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Found 37 hits Enz. Inhib. hit(s) with Target = 'Peroxisome proliferator-activated receptor alpha (PPAR alpha)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190453
PNG
(US9181181, 1)
Show SMILES CS(=O)(=O)Oc1ccc(cc1)C(=O)OCc1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1
Show InChI InChI=1/C26H25FO7S2/c1-36(31,32)34-23-12-8-21(9-13-23)26(30)33-17-20-4-2-19(3-5-20)16-24(25(28)29)35-15-14-18-6-10-22(27)11-7-18/h2-13,24H,14-17H2,1H3,(H,28,29)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190496
PNG
(US9181181, 44)
Show SMILES COc1ccc(CCOC(=O)Cc2cccc(SCc3ccccc3C(O)=O)c2)cc1OC
Show InChI InChI=1S/C26H26O6S/c1-30-23-11-10-18(15-24(23)31-2)12-13-32-25(27)16-19-6-5-8-21(14-19)33-17-20-7-3-4-9-22(20)26(28)29/h3-11,14-15H,12-13,16-17H2,1-2H3,(H,28,29)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190455
PNG
(US9181181, 3)
Show SMILES OC(=O)C(Cc1ccc(CC(=O)OCc2ccc(cc2)C(F)(F)F)cc1)SCCc1ccc(F)cc1
Show InChI InChI=1/C27H24F4O4S/c28-23-11-7-18(8-12-23)13-14-36-24(26(33)34)15-19-1-3-20(4-2-19)16-25(32)35-17-21-5-9-22(10-6-21)27(29,30)31/h1-12,24H,13-17H2,(H,33,34)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190456
PNG
(US9181181, 4)
Show SMILES CS(=O)(=O)Cc1ccc(COC(=O)Cc2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C28H29FO6S2/c1-37(33,34)19-24-8-6-23(7-9-24)18-35-27(30)17-22-4-2-21(3-5-22)16-26(28(31)32)36-15-14-20-10-12-25(29)13-11-20/h2-13,26H,14-19H2,1H3,(H,31,32)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190457
PNG
(US9181181, 5)
Show SMILES CS(=O)(=O)Oc1ccc(CC(=O)OCCc2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C28H29FO7S2/c1-38(33,34)36-25-12-8-23(9-13-25)19-27(30)35-16-14-20-2-4-22(5-3-20)18-26(28(31)32)37-17-15-21-6-10-24(29)11-7-21/h2-13,26H,14-19H2,1H3,(H,31,32)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190468
PNG
(US9181181, 6)
Show SMILES CS(=O)(=O)Oc1ccc(CC(=O)OCCCc2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C29H31FO7S2/c1-39(34,35)37-26-14-10-24(11-15-26)20-28(31)36-17-2-3-21-4-6-23(7-5-21)19-27(29(32)33)38-18-16-22-8-12-25(30)13-9-22/h4-15,27H,2-3,16-20H2,1H3,(H,32,33)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190469
PNG
(US9181181, 7)
Show SMILES CC(C(=O)OCc1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1)c1ccccc1
Show InChI InChI=1/C27H27FO4S/c1-19(23-5-3-2-4-6-23)27(31)32-18-22-9-7-21(8-10-22)17-25(26(29)30)33-16-15-20-11-13-24(28)14-12-20/h2-14,19,25H,15-18H2,1H3,(H,29,30)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190470
PNG
(US9181181, 8)
Show SMILES COc1ccc(CC(=O)OCc2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C27H27FO5S/c1-32-24-12-8-21(9-13-24)17-26(29)33-18-22-4-2-20(3-5-22)16-25(27(30)31)34-15-14-19-6-10-23(28)11-7-19/h2-13,25H,14-18H2,1H3,(H,30,31)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190471
PNG
(US9181181, 9)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)OCc1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1
Show InChI InChI=1/C31H35FO4S/c1-21(2)18-24-8-12-27(13-9-24)22(3)31(35)36-20-26-6-4-25(5-7-26)19-29(30(33)34)37-17-16-23-10-14-28(32)15-11-23/h4-15,21-22,29H,16-20H2,1-3H3,(H,33,34)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190472
PNG
(US9181181, 10)
Show SMILES OC(=O)C(Cc1ccc(COC(=O)Cc2ccccn2)cc1)SCCc1ccc(F)cc1
Show InChI InChI=1/C25H24FNO4S/c26-21-10-8-18(9-11-21)12-14-32-23(25(29)30)15-19-4-6-20(7-5-19)17-31-24(28)16-22-3-1-2-13-27-22/h1-11,13,23H,12,14-17H2,(H,29,30)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190473
PNG
(US9181181, 11)
Show SMILES CN1CCN(CC(=O)OCc2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)CC1
Show InChI InChI=1/C25H31FN2O4S/c1-27-11-13-28(14-12-27)17-24(29)32-18-21-4-2-20(3-5-21)16-23(25(30)31)33-15-10-19-6-8-22(26)9-7-19/h2-9,23H,10-18H2,1H3,(H,30,31)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190475
PNG
(US9181181, 13)
Show SMILES OC(=O)C(Cc1ccc(COC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cc1)SCCc1ccc(F)cc1
Show InChI InChI=1/C29H23F4NO5S/c30-22-12-10-18(11-13-22)14-15-40-23(27(35)36)16-19-6-8-20(9-7-19)17-38-28(37)24-25(29(31,32)33)39-26(34-24)21-4-2-1-3-5-21/h1-13,23H,14-17H2,(H,35,36)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190476
PNG
(US9181181, 14 | US9181181, 20)
Show SMILES Cc1oc(nc1CCOC(=O)c1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1/C30H28FNO5S/c1-20-26(32-28(37-20)23-5-3-2-4-6-23)15-17-36-30(35)24-11-7-22(8-12-24)19-27(29(33)34)38-18-16-21-9-13-25(31)14-10-21/h2-14,27H,15-19H2,1H3,(H,33,34)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190477
PNG
(US9181181, 15 | US9181181, 19)
Show SMILES Cc1oc(nc1CC(=O)OCc1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1/C30H28FNO5S/c1-20-26(32-29(37-20)24-5-3-2-4-6-24)18-28(33)36-19-23-9-7-22(8-10-23)17-27(30(34)35)38-16-15-21-11-13-25(31)14-12-21/h2-14,27H,15-19H2,1H3,(H,34,35)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190478
PNG
(US9181181, 16)
Show SMILES CS(=O)(=O)Oc1ccc(COC(=O)c2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C26H25FO7S2/c1-36(31,32)34-23-12-6-20(7-13-23)17-33-26(30)21-8-2-19(3-9-21)16-24(25(28)29)35-15-14-18-4-10-22(27)11-5-18/h2-13,24H,14-17H2,1H3,(H,28,29)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190479
PNG
(US9181181, 17)
Show SMILES OC(=O)C(Cc1ccc(CC(=O)OCc2ccc(cc2)C(F)(F)F)cc1)S(=O)(=O)CCc1ccc(F)cc1
Show InChI InChI=1/C27H24F4O6S/c28-23-11-7-18(8-12-23)13-14-38(35,36)24(26(33)34)15-19-1-3-20(4-2-19)16-25(32)37-17-21-5-9-22(10-6-21)27(29,30)31/h1-12,24H,13-17H2,(H,33,34)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190480
PNG
(US9181181, 18)
Show SMILES CS(=O)(=O)Oc1ccc(CCSC(=O)c2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C27H27FO6S3/c1-37(32,33)34-24-12-6-20(7-13-24)15-17-36-27(31)22-8-2-21(3-9-22)18-25(26(29)30)35-16-14-19-4-10-23(28)11-5-19/h2-13,25H,14-18H2,1H3,(H,29,30)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190477
PNG
(US9181181, 15 | US9181181, 19)
Show SMILES Cc1oc(nc1CC(=O)OCc1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1/C30H28FNO5S/c1-20-26(32-29(37-20)24-5-3-2-4-6-24)18-28(33)36-19-23-9-7-22(8-10-23)17-27(30(34)35)38-16-15-21-11-13-25(31)14-12-21/h2-14,27H,15-19H2,1H3,(H,34,35)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190476
PNG
(US9181181, 14 | US9181181, 20)
Show SMILES Cc1oc(nc1CCOC(=O)c1ccc(CC(SCCc2ccc(F)cc2)C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1/C30H28FNO5S/c1-20-26(32-28(37-20)23-5-3-2-4-6-23)15-17-36-30(35)24-11-7-22(8-12-24)19-27(29(33)34)38-18-16-21-9-13-25(31)14-10-21/h2-14,27H,15-19H2,1H3,(H,33,34)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190459
PNG
(US9181181, 22)
Show SMILES CCO[C@@H](Cc1ccc(OC(=O)Cc2ccc(NC(=O)OC(C)(C)C)cc2)cc1)C(O)=O
Show InChI InChI=1/C24H29NO7/c1-5-30-20(22(27)28)14-16-8-12-19(13-9-16)31-21(26)15-17-6-10-18(11-7-17)25-23(29)32-24(2,3)4/h6-13,20H,5,14-15H2,1-4H3,(H,25,29)(H,27,28)/t20-/s2
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Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190463
PNG
(US9181181, 28)
Show SMILES OC(=O)c1ccccc1CSc1cccc(CC(=O)OCc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C24H19F3O4S/c25-24(26,27)19-10-8-16(9-11-19)14-31-22(28)13-17-4-3-6-20(12-17)32-15-18-5-1-2-7-21(18)23(29)30/h1-12H,13-15H2,(H,29,30)
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Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190464
PNG
(US9181181, 29)
Show SMILES OC(=O)c1ccccc1CSc1ccc(COC(=O)Cc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H19F3O4S/c25-24(26,27)19-9-5-16(6-10-19)13-22(28)31-14-17-7-11-20(12-8-17)32-15-18-3-1-2-4-21(18)23(29)30/h1-12H,13-15H2,(H,29,30)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190465
PNG
(US9181181, 30)
Show SMILES OC(=O)c1ccccc1CSc1ccc(CC(=O)OCc2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C24H19F3O4S/c25-24(26,27)19-9-5-17(6-10-19)14-31-22(28)13-16-7-11-20(12-8-16)32-15-18-3-1-2-4-21(18)23(29)30/h1-12H,13-15H2,(H,29,30)
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n/an/an/an/a 160n/an/an/an/a



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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190466
PNG
(US9181181, 31)
Show SMILES CC(OC(=O)Cc1cccc(SCc2ccccc2C(O)=O)c1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C25H21F3O4S/c1-16(18-9-11-20(12-10-18)25(26,27)28)32-23(29)14-17-5-4-7-21(13-17)33-15-19-6-2-3-8-22(19)24(30)31/h2-13,16H,14-15H2,1H3,(H,30,31)
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n/an/an/an/a 1.80E+4n/an/an/an/a



Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190467
PNG
(US9181181, 32)
Show SMILES OC(=O)c1ccccc1CSc1cccc(CC(=O)OCCc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C25H21F3O4S/c26-25(27,28)20-10-8-17(9-11-20)12-13-32-23(29)15-18-4-3-6-21(14-18)33-16-19-5-1-2-7-22(19)24(30)31/h1-11,14H,12-13,15-16H2,(H,30,31)
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n/an/an/an/a 5.50E+3n/an/an/an/a



Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190485
PNG
(US9181181, 33)
Show SMILES Cc1cccc(C)c1COC(=O)Cc1ccc(SCc2ccccc2C(O)=O)cc1
Show InChI InChI=1S/C25H24O4S/c1-17-6-5-7-18(2)23(17)15-29-24(26)14-19-10-12-21(13-11-19)30-16-20-8-3-4-9-22(20)25(27)28/h3-13H,14-16H2,1-2H3,(H,27,28)
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n/an/an/an/a 620n/an/an/an/a



Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190486
PNG
(US9181181, 34)
Show SMILES OC(=O)c1ccccc1CSc1ccc(CC(=O)OC(CC=C)c2ccccc2)cc1
Show InChI InChI=1/C26H24O4S/c1-2-8-24(20-9-4-3-5-10-20)30-25(27)17-19-13-15-22(16-14-19)31-18-21-11-6-7-12-23(21)26(28)29/h2-7,9-16,24H,1,8,17-18H2,(H,28,29)
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n/an/an/an/a 1.80E+4n/an/an/an/a



Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190487
PNG
(US9181181, 35)
Show SMILES COC(=O)C(Cc1ccccc1)OC(=O)Cc1cccc(SCc2ccccc2C(O)=O)c1
Show InChI InChI=1/C26H24O6S/c1-31-26(30)23(15-18-8-3-2-4-9-18)32-24(27)16-19-10-7-12-21(14-19)33-17-20-11-5-6-13-22(20)25(28)29/h2-14,23H,15-17H2,1H3,(H,28,29)
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n/an/an/an/a 2.20E+4n/an/an/an/a



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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190488
PNG
(US9181181, 36)
Show SMILES COc1ccc(CCOC(=O)Cc2ccc(SCc3ccccc3C(O)=O)cc2)cc1OC
Show InChI InChI=1S/C26H26O6S/c1-30-23-12-9-19(15-24(23)31-2)13-14-32-25(27)16-18-7-10-21(11-8-18)33-17-20-5-3-4-6-22(20)26(28)29/h3-12,15H,13-14,16-17H2,1-2H3,(H,28,29)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190489
PNG
(US9181181, 37)
Show SMILES COC(=O)C(Cc1ccccc1)OC(=O)Cc1ccc(SCc2ccccc2C(O)=O)cc1
Show InChI InChI=1/C26H24O6S/c1-31-26(30)23(15-18-7-3-2-4-8-18)32-24(27)16-19-11-13-21(14-12-19)33-17-20-9-5-6-10-22(20)25(28)29/h2-14,23H,15-17H2,1H3,(H,28,29)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190490
PNG
(US9181181, 38)
Show SMILES OC(=O)c1ccccc1CSc1cccc(CC(=O)OCCc2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C25H21F3O4S/c26-25(27,28)22-11-4-2-7-18(22)12-13-32-23(29)15-17-6-5-9-20(14-17)33-16-19-8-1-3-10-21(19)24(30)31/h1-11,14H,12-13,15-16H2,(H,30,31)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190491
PNG
(US9181181, 39)
Show SMILES COC(=O)C(c1ncco1)(c1ccccc1)c1ccc(SCc2ccccc2C(O)=O)cc1
Show InChI InChI=1/C26H21NO5S/c1-31-25(30)26(24-27-15-16-32-24,19-8-3-2-4-9-19)20-11-13-21(14-12-20)33-17-18-7-5-6-10-22(18)23(28)29/h2-16H,17H2,1H3,(H,28,29)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190492
PNG
(US9181181, 40)
Show SMILES OC(=O)c1ccccc1CSc1ccc(CC(=O)OCCc2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C25H21F3O4S/c26-25(27,28)22-8-4-2-5-18(22)13-14-32-23(29)15-17-9-11-20(12-10-17)33-16-19-6-1-3-7-21(19)24(30)31/h1-12H,13-16H2,(H,30,31)
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US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190493
PNG
(US9181181, 41)
Show SMILES Cc1cccc(C)c1COC(=O)Cc1cccc(SCc2ccccc2C(O)=O)c1
Show InChI InChI=1S/C25H24O4S/c1-17-7-5-8-18(2)23(17)15-29-24(26)14-19-9-6-11-21(13-19)30-16-20-10-3-4-12-22(20)25(27)28/h3-13H,14-16H2,1-2H3,(H,27,28)
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Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190494
PNG
(US9181181, 42)
Show SMILES OC(=O)c1ccccc1CSc1cccc(CC(=O)OCc2ccc(cc2)-n2cccn2)c1
Show InChI InChI=1S/C26H22N2O4S/c29-25(32-17-19-9-11-22(12-10-19)28-14-4-13-27-28)16-20-5-3-7-23(15-20)33-18-21-6-1-2-8-24(21)26(30)31/h1-15H,16-18H2,(H,30,31)
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Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190495
PNG
(US9181181, 43)
Show SMILES OC(=O)c1ccccc1CSc1ccc(CC(=O)OCc2ccc(cc2)-n2cccn2)cc1
Show InChI InChI=1S/C26H22N2O4S/c29-25(32-17-20-6-10-22(11-7-20)28-15-3-14-27-28)16-19-8-12-23(13-9-19)33-18-21-4-1-2-5-24(21)26(30)31/h1-15H,16-18H2,(H,30,31)
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n/an/an/an/a 1.60E+4n/an/an/an/a



Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM190454
PNG
(US9181181, 2)
Show SMILES CS(=O)(=O)Oc1ccc(CC(=O)OCc2ccc(CC(SCCc3ccc(F)cc3)C(O)=O)cc2)cc1
Show InChI InChI=1/C27H29FO7S2/c1-37(32,33)35-24-12-8-21(9-13-24)17-26(29)34-18-22-4-2-20(3-5-22)16-25(27(30)31)36-15-14-19-6-10-23(28)11-7-19/h2-13,25,37H,14-18H2,1H3,(H,30,31)(H,32,33)
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n/an/an/an/a 240n/an/an/an/a



Albireo AB

US Patent


Assay Description
Transactivation Assay Expression vectors were prepared by inserting the ligand binding domain cDNA (complementary DNA) of human PPARalpha (amino acid...


US Patent US9181181 (2015)

More data for this
Ligand-Target Pair