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Found 22 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase p110γ (p110γ)' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402256
PNG
(CHEMBL2204786)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)-c1cccnc1
Show InChI InChI=1S/C14H12N4O2S/c1-8-12(21-14(17-8)18-9(2)19)11-7-16-13(20-11)10-4-3-5-15-6-10/h3-7H,1-2H3,(H,17,18,19)
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n/an/a 59n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402254
PNG
(CHEMBL2204788)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(CC(F)(F)F)o1
Show InChI InChI=1S/C11H10F3N3O2S/c1-5-9(20-10(16-5)17-6(2)18)7-4-15-8(19-7)3-11(12,13)14/h4H,3H2,1-2H3,(H,16,17,18)
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n/an/a 88n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402251
PNG
(CHEMBL2204791)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)C(C)(C)C
Show InChI InChI=1S/C13H17N3O2S/c1-7-10(19-12(15-7)16-8(2)17)9-6-14-11(18-9)13(3,4)5/h6H,1-5H3,(H,15,16,17)
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n/an/a 113n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50444444
PNG
(CHEMBL3092375)
Show SMILES CC(O)C(C)(C)Cc1noc(n1)-c1sc(NC(C)=O)nc1C
Show InChI InChI=1S/C14H20N4O3S/c1-7-11(22-13(15-7)16-9(3)20)12-17-10(18-21-12)6-14(4,5)8(2)19/h8,19H,6H2,1-5H3,(H,15,16,20)
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n/an/a 155n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50444445
PNG
(CHEMBL3092373)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(C)(C)CO)no1
Show InChI InChI=1S/C13H18N4O3S/c1-7-10(21-12(14-7)15-8(2)19)11-16-9(17-20-11)5-13(3,4)6-18/h18H,5-6H2,1-4H3,(H,14,15,19)
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n/an/a 191n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402266
PNG
(CHEMBL2204778)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)S(C)(=O)=O
Show InChI InChI=1S/C10H11N3O4S2/c1-5-8(18-9(12-5)13-6(2)14)7-4-11-10(17-7)19(3,15)16/h4H,1-3H3,(H,12,13,14)
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n/an/a 222n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50444447
PNG
(CHEMBL3092365)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C(C)(C)C
Show InChI InChI=1S/C12H16N4O2S/c1-6-8(19-11(13-6)14-7(2)17)9-15-10(16-18-9)12(3,4)5/h1-5H3,(H,13,14,17)
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n/an/a 231n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402268
PNG
(CHEMBL2204794)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)N1CCCC(O)C1
Show InChI InChI=1S/C14H18N4O3S/c1-8-12(22-13(16-8)17-9(2)19)11-6-15-14(21-11)18-5-3-4-10(20)7-18/h6,10,20H,3-5,7H2,1-2H3,(H,16,17,19)
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n/an/a 237n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50444446
PNG
(CHEMBL3092367)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(CC(F)(F)F)no1
Show InChI InChI=1S/C10H9F3N4O2S/c1-4-7(20-9(14-4)15-5(2)18)8-16-6(17-19-8)3-10(11,12)13/h3H2,1-2H3,(H,14,15,18)
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n/an/a 278n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402257
PNG
(CHEMBL2204785)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(Sc2cccnc2)o1
Show InChI InChI=1S/C14H12N4O2S2/c1-8-12(22-13(17-8)18-9(2)19)11-7-16-14(20-11)21-10-4-3-5-15-6-10/h3-7H,1-2H3,(H,17,18,19)
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n/an/a 279n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50444443
PNG
(CHEMBL3092376)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)N1CCCC(O)C1
Show InChI InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)
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n/an/a 294n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402267
PNG
(CHEMBL2204777)
Show SMILES CSc1ncc(o1)-c1sc(NC(C)=O)nc1C
Show InChI InChI=1S/C10H11N3O2S2/c1-5-8(7-4-11-10(15-7)16-3)17-9(12-5)13-6(2)14/h4H,1-3H3,(H,12,13,14)
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n/an/a 322n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402252
PNG
(CHEMBL2204790)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)C(C)(C)O
Show InChI InChI=1S/C12H15N3O3S/c1-6-9(19-11(14-6)15-7(2)16)8-5-13-10(18-8)12(3,4)17/h5,17H,1-4H3,(H,14,15,16)
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n/an/a 369n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402260
PNG
(CHEMBL2203302)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(Nc2cccnc2)o1
Show InChI InChI=1S/C14H13N5O2S/c1-8-12(22-14(17-8)18-9(2)20)11-7-16-13(21-11)19-10-4-3-5-15-6-10/h3-7H,1-2H3,(H,16,19)(H,17,18,20)
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n/an/a 431n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50444440
PNG
(CHEMBL3092362)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1nc(no1)C1CCOC1
Show InChI InChI=1S/C12H14N4O3S/c1-6-9(20-12(13-6)14-7(2)17)11-15-10(16-19-11)8-3-4-18-5-8/h8H,3-5H2,1-2H3,(H,13,14,17)
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n/an/a 558n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as C5a-mediated PKB/Akt phosphorylation preincubated for 30 mins followed by C5a stimulation...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402269
PNG
(CHEMBL2204793)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(o1)N1CCOCC1
Show InChI InChI=1S/C13H16N4O3S/c1-8-11(21-12(15-8)16-9(2)18)10-7-14-13(20-10)17-3-5-19-6-4-17/h7H,3-6H2,1-2H3,(H,15,16,18)
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Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402261
PNG
(CHEMBL2204782)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(Nc2ccc(Cl)nc2)o1
Show InChI InChI=1S/C14H12ClN5O2S/c1-7-12(23-14(18-7)19-8(2)21)10-6-17-13(22-10)20-9-3-4-11(15)16-5-9/h3-6H,1-2H3,(H,17,20)(H,18,19,21)
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n/an/a 1.04E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402270
PNG
(CHEMBL2204792)
Show SMILES CN(C)c1ncc(o1)-c1sc(NC(C)=O)nc1C
Show InChI InChI=1S/C11H14N4O2S/c1-6-9(18-10(13-6)14-7(2)16)8-5-12-11(17-8)15(3)4/h5H,1-4H3,(H,13,14,16)
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n/an/a 1.22E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM217352
PNG
(GS-9820)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2ccc(F)cc2c(=O)n1-c1ccccc1
Show InChI InChI=1/C21H16FN7O/c1-12(27-19-17-18(24-10-23-17)25-11-26-19)20-28-16-8-7-13(22)9-15(16)21(30)29(20)14-5-3-2-4-6-14/h2-12H,1H3,(H2,23,24,25,26,27)/t12-/s2
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n/an/a 1.39E+3n/an/an/an/an/an/a



Western University



Assay Description
Biochemical in vitro lipid kinase assays were performed by the SelectScreenŽ biochemical kinase assay service (Invitrogen Ltd.). A stock solution of ...


J Biol Chem 288: 35346-57 (2013)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402258
PNG
(CHEMBL2204784)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(Oc2cccnc2)o1
Show InChI InChI=1S/C14H12N4O3S/c1-8-12(22-13(17-8)18-9(2)19)11-7-16-14(21-11)20-10-4-3-5-15-6-10/h3-7H,1-2H3,(H,17,18,19)
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n/an/a 1.67E+3n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402263
PNG
(CHEMBL2204780)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(Cc2cccc(c2)C(O)=O)o1
Show InChI InChI=1S/C17H15N3O4S/c1-9-15(25-17(19-9)20-10(2)21)13-8-18-14(24-13)7-11-4-3-5-12(6-11)16(22)23/h3-6,8H,7H2,1-2H3,(H,22,23)(H,19,20,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase p110γ (p110γ)


(Mus musculus (Mouse))
BDBM50402264
PNG
(CHEMBL2204779)
Show SMILES CC(=O)Nc1nc(C)c(s1)-c1cnc(Nc2cccc(c2)C(O)=O)o1
Show InChI InChI=1S/C16H14N4O4S/c1-8-13(25-16(18-8)19-9(2)21)12-7-17-15(24-12)20-11-5-3-4-10(6-11)14(22)23/h3-7H,1-2H3,(H,17,20)(H,22,23)(H,18,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as inhibition of C5a-induced PKB/Akt phosphorylation incubated for 30 mins prior to C5a-indu...


Citation and Details
More data for this
Ligand-Target Pair