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Compile Data Set for Download or QSAR

Found 34 hits Enz. Inhib. hit(s) with Target = 'Phenylalanyl-tRNA synthetase mitochondrial' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140728
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22+,23+,26+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140728
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22+,23+,26+/m1/s1
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n/an/a 260n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140729
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22-,23+,26+/m1/s1
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n/an/a 470n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140729
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21+,22-,23+,26+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140727
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2[C@@H](OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H/t21-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140725
PNG
(13N-(3,4-dichlorophenyl)-2,11-dioxo-14-phenyl-(1R,...)
Show SMILES Clc1ccc(NC(=O)[C@H]2[C@@H](O[C@@]34[C@@H](OC(=O)[C@@H]23)c2ccccc2C4=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C26H17Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-21,23H,(H,29,31)/t19-,20-,21+,23+,26+/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140725
PNG
(13N-(3,4-dichlorophenyl)-2,11-dioxo-14-phenyl-(1R,...)
Show SMILES Clc1ccc(NC(=O)[C@H]2[C@@H](O[C@@]34[C@@H](OC(=O)[C@@H]23)c2ccccc2C4=O)c2ccccc2)cc1Cl
Show InChI InChI=1S/C26H17Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-21,23H,(H,29,31)/t19-,20-,21+,23+,26+/m1/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140727
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2[C@@H](OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H/t21-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140730
PNG
(4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phen...)
Show SMILES OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl2NO6/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(33)34)26(35-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,19-21H,(H,29,32)(H,33,34)/t19-,20-,21-/m0/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140726
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21-,22?,23?,26-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140726
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21-,22?,23?,26-/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140726
PNG
(13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-pheny...)
Show SMILES OC1c2ccccc2C2OC(=O)[C@@H]3[C@@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H19Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(31)19-20-25(32)33-23-16-9-5-4-8-15(16)22(30)26(20,23)34-21(19)13-6-2-1-3-7-13/h1-12,19-23,30H,(H,29,31)/t19-,20-,21-,22?,23?,26-/m0/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Escherichia coli phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140730
PNG
(4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phen...)
Show SMILES OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl2NO6/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(33)34)26(35-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,19-21H,(H,29,32)(H,33,34)/t19-,20-,21-/m0/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for the inhibitory activity against Staphylococcus aureus phenylalanyl-tRNA synthetase


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140717
PNG
(5-benzo[d][1,3]dioxol-5-yl-3-phenylspiro[perhydrof...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc2OCOc2c1)c1ccccc1
Show InChI InChI=1S/C27H17NO7/c29-23-16-8-4-5-9-17(16)24(30)27(23)21-20(22(35-27)14-6-2-1-3-7-14)25(31)28(26(21)32)15-10-11-18-19(12-15)34-13-33-18/h1-12,22,31-32H,13H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140714
PNG
(CHEMBL27142 | methyl 5-(3,4-dichlorophenyl)-4,6-di...)
Show SMILES COC(=O)C1NC(c2c(O)n(c(O)c12)-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H16Cl2N2O4/c1-28-20(27)17-15-14(16(23-17)10-5-3-2-4-6-10)18(25)24(19(15)26)11-7-8-12(21)13(22)9-11/h2-9,16-17,23,25-26H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140715
PNG
(3-(4-chlorophenyl)-5-(4-chloro-3-trifluoromethylph...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(c1)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H14Cl2F3NO5/c28-13-7-5-12(6-8-13)21-19-20(26(38-21)22(34)15-3-1-2-4-16(15)23(26)35)25(37)33(24(19)36)14-9-10-18(29)17(11-14)27(30,31)32/h1-11,21,36-37H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140707
PNG
(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,22,32-33H,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140709
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Show SMILES Oc1c2C(NC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H16Cl2N2O4/c27-17-11-10-14(12-18(17)28)30-24(33)19-20(25(30)34)26(29-21(19)13-6-2-1-3-7-13)22(31)15-8-4-5-9-16(15)23(26)32/h1-12,21,29,33-34H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140711
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'R,6a'S)-...)
Show SMILES Oc1c2C(NC3(Cc4ccccc4C3)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H20Cl2N2O2/c27-19-11-10-18(12-20(19)28)30-24(31)21-22(25(30)32)26(13-16-8-4-5-9-17(16)14-26)29-23(21)15-6-2-1-3-7-15/h1-12,23,29,31-32H,13-14H2
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140706
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140707
PNG
(5-(3-chloro-4-methylphenyl)-3-phenyl-(3R,3aS,6aR)-...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H18ClNO5/c1-14-11-12-16(13-19(14)28)29-25(32)20-21(26(29)33)27(34-22(20)15-7-3-2-4-8-15)23(30)17-9-5-6-10-18(17)24(27)31/h2-13,22,32-33H,1H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140713
PNG
(4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,...)
Show SMILES Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1
Show InChI InChI=1S/C25H18Cl2N2O3/c26-17-12-11-16(13-18(17)27)29-24(31)19-20(25(29)32)22(23(30)15-9-5-2-6-10-15)28-21(19)14-7-3-1-4-8-14/h1-13,21-22,28,31-32H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140716
PNG
(5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19ClN2O4/c1-14-11-12-16(13-19(14)28)30-25(33)20-21(26(30)34)27(29-22(20)15-7-3-2-4-8-15)23(31)17-9-5-6-10-18(17)24(27)32/h2-13,22,29,33-34H,1H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140711
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'R,6a'S)-...)
Show SMILES Oc1c2C(NC3(Cc4ccccc4C3)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H20Cl2N2O2/c27-19-11-10-18(12-20(19)28)30-24(31)21-22(25(30)32)26(13-16-8-4-5-9-17(16)14-26)29-23(21)15-6-2-1-3-7-15/h1-12,23,29,31-32H,13-14H2
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140705
PNG
(5-(2-methoxyphenyl)-3-phenylspiro[perhydrofuro[3,4...)
Show SMILES COc1ccccc1-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19NO6/c1-33-19-14-8-7-13-18(19)28-25(31)20-21(26(28)32)27(34-22(20)15-9-3-2-4-10-15)23(29)16-11-5-6-12-17(16)24(27)30/h2-14,22,31-32H,1H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140706
PNG
(5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H15Cl2NO5/c27-17-11-10-14(12-18(17)28)29-24(32)19-20(25(29)33)26(34-21(19)13-6-2-1-3-7-13)22(30)15-8-4-5-9-16(15)23(26)31/h1-12,21,32-33H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140704
PNG
(5-(4-chloro-3-trifluoromethylphenyl)-3-phenyl-(3R,...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(c1)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C27H15ClF3NO5/c28-18-11-10-14(12-17(18)27(29,30)31)32-24(35)19-20(25(32)36)26(37-21(19)13-6-2-1-3-7-13)22(33)15-8-4-5-9-16(15)23(26)34/h1-12,21,35-36H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140722
PNG
(5-benzo[d][1,3]dioxol-5-yl-3-(4-methylphenyl)-(3R,...)
Show SMILES Cc1ccc(cc1)C1OC2(C(=O)c3ccccc3C2=O)c2c(O)n(c(O)c12)-c1ccc2OCOc2c1
Show InChI InChI=1S/C28H19NO7/c1-14-6-8-15(9-7-14)23-21-22(28(36-23)24(30)17-4-2-3-5-18(17)25(28)31)27(33)29(26(21)32)16-10-11-19-20(12-16)35-13-34-19/h2-12,23,32-33H,13H2,1H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140709
PNG
(5'-(3,4-dichlorophenyl)-3'-phenyl-(3'R,3a'S,6a'R)-...)
Show SMILES Oc1c2C(NC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1
Show InChI InChI=1S/C26H16Cl2N2O4/c27-17-11-10-14(12-18(17)28)30-24(33)19-20(25(30)34)26(29-21(19)13-6-2-1-3-7-13)22(31)15-8-4-5-9-16(15)23(26)32/h1-12,21,29,33-34H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140720
PNG
(5-(4-nitrophenyl)-3-phenyl-(3R,3aS,6aR)-spiro[perh...)
Show SMILES Oc1c2C(OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(cc1)[N+]([O-])=O)c1ccccc1
Show InChI InChI=1S/C26H16N2O7/c29-22-17-8-4-5-9-18(17)23(30)26(22)20-19(21(35-26)14-6-2-1-3-7-14)24(31)27(25(20)32)15-10-12-16(13-11-15)28(33)34/h1-13,21,31-32H
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140716
PNG
(5'-(3-chloro-4-methylphenyl)-3'-phenyl-(3'R,3a'S,6...)
Show SMILES Cc1ccc(cc1Cl)-n1c(O)c2C(NC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19ClN2O4/c1-14-11-12-16(13-19(14)28)30-25(33)20-21(26(30)34)27(29-22(20)15-7-3-2-4-8-15)23(31)17-9-5-6-10-18(17)24(27)32/h2-13,22,29,33-34H,1H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140723
PNG
(5-(4-methoxyphenyl)-3-phenyl-(3R,3aS,6aR)-spiro[pe...)
Show SMILES COc1ccc(cc1)-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1
Show InChI InChI=1S/C27H19NO6/c1-33-17-13-11-16(12-14-17)28-25(31)20-21(26(28)32)27(34-22(20)15-7-3-2-4-8-15)23(29)18-9-5-6-10-19(18)24(27)30/h2-14,22,31-32H,1H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair
Phenylalanyl-tRNA synthetase mitochondrial


(Homo sapiens)
BDBM50140708
PNG
(5-(2-methoxyphenyl)-3-(2-methylphenyl)-(3R,3aS,6aR...)
Show SMILES COc1ccccc1-n1c(O)c2C(OC3(C(=O)c4ccccc4C3=O)c2c1O)c1ccccc1C
Show InChI InChI=1S/C28H21NO6/c1-15-9-3-4-10-16(15)23-21-22(27(33)29(26(21)32)19-13-7-8-14-20(19)34-2)28(35-23)24(30)17-11-5-6-12-18(17)25(28)31/h3-14,23,32-33H,1-2H3
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Cubist Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against human phenylalanyl-tRNA synthetase was determined


Citation and Details
More data for this
Ligand-Target Pair