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Found 11 hits Enz. Inhib. hit(s) with Target = 'Pancreatic alpha-amylase' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50351096
PNG
(ASCORBIC ACID)
Show SMILES OC[C@H](O)[C@H]1OC(=O)C(=O)C1O
Show InChI InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-3,5,7-9H,1H2/t2-,3?,5+/m0/s1
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4.34E+4n/an/an/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
Inhibitory constant against Alpha-amylase


Bioorg Med Chem Lett 10: 1575-6 (2000)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005681
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 3-dimethylami...)
Show SMILES CN(C)CCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C20H31NO2/c1-20(17-11-6-4-7-12-17,18-13-8-5-9-14-18)19(22)23-16-10-15-21(2)3/h4,6-7,11-12,18H,5,8-10,13-16H2,1-3H3
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n/an/a 10n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005684
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 3-diethylamin...)
Show SMILES CCN(CC)CCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H35NO2/c1-4-23(5-2)17-12-18-25-21(24)22(3,19-13-8-6-9-14-19)20-15-10-7-11-16-20/h6,8-9,13-14,20H,4-5,7,10-12,15-18H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005685
PNG
(2,2-Diphenyl-propionic acid 2-diethylamino-ethyl e...)
Show SMILES CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
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n/an/a 46n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005686
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 2-diethylamin...)
Show SMILES CCN(CC)CCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C21H33NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6,8-9,12-13,19H,4-5,7,10-11,14-17H2,1-3H3
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n/an/a 52n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005682
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 4-dimethylami...)
Show SMILES CN(C)CCCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C21H33NO2/c1-21(18-12-6-4-7-13-18,19-14-8-5-9-15-19)20(23)24-17-11-10-16-22(2)3/h4,6-7,12-13,19H,5,8-11,14-17H2,1-3H3
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n/an/a 190n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005683
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 4-diethylamin...)
Show SMILES CCN(CC)CCCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C23H37NO2/c1-4-24(5-2)18-12-13-19-26-22(25)23(3,20-14-8-6-9-15-20)21-16-10-7-11-17-21/h6,8-9,14-15,21H,4-5,7,10-13,16-19H2,1-3H3
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n/an/a 380n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50005680
PNG
(2-Cyclohexyl-2-phenyl-propionic acid 5-diethylamin...)
Show SMILES CCN(CC)CCCCCOC(=O)C(C)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C24H39NO2/c1-4-25(5-2)19-13-8-14-20-27-23(26)24(3,21-15-9-6-10-16-21)22-17-11-7-12-18-22/h6,9-10,15-16,22H,4-5,7-8,11-14,17-20H2,1-3H3
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n/an/a 2.70E+3n/an/an/an/an/an/a



Institute of Research

Curated by ChEMBL


Assay Description
Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.


J Med Chem 35: 1290-5 (1992)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50351096
PNG
(ASCORBIC ACID)
Show SMILES OC[C@H](O)[C@H]1OC(=O)C(=O)C1O
Show InChI InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-3,5,7-9H,1H2/t2-,3?,5+/m0/s1
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n/an/a 2.65E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay


Bioorg Med Chem Lett 10: 1575-6 (2000)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50090254
PNG
((R)-5-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3,4-di...)
Show SMILES CC1(C)OC[C@H](O1)c1oc(O)c(O)c1O
Show InChI InChI=1S/C9H12O6/c1-9(2)13-3-4(15-9)7-5(10)6(11)8(12)14-7/h4,10-12H,3H2,1-2H3/t4-/m0/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay


Bioorg Med Chem Lett 10: 1575-6 (2000)

More data for this
Ligand-Target Pair
Pancreatic alpha-amylase


(Rattus norvegicus)
BDBM50451094
PNG
(ASCORBYL PALMITATE | Ascorbyl Palmitate | Ascorbyl...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O
Show InChI InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1
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n/an/a 6.25E+4n/an/an/an/an/an/a



University of Canterbury

Curated by ChEMBL


Assay Description
The compound was tested for inhibition of malt Alpha-amylase by Megazyme assay


Bioorg Med Chem Lett 10: 1575-6 (2000)

More data for this
Ligand-Target Pair