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Compile Data Set for Download or QSAR

Found 194 hits Enz. Inhib. hit(s) with Target = 'P2Y purinoceptor 1' AND taxid = 9103   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50118238
PNG
(CHEMBL339873 | MRS 2279)
Show SMILES CNc1nc(Cl)nc2n(cnc12)[C@H]1CC(OP(O)(O)=O)C2(COP(O)(O)=O)CC12
Show InChI InChI=1S/C13H18ClN5O8P2/c1-15-10-9-11(18-12(14)17-10)19(5-16-9)7-2-8(27-29(23,24)25)13(3-6(7)13)4-26-28(20,21)22/h5-8H,2-4H2,1H3,(H,15,17,18)(H2,20,21,22)(H2,23,24,25)/t6?,7-,8?,13?/m0/s1
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n/an/a 51.6n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085314
PNG
(CHEMBL350828 | Phosphoric acid mono-[4-(6-methylam...)
Show SMILES CNc1ncnc2n(cnc12)[C@@H]1C[C@H](COP(O)(O)=O)[C@@H](C1)OP(O)(O)=O
Show InChI InChI=1S/C12H19N5O8P2/c1-13-11-10-12(15-5-14-11)17(6-16-10)8-2-7(4-24-26(18,19)20)9(3-8)25-27(21,22)23/h5-9H,2-4H2,1H3,(H,13,14,15)(H2,18,19,20)(H2,21,22,23)/t7-,8-,9-/m1/s1
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n/an/a 148n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085821
PNG
(CHEMBL168427 | Phosphoric acid mono-[4-(6-methylam...)
Show SMILES CNc1ncnc2n(cnc12)C1CC(OP(O)(O)=O)C2(COP(O)(O)=O)CC12
Show InChI InChI=1S/C13H19N5O8P2/c1-14-11-10-12(16-5-15-11)18(6-17-10)8-2-9(26-28(22,23)24)13(3-7(8)13)4-25-27(19,20)21/h5-9H,2-4H2,1H3,(H,14,15,16)(H2,19,20,21)(H2,22,23,24)
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n/an/a 157n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076466
PNG
(2-(6-Methylamino-purin-9-yl)-5,7,9,11-tetraoxo-tet...)
Show SMILES CNc1ncnc2n(cnc12)C1CC2OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OCC2O1
Show InChI InChI=1S/C11H17N5O14P4/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6-7(26-8)3-25-31(17,18)28-33(21,22)30-34(23,24)29-32(19,20)27-6/h4-8H,2-3H2,1H3,(H,17,18)(H,19,20)(H,21,22)(H,23,24)(H,12,13,14)
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n/an/a 158n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076460
PNG
(CHEMBL288798 | Phosphoric acid mono-[5-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C11H16ClN5O9P2/c1-13-9-8-10(16-11(12)15-9)17(4-14-8)7-2-5(26-28(21,22)23)6(25-7)3-24-27(18,19)20/h4-7H,2-3H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 206n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085322
PNG
(CHEMBL164811 | Phosphoric acid mono-[5-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(cnc12)[C@H]1C[C@@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C11H16ClN5O9P2/c1-13-9-8-10(16-11(12)15-9)17(4-14-8)7-2-5(26-28(21,22)23)6(25-7)3-24-27(18,19)20/h4-7H,2-3H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)/t5-,6-,7-/m1/s1
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n/an/a 206n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104022
PNG
(3-[2-chloro-6-(methylamino)-9H-purin-9-yl]-2-[(pho...)
Show SMILES CNc1nc(Cl)nc2n(CC(COP(O)(O)=O)COP(O)(=O)OP(O)(O)=O)cnc12
Show InChI InChI=1S/C10H17ClN5O11P3/c1-12-8-7-9(15-10(11)14-8)16(5-13-7)2-6(3-25-28(17,18)19)4-26-30(23,24)27-29(20,21)22/h5-6H,2-4H2,1H3,(H,23,24)(H,12,14,15)(H2,17,18,19)(H2,20,21,22)
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n/an/a 230n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062291
PNG
(CHEMBL54116 | Phosphoric acid mono-[2-(6-methylami...)
Show SMILES CNc1ncnc2n(cnc12)C1OC(COP(O)(O)=O)CC1OP(O)(O)=O
Show InChI InChI=1S/C11H17N5O9P2/c1-12-9-8-10(14-4-13-9)16(5-15-8)11-7(25-27(20,21)22)2-6(24-11)3-23-26(17,18)19/h4-7,11H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)
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n/an/a 324n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP


J Med Chem 41: 183-90 (1998)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50118229
PNG
(CHEMBL129841 | MRS 2179)
Show SMILES CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1
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n/an/a 330n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP


J Med Chem 41: 183-90 (1998)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50118229
PNG
(CHEMBL129841 | MRS 2179)
Show SMILES CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1
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n/an/a 331n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50118229
PNG
(CHEMBL129841 | MRS 2179)
Show SMILES CNc1ncnc2n(cnc12)[C@H]1C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1
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n/an/a 331n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085826
PNG
(CHEMBL167061 | Phosphoric acid mono-[5-(6-methylam...)
Show SMILES CNc1nc(SC)nc2n(cnc12)[C@H]1C[C@@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C12H19N5O9P2S/c1-13-10-9-11(16-12(15-10)29-2)17(5-14-9)8-3-6(26-28(21,22)23)7(25-8)4-24-27(18,19)20/h5-8H,3-4H2,1-2H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)/t6-,7-,8-/m1/s1
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n/an/a 362n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076475
PNG
(CHEMBL43924 | Phosphoric acid mono-[5-(6-methylami...)
Show SMILES CNc1nc(SC)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C12H19N5O9P2S/c1-13-10-9-11(16-12(15-10)29-2)17(5-14-9)8-3-6(26-28(21,22)23)7(25-8)4-24-27(18,19)20/h5-8H,3-4H2,1-2H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 362n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076462
PNG
(CHEMBL440662 | Phosphoric acid mono-[5-(6-methylam...)
Show SMILES CCCSc1nc(NC)c2ncn(C3CC(OP(O)(O)=O)C(COP(O)(O)=O)O3)c2n1
Show InChI InChI=1S/C14H23N5O9P2S/c1-3-4-31-14-17-12(15-2)11-13(18-14)19(7-16-11)10-5-8(28-30(23,24)25)9(27-10)6-26-29(20,21)22/h7-10H,3-6H2,1-2H3,(H,15,17,18)(H2,20,21,22)(H2,23,24,25)
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n/an/a 449n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076461
PNG
(CHEMBL42879 | Phosphoric acid mono-[5-(2-allylsulf...)
Show SMILES CNc1nc(SCC=C)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C14H21N5O9P2S/c1-3-4-31-14-17-12(15-2)11-13(18-14)19(7-16-11)10-5-8(28-30(23,24)25)9(27-10)6-26-29(20,21)22/h3,7-10H,1,4-6H2,2H3,(H,15,17,18)(H2,20,21,22)(H2,23,24,25)
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n/an/a 475n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104014
PNG
(CHEMBL104784 | Phosphoric acid mono-[3-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(CC(COP(O)(O)=O)COP(O)(O)=O)cnc12
Show InChI InChI=1S/C10H16ClN5O8P2/c1-12-8-7-9(15-10(11)14-8)16(5-13-7)2-6(3-23-25(17,18)19)4-24-26(20,21)22/h5-6H,2-4H2,1H3,(H,12,14,15)(H2,17,18,19)(H2,20,21,22)
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n/an/a 480n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085817
PNG
(CHEMBL352881 | Phosphoric acid mono-[5-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(cnc12)C1COC(COP(O)(O)=O)C(C1)OP(O)(O)=O
Show InChI InChI=1S/C12H18ClN5O9P2/c1-14-10-9-11(17-12(13)16-10)18(5-15-9)6-2-7(27-29(22,23)24)8(25-3-6)4-26-28(19,20)21/h5-8H,2-4H2,1H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)
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n/an/a 566n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085824
PNG
(CHEMBL352744 | Phosphoric acid mono-[3-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(cnc12)[C@@H]1C[C@H](OP(O)(O)=O)C1COP(O)(O)=O
Show InChI InChI=1S/C11H16ClN5O8P2/c1-13-9-8-10(16-11(12)15-9)17(4-14-8)6-2-7(25-27(21,22)23)5(6)3-24-26(18,19)20/h4-7H,2-3H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)/t5?,6-,7+/m1/s1
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n/an/a 805n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085327
PNG
(CHEMBL108166 | MRS 2286 | Phosphoric acid mono-[4-...)
Show SMILES CNc1nc(Cl)nc2n(CCC(COP(O)(O)=O)COP(O)(O)=O)cnc12
Show InChI InChI=1S/C11H18ClN5O8P2/c1-13-9-8-10(16-11(12)15-9)17(6-14-8)3-2-7(4-24-26(18,19)20)5-25-27(21,22)23/h6-7H,2-5H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 840n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076470
PNG
(CHEMBL42028 | Phosphoric acid mono-[5-(2-iodo-6-me...)
Show SMILES CNc1nc(I)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C11H16IN5O9P2/c1-13-9-8-10(16-11(12)15-9)17(4-14-8)7-2-5(26-28(21,22)23)6(25-7)3-24-27(18,19)20/h4-7H,2-3H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 891n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076473
PNG
(CHEMBL263774 | Phosphoric acid mono-[5-(7-methylam...)
Show SMILES CNc1ccnc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C12H18N4O9P2/c1-13-7-2-3-14-12-11(7)15-6-16(12)10-4-8(25-27(20,21)22)9(24-10)5-23-26(17,18)19/h2-3,6,8-10H,4-5H2,1H3,(H,13,14)(H2,17,18,19)(H2,20,21,22)
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n/an/a 904n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076467
PNG
(CHEMBL295819 | Phosphoric acid mono-[5-(2-ethylsul...)
Show SMILES CCSc1nc(NC)c2ncn(C3CC(OP(O)(O)=O)C(COP(O)(O)=O)O3)c2n1
Show InChI InChI=1S/C13H21N5O9P2S/c1-3-30-13-16-11(14-2)10-12(17-13)18(6-15-10)9-4-7(27-29(22,23)24)8(26-9)5-25-28(19,20)21/h6-9H,3-5H2,1-2H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)
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n/an/a 980n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062276
PNG
(CHEMBL55247 | Phosphoric acid mono-[5-(6-ethylamin...)
Show SMILES CCNc1ncnc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C12H19N5O9P2/c1-2-13-11-10-12(15-5-14-11)17(6-16-10)9-3-7(26-28(21,22)23)8(25-9)4-24-27(18,19)20/h5-9H,2-4H2,1H3,(H,13,14,15)(H2,18,19,20)(H2,21,22,23)
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n/an/a 1.08E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP


J Med Chem 41: 183-90 (1998)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104026
PNG
(CHEMBL320924 | Phosphoric acid mono-[3-(6-methylam...)
Show SMILES CNc1ncnc2n(CC(COP(O)(O)=O)COP(O)(O)=O)cnc12
Show InChI InChI=1S/C10H17N5O8P2/c1-11-9-8-10(13-5-12-9)15(6-14-8)2-7(3-22-24(16,17)18)4-23-25(19,20)21/h5-7H,2-4H2,1H3,(H,11,12,13)(H2,16,17,18)(H2,19,20,21)
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n/an/a 1.09E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104029
PNG
(CHEMBL104886 | Phosphoric acid mono-[3-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(C[C@@H](COP(O)(O)=O)OP(O)(O)=O)cnc12
Show InChI InChI=1S/C9H14ClN5O8P2/c1-11-7-6-8(14-9(10)13-7)15(4-12-6)2-5(23-25(19,20)21)3-22-24(16,17)18/h4-5H,2-3H2,1H3,(H,11,13,14)(H2,16,17,18)(H2,19,20,21)/t5-/m0/s1
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n/an/a 1.47E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085328
PNG
(CHEMBL432028 | Phosphoric acid mono-[4-(6-methylam...)
Show SMILES CNc1ncnc2n(CCC(COP(O)(O)=O)COP(O)(O)=O)cnc12
Show InChI InChI=1S/C11H19N5O8P2/c1-12-10-9-11(14-6-13-10)16(7-15-9)3-2-8(4-23-25(17,18)19)5-24-26(20,21)22/h6-8H,2-5H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)
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n/an/a 1.60E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085823
PNG
(CHEMBL167191 | Phosphoric acid mono-[5-(6-methylam...)
Show SMILES CNc1ncnc2n(cnc12)C1COC(COP(O)(O)=O)C(C1)OP(O)(O)=O
Show InChI InChI=1S/C12H19N5O9P2/c1-13-11-10-12(15-5-14-11)17(6-16-10)7-2-8(26-28(21,22)23)9(24-3-7)4-25-27(18,19)20/h5-9H,2-4H2,1H3,(H,13,14,15)(H2,18,19,20)(H2,21,22,23)
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n/an/a 1.64E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104016
PNG
(CHEMBL106860 | Phosphoric acid mono-[2-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(C[C@@H]3[C@@H](COP(O)(O)=O)[C@H]3COP(O)(O)=O)cnc12
Show InChI InChI=1S/C12H18ClN5O8P2/c1-14-10-9-11(17-12(13)16-10)18(5-15-9)2-6-7(3-25-27(19,20)21)8(6)4-26-28(22,23)24/h5-8H,2-4H2,1H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)/t6-,7-,8+
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n/an/a 1.74E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076464
PNG
(CHEMBL43507 | Phosphoric acid mono-[5-(2-amino-6-m...)
Show SMILES CNc1nc(N)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C11H18N6O9P2/c1-13-9-8-10(16-11(12)15-9)17(4-14-8)7-2-5(26-28(21,22)23)6(25-7)3-24-27(18,19)20/h4-7H,2-3H2,1H3,(H2,18,19,20)(H2,21,22,23)(H3,12,13,15,16)
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n/an/a 1.85E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085828
PNG
(CHEMBL353089 | Phosphoric acid mono-[5-(2-amino-6-...)
Show SMILES CNc1nc(N)nc2n(cnc12)[C@H]1C[C@@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O1
Show InChI InChI=1S/C11H18N6O9P2/c1-13-9-8-10(16-11(12)15-9)17(4-14-8)7-2-5(26-28(21,22)23)6(25-7)3-24-27(18,19)20/h4-7H,2-3H2,1H3,(H2,18,19,20)(H2,21,22,23)(H3,12,13,15,16)/t5-,6-,7-/m1/s1
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n/an/a 1.85E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062283
PNG
(CHEMBL43531 | Phosphoric acid mono-[5-(6-amino-2-m...)
Show SMILES CSc1nc(N)c2ncn(C3CC(OP(O)(O)=O)C(COP(O)(O)=O)O3)c2n1
Show InChI InChI=1S/C11H17N5O9P2S/c1-28-11-14-9(12)8-10(15-11)16(4-13-8)7-2-5(25-27(20,21)22)6(24-7)3-23-26(17,18)19/h4-7H,2-3H2,1H3,(H2,12,14,15)(H2,17,18,19)(H2,20,21,22)
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n/an/a 1.89E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104021
PNG
(CHEMBL104752 | Phosphoric acid mono-[2-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(CC3CC3(COP(O)(O)=O)COP(O)(O)=O)cnc12
Show InChI InChI=1S/C12H18ClN5O8P2/c1-14-9-8-10(17-11(13)16-9)18(6-15-8)3-7-2-12(7,4-25-27(19,20)21)5-26-28(22,23)24/h6-7H,2-5H2,1H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)
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n/an/a 1.90E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062286
PNG
(CHEMBL44408 | Phosphoric acid mono-[5-(6-amino-2-c...)
Show SMILES Nc1nc(Cl)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C10H14ClN5O9P2/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(25-27(20,21)22)5(24-6)2-23-26(17,18)19/h3-6H,1-2H2,(H2,12,14,15)(H2,17,18,19)(H2,20,21,22)
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n/an/a 2.01E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP


J Med Chem 41: 183-90 (1998)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062286
PNG
(CHEMBL44408 | Phosphoric acid mono-[5-(6-amino-2-c...)
Show SMILES Nc1nc(Cl)nc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C10H14ClN5O9P2/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(25-27(20,21)22)5(24-6)2-23-26(17,18)19/h3-6H,1-2H2,(H2,12,14,15)(H2,17,18,19)(H2,20,21,22)
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n/an/a 2.01E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104024
PNG
(CHEMBL104316 | Phosphoric acid mono-[3-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(CC(CCOP(O)(O)=O)CCOP(O)(O)=O)cnc12
Show InChI InChI=1S/C12H20ClN5O8P2/c1-14-10-9-11(17-12(13)16-10)18(7-15-9)6-8(2-4-25-27(19,20)21)3-5-26-28(22,23)24/h7-8H,2-6H2,1H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)
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n/an/a 2.04E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104018
PNG
(CHEMBL323457 | Phosphoric acid mono-[4-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(CC=C(COP(O)(O)=O)COP(O)(O)=O)cnc12
Show InChI InChI=1S/C11H16ClN5O8P2/c1-13-9-8-10(16-11(12)15-9)17(6-14-8)3-2-7(4-24-26(18,19)20)5-25-27(21,22)23/h2,6H,3-5H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062283
PNG
(CHEMBL43531 | Phosphoric acid mono-[5-(6-amino-2-m...)
Show SMILES CSc1nc(N)c2ncn(C3CC(OP(O)(O)=O)C(COP(O)(O)=O)O3)c2n1
Show InChI InChI=1S/C11H17N5O9P2S/c1-28-11-14-9(12)8-10(15-11)16(4-13-8)7-2-5(25-27(20,21)22)6(24-7)3-23-26(17,18)19/h4-7H,2-3H2,1H3,(H2,12,14,15)(H2,17,18,19)(H2,20,21,22)
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n/an/a 2.11E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP


J Med Chem 41: 183-90 (1998)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104019
PNG
(CHEMBL323265 | Phosphoric acid mono-[2-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(C[C@H]3[C@@H](COP(O)(O)=O)[C@H]3COP(O)(O)=O)cnc12
Show InChI InChI=1S/C12H18ClN5O8P2/c1-14-10-9-11(17-12(13)16-10)18(5-15-9)2-6-7(3-25-27(19,20)21)8(6)4-26-28(22,23)24/h5-8H,2-4H2,1H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)/t6-,7+,8-
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n/an/a 2.17E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104028
PNG
(CHEMBL431649 | Phosphoric acid mono-[2-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(cnc12)C1CC1(COP(O)(O)=O)COP(O)(O)=O
Show InChI InChI=1S/C11H16ClN5O8P2/c1-13-8-7-9(16-10(12)15-8)17(5-14-7)6-2-11(6,3-24-26(18,19)20)4-25-27(21,22)23/h5-6H,2-4H2,1H3,(H,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 2.36E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085818
PNG
(CHEMBL166163 | N6-Methyl-1,5-anhydro-2-(adenin-9-y...)
Show SMILES CNc1ncnc2n(cnc12)C1COC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1
Show InChI InChI=1S/C12H20N5O12P3/c1-13-11-10-12(15-5-14-11)17(6-16-10)7-2-8(18)9(26-3-7)4-27-31(22,23)29-32(24,25)28-30(19,20)21/h5-9,18H,2-4H2,1H3,(H,22,23)(H,24,25)(H,13,14,15)(H2,19,20,21)
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n/an/a 2.37E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085313
PNG
(CHEMBL165225 | Phosphoric acid mono-[4-(6-amino-pu...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1C[C@H](COP(O)(O)=O)[C@@H](C1)OP(O)(O)=O
Show InChI InChI=1S/C11H17N5O8P2/c12-10-9-11(14-4-13-10)16(5-15-9)7-1-6(3-23-25(17,18)19)8(2-7)24-26(20,21)22/h4-8H,1-3H2,(H2,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7-,8-/m1/s1
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n/an/a 2.53E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076455
PNG
(CHEMBL43903 | Phosphoric acid mono-[4-(6-amino-pur...)
Show SMILES Nc1ncnc2n(cnc12)C1CC(COP(O)(O)=O)C(C1)OP(O)(O)=O
Show InChI InChI=1S/C11H17N5O8P2/c12-10-9-11(14-4-13-10)16(5-15-9)7-1-6(3-23-25(17,18)19)8(2-7)24-26(20,21)22/h4-8H,1-3H2,(H2,12,13,14)(H2,17,18,19)(H2,20,21,22)
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n/an/a 2.53E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104023
PNG
(CHEMBL274496 | Phosphoric acid mono-[2-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(CC3[C@H](COP(O)(O)=O)[C@H]3COP(O)(O)=O)cnc12
Show InChI InChI=1S/C12H18ClN5O8P2/c1-14-10-9-11(17-12(13)16-10)18(5-15-9)2-6-7(3-25-27(19,20)21)8(6)4-26-28(22,23)24/h5-8H,2-4H2,1H3,(H,14,16,17)(H2,19,20,21)(H2,22,23,24)/t7-,8-/m0/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076458
PNG
(CHEMBL42627 | Phosphoric acid mono-[5-(2-hexylsulf...)
Show SMILES CCCCCCSc1nc(NC)c2ncn(C3CC(OP(O)(O)=O)C(COP(O)(O)=O)O3)c2n1
Show InChI InChI=1S/C17H29N5O9P2S/c1-3-4-5-6-7-34-17-20-15(18-2)14-16(21-17)22(10-19-14)13-8-11(31-33(26,27)28)12(30-13)9-29-32(23,24)25/h10-13H,3-9H2,1-2H3,(H,18,20,21)(H2,23,24,25)(H2,26,27,28)
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n/an/a 3.37E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062279
PNG
(CHEMBL416789 | Phosphoric acid mono-[5-(6-amino-pu...)
Show SMILES Nc1ncnc2n(cnc12)C1OC(COP(O)(O)=O)C(OP(O)(O)=O)C1O
Show InChI InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)
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n/an/a 4.19E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP


J Med Chem 41: 183-90 (1998)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50104017
PNG
(CHEMBL104600 | Phosphoric acid mono-[2-(2-chloro-6...)
Show SMILES CNc1nc(Cl)nc2n(cnc12)C(COP(O)(O)=O)COP(O)(O)=O
Show InChI InChI=1S/C9H14ClN5O8P2/c1-11-7-6-8(14-9(10)13-7)15(4-12-6)5(2-22-24(16,17)18)3-23-25(19,20)21/h4-5H,2-3H2,1H3,(H,11,13,14)(H2,16,17,18)(H2,19,20,21)
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n/an/a 4.56E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibitory concentration against P2Y1 receptor in turkey erythrocyte membranes


J Med Chem 44: 3092-108 (2001)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076459
PNG
(CHEMBL43868 | Phosphoric acid mono-[5-(6-amino-2-e...)
Show SMILES CCSc1nc(N)c2ncn(C3CC(OP(O)(O)=O)C(COP(O)(O)=O)O3)c2n1
Show InChI InChI=1S/C12H19N5O9P2S/c1-2-29-12-15-10(13)9-11(16-12)17(5-14-9)8-3-6(26-28(21,22)23)7(25-8)4-24-27(18,19)20/h5-8H,2-4H2,1H3,(H2,13,15,16)(H2,18,19,20)(H2,21,22,23)
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n/an/a 4.59E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50085829
PNG
(CHEMBL355406 | Phosphoric acid mono-[4-(2-amino-6-...)
Show SMILES CNc1nc(N)nc2n(cnc12)[C@@H]1C[C@H](COP(O)(O)=O)[C@@H](C1)OP(O)(O)=O
Show InChI InChI=1S/C12H20N6O8P2/c1-14-10-9-11(17-12(13)16-10)18(5-15-9)7-2-6(4-25-27(19,20)21)8(3-7)26-28(22,23)24/h5-8H,2-4H2,1H3,(H2,19,20,21)(H2,22,23,24)(H3,13,14,16,17)/t6-,7-,8-/m1/s1
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n/an/a 5.42E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Inhibition of 30 nM 2-MeSADP stimulation of 2PY1-mediated phospholipase C (PLC) activity in Turkey erythocyte ghosts


J Med Chem 43: 829-42 (2000)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50076463
PNG
(CHEMBL295051 | Phosphoric acid mono-[4-(2-amino-6-...)
Show SMILES CNc1nc(N)nc2n(cnc12)C1CC(COP(O)(O)=O)C(C1)OP(O)(O)=O
Show InChI InChI=1S/C12H20N6O8P2/c1-14-10-9-11(17-12(13)16-10)18(5-15-9)7-2-6(4-25-27(19,20)21)8(3-7)26-28(22,23)24/h5-8H,2-4H2,1H3,(H2,19,20,21)(H2,22,23,24)(H3,13,14,16,17)
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n/an/a 5.42E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
P2Y purinoceptor 1


(Meleagris gallopavo)
BDBM50062287
PNG
(CHEMBL298487 | Phosphoric acid mono-[5-(6-amino-pu...)
Show SMILES Nc1ncnc2n(cnc12)C1CC(OP(O)(O)=O)C(COP(O)(O)=O)O1
Show InChI InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(24-26(19,20)21)6(23-7)2-22-25(16,17)18/h3-7H,1-2H2,(H2,11,12,13)(H2,16,17,18)(H2,19,20,21)
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n/an/a 5.76E+3n/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes.


J Med Chem 42: 1625-38 (1999)

More data for this
Ligand-Target Pair
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