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Found 16 hits Enz. Inhib. hit(s) with Target = 'PI3-kinase p110-alpha subunit' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094943
PNG
(CHEMBL3589372)
Show SMILES CC(N1CCOCC1)c1nc2N(C(=S)N3CCCC3c2c(=O)[nH]1)c1ccccc1
Show InChI InChI=1S/C19H19N3OS/c1-19(2,3)22-18(23)15-12-21(11-13-7-6-10-24-13)16-9-5-4-8-14(16)17(15)20-22/h4-10,12H,11H2,1-3H3
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n/an/a 0.100n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094956
PNG
(CHEMBL3589370)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc([nH]c2=O)C(C)N1CCOCC1
Show InChI InChI=1S/C24H25N3O/c28-24-21-17-26(15-18-9-3-1-4-10-18)22-14-8-7-13-20(22)23(21)25-27(24)16-19-11-5-2-6-12-19/h1,3-4,7-10,13-14,17,19H,2,5-6,11-12,15-16H2
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n/an/a 0.300n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094942
PNG
(CHEMBL3589371)
Show SMILES O=c1[nH]c(CN2CCOCC2)nc2N(C(=S)N3CCCC3c12)c1ccccc1
Show InChI InChI=1S/C20H19N3OS/c24-20-17-13-22(12-15-8-5-11-25-15)18-10-4-3-9-16(18)19(17)21-23(20)14-6-1-2-7-14/h3-5,8-11,13-14H,1-2,6-7,12H2
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n/an/a 0.5n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094955
PNG
(CHEMBL3589324)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(CN1CCOCC1)[nH]c2=O
Show InChI InChI=1S/C21H20ClN3O/c1-2-3-11-25-21(26)18-14-24(13-15-7-6-8-16(22)12-15)19-10-5-4-9-17(19)20(18)23-25/h4-10,12,14H,2-3,11,13H2,1H3
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n/an/a 0.800n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094948
PNG
(CHEMBL3589377)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)cc1)c(C#N)c2N1CCOCC1
Show InChI InChI=1S/C21H27N3O/c1-2-3-13-24-21(25)18-15-23(14-16-9-5-4-6-10-16)19-12-8-7-11-17(19)20(18)22-24/h7-8,11-12,15-16H,2-6,9-10,13-14H2,1H3
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n/an/a 1.20n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094950
PNG
(CHEMBL3589379)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1S/C20H19N3O/c1-2-3-13-23-20(24)17-14-22(15-9-5-4-6-10-15)18-12-8-7-11-16(18)19(17)21-23/h4-12,14H,2-3,13H2,1H3
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n/an/a 1.90n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094949
PNG
(CHEMBL3589378)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1ccc(OC)c(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1/C24H27N5O3S/c1-3-28-23-20(17-5-4-8-29(17)24(28)33)22(27-9-11-32-12-10-27)16(14-25)21(26-23)15-6-7-19(31-2)18(30)13-15/h6-7,13,17,30H,3-5,8-12H2,1-2H3
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n/an/a 3.80n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094947
PNG
(CHEMBL3589376)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(OC)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1S/C22H21N3O/c26-22-19-15-24(13-16-7-2-1-3-8-16)20-12-5-4-11-18(20)21(19)23-25(22)14-17-9-6-10-17/h1-5,7-8,11-12,15,17H,6,9-10,13-14H2
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n/an/a 3.80n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094946
PNG
(CHEMBL3589375)
Show SMILES CCN1C(=S)N2CCCC2c2c1nc(-c1cccc(O)c1)c(C#N)c2N1CCOCC1
Show InChI InChI=1S/C21H27N3O/c1-21(2,3)24-20(25)17-14-23(13-15-9-5-4-6-10-15)18-12-8-7-11-16(18)19(17)22-24/h7-8,11-12,14-15H,4-6,9-10,13H2,1-3H3
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n/an/a 7.70n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094951
PNG
(CHEMBL3589320)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1cccc(OC)c1)N1CCOCC1
Show InChI InChI=1S/C20H19N3O/c1-14(2)23-20(24)17-13-22(12-15-8-4-3-5-9-15)18-11-7-6-10-16(18)19(17)21-23/h3-11,13-14H,12H2,1-2H3
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n/an/a 234n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094952
PNG
(CHEMBL3589321)
Show SMILES CCN1C(=S)N2CCCC2c2c(nc(nc12)-c1ccc(OC)cc1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O/c1-21(2,3)24-20(25)17-14-23(13-15-9-5-4-6-10-15)18-12-8-7-11-16(18)19(17)22-24/h4-12,14H,13H2,1-3H3
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n/an/a 387n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094954
PNG
(CHEMBL3589323)
Show SMILES COc1ccc(cc1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1S/C19H19N3OS/c1-2-3-10-22-19(23)16-13-21(12-14-7-6-11-24-14)17-9-5-4-8-15(17)18(16)20-22/h4-9,11,13H,2-3,10,12H2,1H3
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n/an/a 678n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094953
PNG
(CHEMBL3589322)
Show SMILES COc1cccc(c1)-c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1S/C14H15N3O/c1-2-3-8-17-14(18)11-9-15-12-7-5-4-6-10(12)13(11)16-17/h4-7,9,18H,2-3,8H2,1H3
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n/an/a 695n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094944
PNG
(CHEMBL3589373)
Show SMILES S=C1N2CCCC2c2c(nc(CN3CCOCC3)nc2N1c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C21H21N3O/c1-2-3-13-24-21(25)18-15-23(14-16-9-5-4-6-10-16)19-12-8-7-11-17(19)20(18)22-24/h4-12,15H,2-3,13-14H2,1H3
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n/an/a 2.34E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM50094945
PNG
(CHEMBL3589374)
Show SMILES CC(N1CCOCC1)c1nc(N2CCOCC2)c2C3CCCN3C(=S)N(c3ccccc3)c2n1
Show InChI InChI=1S/C22H23N3O/c1-2-3-14-25-22(26)19-16-24(15-13-17-9-5-4-6-10-17)20-12-8-7-11-18(20)21(19)23-25/h4-12,16H,2-3,13-15H2,1H3
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n/an/a 5.49E+3n/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged bovine p110alpha expressed in Sf9/Baculovirus system using [gamma-33P]ATP by scintillation proximity assay


Citation and Details
More data for this
Ligand-Target Pair
PI3-kinase p110-alpha subunit


(Bos taurus)
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Dundee

Curated by ChEMBL


Assay Description
Inhibition of His-tagged bovine PI3K expressed in Sf9 cells


Biochem J 351: 95-105 (2001)

More data for this
Ligand-Target Pair