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Found 433 hits Enz. Inhib. hit(s) with Target = 'Opioid growth factor receptor-like protein 1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177911
PNG
(US9120797, 10 | US9120797, 9)
Show SMILES CN(C)C1(CCC2(CC1)NCCc1c2[nH]c2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H29N3/c1-27(2)24(18-8-4-3-5-9-18)15-13-23(14-16-24)22-20(12-17-25-23)19-10-6-7-11-21(19)26-22/h3-11,25-26H,12-17H2,1-2H3
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US Patent
0.260n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177903
PNG
(US9120797, 1 | US9120797, 2 | US9120797, 3)
Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H28N2O/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3
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0.300n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177935
PNG
(US9120797, 33)
Show SMILES CC1Cc2c([nH]c3ccccc23)C2(CCC(CC2)(N(C)C)c2ccccc2)N1
Show InChI InChI=1/C25H31N3/c1-18-17-21-20-11-7-8-12-22(20)26-23(21)24(27-18)13-15-25(16-14-24,28(2)3)19-9-5-4-6-10-19/h4-12,18,26-27H,13-17H2,1-3H3
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0.5n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177903
PNG
(US9120797, 1 | US9120797, 2 | US9120797, 3)
Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H28N2O/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3
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0.600n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172430
PNG
(US9090618, ZA53)
Show SMILES O=C1CC[C@@H](Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)N1
Show InChI InChI=1/C30H42N4O/c35-30-13-12-22(31-30)17-29-32-27-10-3-4-11-28(27)34(29)26-18-23-8-5-9-24(19-26)33(23)25-15-20-6-1-2-7-21(14-20)16-25/h3-4,10-11,20-26H,1-2,5-9,12-19H2,(H,31,35)/t20-,21+,22-,23-,24+,25-,26+/s2
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0.800n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177948
PNG
(US9120797, 46)
Show SMILES COC(=O)C1Cc2c([nH]c3ccccc23)C2(CCC(CC2)(N(C)C)c2ccccc2)N1
Show InChI InChI=1/C26H31N3O2/c1-29(2)26(18-9-5-4-6-10-18)15-13-25(14-16-26)23-20(17-22(28-25)24(30)31-3)19-11-7-8-12-21(19)27-23/h4-12,22,27-28H,13-17H2,1-3H3
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0.900n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172419
PNG
(US9090618, ZA42)
Show SMILES COc1cnc(cn1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1/C30H39N5O/c1-36-29-19-31-27(18-32-29)30-33-26-11-4-5-12-28(26)35(30)25-16-22-9-6-10-23(17-25)34(22)24-14-20-7-2-3-8-21(13-20)15-24/h4-5,11-12,18-25H,2-3,6-10,13-17H2,1H3/t20-,21+,22-,23+,24-,25+
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0.920n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177934
PNG
(US9120797, 32)
Show SMILES CN(C)C1(CCC2(CC1)N(CCc1c2[nH]c2cc(F)ccc12)C(C)=O)c1ccccc1
Show InChI InChI=1S/C26H30FN3O/c1-18(31)30-16-11-22-21-10-9-20(27)17-23(21)28-24(22)26(30)14-12-25(13-15-26,29(2)3)19-7-5-4-6-8-19/h4-10,17,28H,11-16H2,1-3H3
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1.10n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177955
PNG
(US9120797, 53)
Show SMILES CN(C)C1(Cc2ccccc2)CCC2(CC1)NCCc1c2[nH]c2ccccc12
Show InChI InChI=1S/C25H31N3/c1-28(2)24(18-19-8-4-3-5-9-19)13-15-25(16-14-24)23-21(12-17-26-25)20-10-6-7-11-22(20)27-23/h3-11,26-27H,12-18H2,1-2H3
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1.10n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM182732
PNG
(US9145408, 405)
Show SMILES C[C@H]1C[C@H]2C[C@@H](C1)C[C@@H](C2)N1[C@H]2CCC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(C([O-])=O)c1=O
Show InChI InChI=1/C27H35N3O3/c1-16-9-17-11-18(10-16)13-21(12-17)29-19-5-4-6-20(29)15-22(14-19)30-24-8-3-2-7-23(24)28-25(26(30)31)27(32)33/h2-3,7-8,16-22H,4-6,9-15H2,1H3,(H,32,33)/p-1/t16-,17-,18+,19-,20+,21+,22+
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1.10n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172418
PNG
(US9090618, ZA41)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1cnccn1
Show InChI InChI=1/C29H37N5/c1-2-7-21-14-20(6-1)15-24(16-21)33-22-8-5-9-23(33)18-25(17-22)34-28-11-4-3-10-26(28)32-29(34)27-19-30-12-13-31-27/h3-4,10-13,19-25H,1-2,5-9,14-18H2/t20-,21+,22-,23+,24-,25+
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1.15n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM150220
PNG
(US8980906, 22)
Show SMILES C[C@H](NC(=O)c1cc2C[C@H]3[C@H]4Cc5ccc(O)cc5[C@@]3(CCN4CC3CC3)Cc2[nH]c1=O)C(N)=O
Show InChI InChI=1/C27H32N4O4/c1-14(24(28)33)29-25(34)19-8-17-9-21-23-10-16-4-5-18(32)11-20(16)27(21,12-22(17)30-26(19)35)6-7-31(23)13-15-2-3-15/h4-5,8,11,14-15,21,23,32H,2-3,6-7,9-10,12-13H2,1H3,(H2,28,33)(H,29,34)(H,30,35)/t14-,21-,23+,27+/s2
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1.20n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...


US Patent US8980906 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177916
PNG
(US9120797, 14 | US9120797, 15)
Show SMILES CC1Cc2c([nH]c3ccccc23)C2(CCC(CC2)(N(C)C)c2ccccc2)O1
Show InChI InChI=1/C25H30N2O/c1-18-17-21-20-11-7-8-12-22(20)26-23(21)25(28-18)15-13-24(14-16-25,27(2)3)19-9-5-4-6-10-19/h4-12,18,26H,13-17H2,1-3H3
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1.20n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177925
PNG
(US9120797, 23)
Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1cccc(F)c1
Show InChI InChI=1S/C24H27FN2O/c1-27(2)23(17-6-5-7-18(25)16-17)11-13-24(14-12-23)22-20(10-15-28-24)19-8-3-4-9-21(19)26-22/h3-9,16,26H,10-15H2,1-2H3
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1.20n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM16434
PNG
(US8846929, 290)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CCCCCCCC2)c1=O
Show InChI InChI=1/C26H35N3O3/c30-25-24(26(31)32)27-22-14-7-8-15-23(22)29(25)21-16-19-12-9-13-20(17-21)28(19)18-10-5-3-1-2-4-6-11-18/h7-8,14-15,18-21H,1-6,9-13,16-17H2,(H,31,32)/t19-,20+,21+
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1.40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177930
PNG
(US9120797, 28)
Show SMILES CNC1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccccc1
Show InChI InChI=1S/C23H26N2O/c1-24-22(17-7-3-2-4-8-17)12-14-23(15-13-22)21-19(11-16-26-23)18-9-5-6-10-20(18)25-21/h2-10,24-25H,11-16H2,1H3
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1.40n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM133966
PNG
(US8846929, 364)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@H](CCN1[C@H]3CC[C@@H]1C[C@@H](C3)n1c3ccccc3nc(C(O)=O)c1=O)CC2
Show InChI InChI=1/C27H35N3O3/c1-27(2)17-8-7-16(21(27)13-17)11-12-29-18-9-10-19(29)15-20(14-18)30-23-6-4-3-5-22(23)28-24(25(30)31)26(32)33/h3-6,16-21H,7-15H2,1-2H3,(H,32,33)/t16-,17-,18-,19+,20+,21-/s2
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1.40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177936
PNG
(US9120797, 34)
Show SMILES CN(C)C1(CCC2(CC1)NCCc1c2[nH]c2ccc(F)cc12)c1ccccc1
Show InChI InChI=1S/C24H28FN3/c1-28(2)24(17-6-4-3-5-7-17)13-11-23(12-14-24)22-19(10-15-26-23)20-16-18(25)8-9-21(20)27-22/h3-9,16,26-27H,10-15H2,1-2H3
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1.40n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177947
PNG
(US9120797, 45)
Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccc(O)cc12)c1ccccc1
Show InChI InChI=1S/C24H28N2O2/c1-26(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(27)8-9-21(20)25-22/h3-9,16,25,27H,10-15H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM11828
PNG
(US8846929, 101)
Show SMILES N[C@@H]1CCN(C1)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)c1=O
Show InChI InChI=1S/C27H39N5O/c28-19-14-15-30(18-19)26-27(33)32(25-11-7-6-10-24(25)29-26)23-16-21-12-13-22(17-23)31(21)20-8-4-2-1-3-5-9-20/h6-7,10-11,19-23H,1-5,8-9,12-18,28H2/t19-,21-,22+,23+/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM16019
PNG
(US8846929, 288)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CCCCCCCCC2)c1=O
Show InChI InChI=1/C27H37N3O3/c31-26-25(27(32)33)28-23-15-8-9-16-24(23)30(26)22-17-20-13-10-14-21(18-22)29(20)19-11-6-4-2-1-3-5-7-12-19/h8-9,15-16,19-22H,1-7,10-14,17-18H2,(H,32,33)/t20-,21+,22+
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1.80n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172382
PNG
(US9090618, H27b(i))
Show SMILES C1CNC(C1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1/C29H42N4/c1-2-8-21-15-20(7-1)16-24(17-21)32-22-9-5-10-23(32)19-25(18-22)33-28-13-4-3-11-26(28)31-29(33)27-12-6-14-30-27/h3-4,11,13,20-25,27,30H,1-2,5-10,12,14-19H2/t20-,21+,22-,23+,24-,25+,27?
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1.90n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172417
PNG
(US9090618, ZA40)
Show SMILES C1C[C@H]2C[C@H](C[C@@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2)n1c(nc2ccccc12)-c1nnc[nH]1
Show InChI InChI=1/C27H36N6/c1-2-7-19-12-18(6-1)13-22(14-19)32-20-8-5-9-21(32)16-23(15-20)33-25-11-4-3-10-24(25)30-27(33)26-28-17-29-31-26/h3-4,10-11,17-23H,1-2,5-9,12-16H2,(H,28,29,31)/t18-,19+,20-,21+,22-,23+
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2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM17605
PNG
(US8846929, 298)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCCC2)c1=O
Show InChI InChI=1/C25H33N3O3/c29-24-23(25(30)31)26-21-11-7-8-12-22(21)28(24)20-15-18-13-14-19(16-20)27(18)17-9-5-3-1-2-4-6-10-17/h7-8,11-12,17-20H,1-6,9-10,13-16H2,(H,30,31)/t18-,19+,20+
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2n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM150219
PNG
(US8980906, 21)
Show SMILES NC(=O)CNC(=O)c1cc2C[C@H]3[C@H]4Cc5ccc(O)cc5[C@@]3(CCN4CC3CC3)Cc2[nH]c1=O
Show InChI InChI=1/C26H30N4O4/c27-23(32)12-28-24(33)18-7-16-8-20-22-9-15-3-4-17(31)10-19(15)26(20,11-21(16)29-25(18)34)5-6-30(22)13-14-1-2-14/h3-4,7,10,14,20,22,31H,1-2,5-6,8-9,11-13H2,(H2,27,32)(H,28,33)(H,29,34)/t20-,22+,26+/s2
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2.04n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (Perkin Elmer, Shelton, Conn.; 87.7 Ci/mmole) with 12 ug mem...


US Patent US8980906 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172433
PNG
(US9090618, ZA56)
Show SMILES C([C@@H]1COCCN1)c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@H]1C[C@@H]2C[C@H](C1)CCCC2
Show InChI InChI=1/C30H44N4O/c1-2-7-22-14-21(6-1)15-26(16-22)33-24-8-5-9-25(33)19-27(18-24)34-29-11-4-3-10-28(29)32-30(34)17-23-20-35-13-12-31-23/h3-4,10-11,21-27,31H,1-2,5-9,12-20H2/t21-,22+,23-,24-,25+,26-,27+/s2
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2.05n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM18569
PNG
(US8846929, 362)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O
Show InChI InChI=1/C26H33N3O3/c30-25-24(26(31)32)27-22-9-1-2-10-23(22)29(25)21-14-18-7-4-8-19(15-21)28(18)20-12-16-5-3-6-17(11-16)13-20/h1-2,9-10,16-21H,3-8,11-15H2,(H,31,32)/t16?,17?,18-,19+,20?,21+
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2.40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM97710
PNG
(US8476271, 16 | US9145408, 362)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CC3CCCC(C3)C2)c1=O
Show InChI InChI=1S/C26H33N3O3/c30-25-24(26(31)32)27-22-9-1-2-10-23(22)29(25)21-14-18-7-4-8-19(15-21)28(18)20-12-16-5-3-6-17(11-16)13-20/h1-2,9-10,16-21H,3-8,11-15H2,(H,31,32)/t16?,17?,18-,19+,20?,21+
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2.40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...


US Patent US9145408 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177913
PNG
(US9120797, 11 | US9120797, 12)
Show SMILES CN(C)C1(CCC2(CC1)N(CCc1c2[nH]c2ccccc12)C(C)=O)c1ccccc1
Show InChI InChI=1S/C26H31N3O/c1-19(30)29-18-13-22-21-11-7-8-12-23(21)27-24(22)26(29)16-14-25(15-17-26,28(2)3)20-9-5-4-6-10-20/h4-12,27H,13-18H2,1-3H3
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2.40n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM17276
PNG
(US8846929, 294)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCCCC2)c1=O
Show InChI InChI=1/C26H35N3O3/c30-25-24(26(31)32)27-22-12-8-9-13-23(22)29(25)21-16-19-14-15-20(17-21)28(19)18-10-6-4-2-1-3-5-7-11-18/h8-9,12-13,18-21H,1-7,10-11,14-17H2,(H,31,32)/t19-,20+,21+
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2.5n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172413
PNG
(US9090618, ZA35)
Show SMILES OCc1nc2ccccc2n1C1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1/C25H35N3O/c29-16-25-26-23-9-1-2-10-24(23)28(25)22-14-19-7-4-8-20(15-22)27(19)21-12-17-5-3-6-18(11-17)13-21/h1-2,9-10,17-22,29H,3-8,11-16H2/t17-,18+,19-,20+,21+,22?
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2.68n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM12729
PNG
(US8846929, 127)
Show SMILES ONC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)c1=O
Show InChI InChI=1S/C24H32N4O3/c29-23(26-31)22-24(30)28(21-11-7-6-10-20(21)25-22)19-14-17-12-13-18(15-19)27(17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-19,31H,1-5,8-9,12-15H2,(H,26,29)/t17-,18+,19+
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2.70n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM15777
PNG
(US8846929, 286)
Show SMILES CC(C)(C)CC(C)(C)N1[C@H]2CC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(C(O)=O)c1=O
Show InChI InChI=1/C24H33N3O3/c1-23(2,3)14-24(4,5)27-15-10-11-16(27)13-17(12-15)26-19-9-7-6-8-18(19)25-20(21(26)28)22(29)30/h6-9,15-17H,10-14H2,1-5H3,(H,29,30)/t15-,16+,17+
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2.80n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177913
PNG
(US9120797, 11 | US9120797, 12)
Show SMILES CN(C)C1(CCC2(CC1)N(CCc1c2[nH]c2ccccc12)C(C)=O)c1ccccc1
Show InChI InChI=1S/C26H31N3O/c1-19(30)29-18-13-22-21-11-7-8-12-23(21)27-24(22)26(29)16-14-25(15-17-26,28(2)3)20-9-5-4-6-10-20/h4-12,27H,13-18H2,1-3H3
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2.90n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177926
PNG
(US9120797, 24 | US9120797, 25)
Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccc(F)cc12)c1ccccc1
Show InChI InChI=1S/C24H27FN2O/c1-27(2)23(17-6-4-3-5-7-17)11-13-24(14-12-23)22-19(10-15-28-24)20-16-18(25)8-9-21(20)26-22/h3-9,16,26H,10-15H2,1-2H3
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2.90n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM12256
PNG
(US8846929, 120)
Show SMILES COc1ccc(NC(=O)c2nc3ccccc3n(c2=O)[C@]2(C)C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)cn1
Show InChI InChI=1/C31H39N5O3/c1-31(18-23-15-16-24(19-31)35(23)22-10-6-4-3-5-7-11-22)36-26-13-9-8-12-25(26)34-28(30(36)38)29(37)33-21-14-17-27(39-2)32-20-21/h8-9,12-14,17,20,22-24H,3-7,10-11,15-16,18-19H2,1-2H3,(H,33,37)/t23-,24+,31+
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3.10n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177924
PNG
(US9120797, 22)
Show SMILES CN(C)C1(CCC2(CC1)OCCc1c2[nH]c2ccccc12)c1ccc(F)cc1
Show InChI InChI=1S/C24H27FN2O/c1-27(2)23(17-7-9-18(25)10-8-17)12-14-24(15-13-23)22-20(11-16-28-24)19-5-3-4-6-21(19)26-22/h3-10,26H,11-16H2,1-2H3
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3.20n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177911
PNG
(US9120797, 10 | US9120797, 9)
Show SMILES CN(C)C1(CCC2(CC1)NCCc1c2[nH]c2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H29N3/c1-27(2)24(18-8-4-3-5-9-18)15-13-23(14-16-24)22-20(12-17-25-23)19-10-6-7-11-21(19)26-22/h3-11,25-26H,12-17H2,1-2H3
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3.40n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM133953
PNG
(US8846929, 336)
Show SMILES OC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CCC[C@H](C2)N3C2CCCCC\C=C/2)c1=O
Show InChI InChI=1/C25H31N3O3/c29-24-23(25(30)31)26-21-13-6-7-14-22(21)28(24)20-15-18-11-8-12-19(16-20)27(18)17-9-4-2-1-3-5-10-17/h4,6-7,9,13-14,17-20H,1-3,5,8,10-12,15-16H2,(H,30,31)/b9-4-/t17?,18-,19+,20+
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3.60n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177906
PNG
(US9120797, 4)
Show SMILES CN(C)C1(CCC2(CC1)SCCc1c2[nH]c2ccccc12)c1ccccc1
Show InChI InChI=1S/C24H28N2S/c1-26(2)23(18-8-4-3-5-9-18)13-15-24(16-14-23)22-20(12-17-27-24)19-10-6-7-11-21(19)25-22/h3-11,25H,12-17H2,1-2H3
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3.70n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172438
PNG
(US9090618, ZA61)
Show SMILES Cc1nnc(Cc2nc3ccccc3n2[C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)[nH]1
Show InChI InChI=1/C29H40N6/c1-19-30-28(33-32-19)18-29-31-26-11-4-5-12-27(26)35(29)25-16-22-9-6-10-23(17-25)34(22)24-14-20-7-2-3-8-21(13-20)15-24/h4-5,11-12,20-25H,2-3,6-10,13-18H2,1H3,(H,30,32,33)/t20-,21+,22-,23+,24-,25+
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3.80n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM133882
PNG
(US8846929, 51)
Show SMILES N[C@@H]1CCN(C1)c1nc2ccccc2n(C2CCN(CC2)C2CCCCCCC2)c1=O
Show InChI InChI=1/C25H37N5O/c26-19-12-15-29(18-19)24-25(31)30(23-11-7-6-10-22(23)27-24)21-13-16-28(17-14-21)20-8-4-2-1-3-5-9-20/h6-7,10-11,19-21H,1-5,8-9,12-18,26H2/t19-/s2
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4n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM15308
PNG
(US8846929, 266)
Show SMILES CC12CC3CC(C)(C1)CC(C3)(C2)N1[C@H]2CC[C@@H]1C[C@@H](C2)n1c2ccccc2nc(C(O)=O)c1=O
Show InChI InChI=1/C28H35N3O3/c1-26-11-17-12-27(2,14-26)16-28(13-17,15-26)31-18-7-8-19(31)10-20(9-18)30-22-6-4-3-5-21(22)29-23(24(30)32)25(33)34/h3-6,17-20H,7-16H2,1-2H3,(H,33,34)/t17?,18-,19+,20+,26?,27?,28?
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4.10n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172440
PNG
(US9090618, ZA63)
Show SMILES COc1cnc(cn1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1/C29H37N5O/c1-35-28-18-30-26(17-31-28)29-32-25-10-2-3-11-27(25)34(29)24-15-21-8-5-9-22(16-24)33(21)23-13-19-6-4-7-20(12-19)14-23/h2-3,10-11,17-24H,4-9,12-16H2,1H3/t19-,20+,21-,22+,23+,24+
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4.11n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM172444
PNG
(US9090618, ZA67)
Show SMILES Cc1cc(no1)-c1nc2ccccc2n1[C@@H]1C[C@@H]2CCC[C@H](C1)N2[C@@H]1C[C@H]2CCC[C@H](C2)C1
Show InChI InChI=1/C28H36N4O/c1-18-12-26(30-33-18)28-29-25-10-2-3-11-27(25)32(28)24-16-21-8-5-9-22(17-24)31(21)23-14-19-6-4-7-20(13-19)15-23/h2-3,10-12,19-24H,4-9,13-17H2,1H3/t19-,20+,21-,22+,23+,24+
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4.20n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...


US Patent US9090618 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM133900
PNG
(US8846929, 69)
Show SMILES COc1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)c1=O
Show InChI InChI=1/C24H33N3O2/c1-29-23-24(28)27(22-12-8-7-11-21(22)25-23)20-15-18-13-14-19(16-20)26(18)17-9-5-3-2-4-6-10-17/h7-8,11-12,17-20H,2-6,9-10,13-16H2,1H3/t18-,19+,20+
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US Patent
4.20n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM13043
PNG
(US8846929, 228)
Show SMILES OC(=O)CN(CCNc1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)c1=O)CC(O)=O
Show InChI InChI=1S/C29H41N5O5/c35-26(36)18-32(19-27(37)38)15-14-30-28-29(39)34(25-11-7-6-10-24(25)31-28)23-16-21-12-13-22(17-23)33(21)20-8-4-2-1-3-5-9-20/h6-7,10-11,20-23H,1-5,8-9,12-19H2,(H,30,31)(H,35,36)(H,37,38)/t21-,22+,23+
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4.40n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM177938
PNG
(US9120797, 36)
Show SMILES CC1Cc2c([nH]c3ccc(C)cc23)C2(CCC(CC2)(N(C)C)c2ccccc2)O1
Show InChI InChI=1/C26H32N2O/c1-18-10-11-23-21(16-18)22-17-19(2)29-26(24(22)27-23)14-12-25(13-15-26,28(3)4)20-8-6-5-7-9-20/h5-11,16,19,27H,12-15,17H2,1-4H3
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4.40n/an/an/an/an/an/an/an/a



Gruenenthal GmbH

US Patent


Assay Description
The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...


US Patent US9120797 (2015)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM133918
PNG
(US8846929, 94)
Show SMILES NC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)c1=O
Show InChI InChI=1/C24H32N4O2/c25-23(29)22-24(30)28(21-11-7-6-10-20(21)26-22)19-14-17-12-13-18(15-19)27(17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-19H,1-5,8-9,12-15H2,(H2,25,29)/t17-,18+,19+
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4.42n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
Opioid growth factor receptor-like protein 1


(Homo sapiens (Human))
BDBM11758
PNG
(US8846929, 94)
Show SMILES NC(=O)c1nc2ccccc2n([C@@H]2C[C@@H]3CC[C@H](C2)N3C2CCCCCCC2)c1=O
Show InChI InChI=1S/C24H32N4O2/c25-23(29)22-24(30)28(21-11-7-6-10-20(21)26-22)19-14-17-12-13-18(15-19)27(17)16-8-4-2-1-3-5-9-16/h6-7,10-11,16-19H,1-5,8-9,12-15H2,(H2,25,29)/t17-,18+,19+
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4.42n/an/an/an/an/an/an/an/a



Purdue Pharma L.P.; Shionogi & Co., Ltd.

US Patent


Assay Description
Radioligand binding assays (screening and dose-displacement) used 0.1nM [3H]-nociceptin (NEN; 87.7 Cl/nimole) with 10-20 ug membrane protein in a fin...


US Patent US8846929 (2014)

More data for this
Ligand-Target Pair
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