Nc2ccccc12
UniProtKB/SwissProt

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n/an/a 12.2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.


US Patent US9273014 (2016)

More data for this
Ligand-Target Pair
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