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Compile Data Set for Download or QSAR

Found 158 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4-kinase, PI4K' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50341209
PNG
(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Show SMILES Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1
Show InChI InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
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n/an/a 18n/an/an/an/an/an/a



Dana Farber Cancer Institute

Curated by ChEMBL


Assay Description
Inhibition of PI4K beta


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005004
PNG
(CHEMBL2397309)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1
Show InChI InChI=1S/C17H22N4O2S/c1-10-15(12-5-8-14(18)19-9-12)24-17(20-10)21-16(22)11-3-6-13(23-2)7-4-11/h5,8-9,11,13H,3-4,6-7H2,1-2H3,(H2,18,19)(H,20,21,22)/t11-,13+
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n/an/a 22n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005008
PNG
(CHEMBL2397312)
Show SMILES CC(CC(F)(F)F)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1
Show InChI InChI=1S/C14H15F3N4OS/c1-7(5-14(15,16)17)12(22)21-13-20-8(2)11(23-13)9-3-4-10(18)19-6-9/h3-4,6-7H,5H2,1-2H3,(H2,18,19)(H,20,21,22)
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n/an/a 35n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50390409
PNG
(CHEMBL1986603)
Show SMILES Cc1cc(NC(=O)CCNC(=O)Nc2nc(C)c(s2)-c2ccc(cc2)-n2cccn2)no1
Show InChI InChI=1S/C21H21N7O3S/c1-13-12-17(27-31-13)25-18(29)8-10-22-20(30)26-21-24-14(2)19(32-21)15-4-6-16(7-5-15)28-11-3-9-23-28/h3-7,9,11-12H,8,10H2,1-2H3,(H,25,27,29)(H2,22,24,26,30)
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n/an/a 40n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005009
PNG
(CHEMBL2397311)
Show SMILES Cc1nc(NC(=O)C2(C)CCCCC2)sc1-c1ccc(N)nc1
Show InChI InChI=1S/C17H22N4OS/c1-11-14(12-6-7-13(18)19-10-12)23-16(20-11)21-15(22)17(2)8-4-3-5-9-17/h6-7,10H,3-5,8-9H2,1-2H3,(H2,18,19)(H,20,21,22)
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n/an/a 40n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50436476
PNG
(CHEMBL2397316)
Show SMILES Cc1nc(NC(=O)C(C)(C)CC(F)(F)F)sc1-c1ccc(N)nc1
Show InChI InChI=1S/C15H17F3N4OS/c1-8-11(9-4-5-10(19)20-6-9)24-13(21-8)22-12(23)14(2,3)7-15(16,17)18/h4-6H,7H2,1-3H3,(H2,19,20)(H,21,22,23)
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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50436477
PNG
(CHEMBL2397315)
Show SMILES C[C@@H](CC(F)(F)F)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1
Show InChI InChI=1S/C14H15F3N4OS/c1-7(5-14(15,16)17)12(22)21-13-20-8(2)11(23-13)9-3-4-10(18)19-6-9/h3-4,6-7H,5H2,1-2H3,(H2,18,19)(H,20,21,22)/t7-/m0/s1
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n/an/a 53n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005007
PNG
(CHEMBL2397310)
Show SMILES Cc1nc(NC(=O)[C@H]2CC[C@H](CC2)C(F)(F)F)sc1-c1ccc(N)nc1
Show InChI InChI=1S/C17H19F3N4OS/c1-9-14(11-4-7-13(21)22-8-11)26-16(23-9)24-15(25)10-2-5-12(6-3-10)17(18,19)20/h4,7-8,10,12H,2-3,5-6H2,1H3,(H2,21,22)(H,23,24,25)/t10-,12+
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n/an/a 53n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50112820
PNG
(CHEMBL3609523)
Show SMILES CC(C)(C)c1ncc2CCc3nc(NC(=O)N4CCC[C@@]4(C)C(N)=O)sc3-c2n1
Show InChI InChI=1/C20H26N6O2S/c1-19(2,3)16-22-10-11-6-7-12-14(13(11)24-16)29-17(23-12)25-18(28)26-9-5-8-20(26,4)15(21)27/h10H,5-9H2,1-4H3,(H2,21,27)(H,23,25,28)/t20-/s2
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n/an/a 65n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta (unknown origin)


Bioorg Med Chem Lett 25: 3575-81 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005010
PNG
(CHEMBL2397313)
Show SMILES Cc1nc(NC(=O)Cc2nc(c(C)o2)-c2ccccc2)sc1-c1ccc(N)nc1
Show InChI InChI=1S/C21H19N5O2S/c1-12-20(15-8-9-16(22)23-11-15)29-21(24-12)25-17(27)10-18-26-19(13(2)28-18)14-6-4-3-5-7-14/h3-9,11H,10H2,1-2H3,(H2,22,23)(H,24,25,27)
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n/an/a 67n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005011
PNG
(CHEMBL2397303)
Show SMILES Nc1ccc(cc1)-c1cnc(NC(=O)CN(Cc2ccccc2)C(=O)c2ccncc2)s1
Show InChI InChI=1S/C24H21N5O2S/c25-20-8-6-18(7-9-20)21-14-27-24(32-21)28-22(30)16-29(15-17-4-2-1-3-5-17)23(31)19-10-12-26-13-11-19/h1-14H,15-16,25H2,(H,27,28,30)
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n/an/a 100n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50005005
PNG
(CHEMBL2397317)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCN3CCOCC3)cc(C)nc12
Show InChI InChI=1S/C22H29N5O3/c1-15-13-20(23-7-8-26-9-11-30-12-10-26)27-22(24-15)21(16(2)25-27)17-5-6-18(28-3)19(14-17)29-4/h5-6,13-14,23H,7-12H2,1-4H3
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n/an/a 137n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50112822
PNG
(CHEMBL3609525)
Show SMILES C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3cnc(nc3-c2s1)C(C)(C)C
Show InChI InChI=1/C20H26N6O2S/c1-10-7-8-26(14(10)16(21)27)19(28)25-18-23-12-6-5-11-9-22-17(20(2,3)4)24-13(11)15(12)29-18/h9-10,14H,5-8H2,1-4H3,(H2,21,27)(H,23,25,28)/t10-,14+/s2
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n/an/a 160n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta (unknown origin)


Bioorg Med Chem Lett 25: 3575-81 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50112816
PNG
(CHEMBL3609519)
Show SMILES C[C@@H]1CCN([C@@H]1C(N)=O)C(=O)Nc1nc2CCc3sc(nc3-c2s1)C(C)(C)C
Show InChI InChI=1/C19H25N5O2S2/c1-9-7-8-24(13(9)15(20)25)18(26)23-17-21-10-5-6-11-12(14(10)28-17)22-16(27-11)19(2,3)4/h9,13H,5-8H2,1-4H3,(H2,20,25)(H,21,23,26)/t9-,13+/s2
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n/an/a 210n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta (unknown origin)


Bioorg Med Chem Lett 25: 3575-81 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50436478
PNG
(CHEMBL2397314)
Show SMILES C[C@H](CC(F)(F)F)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1
Show InChI InChI=1S/C14H15F3N4OS/c1-7(5-14(15,16)17)12(22)21-13-20-8(2)11(23-13)9-3-4-10(18)19-6-9/h3-4,6-7H,5H2,1-2H3,(H2,18,19)(H,20,21,22)/t7-/m1/s1
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n/an/a 225n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PI4K3beta (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50390410
PNG
(CHEMBL2069328)
Show SMILES CC(=O)c1ccc(cc1)-c1sc(NC(=O)NCCC(=O)NC(C)(C)C)nc1C
Show InChI InChI=1S/C20H26N4O3S/c1-12-17(15-8-6-14(7-9-15)13(2)25)28-19(22-12)23-18(27)21-11-10-16(26)24-20(3,4)5/h6-9H,10-11H2,1-5H3,(H,24,26)(H2,21,22,23,27)
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n/an/a 240n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107257
PNG
(CHEMBL3600785)
Show SMILES OC(=O)[C@H]1CC[C@H](CNc2nc3ccc(cc3s2)-c2ccn(CC3CC3)c(=O)c2)CC1
Show InChI InChI=1/C24H27N3O3S/c28-22-12-19(9-10-27(22)14-16-1-2-16)18-7-8-20-21(11-18)31-24(26-20)25-13-15-3-5-17(6-4-15)23(29)30/h7-12,15-17H,1-6,13-14H2,(H,25,26)(H,29,30)/t15-,17-
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107242
PNG
(CHEMBL3600778)
Show SMILES CCn1ccc(cc1=O)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3OS/c1-2-17-6-5-10(8-13(17)18)9-3-4-11-12(7-9)19-14(15)16-11/h3-8H,2H2,1H3,(H2,15,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107241
PNG
(CHEMBL3600777)
Show SMILES Cn1ccc(cc1=O)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3OS/c1-16-5-4-9(7-12(16)17)8-2-3-10-11(6-8)18-13(14)15-10/h2-7H,1H3,(H2,14,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107261
PNG
(CHEMBL3600685)
Show SMILES COCc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3OS/c1-18-8-11-4-2-10(7-16-11)9-3-5-12-13(6-9)19-14(15)17-12/h2-7H,8H2,1H3,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107254
PNG
(CHEMBL3600782)
Show SMILES C[C@@H](Nc1nc2ccc(cc2s1)-c1ccn(CC2CC2)c(=O)c1)C1CCOCC1
Show InChI InChI=1/C23H27N3O2S/c1-15(17-7-10-28-11-8-17)24-23-25-20-5-4-18(12-21(20)29-23)19-6-9-26(22(27)13-19)14-16-2-3-16/h4-6,9,12-13,15-17H,2-3,7-8,10-11,14H2,1H3,(H,24,25)/t15-/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50112827
PNG
(CHEMBL3609514)
Show SMILES CC(C)(C)c1nc-2c(CCc3nc(NC(=O)N4CCC[C@H]4C(N)=O)sc-23)s1
Show InChI InChI=1/C18H23N5O2S2/c1-18(2,3)15-21-12-11(26-15)7-6-9-13(12)27-16(20-9)22-17(25)23-8-4-5-10(23)14(19)24/h10H,4-8H2,1-3H3,(H2,19,24)(H,20,22,25)/t10-/s2
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta (unknown origin)


Bioorg Med Chem Lett 25: 3575-81 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107248
PNG
(CHEMBL3600781)
Show SMILES O=c1cc(ccn1CC1CC1)-c1ccc2nc(NCC3CCOCC3)sc2c1
Show InChI InChI=1S/C22H25N3O2S/c26-21-12-18(5-8-25(21)14-16-1-2-16)17-3-4-19-20(11-17)28-22(24-19)23-13-15-6-9-27-10-7-15/h3-5,8,11-12,15-16H,1-2,6-7,9-10,13-14H2,(H,23,24)
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n/an/a 398n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107269
PNG
(CHEMBL3600694)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(OCCO)nc1
Show InChI InChI=1S/C14H13N3O2S/c15-14-17-11-3-1-9(7-12(11)20-14)10-2-4-13(16-8-10)19-6-5-18/h1-4,7-8,18H,5-6H2,(H2,15,17)
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n/an/a 501n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107266
PNG
(CHEMBL3600691)
Show SMILES Cc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3S/c1-8-2-3-10(7-15-8)9-4-5-11-12(6-9)17-13(14)16-11/h2-7H,1H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107277
PNG
(CHEMBL97245)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C13H10N2S/c14-13-15-11-7-6-10(8-12(11)16-13)9-4-2-1-3-5-9/h1-8H,(H2,14,15)
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n/an/a 501n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107256
PNG
(CHEMBL3600784)
Show SMILES O=c1cc(ccn1CC1CC1)-c1ccc2nc(NCC3CCS(=O)(=O)CC3)sc2c1
Show InChI InChI=1S/C22H25N3O3S2/c26-21-12-18(5-8-25(21)14-16-1-2-16)17-3-4-19-20(11-17)29-22(24-19)23-13-15-6-9-30(27,28)10-7-15/h3-5,8,11-12,15-16H,1-2,6-7,9-10,13-14H2,(H,23,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50106926
PNG
(CHEMBL3600701)
Show SMILES Nc1nc2ccc(cc2s1)-c1cccnc1
Show InChI InChI=1S/C12H9N3S/c13-12-15-10-4-3-8(6-11(10)16-12)9-2-1-5-14-7-9/h1-7H,(H2,13,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50106970
PNG
(CHEMBL3600767)
Show SMILES Nc1nc2ccc(cc2s1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C12H9N3OS/c13-12-15-9-2-1-7(5-10(9)17-12)8-3-4-14-11(16)6-8/h1-6H,(H2,13,15)(H,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107258
PNG
(CHEMBL3600683)
Show SMILES CCOc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3OS/c1-2-18-13-6-4-10(8-16-13)9-3-5-11-12(7-9)19-14(15)17-11/h3-8H,2H2,1H3,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107260
PNG
(CHEMBL3600684)
Show SMILES CCSc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3S2/c1-2-18-13-6-4-10(8-16-13)9-3-5-11-12(7-9)19-14(15)17-11/h3-8H,2H2,1H3,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107275
PNG
(CHEMBL3600690)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(CO)nc1
Show InChI InChI=1S/C13H11N3OS/c14-13-16-11-4-2-8(5-12(11)18-13)9-1-3-10(7-17)15-6-9/h1-6,17H,7H2,(H2,14,16)
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n/an/a 794n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107238
PNG
(CHEMBL3600776)
Show SMILES Nc1nc2ccc(cc2s1)-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C17H14N4S/c18-17-20-15-7-6-13(8-16(15)22-17)14-9-19-21(11-14)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H2,18,20)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50390408
PNG
(CHEMBL2071338)
Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccc(cc1)-n1cccn1
Show InChI InChI=1S/C19H20N6O2S/c1-12-16(13-5-7-14(8-6-13)25-11-3-9-21-25)28-18(22-12)23-19(27)24-10-2-4-15(24)17(20)26/h3,5-9,11,15H,2,4,10H2,1H3,(H2,20,26)(H,22,23,27)/t15-/m0/s1
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n/an/a 920n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50426176
PNG
(CHEMBL2316958)
Show SMILES CC(C)=CC(=O)CCC(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
Show InChI InChI=1S/C30H35N7O3S/c1-20(2)16-21(38)6-7-27(39)36-10-8-35(9-11-36)19-22-17-26-28(41-22)30(37-12-14-40-15-13-37)33-29(32-26)23-4-3-5-25-24(23)18-31-34-25/h3-5,16-18H,6-15,19H2,1-2H3,(H,31,34)
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Celgene Avilomics Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta (unknown origin) by ADP-GLO assay


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50333219
PNG
(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Show SMILES COc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3OS/c1-17-12-5-3-9(7-15-12)8-2-4-10-11(6-8)18-13(14)16-10/h2-7H,1H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107264
PNG
(CHEMBL3600688)
Show SMILES CCNc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H14N4S/c1-2-16-13-6-4-10(8-17-13)9-3-5-11-12(7-9)19-14(15)18-11/h3-8H,2H2,1H3,(H2,15,18)(H,16,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107270
PNG
(CHEMBL3600695)
Show SMILES COCCOc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3O2S/c1-19-6-7-20-14-5-3-11(9-17-14)10-2-4-12-13(8-10)21-15(16)18-12/h2-5,8-9H,6-7H2,1H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107272
PNG
(CHEMBL3600698)
Show SMILES CC(C)Oc1cncc(c1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3OS/c1-9(2)19-12-5-11(7-17-8-12)10-3-4-13-14(6-10)20-15(16)18-13/h3-9H,1-2H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107012
PNG
(CHEMBL3600769)
Show SMILES Cn1nccc1-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C11H10N4S/c1-15-9(4-5-13-15)7-2-3-8-10(6-7)16-11(12)14-8/h2-6H,1H3,(H2,12,14)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50333221
PNG
(6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1
Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107263
PNG
(CHEMBL3600687)
Show SMILES CC(C)Oc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3OS/c1-9(2)19-14-6-4-11(8-17-14)10-3-5-12-13(7-10)20-15(16)18-12/h3-9H,1-2H3,(H2,16,18)
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n/an/a 1.26E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107011
PNG
(CHEMBL3600768)
Show SMILES Cn1ccc(n1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C11H10N4S/c1-15-5-4-8(14-15)7-2-3-9-10(6-7)16-11(12)13-9/h2-6H,1H3,(H2,12,13)
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n/an/a 1.26E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107013
PNG
(CHEMBL3600770)
Show SMILES Cn1cc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C11H10N4S/c1-15-6-8(5-13-15)7-2-3-9-10(4-7)16-11(12)14-9/h2-6H,1H3,(H2,12,14)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50390411
PNG
(CHEMBL2071342)
Show SMILES CCn1nnc(CCNC(=O)Nc2nc(C)c(s2)-c2ccc(c(F)c2)S(C)(=O)=O)n1
Show InChI InChI=1S/C17H20FN7O3S2/c1-4-25-23-14(22-24-25)7-8-19-16(26)21-17-20-10(2)15(29-17)11-5-6-13(12(18)9-11)30(3,27)28/h5-6,9H,4,7-8H2,1-3H3,(H2,19,20,21,26)
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n/an/a 1.33E+3n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI4Kbeta


Citation and Details
More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107243
PNG
(CHEMBL3600779)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccn(CC2CC2)c(=O)c1
Show InChI InChI=1S/C16H15N3OS/c17-16-18-13-4-3-11(7-14(13)21-16)12-5-6-19(15(20)8-12)9-10-1-2-10/h3-8,10H,1-2,9H2,(H2,17,18)
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n/an/a 1.59E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107265
PNG
(CHEMBL3600689)
Show SMILES CCN(C)c1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H16N4S/c1-3-19(2)14-7-5-11(9-17-14)10-4-6-12-13(8-10)20-15(16)18-12/h4-9H,3H2,1-2H3,(H2,16,18)
PDB

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n/an/a 1.59E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107267
PNG
(CHEMBL3600692)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C13H8F3N3S/c14-13(15,16)11-4-2-8(6-18-11)7-1-3-9-10(5-7)20-12(17)19-9/h1-6H,(H2,17,19)
PDB

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PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107014
PNG
(CHEMBL3600771)
Show SMILES CCn1cc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C12H12N4S/c1-2-16-7-9(6-14-16)8-3-4-10-11(5-8)17-12(13)15-10/h3-7H,2H2,1H3,(H2,13,15)
PDB

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UniChem

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PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4-kinase beta (PIK4KB)


(Homo sapiens (Human))
BDBM50107236
PNG
(CHEMBL3600775)
Show SMILES Nc1nc2ccc(cc2s1)-c1cnn(CC2CC2)c1
Show InChI InChI=1S/C14H14N4S/c15-14-17-12-4-3-10(5-13(12)19-14)11-6-16-18(8-11)7-9-1-2-9/h3-6,8-9H,1-2,7H2,(H2,15,17)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length recombinant PI4K3beta expressed in Sf9 cells using D-myo-phosphatidylinositol substrate and ATP...


Bioorg Med Chem Lett 25: 3189-93 (2015)

More data for this
Ligand-Target Pair
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