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Compile Data Set for Download or QSAR

Found 988 hits Enz. Inhib. hit(s) with Target = 'PKC beta' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50391386
PNG
(CHEMBL2148106)
Show SMILES CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H](OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H](C)O)[C@@H]1C)c1cccc(O)c1
Show InChI InChI=1S/C32H48O10/c1-18(11-12-24(38-7)22-9-8-10-23(34)13-22)29-20(3)26-16-32(41-29)30(5,6)15-19(2)31(37,42-32)17-28(36)39-25(21(4)33)14-27(35)40-26/h8-10,13,18-21,24-26,29,33-34,37H,11-12,14-17H2,1-7H3/t18-,19+,20-,21+,24-,25+,26?,29+,31-,32-/m0/s1
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0.170n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKCbeta C1A domain


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50057514
PNG
((10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-5...)
Show SMILES CCCCCCCCc1ccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)Cc3c[nH]c1c23
Show InChI InChI=1S/C25H39N3O2/c1-5-6-7-8-9-10-11-18-12-13-21-22-19(15-26-23(18)22)14-20(16-29)27-25(30)24(17(2)3)28(21)4/h12-13,15,17,20,24,26,29H,5-11,14,16H2,1-4H3,(H,27,30)/t20-,24-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]- PDBu from recombinant PKC beta expressed in baculovirus


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50327943
PNG
(Aplysiatoxin | CHEMBL1256416)
Show SMILES CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@@H](OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H](C)O)[C@@H]1C)c1cc(O)ccc1Br
Show InChI InChI=1S/C32H47BrO10/c1-17(8-11-24(39-7)22-12-21(35)9-10-23(22)33)29-19(3)26-15-32(42-29)30(5,6)14-18(2)31(38,43-32)16-28(37)40-25(20(4)34)13-27(36)41-26/h9-10,12,17-20,24-26,29,34-35,38H,8,11,13-16H2,1-7H3/t17-,18+,19-,20+,24-,25+,26?,29+,31-,32-/m0/s1
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0.450n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKC beta C1A peptide


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50133236
PNG
(CHEMBL337834 | Tetradecanedioic acid ((S)-5-hydrox...)
Show SMILES CC(C)[C@@H]1N(C)c2ccc(NC(=O)CCCCCCCCCCCCC(=O)Nc3ccc4C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c4c3)cc2C[C@@H](CO)NC1=O
Show InChI InChI=1S/C44H68N6O6/c1-29(2)41-43(55)48-36(28-52)25-32-24-33(21-22-37(32)49(41)5)45-39(53)17-15-13-11-9-7-8-10-12-14-16-18-40(54)46-34-20-19-31-23-35(27-51)47-44(56)42(30(3)4)50(6)38(31)26-34/h19-22,24,26,29-30,35-36,41-42,51-52H,7-18,23,25,27-28H2,1-6H3,(H,45,53)(H,46,54)(H,47,56)(H,48,55)/t35-,36-,41-,42-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PKC beta-1


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153901
PNG
(US8999981, A146)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H35N7O3/c1-16-14-31(17(2)13-30(16)18-8-11-35-12-9-18)24(34)32-15-19-21(25(32,3)4)28-29-22(19)27-23(33)20-7-5-6-10-26-20/h5-7,10,16-18H,8-9,11-15H2,1-4H3,(H2,27,28,29,33)/t16-,17+/s2
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US Patent
1.70n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50099066
PNG
(CHEMBL279115 | phorbol 13-acetate 12-myristate)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(C)=O
Show InChI InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30?,32-,34-,35-,36-/m1/s1
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PubMed
1.80n/an/an/an/an/an/an/an/a



Georgetotwn University

Curated by ChEMBL


Assay Description
Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C beta


Bioorg Med Chem Lett 11: 955-9 (2001)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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PubMed
1.80n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of 3[H]PDBu from Protein kinase C beta C1a domain


Bioorg Med Chem Lett 11: 719-22 (2001)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153898
PNG
(US8999981, A143)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C26H37N7O3/c1-17-14-32(18(2)13-31(17)15-19-8-11-36-12-9-19)25(35)33-16-20-22(26(33,3)4)29-30-23(20)28-24(34)21-7-5-6-10-27-21/h5-7,10,17-19H,8-9,11-16H2,1-4H3,(H2,28,29,30,34)/t17-,18+/s2
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US Patent
1.90n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50057512
PNG
((1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-4a,7b-dihydroxy-3-...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22?,24-,26-,27-,28-/m1/s1
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PubMed
2n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of 3[H]PDBu from Protein kinase C beta C1a domain


Bioorg Med Chem Lett 11: 719-22 (2001)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50097750
PNG
(Butyric acid (1aR,1bS,4aS,7aR,7bR,8R,9R,9aS)-9-but...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@H]3CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O7/c1-7-9-21(30)34-25-16(4)27(33)19-11-15(3)23(32)18(19)12-17(14-29)13-20(27)24-26(5,6)28(24,25)35-22(31)10-8-2/h11,13,16,18-20,24-25,29,33H,7-10,12,14H2,1-6H3/t16-,18+,19-,20+,24?,25-,27+,28-/m1/s1
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2.20n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of 3[H]PDBu from Protein kinase C beta C1a domain


Bioorg Med Chem Lett 11: 719-22 (2001)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50097750
PNG
(Butyric acid (1aR,1bS,4aS,7aR,7bR,8R,9R,9aS)-9-but...)
Show SMILES CCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@H]3CC(CO)=C[C@H]2[C@@H]2C(C)(C)[C@]12OC(=O)CCC
Show InChI InChI=1S/C28H40O7/c1-7-9-21(30)34-25-16(4)27(33)19-11-15(3)23(32)18(19)12-17(14-29)13-20(27)24-26(5,6)28(24,25)35-22(31)10-8-2/h11,13,16,18-20,24-25,29,33H,7-10,12,14H2,1-6H3/t16-,18+,19-,20+,24?,25-,27+,28-/m1/s1
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PubMed
2.80n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of 3[H]PDBu from Protein kinase C beta C1a domain


Bioorg Med Chem Lett 11: 719-22 (2001)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153757
PNG
(US8999981, A2)
Show SMILES C[C@H]1CN(C)C2(CCCC2)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C24H33N7O2/c1-16-13-29(4)24(10-6-7-11-24)15-30(16)22(33)31-14-17-19(23(31,2)3)27-28-20(17)26-21(32)18-9-5-8-12-25-18/h5,8-9,12,16H,6-7,10-11,13-15H2,1-4H3,(H2,26,27,28,32)/t16-/s2
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US Patent
3.05n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES CC(C)=C1CC(CO)(COC(=O)c2ccc(cc2)C#Cc2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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4.10n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of phosphatidylserine


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM154004
PNG
(US8999981, F60)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)C(F)(F)F)n[nH]c2C1(C)C
Show InChI InChI=1/C27H36F3N7O3/c1-16-13-36(17(2)12-35(16)14-18-7-9-40-10-8-18)25(39)37-15-20-22(26(37,3)4)33-34-23(20)32-24(38)21-6-5-19(11-31-21)27(28,29)30/h5-6,11,16-18H,7-10,12-15H2,1-4H3,(H2,32,33,34,38)/t16-,17+/s2
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US Patent
4.17n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153933
PNG
(US8999981, E3)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc4ccccc4cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C26H31N7O2/c1-16-13-31-10-6-9-19(31)14-32(16)25(35)33-15-20-22(26(33,2)3)29-30-23(20)28-24(34)21-11-17-7-4-5-8-18(17)12-27-21/h4-5,7-8,11-12,16,19H,6,9-10,13-15H2,1-3H3,(H2,28,29,30,34)/t16-,19-/s2
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US Patent
5.51n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50057511
PNG
((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Show SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
Show InChI InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
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6.10n/an/an/an/an/an/an/an/a



Georgetown University Medical Center

Curated by ChEMBL


Assay Description
Displacement of [3H]- PDBu from recombinant PKC beta expressed in baculovirus


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153934
PNG
(US8999981, E4)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3ccc4cnccc4n3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H30N8O2/c1-15-12-31-10-4-5-17(31)13-32(15)24(35)33-14-18-21(25(33,2)3)29-30-22(18)28-23(34)20-7-6-16-11-26-9-8-19(16)27-20/h6-9,11,15,17H,4-5,10,12-14H2,1-3H3,(H2,28,29,30,34)/t15-,17-/s2
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6.17n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153936
PNG
(US8999981, E6)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(n[nH]3)C3CC3)n[nH]c2C1(C)C
Show InChI InChI=1/C23H32N8O2/c1-13-10-29-8-4-5-15(29)11-30(13)22(33)31-12-16-19(23(31,2)3)27-28-20(16)24-21(32)18-9-17(25-26-18)14-6-7-14/h9,13-15H,4-8,10-12H2,1-3H3,(H,25,26)(H2,24,27,28,32)/t13-,15-/s2
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US Patent
6.81n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153888
PNG
(US8999981, A133)
Show SMILES C[C@H]1CN(C)C2(CCC2)CN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C23H31N7O2/c1-15-12-28(4)23(9-7-10-23)14-29(15)21(32)30-13-16-18(22(30,2)3)26-27-19(16)25-20(31)17-8-5-6-11-24-17/h5-6,8,11,15H,7,9-10,12-14H2,1-4H3,(H2,25,26,27,31)/t15-/s2
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US Patent
8.58n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153850
PNG
(US8999981, A95)
Show SMILES CCN1C[C@H](C)N(C[C@H]1C)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C22H31N7O2/c1-6-27-11-15(3)28(12-14(27)2)21(31)29-13-16-18(22(29,4)5)25-26-19(16)24-20(30)17-9-7-8-10-23-17/h7-10,14-15H,6,11-13H2,1-5H3,(H2,24,25,26,30)/t14-,15+/s2
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US Patent
9.11n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153838
PNG
(US8999981, A83)
Show SMILES CCCN1C[C@H](C)N(C[C@H]1CCO)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C24H35N7O3/c1-5-11-29-13-16(2)30(14-17(29)9-12-32)23(34)31-15-18-20(24(31,3)4)27-28-21(18)26-22(33)19-8-6-7-10-25-19/h6-8,10,16-17,32H,5,9,11-15H2,1-4H3,(H2,26,27,28,33)/t16-,17+/s2
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9.53n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50229772
PNG
(1-hexylindolactam-V | CHEMBL399981)
Show SMILES CCCCCCn1cc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c3cccc1c23
Show InChI InChI=1S/C23H35N3O2/c1-5-6-7-8-12-26-14-17-13-18(15-27)24-23(28)22(16(2)3)25(4)19-10-9-11-20(26)21(17)19/h9-11,14,16,18,22,27H,5-8,12-13,15H2,1-4H3,(H,24,28)/t18-,22-/m0/s1
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Article
PubMed
9.80n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCbeta C1A domain


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153902
PNG
(US8999981, A147)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H35N7O3/c1-16-12-31(17(2)11-30(16)13-18-8-10-35-15-18)24(34)32-14-19-21(25(32,3)4)28-29-22(19)27-23(33)20-7-5-6-9-26-20/h5-7,9,16-18H,8,10-15H2,1-4H3,(H2,27,28,29,33)/t16-,17+,18?/s2
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US Patent
<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153904
PNG
(US8999981, A149)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H34FN7O3/c1-15-13-32(16(2)12-31(15)18-7-9-36-10-8-18)24(35)33-14-19-21(25(33,3)4)29-30-22(19)28-23(34)20-6-5-17(26)11-27-20/h5-6,11,15-16,18H,7-10,12-14H2,1-4H3,(H2,28,29,30,34)/t15-,16+/s2
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US Patent
<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153988
PNG
(US8999981, F44)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cccc(C)c3)n[nH]c2C1(C)C
Show InChI InChI=1/C27H38N6O3.CH4/c1-18-6-5-7-21(14-18)25(34)28-24-22-17-33(27(3,4)23(22)29-30-24)26(35)32-11-10-31(15-19(32)2)16-20-8-12-36-13-9-20;/h5-7,14,19-20H,8-13,15-17H2,1-4H3,(H2,28,29,30,34);1H4/t19-;/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM154005
PNG
(US8999981, G1 | US8999981, G3)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)C#N)n[nH]c2C1(C)C
Show InChI InChI=1/C27H36N8O3/c1-17-14-34(18(2)13-33(17)15-19-7-9-38-10-8-19)26(37)35-16-21-23(27(35,3)4)31-32-24(21)30-25(36)22-6-5-20(11-28)12-29-22/h5-6,12,17-19H,7-10,13-16H2,1-4H3,(H2,30,31,32,36)/t17-,18+/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153973
PNG
(US8999981, F29)
Show SMILES C.COc1ccc(nc1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1CCN(CC3CCOCC3)C[C@@H]1C)C2(C)C
Show InChI InChI=1/C26H37N7O4.CH4/c1-17-14-31(15-18-7-11-37-12-8-18)9-10-32(17)25(35)33-16-20-22(26(33,2)3)29-30-23(20)28-24(34)21-6-5-19(36-4)13-27-21;/h5-6,13,17-18H,7-12,14-16H2,1-4H3,(H2,28,29,30,34);1H4/t17-;/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153978
PNG
(US8999981, F34)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cc(C)nn3C)n[nH]c2C1(C)C
Show InChI InChI=1/C25H38N8O3.CH4/c1-16-12-20(30(5)29-16)23(34)26-22-19-15-33(25(3,4)21(19)27-28-22)24(35)32-9-8-31(13-17(32)2)14-18-6-10-36-11-7-18;/h12,17-18H,6-11,13-15H2,1-5H3,(H2,26,27,28,34);1H4/t17-;/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM154005
PNG
(US8999981, G1 | US8999981, G3)
Show SMILES C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)C#N)n[nH]c2C1(C)C
Show InChI InChI=1/C27H36N8O3/c1-17-14-34(18(2)13-33(17)15-19-7-9-38-10-8-19)26(37)35-16-21-23(27(35,3)4)31-32-24(21)30-25(36)22-6-5-20(11-28)12-29-22/h5-6,12,17-19H,7-10,13-16H2,1-4H3,(H2,30,31,32,36)/t17-,18+/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153991
PNG
(US8999981, F47)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3cccc(F)c3)n[nH]c2C1(C)C
Show InChI InChI=1/C26H35FN6O3.CH4/c1-17-14-31(15-18-7-11-36-12-8-18)9-10-32(17)25(35)33-16-21-22(26(33,2)3)29-30-23(21)28-24(34)19-5-4-6-20(27)13-19;/h4-6,13,17-18H,7-12,14-16H2,1-3H3,(H2,28,29,30,34);1H4/t17-;/s2
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US Patent
<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153995
PNG
(US8999981, F51)
Show SMILES CCc1ccc(nc1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C[C@@H]1C)C1CCOCC1)C2(C)C
Show InChI InChI=1/C27H39N7O3/c1-6-19-7-8-22(28-13-19)25(35)29-24-21-16-34(27(4,5)23(21)30-31-24)26(36)33-15-17(2)32(14-18(33)3)20-9-11-37-12-10-20/h7-8,13,17-18,20H,6,9-12,14-16H2,1-5H3,(H2,29,30,31,35)/t17-,18+/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153996
PNG
(US8999981, F52)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(cn3)N3CCOCC3)n[nH]c2C1(C)C
Show InChI InChI=1/C29H42N8O4/c1-19-17-36(20(2)16-35(19)21-7-11-40-12-8-21)28(39)37-18-23-25(29(37,3)4)32-33-26(23)31-27(38)24-6-5-22(15-30-24)34-9-13-41-14-10-34/h5-6,15,19-21H,7-14,16-18H2,1-4H3,(H2,31,32,33,38)/t19-,20+/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153999
PNG
(US8999981, F55)
Show SMILES COc1ccc(nc1)C(=O)Nc1n[nH]c2c1CN(C(=O)N1C[C@@H](C)N(C[C@@H]1C)C1CCOCC1)C2(C)C
Show InChI InChI=1/C26H37N7O4/c1-16-14-32(17(2)13-31(16)18-8-10-37-11-9-18)25(35)33-15-20-22(26(33,3)4)29-30-23(20)28-24(34)21-7-6-19(36-5)12-27-21/h6-7,12,16-18H,8-11,13-15H2,1-5H3,(H2,28,29,30,34)/t16-,17+/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM154000
PNG
(US8999981, F56)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H34ClN7O3/c1-15-13-32(16(2)12-31(15)18-7-9-36-10-8-18)24(35)33-14-19-21(25(33,3)4)29-30-22(19)28-23(34)20-6-5-17(26)11-27-20/h5-6,11,15-16,18H,7-10,12-14H2,1-4H3,(H2,28,29,30,34)/t15-,16+/s2
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<10n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153829
PNG
(US8999981, A74)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3nc(Cl)c(Cl)s3)n[nH]c2C1(C)C
Show InChI InChI=1/C20H25Cl2N7O2S/c1-10-7-27-6-4-5-11(27)8-28(10)19(31)29-9-12-13(20(29,2)3)25-26-16(12)24-17(30)18-23-14(21)15(22)32-18/h10-11H,4-9H2,1-3H3,(H2,24,25,26,30)/t10-,11-/s2
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10.4n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153940
PNG
(US8999981, E10)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc(nn3C)C(C)(C)C)n[nH]c2C1(C)C
Show InChI InChI=1/C25H38N8O2/c1-15-12-31-10-8-9-16(31)13-32(15)23(35)33-14-17-20(25(33,5)6)27-28-21(17)26-22(34)18-11-19(24(2,3)4)29-30(18)7/h11,15-16H,8-10,12-14H2,1-7H3,(H2,26,27,28,34)/t15-,16-/s2
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10.6n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50229772
PNG
(1-hexylindolactam-V | CHEMBL399981)
Show SMILES CCCCCCn1cc2C[C@@H](CO)NC(=O)[C@H](C(C)C)N(C)c3cccc1c23
Show InChI InChI=1S/C23H35N3O2/c1-5-6-7-8-12-26-14-17-13-18(15-27)24-23(28)22(16(2)3)25(4)19-10-9-11-20(26)21(17)19/h9-11,14,16,18,22,27H,5-8,12-13,15H2,1-4H3,(H,24,28)/t18-,22-/m0/s1
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11n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu from PKCbeta C1B domain


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153990
PNG
(US8999981, F46)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cc3)n[nH]c2C1(C)C
Show InChI InChI=1/C26H35FN6O3.CH4/c1-17-14-31(15-18-8-12-36-13-9-18)10-11-32(17)25(35)33-16-21-22(26(33,2)3)29-30-23(21)28-24(34)19-4-6-20(27)7-5-19;/h4-7,17-18H,8-16H2,1-3H3,(H2,28,29,30,34);1H4/t17-;/s2
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11.2n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153974
PNG
(US8999981, F30)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(Cl)cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H34ClN7O3.CH4/c1-16-13-31(14-17-6-10-36-11-7-17)8-9-32(16)24(35)33-15-19-21(25(33,2)3)29-30-22(19)28-23(34)20-5-4-18(26)12-27-20;/h4-5,12,16-17H,6-11,13-15H2,1-3H3,(H2,28,29,30,34);1H4/t16-;/s2
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11.9n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50391388
PNG
(CHEMBL2148108)
Show SMILES C[C@@H]1[C@@H](CCCCc2cccc(O)c2)O[C@]23C[C@@H]1OC(=O)C[C@H](CO)OC(=O)C[C@@H](CCC2(C)C)O3
Show InChI InChI=1S/C28H40O8/c1-18-23(10-5-4-7-19-8-6-9-20(30)13-19)36-28-16-24(18)34-26(32)15-22(17-29)33-25(31)14-21(35-28)11-12-27(28,2)3/h6,8-9,13,18,21-24,29-30H,4-5,7,10-12,14-17H2,1-3H3/t18-,21-,22-,23-,24?,28-/m1/s1
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12n/an/an/an/an/an/an/an/a



Kyoto University

Curated by ChEMBL


Assay Description
Inhibition of [3H]PDBu binding to PKCbeta C1A domain


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153998
PNG
(US8999981, F54)
Show SMILES C[C@@H]1CN([C@@H](C)CN1C1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccc(C)cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C26H37N7O3/c1-16-6-7-21(27-12-16)24(34)28-23-20-15-33(26(4,5)22(20)29-30-23)25(35)32-14-17(2)31(13-18(32)3)19-8-10-36-11-9-19/h6-7,12,17-19H,8-11,13-15H2,1-5H3,(H2,28,29,30,34)/t17-,18+/s2
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12.2n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153937
PNG
(US8999981, E7)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cnc4ccccc4n3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H30N8O2/c1-15-12-31-10-6-7-16(31)13-32(15)24(35)33-14-17-21(25(33,2)3)29-30-22(17)28-23(34)20-11-26-18-8-4-5-9-19(18)27-20/h4-5,8-9,11,15-16H,6-7,10,12-14H2,1-3H3,(H2,28,29,30,34)/t15-,16-/s2
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12.5n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153970
PNG
(US8999981, F26)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccc(F)cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C25H34FN7O3.CH4/c1-16-13-31(14-17-6-10-36-11-7-17)8-9-32(16)24(35)33-15-19-21(25(33,2)3)29-30-22(19)28-23(34)20-5-4-18(26)12-27-20;/h4-5,12,16-17H,6-11,13-15H2,1-3H3,(H2,28,29,30,34);1H4/t16-;/s2
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12.8n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153976
PNG
(US8999981, F32)
Show SMILES C.C[C@H]1CN(CC2CCOCC2)CCN1C(=O)N1Cc2c(NC(=O)c3csc(C)n3)n[nH]c2C1(C)C
Show InChI InChI=1/C24H35N7O3S.CH4/c1-15-11-29(12-17-5-9-34-10-6-17)7-8-30(15)23(33)31-13-18-20(24(31,3)4)27-28-21(18)26-22(32)19-14-35-16(2)25-19;/h14-15,17H,5-13H2,1-4H3,(H2,26,27,28,32);1H4/t15-;/s2
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12.8n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153858
PNG
(US8999981, A103)
Show SMILES C[C@H]1CN2CCC[C@H]2CC1C(=O)N1Cc2c(NC(=O)c3csc(Br)n3)n[nH]c2C1(C)C
Show InChI InChI=1/C21H27BrN6O2S/c1-11-8-27-6-4-5-12(27)7-13(11)19(30)28-9-14-16(21(28,2)3)25-26-17(14)24-18(29)15-10-31-20(22)23-15/h10-13H,4-9H2,1-3H3,(H2,24,25,26,29)/t11-,12-,13?/s2
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12.9n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50249959
PNG
(CHEMBL522428 | [2-(Hydroxymethyl)-4-(methylethylid...)
Show SMILES CC(C)=C1CC(CO)(COC(=O)c2ccc(cc2)C#Cc2ccc(C)cc2)OC1=O
Show InChI InChI=1S/C25H24O5/c1-17(2)22-14-25(15-26,30-24(22)28)16-29-23(27)21-12-10-20(11-13-21)9-8-19-6-4-18(3)5-7-19/h4-7,10-13,26H,14-16H2,1-3H3
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13n/an/an/an/an/an/an/an/a



National Cancer Institute-Frederick

Curated by ChEMBL


Assay Description
Displacement of [3H]PDBu form human PKCbeta in presence of plasma membrane lipid mimetic mixture


Citation and Details
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153853
PNG
(US8999981, A122 | US8999981, A98)
Show SMILES C.C[C@H]1CN(CC2CC2)CCN1C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C23H31N7O2.CH4/c1-15-12-28(13-16-7-8-16)10-11-29(15)22(32)30-14-17-19(23(30,2)3)26-27-20(17)25-21(31)18-6-4-5-9-24-18;/h4-6,9,15-16H,7-8,10-14H2,1-3H3,(H2,25,26,27,31);1H4/t15-;/s2
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13.3n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153878
PNG
(US8999981, A123)
Show SMILES C.CCCCN1CCN([C@@H](C)C1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Show InChI InChI=1/C23H33N7O2.CH4/c1-5-6-11-28-12-13-29(16(2)14-28)22(32)30-15-17-19(23(30,3)4)26-27-20(17)25-21(31)18-9-7-8-10-24-18;/h7-10,16H,5-6,11-15H2,1-4H3,(H2,25,26,27,31);1H4/t16-;/s2
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13.3n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM50078562
PNG
(11,21-dihydroxy-17-[1-hydroxy-(1R)-ethyl]-10,10-di...)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(CC2C[C@@H](OC(=O)C[C@H](O)C[C@@H]3CCC[C@H](C[C@@H]4CCO[C@@H](O4)\C=C\C(C)(C)[C@]1(O)O2)O3)[C@@H](C)O)=C\C(=O)OC
Show InChI InChI=1S/C39H62O13/c1-6-7-8-9-10-14-33(42)51-37-26(20-34(43)46-5)19-31-24-32(25(2)40)50-35(44)22-27(41)21-28-12-11-13-29(48-28)23-30-16-18-47-36(49-30)15-17-38(3,4)39(37,45)52-31/h15,17,20,25,27-32,36-37,40-41,45H,6-14,16,18-19,21-24H2,1-5H3/b17-15+,26-20+/t25-,27-,28+,29-,30+,31?,32-,36+,37+,39-/m1/s1
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13.4n/an/an/an/an/an/an/an/a



Stanford University

Curated by ChEMBL


Assay Description
Displacement of [3H]-PDBu from protein kinase C beta C1b domain


Bioorg Med Chem Lett 9: 1687-90 (1999)

More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM153831
PNG
(US8999981, A76)
Show SMILES C[C@H]1CN2CCC[C@H]2CN1C(=O)N1Cc2c(NC(=O)c3cc4cccn4cn3)n[nH]c2C1(C)C
Show InChI InChI=1/C24H30N8O2/c1-15-11-29-8-5-7-17(29)12-31(15)23(34)32-13-18-20(24(32,2)3)27-28-21(18)26-22(33)19-10-16-6-4-9-30(16)14-25-19/h4,6,9-10,14-15,17H,5,7-8,11-13H2,1-3H3,(H2,26,27,28,33)/t15-,17-/s2
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13.9n/an/an/an/an/an/an/an/a



Pfizer Inc.; Pfizer Products Inc.

US Patent


Assay Description
Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...


US Patent US8999981 (2015)

More data for this
Ligand-Target Pair
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