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Found 289 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 10A (PDE10A2)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194105
PNG
(US9200001, 19)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccccn3)nc(C)n2)cc1OC
Show InChI InChI=1S/C24H24N6O2/c1-16-26-20(10-9-19-7-5-6-12-25-19)15-24(27-16)30-23(28-17(2)29-30)14-18-8-11-21(31-3)22(13-18)32-4/h5-13,15H,14H2,1-4H3/b10-9+
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US Patent
0.00200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194104
PNG
(US9200001, 18)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccc4ccccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C28H26N6O2/c1-18-29-23(13-12-22-11-10-21-7-5-6-8-24(21)32-22)17-28(30-18)34-27(31-19(2)33-34)16-20-9-14-25(35-3)26(15-20)36-4/h5-15,17H,16H2,1-4H3/b13-12+
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US Patent
0.00200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194113
PNG
(US9200001, 28)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2nc3ccccc3n2C)cc1OC
Show InChI InChI=1/C28H29N7O2/c1-16-29-22(19-14-20(19)28-32-21-8-6-7-9-23(21)34(28)3)15-27(30-16)35-26(31-17(2)33-35)13-18-10-11-24(36-4)25(12-18)37-5/h6-12,15,19-20H,13-14H2,1-5H3
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US Patent
0.00300n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194090
PNG
(US9200001, 3)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C28H28N6O2/c1-18-29-23(13-12-22-11-10-21-7-5-6-8-24(21)32-22)17-28(30-18)34-27(31-19(2)33-34)16-20-9-14-25(35-3)26(15-20)36-4/h5-11,14-15,17H,12-13,16H2,1-4H3
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US Patent
0.00400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194122
PNG
(US9200001, 38)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2nc3ccccc3[nH]2)cc1OC
Show InChI InChI=1/C27H27N7O2/c1-15-28-22(18-13-19(18)27-31-20-7-5-6-8-21(20)32-27)14-26(29-15)34-25(30-16(2)33-34)12-17-9-10-23(35-3)24(11-17)36-4/h5-11,14,18-19H,12-13H2,1-4H3,(H,31,32)
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US Patent
0.00500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194223
PNG
(US9200001, 26)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)[C@@H]2C[C@H]2c2nc3ccccc3[nH]2)cc1OC
Show InChI InChI=1/C27H27N7O2/c1-15-28-22(18-13-19(18)27-31-20-7-5-6-8-21(20)32-27)14-26(29-15)34-25(30-16(2)33-34)12-17-9-10-23(35-3)24(11-17)36-4/h5-11,14,18-19H,12-13H2,1-4H3,(H,31,32)/t18-,19-/s2
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US Patent
0.00500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194099
PNG
(US9200001, 13)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccc4ncccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C27H25N7O2/c1-17-29-21(9-8-20-10-11-22-23(32-20)6-5-13-28-22)16-27(30-17)34-26(31-18(2)33-34)15-19-7-12-24(35-3)25(14-19)36-4/h5-14,16H,15H2,1-4H3/b9-8+
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US Patent
0.0100n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194089
PNG
(US9200001, 2)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C#Cc2ccc3ccccc3n2)cc1OC
Show InChI InChI=1S/C28H24N6O2/c1-18-29-23(13-12-22-11-10-21-7-5-6-8-24(21)32-22)17-28(30-18)34-27(31-19(2)33-34)16-20-9-14-25(35-3)26(15-20)36-4/h5-11,14-15,17H,16H2,1-4H3
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US Patent
0.0230n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194102
PNG
(US9200001, 16)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ncccc4n3)nc(C)n2)cc1OC
Show InChI InChI=1S/C27H27N7O2/c1-17-29-21(9-8-20-10-11-22-23(32-20)6-5-13-28-22)16-27(30-17)34-26(31-18(2)33-34)15-19-7-12-24(35-3)25(14-19)36-4/h5-7,10-14,16H,8-9,15H2,1-4H3
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US Patent
0.0270n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194111
PNG
(US9200001, 25)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)[C@H]2C[C@@H]2c2nc3ccccc3[nH]2)cc1OC
Show InChI InChI=1/C27H27N7O2/c1-15-28-22(18-13-19(18)27-31-20-7-5-6-8-21(20)32-27)14-26(29-15)34-25(30-16(2)33-34)12-17-9-10-23(35-3)24(11-17)36-4/h5-11,14,18-19H,12-13H2,1-4H3,(H,31,32)/t18-,19-/s2
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US Patent
0.0270n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194095
PNG
(US9200001, 8)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)nc1OC
Show InChI InChI=1S/C27H27N7O2/c1-17-28-21(12-11-20-10-9-19-7-5-6-8-23(19)31-20)15-25(29-17)34-26(30-18(2)33-34)16-22-13-14-24(35-3)27(32-22)36-4/h5-10,13-15H,11-12,16H2,1-4H3
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US Patent
0.0280n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194101
PNG
(US9200001, 15)
Show SMILES COc1ncc(Cc2nc(C)nn2-c2cc(CCc3ccc4ccccc4n3)nc(C)n2)nc1OC
Show InChI InChI=1S/C26H26N8O2/c1-16-28-20(12-11-19-10-9-18-7-5-6-8-22(18)31-19)13-23(29-16)34-24(30-17(2)33-34)14-21-15-27-25(35-3)26(32-21)36-4/h5-10,13,15H,11-12,14H2,1-4H3
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US Patent
0.0560n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194119
PNG
(US9200001, 34)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2ccc3ncccc3n2)cc1OC
Show InChI InChI=1/C28H27N7O2/c1-16-30-24(20-14-19(20)21-8-9-22-23(33-21)6-5-11-29-22)15-28(31-16)35-27(32-17(2)34-35)13-18-7-10-25(36-3)26(12-18)37-4/h5-12,15,19-20H,13-14H2,1-4H3
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US Patent
0.0680n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194094
PNG
(US9200001, 7)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C#Cc2ccc3ccccc3n2)nc1OC
Show InChI InChI=1S/C27H23N7O2/c1-17-28-21(12-11-20-10-9-19-7-5-6-8-23(19)31-20)15-25(29-17)34-26(30-18(2)33-34)16-22-13-14-24(35-3)27(32-22)36-4/h5-10,13-15H,16H2,1-4H3
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US Patent
0.0730n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194145
PNG
(US9200001, 61)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C#N)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C20H18N8/c1-11-22-12(2)28(26-11)19-9-16(23-18(10-21)25-19)13-8-14(13)20-24-15-6-4-5-7-17(15)27(20)3/h4-7,9,13-14H,8H2,1-3H3/t13-,14-/s2
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US Patent
0.0850n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194106
PNG
(US9200001, 20)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(\C=C\c3ccc(C)cn3)nc(C)n2)cc1OC
Show InChI InChI=1S/C25H26N6O2/c1-16-6-8-20(26-15-16)9-10-21-14-25(28-17(2)27-21)31-24(29-18(3)30-31)13-19-7-11-22(32-4)23(12-19)33-5/h6-12,14-15H,13H2,1-5H3/b10-9+
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US Patent
0.110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194092
PNG
(US9200001, 5)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(CCc3ccc(C)cn3)nc(C)n2)cc1OC
Show InChI InChI=1S/C25H28N6O2/c1-16-6-8-20(26-15-16)9-10-21-14-25(28-17(2)27-21)31-24(29-18(3)30-31)13-19-7-11-22(32-4)23(12-19)33-5/h6-8,11-12,14-15H,9-10,13H2,1-5H3
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US Patent
0.140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194134
PNG
(US9200001, 50)
Show SMILES Cc1nc(C)n(n1)-c1cc(CCc2ccc(C)cn2)nc(C)n1
Show InChI InChI=1S/C17H20N6/c1-11-5-6-15(18-10-11)7-8-16-9-17(21-12(2)20-16)23-14(4)19-13(3)22-23/h5-6,9-10H,7-8H2,1-4H3
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0.140n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194120
PNG
(US9200001, 35)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2ccc(C)cn2)cc1OC
Show InChI InChI=1/C26H28N6O2/c1-15-6-8-21(27-14-15)19-12-20(19)22-13-26(29-16(2)28-22)32-25(30-17(3)31-32)11-18-7-9-23(33-4)24(10-18)34-5/h6-10,13-14,19-20H,11-12H2,1-5H3
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US Patent
0.210n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194133
PNG
(US9200001, 49)
Show SMILES Cc1nc(Cc2ccccc2)n(n1)-c1cc(nc(C)n1)C1CC1c1ccc(C)cn1
Show InChI InChI=1/C24H24N6/c1-15-9-10-21(25-14-15)19-12-20(19)22-13-24(27-16(2)26-22)30-23(28-17(3)29-30)11-18-7-5-4-6-8-18/h4-10,13-14,19-20H,11-12H2,1-3H3
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0.210n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194217
PNG
(US9200001, 133)
Show SMILES C[C@@H]1CCCN1c1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C24H28N8/c1-14-8-7-11-31(14)24-27-20(13-22(28-24)32-16(3)25-15(2)29-32)17-12-18(17)23-26-19-9-5-6-10-21(19)30(23)4/h5-6,9-10,13-14,17-18H,7-8,11-12H2,1-4H3/t14-,17-,18-/s2
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US Patent
0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194153
PNG
(US9200001, 69)
Show SMILES CSc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C20H21N7S/c1-11-21-12(2)27(25-11)18-10-16(23-20(24-18)28-4)13-9-14(13)19-22-15-7-5-6-8-17(15)26(19)3/h5-8,10,13-14H,9H2,1-4H3/t13-,14-/s2
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US Patent
0.370n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194127
PNG
(US9200001, 43)
Show SMILES COc1ccc(nc1)C1CC1c1cc(nc(C)n1)-n1nc(C)nc1Cc1ccc(OC)c(OC)c1
Show InChI InChI=1/C26H28N6O3/c1-15-28-22(20-12-19(20)21-8-7-18(33-3)14-27-21)13-26(29-15)32-25(30-16(2)31-32)11-17-6-9-23(34-4)24(10-17)35-5/h6-10,13-14,19-20H,11-12H2,1-5H3
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US Patent
0.390n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194176
PNG
(US9200001, 92)
Show SMILES CCc1nc(C)nn1-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H23N7/c1-5-19-24-13(3)26-28(19)20-11-17(22-12(2)23-20)14-10-15(14)21-25-16-8-6-7-9-18(16)27(21)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
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US Patent
0.400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194220
PNG
(US9200001, 136)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OC2CCC2)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H25N7O/c1-13-24-14(2)30(28-13)21-12-19(26-23(27-21)31-15-7-6-8-15)16-11-17(16)22-25-18-9-4-5-10-20(18)29(22)3/h4-5,9-10,12,15-17H,6-8,11H2,1-3H3/t16-,17-/s2
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US Patent
0.420n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194175
PNG
(US9200001, 91)
Show SMILES CCOc1nc(C)nn1-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H23N7O/c1-5-29-21-24-13(3)26-28(21)19-11-17(22-12(2)23-19)14-10-15(14)20-25-16-8-6-7-9-18(16)27(20)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
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US Patent
0.490n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194126
PNG
(US9200001, 42)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C2CC2c2cc3CCCn3n2)cc1OC
Show InChI InChI=1/C26H29N7O2/c1-15-27-21(19-13-20(19)22-12-18-6-5-9-32(18)31-22)14-26(28-15)33-25(29-16(2)30-33)11-17-7-8-23(34-3)24(10-17)35-4/h7-8,10,12,14,19-20H,5-6,9,11,13H2,1-4H3
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US Patent
0.5n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194147
PNG
(US9200001, 63)
Show SMILES CCOc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H23N7O/c1-5-29-21-24-17(11-19(25-21)28-13(3)22-12(2)26-28)14-10-15(14)20-23-16-8-6-7-9-18(16)27(20)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
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US Patent
0.540n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194218
PNG
(US9200001, 134)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC[C@@H](F)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H25FN8/c1-13-25-14(2)32(29-13)21-11-19(27-23(28-21)31-9-8-15(24)12-31)16-10-17(16)22-26-18-6-4-5-7-20(18)30(22)3/h4-7,11,15-17H,8-10,12H2,1-3H3/t15-,16-,17-/s2
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US Patent
0.580n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194197
PNG
(US9200001, 113)
Show SMILES CC(C)Oc1nc(cc(n1)-n1nc(C)nc1C)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C22H25N7O/c1-12(2)30-22-25-18(11-20(26-22)29-14(4)23-13(3)27-29)15-10-16(15)21-24-17-8-6-7-9-19(17)28(21)5/h6-9,11-12,15-16H,10H2,1-5H3/t15-,16-/s2
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US Patent
0.620n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194150
PNG
(US9200001, 66)
Show SMILES COC[C@@H](C)Oc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H27N7O2/c1-13(12-31-5)32-23-26-19(11-21(27-23)30-15(3)24-14(2)28-30)16-10-17(16)22-25-18-8-6-7-9-20(18)29(22)4/h6-9,11,13,16-17H,10,12H2,1-5H3/t13-,16-,17-/s2
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US Patent
0.630n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194196
PNG
(US9200001, 112)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C1CC1)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C22H23N7/c1-12-23-13(2)29(27-12)20-11-18(24-21(26-20)14-8-9-14)15-10-16(15)22-25-17-6-4-5-7-19(17)28(22)3/h4-7,11,14-16H,8-10H2,1-3H3/t15-,16-/s2
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US Patent
0.680n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194216
PNG
(US9200001, 132)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC(F)(F)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C22H22F2N8/c1-12-25-13(2)32(29-12)19-9-17(27-21(28-19)31-10-22(23,24)11-31)14-8-15(14)20-26-16-6-4-5-7-18(16)30(20)3/h4-7,9,14-15H,8,10-11H2,1-3H3/t14-,15-/s2
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US Patent
0.75n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194146
PNG
(US9200001, 62)
Show SMILES CNc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C20H22N8/c1-11-22-12(2)28(26-11)18-10-16(24-20(21-3)25-18)13-9-14(13)19-23-15-7-5-6-8-17(15)27(19)4/h5-8,10,13-14H,9H2,1-4H3,(H,21,24,25)/t13-,14-/s2
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US Patent
0.770n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194100
PNG
(US9200001, 14)
Show SMILES COc1ccc(Cc2nc(C)nn2-c2cc(nc(C)n2)C#Cc2ccc3ncccc3n2)cc1OC
Show InChI InChI=1S/C27H23N7O2/c1-17-29-21(9-8-20-10-11-22-23(32-20)6-5-13-28-22)16-27(30-17)34-26(31-18(2)33-34)15-19-7-12-24(35-3)25(14-19)36-4/h5-7,10-14,16H,15H2,1-4H3
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US Patent
0.820n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194221
PNG
(US9200001, 137)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCC2(C)CC2)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C24H27N7O/c1-14-25-15(2)31(29-14)21-12-19(27-23(28-21)32-13-24(3)9-10-24)16-11-17(16)22-26-18-7-5-6-8-20(18)30(22)4/h5-8,12,16-17H,9-11,13H2,1-4H3/t16-,17-/s2
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US Patent
0.840n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194215
PNG
(US9200001, 131)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C(C)(C)O)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C22H25N7O/c1-12-23-13(2)29(27-12)19-11-17(25-21(26-19)22(3,4)30)14-10-15(14)20-24-16-8-6-7-9-18(16)28(20)5/h6-9,11,14-15,30H,10H2,1-5H3/t14-,15-/s2
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US Patent
0.880n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194151
PNG
(US9200001, 67)
Show SMILES COC[C@H](C)Oc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H27N7O2/c1-13(12-31-5)32-23-26-19(11-21(27-23)30-15(3)24-14(2)28-30)16-10-17(16)22-25-18-8-6-7-9-20(18)29(22)4/h6-9,11,13,16-17H,10,12H2,1-5H3/t13-,16+,17+/s2
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US Patent
0.900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194167
PNG
(US9200001, 83)
Show SMILES CCc1nc(C)nn1-c1cc(nc(C)n1)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H23N7/c1-5-19-24-13(3)26-28(19)20-11-17(22-12(2)23-20)14-10-15(14)21-25-16-8-6-7-9-18(16)27(21)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
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US Patent
0.960n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194149
PNG
(US9200001, 65)
Show SMILES COCCOc1nc(cc(n1)-n1nc(C)nc1C)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C22H25N7O2/c1-13-23-14(2)29(27-13)20-12-18(25-22(26-20)31-10-9-30-4)15-11-16(15)21-24-17-7-5-6-8-19(17)28(21)3/h5-8,12,15-16H,9-11H2,1-4H3/t15-,16-/s2
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US Patent
1.08n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194148
PNG
(US9200001, 64)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCCO)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H23N7O2/c1-12-22-13(2)28(26-12)19-11-17(24-21(25-19)30-9-8-29)14-10-15(14)20-23-16-6-4-5-7-18(16)27(20)3/h4-7,11,14-15,29H,8-10H2,1-3H3/t14-,15-/s2
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US Patent
1.09n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194219
PNG
(US9200001, 135)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CC(C)(O)C1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H26N8O/c1-13-24-14(2)31(28-13)20-10-18(26-22(27-20)30-11-23(3,32)12-30)15-9-16(15)21-25-17-7-5-6-8-19(17)29(21)4/h5-8,10,15-16,32H,9,11-12H2,1-4H3/t15-,16-/s2
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US Patent
1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194204
PNG
(US9200001, 120)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCC2CC2)n1)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H25N7O/c1-13-24-14(2)30(28-13)21-11-19(26-23(27-21)31-12-15-8-9-15)16-10-17(16)22-25-18-6-4-5-7-20(18)29(22)3/h4-7,11,15-17H,8-10,12H2,1-3H3/t16-,17-/s2
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US Patent
1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194181
PNG
(US9200001, 97)
Show SMILES Cc1nc(C2CCOCC2)n(n1)-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C24H27N7O/c1-14-25-20(17-12-18(17)24-28-19-6-4-5-7-21(19)30(24)3)13-22(26-14)31-23(27-15(2)29-31)16-8-10-32-11-9-16/h4-7,13,16-18H,8-12H2,1-3H3/t17-,18-/s2
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US Patent
1.10n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194203
PNG
(US9200001, 119)
Show SMILES CCc1nc(cc(n1)-n1nc(C)nc1C)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H23N7/c1-5-19-23-17(11-20(25-19)28-13(3)22-12(2)26-28)14-10-15(14)21-24-16-8-6-7-9-18(16)27(21)4/h6-9,11,14-15H,5,10H2,1-4H3/t14-,15-/s2
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US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194200
PNG
(US9200001, 116)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CCCC1)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H26N8/c1-14-24-15(2)31(28-14)21-13-19(26-23(27-21)30-10-6-7-11-30)16-12-17(16)22-25-18-8-4-5-9-20(18)29(22)3/h4-5,8-9,13,16-17H,6-7,10-12H2,1-3H3/t16-,17-/s2
PDB

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US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194198
PNG
(US9200001, 114)
Show SMILES CN(C)c1nc(cc(n1)-n1nc(C)nc1C)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H24N8/c1-12-22-13(2)29(26-12)19-11-17(24-21(25-19)27(3)4)14-10-15(14)20-23-16-8-6-7-9-18(16)28(20)5/h6-9,11,14-15H,10H2,1-5H3/t14-,15-/s2
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US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194206
PNG
(US9200001, 122)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCCF)n1)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C21H22FN7O/c1-12-23-13(2)29(27-12)19-11-17(25-21(26-19)30-9-8-22)14-10-15(14)20-24-16-6-4-5-7-18(16)28(20)3/h4-7,11,14-15H,8-10H2,1-3H3/t14-,15-/s2
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US Patent
1.20n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194195
PNG
(US9200001, 111)
Show SMILES COc1nc(cc(n1)-n1nc(C)nc1C)[C@H]1C[C@@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C20H21N7O/c1-11-21-12(2)27(25-11)18-10-16(23-20(24-18)28-4)13-9-14(13)19-22-15-7-5-6-8-17(15)26(19)3/h5-8,10,13-14H,9H2,1-4H3/t13-,14-/s2
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US Patent
1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM194222
PNG
(US9200001, 138)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCC2CCO2)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1/C23H25N7O2/c1-13-24-14(2)30(28-13)21-11-19(26-23(27-21)32-12-15-8-9-31-15)16-10-17(16)22-25-18-6-4-5-7-20(18)29(22)3/h4-7,11,15-17H,8-10,12H2,1-3H3/t15?,16-,17-/s2
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US Patent
1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exp...


US Patent US9200001 (2015)

More data for this
Ligand-Target Pair
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