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Compile Data Set for Download or QSAR

Found 419 hits Enz. Inhib. hit(s) with Target = 'P2X2/3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X2/3


()
BDBM319936
PNG
(3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1
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UniChem
Article
US Patent
n/an/a 14n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320093
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 14n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319933
PNG
(N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1
Show InChI InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 16n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319940
PNG
(N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- m...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1
Show InChI InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 17n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319931
PNG
(3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H...)
Show SMILES C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 19n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320075
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 22n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320102
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 23n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319958
PNG
(3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpy...)
Show SMILES CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1
Show InChI InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320137
PNG
(3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319932
PNG
(N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5...)
Show SMILES C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1
Show InChI InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 27n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM322574
PNG
(US10183937, Example 385 | US10202369, Example 385)
Show SMILES C[C@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m0/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 28n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319962
PNG
(3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyra...)
Show SMILES CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 33n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319914
PNG
(N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (...)
Show SMILES CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F
Show InChI InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29)
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 34n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320216
PNG
(3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy...)
Show SMILES C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320144
PNG
(N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- m...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1
Show InChI InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320073
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Show SMILES CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1
Show InChI InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320102
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 35n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319918
PNG
(3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 36n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320136
PNG
(3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trif...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319839
PNG
(N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cycl...)
Show SMILES CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F
Show InChI InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28)
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 38n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320091
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1
Show InChI InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1
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UniChem
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US Patent
n/an/a 38n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320084
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1
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UniChem
Article
US Patent
n/an/a 38n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319938
PNG
(3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1
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UniChem
Article
US Patent
n/an/a 39n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319939
PNG
(3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylp...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1
Show InChI InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1
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UniChem
Article
US Patent
n/an/a 41n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320138
PNG
(3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- ...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1
Show InChI InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1
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UniChem
Article
US Patent
n/an/a 44n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320045
PNG
(3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- m...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1
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UniChem
Article
US Patent
n/an/a 46n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320125
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15-/m1/s1
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UniChem
Article
US Patent
n/an/a 52n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319898
PNG
(N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (...)
Show SMILES CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F
Show InChI InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1
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UniChem
Article
US Patent
n/an/a 54n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320061
PNG
(Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1...)
Show SMILES CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1
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UniChem
Article
US Patent
n/an/a 54n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319935
PNG
(N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- m...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1
Show InChI InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1
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UniChem
Article
US Patent
n/an/a 57n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320117
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydro...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1
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UniChem
Article
US Patent
n/an/a 57n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320073
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Show SMILES CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1
Show InChI InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1
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UniChem
Article
US Patent
n/an/a 57n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320059
PNG
(Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1...)
Show SMILES COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1
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UniChem
Article
US Patent
n/an/a 59n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319934
PNG
(N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- met...)
Show SMILES Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1
Show InChI InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29)
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UniChem
Article
US Patent
n/an/a 60n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320002
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)-...)
Show SMILES CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1
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UniChem
Article
US Patent
n/an/a 70n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320142
PNG
(3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- ...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1
Show InChI InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1
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UniChem
Article
US Patent
n/an/a 70n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320068
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridaz...)
Show SMILES CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1
Show InChI InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28)
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UniChem
Article
US Patent
n/an/a 70n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319995
PNG
(3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiaz...)
Show SMILES CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1
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UniChem
Article
US Patent
n/an/a 72n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319995
PNG
(3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiaz...)
Show SMILES CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1
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UniChem
Article
US Patent
n/an/a 74n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320216
PNG
(3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy...)
Show SMILES C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1
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UniChem
Article
US Patent
n/an/a 75n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320100
PNG
(3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methy...)
Show SMILES CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1
Show InChI InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1
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UniChem
Article
US Patent
n/an/a 76n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319834
PNG
(3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-y...)
Show SMILES C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 76n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319903
PNG
(3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydr...)
Show SMILES C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 78n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320046
PNG
(3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5...)
Show SMILES C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 81n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320037
PNG
(3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1
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PC sid
UniChem
Article
US Patent
n/an/a 82n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319983
PNG
(3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 83n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319911
PNG
(N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (...)
Show SMILES CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F
Show InChI InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 83n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319941
PNG
(3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thia...)
Show SMILES C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 83n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM320145
PNG
(3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trif...)
Show SMILES C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F
Show InChI InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 83n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
P2X2/3


()
BDBM319996
PNG
(US10174016, Example 163 | US10202369, Example 340)
Show SMILES CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1
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PC cid
PC sid
UniChem
Article
US Patent
n/an/a 83n/an/an/an/an/an/a



Bayer Aktiengesellschaft

US Patent


Assay Description
A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...


US Patent US10202369 (2019)


Article DOI: 10.1016/j.str.2004.10.004
More data for this
Ligand-Target Pair
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