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Found 388 hits Enz. Inhib. hit(s) with Target = 'PDGFR-beta/Platelet-derived growth factor receptor alpha' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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14n/an/an/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of PDGF-stimulated autophosphorylation of PDGF-receptor


J Med Chem 37: 2627-9 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor in P19 cells


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3049-53 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132388
PNG
((3-Chloro-phenyl)-(6,7-dimethoxy-quinoxalin-2-yl)-...)
Show SMILES COc1cc2ncc(Nc3cccc(Cl)c3)nc2cc1OC
Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)20-16(9-18-12)19-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,19,20)
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n/an/a 4n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039041
PNG
(6,7-Dimethoxy-3-((E)-styryl)-quinoline | CHEMBL701...)
Show SMILES COc1cc2cc(\C=C\c3ccccc3)cnc2cc1OC
Show InChI InChI=1S/C19H17NO2/c1-21-18-11-16-10-15(9-8-14-6-4-3-5-7-14)13-20-17(16)12-19(18)22-2/h3-13H,1-2H3/b9-8+
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.001-0.005


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039087
PNG
(3-(3-Fluoro-4-methoxy-phenyl)-6,7-dimethoxy-quinol...)
Show SMILES COc1ccc(cc1F)-c1cnc2cc(OC)c(OC)cc2c1
Show InChI InChI=1S/C18H16FNO3/c1-21-16-5-4-11(7-14(16)19)13-6-12-8-17(22-2)18(23-3)9-15(12)20-10-13/h4-10H,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.003-0.005


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039073
PNG
(5,7-Dimethyl-3-thiophen-3-yl-quinoline | CHEMBL304...)
Show SMILES Cc1cc(C)c2cc(cnc2c1)-c1ccsc1
Show InChI InChI=1S/C15H13NS/c1-10-5-11(2)14-7-13(8-16-15(14)6-10)12-3-4-17-9-12/h3-9H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.001-0.005


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132386
PNG
((6,7-Dimethoxy-quinoxalin-2-yl)-phenyl-amine | CHE...)
Show SMILES COc1cc2ncc(Nc3ccccc3)nc2cc1OC
Show InChI InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)19-16(10-17-12)18-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,18,19)
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n/an/a 6n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132386
PNG
((6,7-Dimethoxy-quinoxalin-2-yl)-phenyl-amine | CHE...)
Show SMILES COc1cc2ncc(Nc3ccccc3)nc2cc1OC
Show InChI InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)19-16(10-17-12)18-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,18,19)
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n/an/a 6n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50287090
PNG
(4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Show SMILES Cc1ccc(NC(=O)c2ccc(Cl)cc2)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C23H18ClN5O/c1-15-4-9-19(27-22(30)16-5-7-18(24)8-6-16)13-21(15)29-23-26-12-10-20(28-23)17-3-2-11-25-14-17/h2-14H,1H3,(H,27,30)(H,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of tyrosine kinase(PDGF-R)


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50175491
PNG
(4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1
Show InChI InChI=1S/C24H21N5O/c1-16-5-8-18(9-6-16)23(30)27-20-10-7-17(2)22(14-20)29-24-26-13-11-21(28-24)19-4-3-12-25-15-19/h3-15H,1-2H3,(H,27,30)(H,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of the platelet-derived growth factor receptor.


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50175491
PNG
(4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1
Show InChI InChI=1S/C24H21N5O/c1-16-5-8-18(9-6-16)23(30)27-20-10-7-17(2)22(14-20)29-24-26-13-11-21(28-24)19-4-3-12-25-15-19/h3-15H,1-2H3,(H,27,30)(H,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



Organon Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50026673
PNG
(CHEMBL3335387)
Show SMILES CCN1CCN(CC(=O)Nc2cc(Oc3ccc4n(C)c(Nc5cc(ccc5F)C(F)(F)F)nc4c3)ccn2)CC1
Show InChI InChI=1S/C28H29F4N7O2/c1-3-38-10-12-39(13-11-38)17-26(40)36-25-16-20(8-9-33-25)41-19-5-7-24-23(15-19)35-27(37(24)2)34-22-14-18(28(30,31)32)4-6-21(22)29/h4-9,14-16H,3,10-13,17H2,1-2H3,(H,34,35)(H,33,36,40)
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n/an/a<10n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of PDGFR (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50175491
PNG
(4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1
Show InChI InChI=1S/C24H21N5O/c1-16-5-8-18(9-6-16)23(30)27-20-10-7-17(2)22(14-20)29-24-26-13-11-21(28-24)19-4-3-12-25-15-19/h3-15H,1-2H3,(H,27,30)(H,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of tyrosine kinase(PDGF-R)


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50287090
PNG
(4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Show SMILES Cc1ccc(NC(=O)c2ccc(Cl)cc2)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C23H18ClN5O/c1-15-4-9-19(27-22(30)16-5-7-18(24)8-6-16)13-21(15)29-23-26-12-10-20(28-23)17-3-2-11-25-14-17/h2-14H,1H3,(H,27,30)(H,26,28,29)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of the platelet-derived growth factor receptor.


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039071
PNG
(6,7-Dimethoxy-3-(4-methoxy-phenyl)-quinoline | CHE...)
Show SMILES COc1ccc(cc1)-c1cnc2cc(OC)c(OC)cc2c1
Show InChI InChI=1S/C18H17NO3/c1-20-15-6-4-12(5-7-15)14-8-13-9-17(21-2)18(22-3)10-16(13)19-11-14/h4-11H,1-3H3
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n/an/a 15n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.001-0.015


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132397
PNG
((+)(R)-Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxy-quin...)
Show SMILES COc1cc2ncc(N[C@@H]3CC4CCC3C4)nc2cc1OC
Show InChI InChI=1S/C17H21N3O2/c1-21-15-7-13-14(8-16(15)22-2)20-17(9-18-13)19-12-6-10-3-4-11(12)5-10/h7-12H,3-6H2,1-2H3,(H,19,20)/t10?,11?,12-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132406
PNG
(4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-2-methyl-cy...)
Show SMILES COc1cc2ncc(N[C@@H]3CC[C@H](O)[C@@H](C)C3)nc2cc1OC
Show InChI InChI=1S/C17H23N3O3/c1-10-6-11(4-5-14(10)21)19-17-9-18-12-7-15(22-2)16(23-3)8-13(12)20-17/h7-11,14,21H,4-6H2,1-3H3,(H,19,20)/t10-,11+,14-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039047
PNG
(5-Fluoro-3-thiophen-3-yl-quinoline | CHEMBL305056)
Show SMILES Fc1cccc2ncc(cc12)-c1ccsc1
Show InChI InChI=1S/C13H8FNS/c14-12-2-1-3-13-11(12)6-10(7-15-13)9-4-5-16-8-9/h1-8H
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of isolated human PDGF receptor phosphorylation


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039082
PNG
(6,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccsc1
Show InChI InChI=1S/C15H13NO2S/c1-17-14-6-11-5-12(10-3-4-19-9-10)8-16-13(11)7-15(14)18-2/h3-9H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.01-0.02


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132392
PNG
((+/-)Bicyclo[2.2.1]hept-2-yl-(6,7-dimethoxy-quinox...)
Show SMILES COc1cc2ncc(NC3CC4CCC3C4)nc2cc1OC
Show InChI InChI=1S/C17H21N3O2/c1-21-15-7-13-14(8-16(15)22-2)20-17(9-18-13)19-12-6-10-3-4-11(12)5-10/h7-12H,3-6H2,1-2H3,(H,19,20)
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Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132405
PNG
(5-(6,7-Dimethoxy-quinoxalin-2-ylamino)-bicyclo[2.2...)
Show SMILES COc1cc2ncc(N[C@@H]3CC4CC3C[C@H]4O)nc2cc1OC
Show InChI InChI=1S/C17H21N3O3/c1-22-15-6-12-13(7-16(15)23-2)20-17(8-18-12)19-11-4-10-3-9(11)5-14(10)21/h6-11,14,21H,3-5H2,1-2H3,(H,19,20)/t9?,10?,11-,14-/m1/s1
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Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50404045
PNG
(CHEMBL2112463)
Show SMILES COc1cc2ncc(O[C@H]3CC4CCC3C4)nc2cc1OC
Show InChI InChI=1S/C17H20N2O3/c1-20-15-7-12-13(8-16(15)21-2)19-17(9-18-12)22-14-6-10-3-4-11(14)5-10/h7-11,14H,3-6H2,1-2H3/t10?,11?,14-/m0/s1
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Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039084
PNG
(3-(3-Fluoro-phenyl)-6,7-dimethoxy-quinoline | CHEM...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1cccc(F)c1
Show InChI InChI=1S/C17H14FNO2/c1-20-16-8-12-6-13(11-4-3-5-14(18)7-11)10-19-15(12)9-17(16)21-2/h3-10H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.015-0.025


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039069
PNG
(7-Fluoro-3-thiophen-3-yl-quinoline | CHEMBL307093)
Show SMILES Fc1ccc2cc(cnc2c1)-c1ccsc1
Show InChI InChI=1S/C13H8FNS/c14-12-2-1-9-5-11(7-15-13(9)6-12)10-3-4-16-8-10/h1-8H
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.004-0.025


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132409
PNG
(4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexane...)
Show SMILES COC(=O)C1CCC(CC1)Nc1cnc2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C18H23N3O4/c1-23-15-8-13-14(9-16(15)24-2)21-17(10-19-13)20-12-6-4-11(5-7-12)18(22)25-3/h8-12H,4-7H2,1-3H3,(H,20,21)
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n/an/a 28n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132409
PNG
(4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexane...)
Show SMILES COC(=O)C1CCC(CC1)Nc1cnc2cc(OC)c(OC)cc2n1
Show InChI InChI=1S/C18H23N3O4/c1-23-15-8-13-14(9-16(15)24-2)21-17(10-19-13)20-12-6-4-11(5-7-12)18(22)25-3/h8-12H,4-7H2,1-3H3,(H,20,21)
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n/an/a 28n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50118881
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C22H24BrN5O2S/c1-29-19-11-17-18(12-20(19)30-2)25-14-26-21(17)27-7-9-28(10-8-27)22(31)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,31)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...


J Med Chem 45: 4513-23 (2002)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039067
PNG
(5-(6,7-Dimethoxy-quinolin-3-yl)-1H-pyridin-2-one |...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C16H14N2O3/c1-20-14-6-11-5-12(10-3-4-16(19)18-8-10)9-17-13(11)7-15(14)21-2/h3-9H,1-2H3,(H,18,19)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.015-0.03


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50118880
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O2S/c1-16-4-6-17(7-5-16)14-24-23(31)28-10-8-27(9-11-28)22-18-12-20(29-2)21(30-3)13-19(18)25-15-26-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,24,31)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...


J Med Chem 45: 4513-23 (2002)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039042
PNG
(5,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccsc1
Show InChI InChI=1S/C15H13NO2S/c1-17-12-6-14-13(15(7-12)18-2)5-11(8-16-14)10-3-4-19-9-10/h3-9H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.025-0.03


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039072
PNG
(3-(5-Chloro-thiophen-2-yl)-6,7-dimethoxy-quinoline...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccc(Cl)s1
Show InChI InChI=1S/C15H12ClNO2S/c1-18-12-6-9-5-10(14-3-4-15(16)20-14)8-17-11(9)7-13(12)19-2/h3-8H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.007-0.03


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50115347
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C25H31N5O3/c1-25(2,3)17-6-8-18(9-7-17)28-24(31)30-12-10-29(11-13-30)23-19-14-21(32-4)22(33-5)15-20(19)26-16-27-23/h6-9,14-16H,10-13H2,1-5H3,(H,28,31)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...


J Med Chem 45: 4513-23 (2002)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039037
PNG
(4-(6,7-Dimethoxy-quinolin-3-yl)-phenol | CHEMBL303...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccc(O)cc1
Show InChI InChI=1S/C17H15NO3/c1-20-16-8-12-7-13(11-3-5-14(19)6-4-11)10-18-15(12)9-17(16)21-2/h3-10,19H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.02-0.03


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039090
PNG
(3-Cyclopent-1-enyl-6,7-dimethoxy-quinoline | CHEMB...)
Show SMILES COc1cc2cc(cnc2cc1OC)C1=CCCC1
Show InChI InChI=1S/C16H17NO2/c1-18-15-8-12-7-13(11-5-3-4-6-11)10-17-14(12)9-16(15)19-2/h5,7-10H,3-4,6H2,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.02-0.04


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132395
PNG
((6,7-Dimethoxy-quinoxalin-2-yl)-(3-methyl-cyclohex...)
Show SMILES COc1cc2ncc(NC3CCCC(C)C3)nc2cc1OC
Show InChI InChI=1S/C17H23N3O2/c1-11-5-4-6-12(7-11)19-17-10-18-13-8-15(21-2)16(22-3)9-14(13)20-17/h8-12H,4-7H2,1-3H3,(H,19,20)
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n/an/a 41n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132395
PNG
((6,7-Dimethoxy-quinoxalin-2-yl)-(3-methyl-cyclohex...)
Show SMILES COc1cc2ncc(NC3CCCC(C)C3)nc2cc1OC
Show InChI InChI=1S/C17H23N3O2/c1-11-5-4-6-12(7-11)19-17-10-18-13-8-15(21-2)16(22-3)9-14(13)20-17/h8-12H,4-7H2,1-3H3,(H,19,20)
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n/an/a 41n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132387
PNG
((7-Methoxy-quinoxalin-2-yl)-phenyl-amine | CHEMBL1...)
Show SMILES COc1ccc2ncc(Nc3ccccc3)nc2c1
Show InChI InChI=1S/C15H13N3O/c1-19-12-7-8-13-14(9-12)18-15(10-16-13)17-11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
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Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/a 50n/an/an/an/an/an/a



Organon Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against platelet-derived growth factor receptor


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of the platelet-derived growth factor receptor.


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50287091
PNG
(CHEMBL20252 | Naphthalene-2-carboxylic acid [4-met...)
Show SMILES Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C27H21N5O/c1-18-8-11-23(30-26(33)21-10-9-19-5-2-3-6-20(19)15-21)16-25(18)32-27-29-14-12-24(31-27)22-7-4-13-28-17-22/h2-17H,1H3,(H,30,33)(H,29,31,32)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of tyrosine kinase(PDGF-R)


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039094
PNG
(6,7-Dimethoxy-3-phenylethynyl-quinoline | CHEMBL67...)
Show SMILES COc1cc2cc(cnc2cc1OC)C#Cc1ccccc1
Show InChI InChI=1S/C19H15NO2/c1-21-18-11-16-10-15(9-8-14-6-4-3-5-7-14)13-20-17(16)12-19(18)22-2/h3-7,10-13H,1-2H3
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.02-0.05


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50287091
PNG
(CHEMBL20252 | Naphthalene-2-carboxylic acid [4-met...)
Show SMILES Cc1ccc(NC(=O)c2ccc3ccccc3c2)cc1Nc1nccc(n1)-c1cccnc1
Show InChI InChI=1S/C27H21N5O/c1-18-8-11-23(30-26(33)21-10-9-19-5-2-3-6-20(19)15-21)16-25(18)32-27-29-14-12-24(31-27)22-7-4-13-28-17-22/h2-17H,1H3,(H,30,33)(H,29,31,32)
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TBA

Curated by ChEMBL


Assay Description
Inhibition of the platelet-derived growth factor receptor.


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50210272
PNG
(6-((4-methylpiperazin-1-yl)methyl)-3-(5-(3-phenoxy...)
Show SMILES CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3csc(c3)C#CCOc3ccccc3)c2)CC1
Show InChI InChI=1S/C29H28N4OS/c1-32-11-13-33(14-12-32)19-21-9-10-26-22(16-21)18-27-28(30-31-29(26)27)23-17-25(35-20-23)8-5-15-34-24-6-3-2-4-7-24/h2-4,6-7,9-10,16-17,20H,11-15,18-19H2,1H3,(H,30,31)
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n/an/a 58n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PDGFR by ELISA


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039057
PNG
(7-Methoxy-3-thiophen-3-yl-quinoline | CHEMBL68185)
Show SMILES COc1ccc2cc(cnc2c1)-c1ccsc1
Show InChI InChI=1S/C14H11NOS/c1-16-13-3-2-10-6-12(8-15-14(10)7-13)11-4-5-17-9-11/h2-9H,1H3
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n/an/a 60n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.002-0.06


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50039044
PNG
(3-(4-Fluoro-phenyl)-6,7-dimethoxy-quinoline | CHEM...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccc(F)cc1
Show InChI InChI=1S/C17H14FNO2/c1-20-16-8-12-7-13(11-3-5-14(18)6-4-11)10-19-15(12)9-17(16)21-2/h3-10H,1-2H3
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n/an/a 60n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.035-0.06


J Med Chem 37: 2129-37 (1994)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132384
PNG
(2-Cyclohexyloxy-6,7-dimethoxy-quinoxaline | CHEMBL...)
Show SMILES COc1cc2ncc(OC3CCCCC3)nc2cc1OC
Show InChI InChI=1S/C16H20N2O3/c1-19-14-8-12-13(9-15(14)20-2)18-16(10-17-12)21-11-6-4-3-5-7-11/h8-11H,3-7H2,1-2H3
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n/an/a 65n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50132407
PNG
(4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexano...)
Show SMILES COc1cc2ncc(N[C@@H]3CC[C@H](O)CC3)nc2cc1OC
Show InChI InChI=1S/C16H21N3O3/c1-21-14-7-12-13(8-15(14)22-2)19-16(9-17-12)18-10-3-5-11(20)6-4-10/h7-11,20H,3-6H2,1-2H3,(H,18,19)/t10-,11+
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n/an/a 68n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)

More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Mus musculus (mouse))
BDBM3104
PNG
(2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H...)
Show SMILES Cn1c2nc(Nc3ccc(CC(O)=O)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C22H16Cl2N4O3/c1-28-20-13(10-15(21(28)31)19-16(23)3-2-4-17(19)24)11-25-22(27-20)26-14-7-5-12(6-8-14)9-18(29)30/h2-8,10-11H,9H2,1H3,(H,29,30)(H,25,26,27)
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n/an/a 70n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration of compound against mouse Platelet-derived growth factor receptor


Citation and Details
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (human)-Homo sapiens (Human))
BDBM50118859
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C22H24ClN5O2S/c1-29-19-11-17-18(12-20(19)30-2)25-14-26-21(17)27-7-9-28(10-8-27)22(31)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,31)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...


J Med Chem 45: 4513-23 (2002)

More data for this
Ligand-Target Pair
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