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Compile Data Set for Download or QSAR

Found 13 hits Enz. Inhib. hit(s) with Target = 'Oligosaccharyl transferase 48 kDa subunit' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085483
PNG
((2-{(3R,6S)-3-[(1S,2R)-2-Hydroxy-1-((S)-1-{(1S,2R)...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH2+]c2ccc3ccccc3c2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C44H60N8O10S/c1-26(2)37(43(59)51-38(27(3)53)42(58)46-21-19-29-13-17-33(18-14-29)52(61)62)49-44(60)39(28(4)54)50-41(57)35-25-63-23-9-5-6-12-36(55)47-34(40(56)48-35)20-22-45-32-16-15-30-10-7-8-11-31(30)24-32/h7-8,10-11,13-18,24,26-28,34-35,37-39,45,53-54H,5-6,9,12,19-23,25H2,1-4H3,(H,46,58)(H,47,55)(H,48,56)(H,49,60)(H,50,57)(H,51,59)/p+1/t27-,28-,34+,35+,37+,38+,39+/m1/s1
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10n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085481
PNG
(CID44328462 | [2-((3R,6S)-3-{(1S,2R)-2-Hydroxy-1-[...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH2+]c2ccc3ccccc3c2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C44H61N7O8S/c1-27(2)37(43(58)51-38(28(3)52)42(57)46-22-20-30-13-7-5-8-14-30)49-44(59)39(29(4)53)50-41(56)35-26-60-24-12-6-9-17-36(54)47-34(40(55)48-35)21-23-45-33-19-18-31-15-10-11-16-32(31)25-33/h5,7-8,10-11,13-16,18-19,25,27-29,34-35,37-39,45,52-53H,6,9,12,17,20-24,26H2,1-4H3,(H,46,57)(H,47,54)(H,48,55)(H,49,59)(H,50,56)(H,51,58)/p+1/t28-,29-,34+,35+,37+,38+,39+/m1/s1
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18n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085488
PNG
(2-{(3R,6S)-3-[(1S,2R)-2-Hydroxy-1-((S)-1-{(1S,2R)-...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH3+])C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C34H54N8O10S/c1-19(2)27(33(49)41-28(20(3)43)32(48)36-16-14-22-9-11-23(12-10-22)42(51)52)39-34(50)29(21(4)44)40-31(47)25-18-53-17-7-5-6-8-26(45)37-24(13-15-35)30(46)38-25/h9-12,19-21,24-25,27-29,43-44H,5-8,13-18,35H2,1-4H3,(H,36,48)(H,37,45)(H,38,46)(H,39,50)(H,40,47)(H,41,49)/p+1/t20-,21-,24+,25+,27+,28+,29+/m1/s1
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20n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085489
PNG
(2-{(3R,6S)-3-[(1S,2R)-1-((S)-1-{(1S,2R)-1-[(S)-1-C...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH3+])C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O
Show InChI InChI=1S/C35H55N9O11S/c1-18(2)27(33(51)43-28(19(3)45)34(52)39-24(30(37)48)16-21-9-11-22(12-10-21)44(54)55)41-35(53)29(20(4)46)42-32(50)25-17-56-15-7-5-6-8-26(47)38-23(13-14-36)31(49)40-25/h9-12,18-20,23-25,27-29,45-46H,5-8,13-17,36H2,1-4H3,(H2,37,48)(H,38,47)(H,39,52)(H,40,49)(H,41,53)(H,42,50)(H,43,51)/p+1/t19-,20-,23+,24+,25+,27+,28+,29+/m1/s1
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37n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085491
PNG
(c[Hex-gamma-{N-2-naphthyl}-Dab-Cys]-Thr-val-Thr-Np...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH2+]c2ccc3ccccc3c2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O
Show InChI InChI=1S/C45H61N9O11S/c1-25(2)37(43(61)53-38(26(3)55)44(62)49-34(40(46)58)22-28-13-17-32(18-14-28)54(64)65)51-45(63)39(27(4)56)52-42(60)35-24-66-21-9-5-6-12-36(57)48-33(41(59)50-35)19-20-47-31-16-15-29-10-7-8-11-30(29)23-31/h7-8,10-11,13-18,23,25-27,33-35,37-39,47,55-56H,5-6,9,12,19-22,24H2,1-4H3,(H2,46,58)(H,48,57)(H,49,62)(H,50,59)(H,51,63)(H,52,60)(H,53,61)/p+1/t26-,27-,33+,34+,35+,37+,38+,39+/m1/s1
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40n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085487
PNG
(2-((3R,6S)-3-{(1S,2R)-2-Hydroxy-1-[(S)-1-((1S,2R)-...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH3+])C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C34H55N7O8S/c1-20(2)27(33(48)41-28(21(3)42)32(47)36-17-15-23-11-7-5-8-12-23)39-34(49)29(22(4)43)40-31(46)25-19-50-18-10-6-9-13-26(44)37-24(14-16-35)30(45)38-25/h5,7-8,11-12,20-22,24-25,27-29,42-43H,6,9-10,13-19,35H2,1-4H3,(H,36,47)(H,37,44)(H,38,45)(H,39,49)(H,40,46)(H,41,48)/p+1/t21-,22-,24+,25+,27+,28+,29+/m1/s1
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44n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085482
PNG
(2-[(3R,6S)-3-((1S,2R)-2-Hydroxy-1-{(S)-1-[(1S,2R)-...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH3+])C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C36H59N7O8S/c1-22(2)29(35(50)43-30(23(3)44)34(49)38-19-11-10-15-25-13-7-5-8-14-25)41-36(51)31(24(4)45)42-33(48)27-21-52-20-12-6-9-16-28(46)39-26(17-18-37)32(47)40-27/h5,7-8,13-14,22-24,26-27,29-31,44-45H,6,9-12,15-21,37H2,1-4H3,(H,38,49)(H,39,46)(H,40,47)(H,41,51)(H,42,48)(H,43,50)/p+1/t23-,24-,26+,27+,29+,30+,31+/m1/s1
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50n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085490
PNG
((2-{(3R,6S)-3-[(1S,2R)-1-((S)-1-{(1S,2R)-1-[(S)-1-...)
Show SMILES CCCCCCCCCC[NH2+]CC[C@@H]1NC(=O)CCCCCSC[C@H](NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O
Show InChI InChI=1S/C45H75N9O11S/c1-6-7-8-9-10-11-12-15-23-47-24-22-33-41(59)50-35(27-66-25-16-13-14-17-36(57)48-33)42(60)52-39(30(5)56)45(63)51-37(28(2)3)43(61)53-38(29(4)55)44(62)49-34(40(46)58)26-31-18-20-32(21-19-31)54(64)65/h18-21,28-30,33-35,37-39,47,55-56H,6-17,22-27H2,1-5H3,(H2,46,58)(H,48,57)(H,49,62)(H,50,59)(H,51,63)(H,52,60)(H,53,61)/p+1/t29-,30-,33+,34+,35+,37+,38+,39+/m1/s1
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61n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085486
PNG
(2-((3R,6S)-3-{(1S,2R)-1-[(S)-1-((1S,2R)-1-Carbamoy...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH3+])C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C26H47N7O8S/c1-13(2)19(25(40)32-20(14(3)34)22(28)37)31-26(41)21(15(4)35)33-24(39)17-12-42-11-7-5-6-8-18(36)29-16(9-10-27)23(38)30-17/h13-17,19-21,34-35H,5-12,27H2,1-4H3,(H2,28,37)(H,29,36)(H,30,38)(H,31,41)(H,32,40)(H,33,39)/p+1/t14-,15-,16+,17+,19+,20+,21+/m1/s1
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82n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085493
PNG
(c[Hex-gamma-{N-1-naphthyl}-Dab-Cys]-Thr-val-Thr-Np...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSCCCCCC(=O)N[C@@H](CC[NH2+]c2cccc3ccccc23)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O
Show InChI InChI=1S/C45H61N9O11S/c1-25(2)37(43(61)53-38(26(3)55)44(62)49-34(40(46)58)23-28-16-18-30(19-17-28)54(64)65)51-45(63)39(27(4)56)52-42(60)35-24-66-22-9-5-6-15-36(57)48-33(41(59)50-35)20-21-47-32-14-10-12-29-11-7-8-13-31(29)32/h7-8,10-14,16-19,25-27,33-35,37-39,47,55-56H,5-6,9,15,20-24H2,1-4H3,(H2,46,58)(H,48,57)(H,49,62)(H,50,59)(H,51,63)(H,52,60)(H,53,61)/p+1/t26-,27-,33+,34+,35+,37+,38+,39+/m1/s1
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98n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085485
PNG
(2-Benzylamino-5-(4-nitro-benzylamino)-pentanoic ac...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNCc1ccc(cc1)[N+]([O-])=O)NCc1ccccc1)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C34H50N8O9/c1-20(2)28(33(48)41-29(21(3)43)31(35)46)40-34(49)30(22(4)44)39-27(45)19-38-32(47)26(37-18-23-9-6-5-7-10-23)11-8-16-36-17-24-12-14-25(15-13-24)42(50)51/h5-7,9-10,12-15,20-22,26,28-30,36-37,43-44H,8,11,16-19H2,1-4H3,(H2,35,46)(H,38,47)(H,39,45)(H,40,49)(H,41,48)/t21-,22-,26+,28+,29+,30+/m1/s1
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154n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085484
PNG
(2-Benzylamino-5-(4-methoxy-benzylamino)-pentanoic ...)
Show SMILES COc1ccc(CNCCC[C@H](NCc2ccccc2)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)cc1
Show InChI InChI=1S/C35H53N7O8/c1-21(2)29(34(48)42-30(22(3)43)32(36)46)41-35(49)31(23(4)44)40-28(45)20-39-33(47)27(38-19-24-10-7-6-8-11-24)12-9-17-37-18-25-13-15-26(50-5)16-14-25/h6-8,10-11,13-16,21-23,27,29-31,37-38,43-44H,9,12,17-20H2,1-5H3,(H2,36,46)(H,39,47)(H,40,45)(H,41,49)(H,42,48)/t22-,23-,27+,29+,30+,31+/m1/s1
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305n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair
Oligosaccharyl transferase 48 kDa subunit


(Homo sapiens)
BDBM50085492
PNG
(2,5-Bis-benzylamino-pentanoic acid ({1-[1-(1-carba...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNCc1ccccc1)NCc1ccccc1)[C@@H](C)O)C(=O)N[C@@H]([C@H](C)O)C(N)=O
Show InChI InChI=1S/C34H51N7O7/c1-21(2)28(33(47)41-29(22(3)42)31(35)45)40-34(48)30(23(4)43)39-27(44)20-38-32(46)26(37-19-25-14-9-6-10-15-25)16-11-17-36-18-24-12-7-5-8-13-24/h5-10,12-15,21-23,26,28-30,36-37,42-43H,11,16-20H2,1-4H3,(H2,35,45)(H,38,46)(H,39,44)(H,40,48)(H,41,47)/t22-,23+,26-,28-,29-,30-/m0/s1
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>5.00E+3n/an/an/an/an/an/an/an/a



Institute of Technology

Curated by ChEMBL


Assay Description
Inhibition of asparagine-linked glycosylation by oligosaccharyl transferase


Bioorg Med Chem Lett 10: 281-4 (2000)

More data for this
Ligand-Target Pair