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Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with Target = 'P2Y purinoceptor 14' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2Y purinoceptor 14


(Mus musculus)
BDBM50343131
PNG
(2-(2-cyanopyrimidin-5-yl)-N-(3-ethylphenyl)-4-o-to...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cnc(nc2)C#N)c1
Show InChI InChI=1S/C28H25N7O/c1-3-19-8-6-9-21(13-19)32-28(36)35-12-11-24-23(17-35)26(22-10-5-4-7-18(22)2)34-27(33-24)20-15-30-25(14-29)31-16-20/h4-10,13,15-16H,3,11-12,17H2,1-2H3,(H,32,36)
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n/an/a 1n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343129
PNG
(2-(4-cyanopyridin-3-yl)-N-(3-ethylphenyl)-4-o-toly...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cnccc2C#N)c1
Show InChI InChI=1S/C29H26N6O/c1-3-20-8-6-9-22(15-20)32-29(36)35-14-12-26-25(18-35)27(23-10-5-4-7-19(23)2)34-28(33-26)24-17-31-13-11-21(24)16-30/h4-11,13,15,17H,3,12,14,18H2,1-2H3,(H,32,36)
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n/an/a 3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343132
PNG
(2-(3,5-dimethylisoxazol-4-yl)-N-(3-ethylphenyl)-4-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2c(C)noc2C)c1
Show InChI InChI=1S/C28H29N5O2/c1-5-20-10-8-11-21(15-20)29-28(34)33-14-13-24-23(16-33)26(22-12-7-6-9-17(22)2)31-27(30-24)25-18(3)32-35-19(25)4/h6-12,15H,5,13-14,16H2,1-4H3,(H,29,34)
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n/an/a 4n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343886
PNG
((R)-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7...)
Show SMILES O[C@H](c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C26H16F6O3/c27-25(28,29)20-8-5-14(6-9-20)17-7-10-21-18(11-17)12-19(24(34)35)13-22(21)15-1-3-16(4-2-15)23(33)26(30,31)32/h1-13,23,33H,(H,34,35)/t23-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343888
PNG
((R)-4-(4-(2,2-difluoro-1-hydroxyethyl)phenyl)-7-(4...)
Show SMILES O[C@@H](C(F)F)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C26H17F5O3/c27-24(28)23(32)16-3-1-15(2-4-16)22-13-19(25(33)34)12-18-11-17(7-10-21(18)22)14-5-8-20(9-6-14)26(29,30)31/h1-13,23-24,32H,(H,33,34)/t23-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343120
PNG
(4-(2,6-dimethylphenyl)-N-(3-ethylphenyl)-2-(pyridi...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2c(C)cccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C29H29N5O/c1-4-21-10-6-12-23(16-21)31-29(35)34-15-13-25-24(18-34)27(26-19(2)8-5-9-20(26)3)33-28(32-25)22-11-7-14-30-17-22/h5-12,14,16-17H,4,13,15,18H2,1-3H3,(H,31,35)
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n/an/a 9n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343128
PNG
(2-(benzo[d][1,3]dioxol-5-yl)-N-(3-ethylphenyl)-4-o...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C30H28N4O3/c1-3-20-8-6-9-22(15-20)31-30(35)34-14-13-25-24(17-34)28(23-10-5-4-7-19(23)2)33-29(32-25)21-11-12-26-27(16-21)37-18-36-26/h4-12,15-16H,3,13-14,17-18H2,1-2H3,(H,31,35)
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n/an/a 10n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343130
PNG
(CHEMBL1771458 | N-(3-ethylphenyl)-2-(pyrimidin-5-y...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cncnc2)c1
Show InChI InChI=1S/C27H26N6O/c1-3-19-8-6-9-21(13-19)30-27(34)33-12-11-24-23(16-33)25(22-10-5-4-7-18(22)2)32-26(31-24)20-14-28-17-29-15-20/h4-10,13-15,17H,3,11-12,16H2,1-2H3,(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343885
PNG
(4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7-(4-...)
Show SMILES OC(c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C26H16F6O3/c27-25(28,29)20-8-5-14(6-9-20)17-7-10-21-18(11-17)12-19(24(34)35)13-22(21)15-1-3-16(4-2-15)23(33)26(30,31)32/h1-13,23,33H,(H,34,35)
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n/an/a 13n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343127
PNG
(CHEMBL1771455 | N-(3-ethylphenyl)-2-(quinolin-3-yl...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cnc3ccccc3c2)c1
Show InChI InChI=1S/C32H29N5O/c1-3-22-10-8-12-25(17-22)34-32(38)37-16-15-29-27(20-37)30(26-13-6-4-9-21(26)2)36-31(35-29)24-18-23-11-5-7-14-28(23)33-19-24/h4-14,17-19H,3,15-16,20H2,1-2H3,(H,34,38)
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n/an/a 13n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343877
PNG
(7-(4-fluoro-2,6-dimethylbenzyloxy)-4-(thiophen-3-y...)
Show SMILES Cc1cc(F)cc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccsc1
Show InChI InChI=1S/C24H19FO3S/c1-14-7-19(25)8-15(2)23(14)12-28-20-3-4-21-17(10-20)9-18(24(26)27)11-22(21)16-5-6-29-13-16/h3-11,13H,12H2,1-2H3,(H,26,27)
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n/an/a 14n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343094
PNG
(2-(4-cyanophenyl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C30H27N5O/c1-3-21-8-6-9-24(17-21)32-30(36)35-16-15-27-26(19-35)28(25-10-5-4-7-20(25)2)34-29(33-27)23-13-11-22(18-31)12-14-23/h4-14,17H,3,15-16,19H2,1-2H3,(H,32,36)
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n/an/a 16n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343884
PNG
(4-(4-(methylsulfonyl)phenyl)-7-(4-(trifluoromethyl...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C25H17F3O4S/c1-33(31,32)21-9-4-16(5-10-21)23-14-19(24(29)30)13-18-12-17(6-11-22(18)23)15-2-7-20(8-3-15)25(26,27)28/h2-14H,1H3,(H,29,30)
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n/an/a 20n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343095
PNG
(CHEMBL1771452 | N-(3-ethylphenyl)-2-(4-fluoropheny...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc(F)cc2)c1
Show InChI InChI=1S/C29H27FN4O/c1-3-20-8-6-9-23(17-20)31-29(35)34-16-15-26-25(18-34)27(24-10-5-4-7-19(24)2)33-28(32-26)21-11-13-22(30)14-12-21/h4-14,17H,3,15-16,18H2,1-2H3,(H,31,35)
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n/an/a 25n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343876
PNG
(7-(2,6-dimethylbenzyloxy)-4-(thiophen-3-yl)-2-naph...)
Show SMILES Cc1cccc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccsc1
Show InChI InChI=1S/C24H20O3S/c1-15-4-3-5-16(2)23(15)13-27-20-6-7-21-18(11-20)10-19(24(25)26)12-22(21)17-8-9-28-14-17/h3-12,14H,13H2,1-2H3,(H,25,26)
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n/an/a 26n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343109
PNG
(CHEMBL1771244 | N-(3-(1-fluoroethyl)phenyl)-2-(pyr...)
Show SMILES CC(F)c1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C28H26FN5O/c1-18-7-3-4-11-23(18)26-24-17-34(28(35)31-22-10-5-8-20(15-22)19(2)29)14-12-25(24)32-27(33-26)21-9-6-13-30-16-21/h3-11,13,15-16,19H,12,14,17H2,1-2H3,(H,31,35)
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n/an/a 29n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343125
PNG
(CHEMBL1771453 | N-(3-ethylphenyl)-2-(3-fluoropheny...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccc(F)c2)c1
Show InChI InChI=1S/C29H27FN4O/c1-3-20-9-6-12-23(16-20)31-29(35)34-15-14-26-25(18-34)27(24-13-5-4-8-19(24)2)33-28(32-26)21-10-7-11-22(30)17-21/h4-13,16-17H,3,14-15,18H2,1-2H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343121
PNG
(4-(2-chloro-6-methylphenyl)-N-(3-ethylphenyl)-2-(p...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2c(C)cccc2Cl)-c2cccnc2)c1
Show InChI InChI=1S/C28H26ClN5O/c1-3-19-8-5-10-21(15-19)31-28(35)34-14-12-24-22(17-34)26(25-18(2)7-4-11-23(25)29)33-27(32-24)20-9-6-13-30-16-20/h4-11,13,15-16H,3,12,14,17H2,1-2H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343887
PNG
((S)-4-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)-7...)
Show SMILES O[C@@H](c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C26H16F6O3/c27-25(28,29)20-8-5-14(6-9-20)17-7-10-21-18(11-17)12-19(24(34)35)13-22(21)15-1-3-16(4-2-15)23(33)26(30,31)32/h1-13,23,33H,(H,34,35)/t23-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343122
PNG
(4-(2,6-dichlorophenyl)-N-(3-ethylphenyl)-2-(pyridi...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2c(Cl)cccc2Cl)-c2cccnc2)c1
Show InChI InChI=1S/C27H23Cl2N5O/c1-2-17-6-3-8-19(14-17)31-27(35)34-13-11-23-20(16-34)25(24-21(28)9-4-10-22(24)29)33-26(32-23)18-7-5-12-30-15-18/h3-10,12,14-15H,2,11,13,16H2,1H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343878
PNG
(4-(thiophen-3-yl)-7-(4-(trifluoromethoxy)phenyl)-2...)
Show SMILES OC(=O)c1cc(-c2ccsc2)c2ccc(cc2c1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H13F3O3S/c23-22(24,25)28-18-4-1-13(2-5-18)14-3-6-19-16(9-14)10-17(21(26)27)11-20(19)15-7-8-29-12-15/h1-12H,(H,26,27)
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n/an/a 54n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343090
PNG
(CHEMBL1771446 | N-(3-ethylphenyl)-4-o-tolyl-2-p-to...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc(C)cc2)c1
Show InChI InChI=1S/C30H30N4O/c1-4-22-9-7-10-24(18-22)31-30(35)34-17-16-27-26(19-34)28(25-11-6-5-8-21(25)3)33-29(32-27)23-14-12-20(2)13-15-23/h5-15,18H,4,16-17,19H2,1-3H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343103
PNG
(CHEMBL1771238 | N-(3-ethylphenyl)-2-(pyridin-3-yl)...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C28H27N5O/c1-3-20-9-6-11-22(16-20)30-28(34)33-15-13-25-24(18-33)26(23-12-5-4-8-19(23)2)32-27(31-25)21-10-7-14-29-17-21/h4-12,14,16-17H,3,13,15,18H2,1-2H3,(H,30,34)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343089
PNG
(CHEMBL1771445 | N-(3-ethylphenyl)-2-phenyl-4-o-tol...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccccc2)c1
Show InChI InChI=1S/C29H28N4O/c1-3-21-11-9-14-23(18-21)30-29(34)33-17-16-26-25(19-33)27(24-15-8-7-10-20(24)2)32-28(31-26)22-12-5-4-6-13-22/h4-15,18H,3,16-17,19H2,1-2H3,(H,30,34)
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n/an/a 87n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343875
PNG
(4-(benzyloxy)-7-(2,6-dimethylbenzyloxy)-2-naphthoi...)
Show SMILES Cc1cccc(C)c1COc1ccc2c(OCc3ccccc3)cc(cc2c1)C(O)=O
Show InChI InChI=1S/C27H24O4/c1-18-7-6-8-19(2)25(18)17-30-23-11-12-24-21(14-23)13-22(27(28)29)15-26(24)31-16-20-9-4-3-5-10-20/h3-15H,16-17H2,1-2H3,(H,28,29)
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n/an/a 110n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343872
PNG
(7-(2,6-dimethylbenzyloxy)-4-phenyl-2-naphthoic aci...)
Show SMILES Cc1cccc(C)c1COc1ccc2c(cc(cc2c1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H22O3/c1-17-7-6-8-18(2)25(17)16-29-22-11-12-23-20(14-22)13-21(26(27)28)15-24(23)19-9-4-3-5-10-19/h3-15H,16H2,1-2H3,(H,27,28)
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Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343093
PNG
(2-(3-cyanophenyl)-N-(3-ethylphenyl)-4-o-tolyl-7,8-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccc(c2)C#N)c1
Show InChI InChI=1S/C30H27N5O/c1-3-21-9-7-12-24(17-21)32-30(36)35-15-14-27-26(19-35)28(25-13-5-4-8-20(25)2)34-29(33-27)23-11-6-10-22(16-23)18-31/h4-13,16-17H,3,14-15,19H2,1-2H3,(H,32,36)
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n/an/a 140n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343104
PNG
(CHEMBL1771239 | N-(3-propylphenyl)-2-(pyridin-3-yl...)
Show SMILES CCCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C29H29N5O/c1-3-8-21-10-6-12-23(17-21)31-29(35)34-16-14-26-25(19-34)27(24-13-5-4-9-20(24)2)33-28(32-26)22-11-7-15-30-18-22/h4-7,9-13,15,17-18H,3,8,14,16,19H2,1-2H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343111
PNG
(CHEMBL1771246 | N-(3-chloro-5-ethylphenyl)-2-(pyri...)
Show SMILES CCc1cc(Cl)cc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C28H26ClN5O/c1-3-19-13-21(29)15-22(14-19)31-28(35)34-12-10-25-24(17-34)26(23-9-5-4-7-18(23)2)33-27(32-25)20-8-6-11-30-16-20/h4-9,11,13-16H,3,10,12,17H2,1-2H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343883
PNG
(4-(4-(methylsulfonyl)thiophen-3-yl)-7-(4-(trifluor...)
Show SMILES CS(=O)(=O)c1cscc1-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C23H15F3O4S2/c1-32(29,30)21-12-31-11-20(21)19-10-16(22(27)28)9-15-8-14(4-7-18(15)19)13-2-5-17(6-3-13)23(24,25)26/h2-12H,1H3,(H,27,28)
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n/an/a 190n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343871
PNG
(7-(2,6-dichlorobenzyloxy)-4-phenyl-2-naphthoic aci...)
Show SMILES OC(=O)c1cc(-c2ccccc2)c2ccc(OCc3c(Cl)cccc3Cl)cc2c1
Show InChI InChI=1S/C24H16Cl2O3/c25-22-7-4-8-23(26)21(22)14-29-18-9-10-19-16(12-18)11-17(24(27)28)13-20(19)15-5-2-1-3-6-15/h1-13H,14H2,(H,27,28)
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n/an/a 190n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343882
PNG
(4-(4-(methylsulfonyl)thiophen-3-yl)-7-(4-(trifluor...)
Show SMILES CS(=O)(=O)c1cscc1-c1cc(cc2cc(ccc12)-c1ccc(OC(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C23H15F3O5S2/c1-33(29,30)21-12-32-11-20(21)19-10-16(22(27)28)9-15-8-14(4-7-18(15)19)13-2-5-17(6-3-13)31-23(24,25)26/h2-12H,1H3,(H,27,28)
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Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343881
PNG
(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)...)
Show SMILES OC(=O)c1cc(-c2cscc2C(O)(C(F)(F)F)C(F)(F)F)c2ccc(cc2c1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C25H13F9O4S/c26-23(27,28)22(37,24(29,30)31)20-11-39-10-19(20)18-9-15(21(35)36)8-14-7-13(3-6-17(14)18)12-1-4-16(5-2-12)38-25(32,33)34/h1-11,37H,(H,35,36)
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Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343879
PNG
(3-fluoro-4-(thiophen-3-yl)-7-(4-(trifluoromethoxy)...)
Show SMILES OC(=O)c1cc2cc(ccc2c(-c2ccsc2)c1F)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H12F4O3S/c23-20-18(21(27)28)10-15-9-13(3-6-17(15)19(20)14-7-8-30-11-14)12-1-4-16(5-2-12)29-22(24,25)26/h1-11H,(H,27,28)
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n/an/a 380n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343116
PNG
(4-(2-ethylphenyl)-N-(3-ethylphenyl)-2-(pyridin-3-y...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2CC)-c2cccnc2)c1
Show InChI InChI=1S/C29H29N5O/c1-3-20-9-7-12-23(17-20)31-29(35)34-16-14-26-25(19-34)27(24-13-6-5-10-21(24)4-2)33-28(32-26)22-11-8-15-30-18-22/h5-13,15,17-18H,3-4,14,16,19H2,1-2H3,(H,31,35)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343100
PNG
(CHEMBL1771235 | N-(3-ethoxyphenyl)-2-(pyridin-3-yl...)
Show SMILES CCOc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C28H27N5O2/c1-3-35-22-11-6-10-21(16-22)30-28(34)33-15-13-25-24(18-33)26(23-12-5-4-8-19(23)2)32-27(31-25)20-9-7-14-29-17-20/h4-12,14,16-17H,3,13,15,18H2,1-2H3,(H,30,34)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343112
PNG
(4-(2-chlorophenyl)-N-(3-ethylphenyl)-2-(pyridin-3-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2Cl)-c2cccnc2)c1
Show InChI InChI=1S/C27H24ClN5O/c1-2-18-7-5-9-20(15-18)30-27(34)33-14-12-24-22(17-33)25(21-10-3-4-11-23(21)28)32-26(31-24)19-8-6-13-29-16-19/h3-11,13,15-16H,2,12,14,17H2,1H3,(H,30,34)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343097
PNG
(CHEMBL1771232 | N-(3-chlorophenyl)-2-(pyridin-3-yl...)
Show SMILES Cc1ccccc1-c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(Cl)c1)-c1cccnc1
Show InChI InChI=1S/C26H22ClN5O/c1-17-6-2-3-10-21(17)24-22-16-32(26(33)29-20-9-4-8-19(27)14-20)13-11-23(22)30-25(31-24)18-7-5-12-28-15-18/h2-10,12,14-15H,11,13,16H2,1H3,(H,29,33)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343110
PNG
(CHEMBL1771245 | N-(3-(1,1-difluoroethyl)phenyl)-2-...)
Show SMILES Cc1ccccc1-c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(c1)C(C)(F)F)-c1cccnc1
Show InChI InChI=1S/C28H25F2N5O/c1-18-7-3-4-11-22(18)25-23-17-35(27(36)32-21-10-5-9-20(15-21)28(2,29)30)14-12-24(23)33-26(34-25)19-8-6-13-31-16-19/h3-11,13,15-16H,12,14,17H2,1-2H3,(H,32,36)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343101
PNG
(CHEMBL1771236 | N-(3-(methylthio)phenyl)-2-(pyridi...)
Show SMILES CSc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C27H25N5OS/c1-18-7-3-4-11-22(18)25-23-17-32(27(33)29-20-9-5-10-21(15-20)34-2)14-12-24(23)30-26(31-25)19-8-6-13-28-16-19/h3-11,13,15-16H,12,14,17H2,1-2H3,(H,29,33)
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Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343126
PNG
(CHEMBL1771454 | N-(3-ethylphenyl)-2-(naphthalen-2-...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C33H30N4O/c1-3-23-10-8-13-27(19-23)34-33(38)37-18-17-30-29(21-37)31(28-14-7-4-9-22(28)2)36-32(35-30)26-16-15-24-11-5-6-12-25(24)20-26/h4-16,19-20H,3,17-18,21H2,1-2H3,(H,34,38)
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n/an/a 880n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343119
PNG
(CHEMBL1771438 | N-(3-ethylphenyl)-4-(2-(hydroxymet...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2CO)-c2cccnc2)c1
Show InChI InChI=1S/C28H27N5O2/c1-2-19-7-5-10-22(15-19)30-28(35)33-14-12-25-24(17-33)26(23-11-4-3-8-21(23)18-34)32-27(31-25)20-9-6-13-29-16-20/h3-11,13,15-16,34H,2,12,14,17-18H2,1H3,(H,30,35)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343106
PNG
(CHEMBL1771241 | N-(3-cyclopropylphenyl)-2-(pyridin...)
Show SMILES Cc1ccccc1-c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(c1)C1CC1)-c1cccnc1
Show InChI InChI=1S/C29H27N5O/c1-19-6-2-3-10-24(19)27-25-18-34(29(35)31-23-9-4-7-21(16-23)20-11-12-20)15-13-26(25)32-28(33-27)22-8-5-14-30-17-22/h2-10,14,16-17,20H,11-13,15,18H2,1H3,(H,31,35)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343105
PNG
(2-(pyridin-3-yl)-4-o-tolyl-N-(3-vinylphenyl)-7,8-d...)
Show SMILES Cc1ccccc1-c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(C=C)c1)-c1cccnc1
Show InChI InChI=1S/C28H25N5O/c1-3-20-9-6-11-22(16-20)30-28(34)33-15-13-25-24(18-33)26(23-12-5-4-8-19(23)2)32-27(31-25)21-10-7-14-29-17-21/h3-12,14,16-17H,1,13,15,18H2,2H3,(H,30,34)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343880
PNG
(3-hydroxy-4-(thiophen-3-yl)-7-(4-(trifluoromethoxy...)
Show SMILES OC(=O)c1cc2cc(ccc2c(-c2ccsc2)c1O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C22H13F3O4S/c23-22(24,25)29-16-4-1-12(2-5-16)13-3-6-17-15(9-13)10-18(21(27)28)20(26)19(17)14-7-8-30-11-14/h1-11,26H,(H,27,28)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343091
PNG
(CHEMBL1771447 | N-(3-ethylphenyl)-2-m-tolyl-4-o-to...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccc(C)c2)c1
Show InChI InChI=1S/C30H30N4O/c1-4-22-11-8-13-24(18-22)31-30(35)34-16-15-27-26(19-34)28(25-14-6-5-10-21(25)3)33-29(32-27)23-12-7-9-20(2)17-23/h5-14,17-18H,4,15-16,19H2,1-3H3,(H,31,35)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343124
PNG
(CHEMBL1771444 | N-(3-ethylphenyl)-2-(pyridin-4-yl)...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccncc2)c1
Show InChI InChI=1S/C28H27N5O/c1-3-20-8-6-9-22(17-20)30-28(34)33-16-13-25-24(18-33)26(23-10-5-4-7-19(23)2)32-27(31-25)21-11-14-29-15-12-21/h4-12,14-15,17H,3,13,16,18H2,1-2H3,(H,30,34)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343102
PNG
(2-(pyridin-3-yl)-N-m-tolyl-4-o-tolyl-7,8-dihydropy...)
Show SMILES Cc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2cccnc2)c1
Show InChI InChI=1S/C27H25N5O/c1-18-7-5-10-21(15-18)29-27(33)32-14-12-24-23(17-32)25(22-11-4-3-8-19(22)2)31-26(30-24)20-9-6-13-28-16-20/h3-11,13,15-16H,12,14,17H2,1-2H3,(H,29,33)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343873
PNG
(7-((2,6-dimethylphenoxy)methyl)-4-phenyl-2-naphtho...)
Show SMILES Cc1cccc(C)c1OCc1ccc2c(cc(cc2c1)C(O)=O)-c1ccccc1
Show InChI InChI=1S/C26H22O3/c1-17-7-6-8-18(2)25(17)29-16-19-11-12-23-21(13-19)14-22(26(27)28)15-24(23)20-9-4-3-5-10-20/h3-15H,16H2,1-2H3,(H,27,28)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay


Citation and Details
More data for this
Ligand-Target Pair
P2Y purinoceptor 14


(Mus musculus)
BDBM50343123
PNG
(3-(6-(3-ethylphenylcarbamoyl)-4-o-tolyl-5,6,7,8-te...)
Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(c3C2)-c2ccccc2C)-c2ccc[n+]([O-])c2)c1
Show InChI InChI=1S/C28H27N5O2/c1-3-20-9-6-11-22(16-20)29-28(34)32-15-13-25-24(18-32)26(23-12-5-4-8-19(23)2)31-27(30-25)21-10-7-14-33(35)17-21/h4-12,14,16-17H,3,13,15,18H2,1-2H3,(H,29,34)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Antagonist activity at mouse P2Y14 expressed in human HEK cells coexpressing Galphai5 assessed as inhibition of UDP-glucose stimulated calcium releas...


Citation and Details
More data for this
Ligand-Target Pair
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