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Found 21 hits Enz. Inhib. hit(s) with Target = 'Peptide deformylase' AND taxid = 83333   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50291695
PNG
(CHEMBL84822 | H-PHOSPHONATE DERIVATIVE)
Show SMILES CCCC[C@H](OP(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H28N3O7P/c1-4-5-6-16(28-29(26)27)18(23)20-15(11-12(2)3)17(22)19-13-7-9-14(10-8-13)21(24)25/h7-10,12,15-16,29H,4-6,11H2,1-3H3,(H,19,22)(H,20,23)(H,26,27)/t15-,16-/m0/s1
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3.70E+4n/an/an/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against Peptide deformylase


Bioorg Med Chem Lett 8: 2479-82 (1999)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50071663
PNG
(CHEMBL309477 | H-PHOSPHONATE DERIVATIVE)
Show SMILES CCCCC(O[PH+](O)[O-])C(=O)NC(CC(C)C)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C18H28N3O7P/c1-4-5-6-16(28-29(26)27)18(23)20-15(11-12(2)3)17(22)19-13-7-9-14(10-8-13)21(24)25/h7-10,12,15-16,26,29H,4-6,11H2,1-3H3,(H,19,22)(H,20,23)
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1.25E+5n/an/an/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against Peptide deformylase


Bioorg Med Chem Lett 8: 2479-82 (1999)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100105
PNG
(2-(5-Bromo-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-N...)
Show SMILES ONC(=O)CN1Cc2c(Br)cccc2NC1=O
Show InChI InChI=1S/C10H10BrN3O3/c11-7-2-1-3-8-6(7)4-14(10(16)12-8)5-9(15)13-17/h1-3,17H,4-5H2,(H,12,16)(H,13,15)
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n/an/a 49n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100101
PNG
(2-(5-Bromo-1-cyclopropylmethyl-2,2-dioxo-1,4-dihyd...)
Show SMILES ONC(=O)CN1Cc2c(Br)cccc2N(CC2CC2)S1(=O)=O
Show InChI InChI=1S/C13H16BrN3O4S/c14-11-2-1-3-12-10(11)7-16(8-13(18)15-19)22(20,21)17(12)6-9-4-5-9/h1-3,9,19H,4-8H2,(H,15,18)
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n/an/a 69n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100094
PNG
(2-(5-Bromo-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-ben...)
Show SMILES ONC(=O)CN1Cc2c(Br)cccc2NS1(=O)=O
Show InChI InChI=1S/C9H10BrN3O4S/c10-7-2-1-3-8-6(7)4-13(5-9(14)11-15)18(16,17)12-8/h1-3,12,15H,4-5H2,(H,11,14)
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n/an/a 98n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100102
PNG
(2-(5-Chloro-1-cyclopropylmethyl-2,2-dioxo-1,4-dihy...)
Show SMILES ONC(=O)CN1Cc2c(Cl)cccc2N(CC2CC2)S1(=O)=O
Show InChI InChI=1S/C13H16ClN3O4S/c14-11-2-1-3-12-10(11)7-16(8-13(18)15-19)22(20,21)17(12)6-9-4-5-9/h1-3,9,19H,4-8H2,(H,15,18)
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n/an/a 110n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100097
PNG
(2-(5-Chloro-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-be...)
Show SMILES ONC(=O)CN1Cc2c(Cl)cccc2NS1(=O)=O
Show InChI InChI=1S/C9H10ClN3O4S/c10-7-2-1-3-8-6(7)4-13(5-9(14)11-15)18(16,17)12-8/h1-3,12,15H,4-5H2,(H,11,14)
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n/an/a 120n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100096
PNG
(2-(2,2-Dioxo-5-trifluoromethyl-1,4-dihydro-2H-2lam...)
Show SMILES ONC(=O)CN1Cc2c(NS1(=O)=O)cccc2C(F)(F)F
Show InChI InChI=1S/C10H10F3N3O4S/c11-10(12,13)7-2-1-3-8-6(7)4-16(5-9(17)14-18)21(19,20)15-8/h1-3,15,18H,4-5H2,(H,14,17)
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n/an/a 130n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM21683
PNG
(N-hydroxy-N-(3-phenylpropyl)formamide | SB-485345)
Show SMILES ON(CCCc1ccccc1)C=O
Show InChI InChI=1S/C10H13NO2/c12-9-11(13)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,9,13H,4,7-8H2
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n/an/a 160n/an/an/an/a7.625



GSK



Assay Description
Enzyme assay was carried out in 96-well microtiter plates with a SpectraMax plate reader (Molecular Devices Corp.). PDF activity was measured using a...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100107
PNG
(CHEMBL53345 | N-Hydroxy-2-(2-oxo-5-trifluoromethyl...)
Show SMILES ONC(=O)CN1Cc2c(NC1=O)cccc2C(F)(F)F
Show InChI InChI=1S/C11H10F3N3O3/c12-11(13,14)7-2-1-3-8-6(7)4-17(10(19)15-8)5-9(18)16-20/h1-3,20H,4-5H2,(H,15,19)(H,16,18)
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n/an/a 230n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100108
PNG
(2-[5-Chloro-2,2-dioxo-1-(3-phenyl-propyl)-1,4-dihy...)
Show SMILES ONC(=O)CN1Cc2c(Cl)cccc2N(CCCc2ccccc2)S1(=O)=O
Show InChI InChI=1S/C18H20ClN3O4S/c19-16-9-4-10-17-15(16)12-21(13-18(23)20-24)27(25,26)22(17)11-5-8-14-6-2-1-3-7-14/h1-4,6-7,9-10,24H,5,8,11-13H2,(H,20,23)
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n/an/a 290n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100095
PNG
(2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Show SMILES ONC(=O)CN1Cc2c(Cl)cccc2NC1=O
Show InChI InChI=1S/C10H10ClN3O3/c11-7-2-1-3-8-6(7)4-14(10(16)12-8)5-9(15)13-17/h1-3,17H,4-5H2,(H,12,16)(H,13,15)
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n/an/a 310n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100100
PNG
(2-(1-Butyl-5-chloro-2,2-dioxo-1,4-dihydro-2H-2lamb...)
Show SMILES CCCCN1c2cccc(Cl)c2CN(CC(=O)NO)S1(=O)=O
Show InChI InChI=1S/C13H18ClN3O4S/c1-2-3-7-17-12-6-4-5-11(14)10(12)8-16(22(17,20)21)9-13(18)15-19/h4-6,19H,2-3,7-9H2,1H3,(H,15,18)
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n/an/a 590n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100104
PNG
(2-(2,2-Dioxo-1,4-dihydro-2H-2lambda*6*-benzo[1,2,6...)
Show SMILES ONC(=O)CN1Cc2ccccc2NS1(=O)=O
Show InChI InChI=1S/C9H11N3O4S/c13-9(10-14)6-12-5-7-3-1-2-4-8(7)11-17(12,15)16/h1-4,11,14H,5-6H2,(H,10,13)
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n/an/a 760n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100103
PNG
(2-(5-Fluoro-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-be...)
Show SMILES ONC(=O)CN1Cc2c(F)cccc2NS1(=O)=O
Show InChI InChI=1S/C9H10FN3O4S/c10-7-2-1-3-8-6(7)4-13(5-9(14)11-15)18(16,17)12-8/h1-3,12,15H,4-5H2,(H,11,14)
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n/an/a 870n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100099
PNG
(2-(5-Fluoro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-...)
Show SMILES ONC(=O)CN1Cc2c(F)cccc2NC1=O
Show InChI InChI=1S/C10H10FN3O3/c11-7-2-1-3-8-6(7)4-14(10(16)12-8)5-9(15)13-17/h1-3,17H,4-5H2,(H,12,16)(H,13,15)
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n/an/a 870n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM21684
PNG
(N-[2-(3-benzoylphenoxy)ethyl]-N-hydroxyformamide |...)
Show SMILES ON(CCOc1cccc(c1)C(=O)c1ccccc1)C=O
Show InChI InChI=1S/C16H15NO4/c18-12-17(20)9-10-21-15-8-4-7-14(11-15)16(19)13-5-2-1-3-6-13/h1-8,11-12,20H,9-10H2
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n/an/a 1.15E+3n/an/an/an/a7.625



GSK



Assay Description
Enzyme assay was carried out in 96-well microtiter plates with a SpectraMax plate reader (Molecular Devices Corp.). PDF activity was measured using a...


Citation and Details
More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100098
PNG
(CHEMBL54689 | N-Hydroxy-2-(2-oxo-1,4-dihydro-2H-qu...)
Show SMILES ONC(=O)CN1Cc2ccccc2NC1=O
Show InChI InChI=1S/C10H11N3O3/c14-9(12-16)6-13-5-7-3-1-2-4-8(7)11-10(13)15/h1-4,16H,5-6H2,(H,11,15)(H,12,14)
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n/an/a 1.90E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100106
PNG
(2-(1-Benzyl-5-chloro-2,2-dioxo-1,4-dihydro-2H-2lam...)
Show SMILES ONC(=O)CN1Cc2c(Cl)cccc2N(Cc2ccccc2)S1(=O)=O
Show InChI InChI=1S/C16H16ClN3O4S/c17-14-7-4-8-15-13(14)10-19(11-16(21)18-22)25(23,24)20(15)9-12-5-2-1-3-6-12/h1-8,22H,9-11H2,(H,18,21)
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n/an/a 2.00E+3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM21685
PNG
(N-hydroxy-N-[3-(6-methylpyridin-2-yl)propyl]formam...)
Show SMILES Cc1cccc(CCCN(O)C=O)n1
Show InChI InChI=1S/C10H14N2O2/c1-9-4-2-5-10(11-9)6-3-7-12(14)8-13/h2,4-5,8,14H,3,6-7H2,1H3
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n/an/a 2.80E+3n/an/an/an/a7.625



GSK



Assay Description
Enzyme assay was carried out in 96-well microtiter plates with a SpectraMax plate reader (Molecular Devices Corp.). PDF activity was measured using a...


Citation and Details
More data for this
Ligand-Target Pair
Peptide Deformylase


(Escherichia coli (strain K12))
BDBM50100093
PNG
((5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-ac...)
Show SMILES NNC(=O)CN1Cc2c(Cl)cccc2NC1=O
Show InChI InChI=1S/C10H11ClN4O2/c11-7-2-1-3-8-6(7)4-15(10(17)13-8)5-9(16)14-12/h1-3H,4-5,12H2,(H,13,17)(H,14,16)
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n/an/a 2.70E+4n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of the isolated native E. coli peptide deformylase (PDF)


J Med Chem 44: 1847-52 (2001)

More data for this
Ligand-Target Pair