BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 298 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 1' AND taxid = 9913   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 1


(BOVINE)
BDBM86694
PNG
(N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyform...)
Show SMILES ONC=Nc1ccc(N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by PDSP Ki Database




Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50059033
PNG
((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Show SMILES CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@H]23)n1c1ccccc41
Show InChI InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
1.40E+4n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144388
PNG
(US8969376, 1.002 (3/2 HCl))
Show SMILES CN(C1CCOCC1)c1cc(nc2cc(nn12)-c1nc2ccccc2nc1C)N1CCCC1
Show InChI InChI=1S/C25H29N7O/c1-17-25(27-20-8-4-3-7-19(20)26-17)21-15-23-28-22(31-11-5-6-12-31)16-24(32(23)29-21)30(2)18-9-13-33-14-10-18/h3-4,7-8,15-16,18H,5-6,9-14H2,1-2H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.00450n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144415
PNG
(US8969376, 1.152)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(N(C3CC3)C3CCOCC3)n2n1)N1CCC[C@H]1CO
Show InChI InChI=1/C29H35N7O2/c1-18-5-8-23-24(14-18)31-29(19(2)30-23)25-15-27-32-26(34-11-3-4-22(34)17-37)16-28(36(27)33-25)35(20-6-7-20)21-9-12-38-13-10-21/h5,8,14-16,20-22,37H,3-4,6-7,9-13,17H2,1-2H3/t22-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.00680n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144408
PNG
(US8969376, 1.112)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(N[C@@H]3CCS(=O)(=O)C3)n2n1)N1CCCC1
Show InChI InChI=1/C24H27N7O2S/c1-15-5-6-18-19(11-15)27-24(16(2)25-18)20-12-22-28-21(30-8-3-4-9-30)13-23(31(22)29-20)26-17-7-10-34(32,33)14-17/h5-6,11-13,17,26H,3-4,7-10,14H2,1-2H3/t17-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.00850n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144399
PNG
(US8969376, 1.050)
Show SMILES COCCN(CCCO)c1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C26H33N7O2/c1-18-7-8-20-21(15-18)28-26(19(2)27-20)22-16-24-29-23(31-9-4-5-10-31)17-25(33(24)30-22)32(11-6-13-34)12-14-35-3/h7-8,15-17,34H,4-6,9-14H2,1-3H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0190n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144405
PNG
(US8969376, 1.097)
Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(N[C@H]3CCCC[C@@H]3O)n2n1)N1CCCC1
Show InChI InChI=1/C25H28FN7O/c1-15-25(29-19-12-16(26)8-9-17(19)27-15)20-13-23-30-22(32-10-4-5-11-32)14-24(33(23)31-20)28-18-6-2-3-7-21(18)34/h8-9,12-14,18,21,28,34H,2-7,10-11H2,1H3/t18-,21-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0350n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144409
PNG
(US8969376, 1.114)
Show SMILES CC(=O)N1CCC(CC1)Nc1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C27H32N8O/c1-17-6-7-21-22(14-17)30-27(18(2)28-21)23-15-25-31-24(34-10-4-5-11-34)16-26(35(25)32-23)29-20-8-12-33(13-9-20)19(3)36/h6-7,14-16,20,29H,4-5,8-13H2,1-3H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0440n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144398
PNG
(US8969376, 1.047)
Show SMILES CO[C@H]1CC[C@@H](CC1)Nc1cc(nc2cc(nn12)-c1nc2cc(ccc2nc1C)C(F)(F)F)N1CCCC1
Show InChI InChI=1/C27H30F3N7O/c1-16-26(33-21-13-17(27(28,29)30)5-10-20(21)31-16)22-14-24-34-23(36-11-3-4-12-36)15-25(37(24)35-22)32-18-6-8-19(38-2)9-7-18/h5,10,13-15,18-19,32H,3-4,6-9,11-12H2,1-2H3/t18-,19-
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0450n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144397
PNG
(US8969376, 1.031)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NCCC#N)n2n1)N1CCCC1
Show InChI InChI=1S/C22H22N8/c1-15-22(26-17-8-3-2-7-16(17)25-15)18-13-21-27-20(29-11-4-5-12-29)14-19(30(21)28-18)24-10-6-9-23/h2-3,7-8,13-14,24H,4-6,10-12H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0520n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144390
PNG
(US8969376, 1.006)
Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C23H25F2N7O/c1-13-22(28-17-8-14(24)4-5-16(17)27-13)18-9-21-29-20(31-7-6-15(25)11-31)10-19(32(21)30-18)26-12-23(2,3)33/h4-5,8-10,15,26,33H,6-7,11-12H2,1-3H3/t15-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0900n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144394
PNG
(US8969376, 1.013)
Show SMILES Cc1nc2ccc(F)cc2nc1-c1cc2nc(cc(N[C@H]3CC[C@](C)(O)CC3)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C26H29F2N7O/c1-15-25(31-20-11-16(27)3-4-19(20)29-15)21-12-23-32-22(34-10-7-17(28)14-34)13-24(35(23)33-21)30-18-5-8-26(2,36)9-6-18/h3-4,11-13,17-18,30,36H,5-10,14H2,1-2H3/t17-,18-,26-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.0900n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144387
PNG
(US8969376, 1.001 (HCl))
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3CCOCC3)n2n1)N1CCCC1
Show InChI InChI=1S/C24H27N7O/c1-16-24(27-19-7-3-2-6-18(19)25-16)20-14-22-28-21(30-10-4-5-11-30)15-23(31(22)29-20)26-17-8-12-32-13-9-17/h2-3,6-7,14-15,17,26H,4-5,8-13H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.110n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144396
PNG
(US8969376, 1.027)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC[C@H](O)C(F)(F)F)n2n1)N1CCCC1
Show InChI InChI=1/C22H22F3N7O/c1-13-21(28-15-7-3-2-6-14(15)27-13)16-10-20-29-19(31-8-4-5-9-31)11-18(32(20)30-16)26-12-17(33)22(23,24)25/h2-3,6-7,10-11,17,26,33H,4-5,8-9,12H2,1H3/t17-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.130n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144410
PNG
(US8969376, 1.123)
Show SMILES CCCN1CCC(CC1)Nc1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C28H36N8/c1-4-11-34-14-9-21(10-15-34)30-27-18-25(35-12-5-6-13-35)32-26-17-24(33-36(26)27)28-20(3)29-22-8-7-19(2)16-23(22)31-28/h7-8,16-18,21,30H,4-6,9-15H2,1-3H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.150n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144411
PNG
(US8969376, 1.126)
Show SMILES CN(C)CCNc1cc(nc2cc(nn12)-c1nc2cc(C)ccc2nc1C)N1CCCC1
Show InChI InChI=1S/C24H30N8/c1-16-7-8-18-19(13-16)27-24(17(2)26-18)20-14-23-28-22(31-10-5-6-11-31)15-21(32(23)29-20)25-9-12-30(3)4/h7-8,13-15,25H,5-6,9-12H2,1-4H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.170n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144404
PNG
(US8969376, 1.085)
Show SMILES C[C@]1(O)CC[C@@H](CC1)Nc1cc(nc2cc(nn12)-c1nc2ccccc2nc1C(F)(F)F)N1CC[C@@H](F)C1
Show InChI InChI=1/C26H27F4N7O/c1-25(38)9-6-16(7-10-25)31-22-13-20(36-11-8-15(27)14-36)34-21-12-19(35-37(21)22)23-24(26(28,29)30)33-18-5-3-2-4-17(18)32-23/h2-5,12-13,15-16,31,38H,6-11,14H2,1H3/t15-,16-,25-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.180n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144391
PNG
(US8969376, 1.009)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3CCOCC3)n2n1)N1CC=CC1
Show InChI InChI=1S/C24H25N7O/c1-16-24(27-19-7-3-2-6-18(19)25-16)20-14-22-28-21(30-10-4-5-11-30)15-23(31(22)29-20)26-17-8-12-32-13-9-17/h2-7,14-15,17,26H,8-13H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144393
PNG
(US8969376, 1.011)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3CCOCC3)n2n1)C1=CCCC1
Show InChI InChI=1S/C25H26N6O/c1-16-25(29-20-9-5-4-8-19(20)26-16)22-15-24-28-21(17-6-2-3-7-17)14-23(31(24)30-22)27-18-10-12-32-13-11-18/h4-6,8-9,14-15,18,27H,2-3,7,10-13H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.220n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144412
PNG
(US8969376, 1.133)
Show SMILES Cc1nc2CCCCc2nc1-c1cc2nc(cc(NC3CCC(F)(F)CC3)n2n1)N1CCCC1
Show InChI InChI=1S/C25H31F2N7/c1-16-24(30-19-7-3-2-6-18(19)28-16)20-14-22-31-21(33-12-4-5-13-33)15-23(34(22)32-20)29-17-8-10-25(26,27)11-9-17/h14-15,17,29H,2-13H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.230n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144401
PNG
(US8969376, 1.059)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NCC(C)(C)O)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C23H26FN7O/c1-14-22(27-17-7-5-4-6-16(17)26-14)18-10-21-28-20(30-9-8-15(24)12-30)11-19(31(21)29-18)25-13-23(2,3)32/h4-7,10-11,15,25,32H,8-9,12-13H2,1-3H3/t15-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144427
PNG
(US8969376, 2.001)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(CC3CCOCC3)n2n1)N1CCCC1
Show InChI InChI=1S/C25H28N6O/c1-17-25(27-21-7-3-2-6-20(21)26-17)22-16-24-28-23(30-10-4-5-11-30)15-19(31(24)29-22)14-18-8-12-32-13-9-18/h2-3,6-7,15-16,18H,4-5,8-14H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.360n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144392
PNG
(US8969376, 1.010 (HCl))
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(OC3CCOCC3)n2n1)N1CCCC1
Show InChI InChI=1S/C24H26N6O2/c1-16-24(26-19-7-3-2-6-18(19)25-16)20-14-22-27-21(29-10-4-5-11-29)15-23(30(22)28-20)32-17-8-12-31-13-9-17/h2-3,6-7,14-15,17H,4-5,8-13H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
AffyNet 
US Patent
n/an/a 0.380n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144403
PNG
(US8969376, 1.081)
Show SMILES CCc1nc2ccccc2nc1-c1cc2nc(cc(N[C@H]3CC[C@@H](CC3)OC)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C27H32FN7O/c1-3-20-27(31-22-7-5-4-6-21(22)30-20)23-14-25-32-24(34-13-12-17(28)16-34)15-26(35(25)33-23)29-18-8-10-19(36-2)11-9-18/h4-7,14-15,17-19,29H,3,8-13,16H2,1-2H3/t17-,18-,19-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.390n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144414
PNG
(US8969376, 1.147)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(N[C@@H]3CCCOC3)n2n1)N1CCC[C@H]1CO
Show InChI InChI=1/C25H29N7O2/c1-16-25(28-20-9-3-2-8-19(20)26-16)21-12-23-29-22(31-10-4-7-18(31)14-33)13-24(32(23)30-21)27-17-6-5-11-34-15-17/h2-3,8-9,12-13,17-18,27,33H,4-7,10-11,14-15H2,1H3/t17-,18+/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.390n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144407
PNG
(US8969376, 1.111)
Show SMILES Cc1ccc2nc(-c3cc4nc(cc(NC5CCOCC5)n4n3)N3CCCC3)c(C)nc2c1
Show InChI InChI=1S/C25H29N7O/c1-16-5-6-19-20(13-16)26-17(2)25(28-19)21-14-23-29-22(31-9-3-4-10-31)15-24(32(23)30-21)27-18-7-11-33-12-8-18/h5-6,13-15,18,27H,3-4,7-12H2,1-2H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.460n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144413
PNG
(US8969376, 1.144 (Free))
Show SMILES CN(C1CCOCC1)c1cc(nc2cc(nn12)-c1nc(C)c(C)nc1C)N1CCCC1
Show InChI InChI=1S/C23H31N7O/c1-15-16(2)25-23(17(3)24-15)19-13-21-26-20(29-9-5-6-10-29)14-22(30(21)27-19)28(4)18-7-11-31-12-8-18/h13-14,18H,5-12H2,1-4H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.480n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144395
PNG
(US8969376, 1.019)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(N3CCCC3)n2n1)N1CCCC1
Show InChI InChI=1S/C23H25N7/c1-16-23(25-18-9-3-2-8-17(18)24-16)19-14-21-26-20(28-10-4-5-11-28)15-22(30(21)27-19)29-12-6-7-13-29/h2-3,8-9,14-15H,4-7,10-13H2,1H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.570n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144400
PNG
(US8969376, 1.058)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3COC3)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C22H22FN7O/c1-13-22(26-17-5-3-2-4-16(17)24-13)18-8-20-27-19(29-7-6-14(23)10-29)9-21(30(20)28-18)25-15-11-31-12-15/h2-5,8-9,14-15,25H,6-7,10-12H2,1H3/t14-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.650n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144406
PNG
(US8969376, 1.109)
Show SMILES Cc1cccc2nc(-c3cc4nc(cc(NC5CCOCC5)n4n3)N3CCCC3)c(C)nc12
Show InChI InChI=1S/C25H29N7O/c1-16-6-5-7-19-24(16)26-17(2)25(28-19)20-14-22-29-21(31-10-3-4-11-31)15-23(32(22)30-20)27-18-8-12-33-13-9-18/h5-7,14-15,18,27H,3-4,8-13H2,1-2H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.780n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144389
PNG
(US8969376, 1.003 (HCl))
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3CCOCC3)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C24H26FN7O/c1-15-24(28-19-5-3-2-4-18(19)26-15)20-12-22-29-21(31-9-6-16(25)14-31)13-23(32(22)30-20)27-17-7-10-33-11-8-17/h2-5,12-13,16-17,27H,6-11,14H2,1H3/t16-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.830n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144402
PNG
(US8969376, 1.062)
Show SMILES Cc1nc2ccccc2nc1-c1cc2nc(cc(NC3CC3)n2n1)N1CC[C@@H](F)C1
Show InChI InChI=1/C22H22FN7/c1-13-22(26-17-5-3-2-4-16(17)24-13)18-10-20-27-19(29-9-8-14(23)12-29)11-21(30(20)28-18)25-15-6-7-15/h2-5,10-11,14-15,25H,6-9,12H2,1H3/t14-/s2
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 0.870n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A)


(Bos taurus (Bovine))
BDBM144416
PNG
(US8969376, 1.154)
Show SMILES Cc1ccc2nc(C)c(nc2c1)-c1cc2nc(cc(NC3CCOCC3)n2n1)N1CC(O)C1
Show InChI InChI=1S/C24H27N7O2/c1-14-3-4-18-19(9-14)27-24(15(2)25-18)20-10-22-28-21(30-12-17(32)13-30)11-23(31(22)29-20)26-16-5-7-33-8-6-16/h3-4,9-11,16-17,26,32H,5-8,12-13H2,1-2H3
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
US Patent
n/an/a 1.08n/an/an/an/an/an/a



Mitsubishi Tanabe Pharma Corporation

US Patent


Assay Description
The PDE assay was performed according to a modified method referred to a report of Kotera et al. (Kotera et al., Biochem. Pharmacol., vol. 60, pp. 13...


US Patent US8969376 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073692
PNG
(5-methyl-2-(4-methylpentyl)-(6aR,9aS)-3,4,5,8-tetr...)
Show SMILES CC(C)CCCc1nc2N3[C@H]4CCC[C@H]4N=C3N(C)C(=O)c2[nH]1
Show InChI InChI=1S/C17H25N5O/c1-10(2)6-4-9-13-19-14-15(20-13)22-12-8-5-7-11(12)18-17(22)21(3)16(14)23/h10-12H,4-9H2,1-3H3,(H,19,20)/t11-,12+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 6n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169633
PNG
(7-Cyclopentyl-2-[2-ethoxy-5-(4-methyl-piperazine-1...)
Show SMILES CCOc1ccc(cc1-c1nn2c(nc(C)c2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C24H32N6O4S/c1-4-34-20-10-9-18(35(32,33)29-13-11-28(3)12-14-29)15-19(20)22-26-24(31)21-16(2)25-23(30(21)27-22)17-7-5-6-8-17/h9-10,15,17H,4-8,11-14H2,1-3H3,(H,26,27,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169627
PNG
(7-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCOc1ccc(cc1-c1nn2c(nc(C)c2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H34N6O5S/c1-3-36-21-9-8-19(37(34,35)30-12-10-29(11-13-30)14-15-32)16-20(21)23-27-25(33)22-17(2)26-24(31(22)28-23)18-6-4-5-7-18/h8-9,16,18,32H,3-7,10-15H2,1-2H3,(H,27,28,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50024352
PNG
(CHEMBL183857)
Show SMILES CCCn1cnc2c(O)nc(nc12)-c1ccccc1OCC
Show InChI InChI=1S/C16H18N4O2/c1-3-9-20-10-17-13-15(20)18-14(19-16(13)21)11-7-5-6-8-12(11)22-4-2/h5-8,10H,3-4,9H2,1-2H3,(H,18,19,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169634
PNG
(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCOc1ccc(cc1-c1nc2c(nn(C)c2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H34N6O5S/c1-3-36-20-9-8-18(37(34,35)31-12-10-30(11-13-31)14-15-32)16-19(20)24-26-22-21(17-6-4-5-7-17)28-29(2)23(22)25(33)27-24/h8-9,16-17,32H,3-7,10-15H2,1-2H3,(H,26,27,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 10n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073694
PNG
((R)-7-Isopropyl-5-methyl-2-(4-methyl-pentyl)-7,8-d...)
Show SMILES CC(C)CCCc1nc2N3C[C@H](N=C3N(C)C(=O)c2[nH]1)C(C)C
Show InChI InChI=1S/C17H27N5O/c1-10(2)7-6-8-13-19-14-15(20-13)22-9-12(11(3)4)18-17(22)21(5)16(14)23/h10-12H,6-9H2,1-5H3,(H,19,20)/t12-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 12n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073701
PNG
(2'-hexyl-5'-methylspiro[cyclopentane-1,7'-(4',5',7...)
Show SMILES CCCCCCc1nc2N3CC4(CCCC4)N=C3N(C)C(=O)c2[nH]1
Show InChI InChI=1S/C18H27N5O/c1-3-4-5-6-9-13-19-14-15(20-13)23-12-18(10-7-8-11-18)21-17(23)22(2)16(14)24/h3-12H2,1-2H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 14n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50059032
PNG
((6aR,9aS)-2-(3-methylbutyl)-5,6a,7,8,9,9a-hexahydr...)
Show SMILES CC(C)CCc1nc2N3[C@H]4CCC[C@H]4N=C3N(C)C(=O)c2[nH]1
Show InChI InChI=1S/C16H23N5O/c1-9(2)7-8-12-18-13-14(19-12)21-11-6-4-5-10(11)17-16(21)20(3)15(13)22/h9-11H,4-8H2,1-3H3,(H,18,19)/t10-,11+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 14n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073695
PNG
((R)-7-Isopropyl-5-methyl-2-(3-methyl-butyl)-7,8-di...)
Show SMILES CC(C)CCc1nc2N3C[C@H](N=C3N(C)C(=O)c2[nH]1)C(C)C
Show InChI InChI=1S/C16H25N5O/c1-9(2)6-7-12-18-13-14(19-12)21-8-11(10(3)4)17-16(21)20(5)15(13)22/h9-11H,6-8H2,1-5H3,(H,18,19)/t11-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 15n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169641
PNG
(2-{2-Ethoxy-5-[4-(2-hydroxy-ethyl)-piperazine-1-su...)
Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C23H32N6O5S/c1-4-6-20-24-16(3)21-23(31)25-22(26-29(20)21)18-15-17(7-8-19(18)34-5-2)35(32,33)28-11-9-27(10-12-28)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,25,26,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073700
PNG
((R)-2-Hexyl-7-isopropyl-5-methyl-7,8-dihydro-3H,5H...)
Show SMILES CCCCCCc1nc2N3C[C@H](N=C3N(C)C(=O)c2[nH]1)C(C)C
Show InChI InChI=1S/C17H27N5O/c1-5-6-7-8-9-13-19-14-15(20-13)22-10-12(11(2)3)18-17(22)21(4)16(14)23/h11-12H,5-10H2,1-4H3,(H,19,20)/t12-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 25n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073703
PNG
(2-Hexyl-5,7,7-trimethyl-7,8-dihydro-3H,5H-imidazo[...)
Show SMILES CCCCCCc1nc2N3CC(C)(C)N=C3N(C)C(=O)c2[nH]1
Show InChI InChI=1S/C16H25N5O/c1-5-6-7-8-9-11-17-12-13(18-11)21-10-16(2,3)19-15(21)20(4)14(12)22/h5-10H2,1-4H3,(H,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 25n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169643
PNG
(8-Cyclopentyl-2-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCOc1ccc(cc1-c1nc2c(nc(C)n2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C25H34N6O5S/c1-3-36-21-9-8-19(37(34,35)30-12-10-29(11-13-30)14-15-32)16-20(21)23-27-24-22(18-6-4-5-7-18)26-17(2)31(24)25(33)28-23/h8-9,16,18,32H,3-7,10-15H2,1-2H3,(H,27,28,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169648
PNG
(3-Cyclopentyl-5-{2-ethoxy-5-[4-(2-hydroxy-ethyl)-p...)
Show SMILES CCOc1ccc(cc1-c1nc2c(noc2c(=O)[nH]1)C1CCCC1)S(=O)(=O)N1CCN(CCO)CC1
Show InChI InChI=1S/C24H31N5O6S/c1-2-34-19-8-7-17(36(32,33)29-11-9-28(10-12-29)13-14-30)15-18(19)23-25-21-20(16-5-3-4-6-16)27-35-22(21)24(31)26-23/h7-8,15-16,30H,2-6,9-14H2,1H3,(H,25,26,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(Homo sapiens (Human)-Homo sapiens (human))
BDBM50169635
PNG
(7-Cyclopentyl-2-(2-ethoxy-phenyl)-5-methyl-3H-imid...)
Show SMILES CCOc1ccccc1-c1nn2c(nc(C)c2c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C19H22N4O2/c1-3-25-15-11-7-6-10-14(15)17-21-19(24)16-12(2)20-18(23(16)22-17)13-8-4-5-9-13/h6-7,10-11,13H,3-5,8-9H2,1-2H3,(H,21,22,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 30n/an/an/an/an/an/a



BAYER HealthCare AG

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 1


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073696
PNG
(5-methyl-2-pentyl-(6aR,9aS)-3,4,5,8-tetrahydrocycl...)
Show SMILES CCCCCc1nc2N3[C@H]4CCC[C@H]4N=C3N(C)C(=O)c2[nH]1
Show InChI InChI=1S/C16H23N5O/c1-3-4-5-9-12-18-13-14(19-12)21-11-8-6-7-10(11)17-16(21)20(2)15(13)22/h10-11H,3-9H2,1-2H3,(H,18,19)/t10-,11+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 31n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Phosphodiesterase 1


(BOVINE)
BDBM50073702
PNG
(2-heptyl-5-methyl-(6aR,9aS)-3,4,5,8-tetrahydrocycl...)
Show SMILES CCCCCCCCc1nc2N3[C@H]4CCC[C@H]4N=C3N(C)C(=O)c2[nH]1
Show InChI InChI=1S/C19H29N5O/c1-3-4-5-6-7-8-12-15-21-16-17(22-15)24-14-11-9-10-13(14)20-19(24)23(2)18(16)25/h13-14H,3-12H2,1-2H3,(H,21,22)/t13-,14+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 33n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Optimum inhibitory concentration required to inhibit c-GMP specific phosphodiesterase 1 (PDE1) of bovine aorta


Bioorg Med Chem Lett 9: 7-12 (1999)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 298 total )  |  Next  |  Last  >>
Jump to: