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Found 7 hits Enz. Inhib. hit(s) with Target = 'PTPsigma-(Brain)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PTPsigma-(Brain)


(Homo sapiens)
BDBM50391713
PNG
(CHEMBL2146956)
Show SMILES c1ccc2nc(ccc2c1)-c1nnc2sc(nn12)-c1cnccn1
Show InChI InChI=1S/C16H9N7S/c1-2-4-11-10(3-1)5-6-12(19-11)14-20-21-16-23(14)22-15(24-16)13-9-17-7-8-18-13/h1-9H
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n/an/a 100n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
PTPsigma-(Brain)


(Homo sapiens)
BDBM50237957
PNG
(4-(2-((2,5-dioxoimidazolidin-4-ylidene)methyl)-1H-...)
Show SMILES OC(=O)c1ccc(cc1)-n1cccc1\C=C1\NC(=O)NC1=O
Show InChI InChI=1S/C15H11N3O4/c19-13-12(16-15(22)17-13)8-11-2-1-7-18(11)10-5-3-9(4-6-10)14(20)21/h1-8H,(H,20,21)(H2,16,17,19,22)/b12-8+
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n/an/a 200n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
PTPsigma-(Brain)


(Homo sapiens)
BDBM50391714
PNG
(CHEMBL2146957)
Show SMILES SC1=NC(=O)C(S1)=Cc1cn(nc1-c1cccc(OCc2ccccc2Cl)c1)-c1ccccc1
Show InChI InChI=1S/C26H18ClN3O2S2/c27-22-12-5-4-7-18(22)16-32-21-11-6-8-17(13-21)24-19(14-23-25(31)28-26(33)34-23)15-30(29-24)20-9-2-1-3-10-20/h1-15H,16H2,(H,28,31,33)
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n/an/a 600n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
PTPsigma-(Brain)


(Homo sapiens)
BDBM50391715
PNG
(CHEMBL2146960)
Show SMILES Oc1ccc(C=c2c(=O)[nH]c3cc(=C)on3c2=N)cc1O
Show InChI InChI=1S/C14H11N3O4/c1-7-4-12-16-14(20)9(13(15)17(12)21-7)5-8-2-3-10(18)11(19)6-8/h2-6,15,18-19H,1H2,(H,16,20)
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n/an/a 700n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
PTPsigma-(Brain)


(Homo sapiens)
BDBM50391711
PNG
(CHEMBL2146958)
Show SMILES Oc1ccc(\C=c2/sc3nc4ccccc4n3c2=O)cc1O
Show InChI InChI=1S/C16H10N2O3S/c19-12-6-5-9(7-13(12)20)8-14-15(21)18-11-4-2-1-3-10(11)17-16(18)22-14/h1-8,19-20H/b14-8-
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n/an/a 900n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
PTPsigma-(Brain)


(Homo sapiens)
BDBM50387974
PNG
(CHEMBL2057830)
Show SMILES Oc1ccc(cc1)C1=NN2C(S1)=NC(=O)\C(=C\c1ccc(O)c(O)c1)C2=N
Show InChI InChI=1S/C18H12N4O4S/c19-15-12(7-9-1-6-13(24)14(25)8-9)16(26)20-18-22(15)21-17(27-18)10-2-4-11(23)5-3-10/h1-8,19,23-25H/b12-7+,19-15?
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n/an/a 1.20E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair
PTPsigma-(Brain)


(Homo sapiens)
BDBM50391712
PNG
(CHEMBL2146959)
Show SMILES [O-][N+](=O)c1ccccc1NC(=O)CSc1nnc(-c2ccco2)c(n1)-c1ccco1
Show InChI InChI=1S/C19H13N5O5S/c25-16(20-12-5-1-2-6-13(12)24(26)27)11-30-19-21-17(14-7-3-9-28-14)18(22-23-19)15-8-4-10-29-15/h1-10H,11H2,(H,20,25)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis


Citation and Details
More data for this
Ligand-Target Pair