BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 354 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 3' AND taxid = 10141   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50027177
PNG
(CILOSTAMIDE | Cilostamide)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2nc(O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 3


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
150n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 3


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(GUINEA PIG)
BDBM86694
PNG
(N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyform...)
Show SMILES ONC=Nc1ccc(N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14)
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by PDSP Ki Database




J Pharmacol Exp Ther 314: 77-85 (2005)


Article DOI: 10.1124/jpet.105.083964
BindingDB Entry DOI: 10.7270/Q2MW2FQQ
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203459
PNG
(US9242982, 1k)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccc(Br)cc3)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14BrN3O3/c1-19-13-12(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-3-5-11(17)6-4-9/h3-6,8H,7H2,1-2H3,(H,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.80n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)


BindingDB Entry DOI: 10.7270/Q2BV7FF6
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203457
PNG
(US9242982, 1i)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccccc3Br)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14BrN3O3/c1-19-13-11(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-5-3-4-6-12(9)17/h3-6,8H,7H2,1-2H3,(H,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.60n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)


BindingDB Entry DOI: 10.7270/Q2BV7FF6
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM15297
PNG
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against phosphodiesterase 3 from human platelet


Bioorg Med Chem Lett 14: 2955-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.021
BindingDB Entry DOI: 10.7270/Q2M044W1
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205353
PNG
(US9249139, 1j)
Show SMILES CCOC(=O)c1cc(Cc2cccc(Br)c2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18BrNO3/c1-2-23-18(22)15-11-13(9-12-5-3-6-14(19)10-12)17(21)20-8-4-7-16(15)20/h3,5-6,10-11H,2,4,7-9H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11.3n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203455
PNG
(US9242982, 1g)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccc(Cl)cc3)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14ClN3O3/c1-19-13-12(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-3-5-11(17)6-4-9/h3-6,8H,7H2,1-2H3,(H,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12.5n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)


BindingDB Entry DOI: 10.7270/Q2BV7FF6
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205346
PNG
(US9249139, 1c)
Show SMILES CCOC(=O)c1cc(Cc2cccc(F)c2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18FNO3/c1-2-23-18(22)15-11-13(9-12-5-3-6-14(19)10-12)17(21)20-8-4-7-16(15)20/h3,5-6,10-11H,2,4,7-9H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 13.5n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50072197
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethyl-6...)
Show SMILES CCc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O5/c1-3-26-28-23-14-25(32-9-8-30)24(31-2)13-22(23)27(29-26)19-10-20(33-15-17-4-5-17)12-21(11-19)34-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE3.


Bioorg Med Chem Lett 8: 2891-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00508-3
BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203451
PNG
(US9242982, 1c)
Show SMILES Cn1c2[nH]c(=O)c(Cc3cccc(F)c3)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14FN3O3/c1-19-13-12(15(22)20(2)16(19)23)8-10(14(21)18-13)6-9-4-3-5-11(17)7-9/h3-5,7-8H,6H2,1-2H3,(H,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 32.3n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)


BindingDB Entry DOI: 10.7270/Q2BV7FF6
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074896
PNG
(2-[4-(6-Ethoxy-2,3-bis-hydroxymethyl-7-methoxy-nap...)
Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-14-22-13-23(18-38)27(19-39)31(26(22)16-28(29)41-2)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50026877
PNG
(CHEMBL12346)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N2O5/c1-38-28-14-20-13-21(17-35)26(18-36)31(25(20)16-29(28)39-2)19-11-12-33-30(15-19)34-27-10-6-5-8-23(27)22-7-3-4-9-24(22)32(34)37/h3-16,35-36H,17-18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM203450
PNG
(US9242982, 1b)
Show SMILES Cn1c2[nH]c(=O)c(Cc3ccccc3F)cc2c(=O)n(C)c1=O
Show InChI InChI=1S/C16H14FN3O3/c1-19-13-11(15(22)20(2)16(19)23)8-10(14(21)18-13)7-9-5-3-4-6-12(9)17/h3-6,8H,7H2,1-2H3,(H,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 48.8n/an/an/an/an/an/a



COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9242982 (2016)


BindingDB Entry DOI: 10.7270/Q2BV7FF6
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50212472
PNG
(CHEMBL314612 | EMD-53998 | EMD-57033 | EMD-57439)
Show SMILES COc1ccc(cc1OC)C(=O)N1CCCc2cc(ccc12)C1=NNC(=O)SC1C
Show InChI InChI=1S/C22H23N3O4S/c1-13-20(23-24-22(27)30-13)15-6-8-17-14(11-15)5-4-10-25(17)21(26)16-7-9-18(28-2)19(12-16)29-3/h6-9,11-13H,4-5,10H2,1-3H3,(H,24,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN)


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50212472
PNG
(CHEMBL314612 | EMD-53998 | EMD-57033 | EMD-57439)
Show SMILES COc1ccc(cc1OC)C(=O)N1CCCc2cc(ccc12)C1=NNC(=O)SC1C
Show InChI InChI=1S/C22H23N3O4S/c1-13-20(23-24-22(27)30-13)15-6-8-17-14(11-15)5-4-10-25(17)21(26)16-7-9-18(28-2)19(12-16)29-3/h6-9,11-13H,4-5,10H2,1-3H3,(H,24,27)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem

Similars

n/an/a 60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of guinea pig heart Phosphodiesterase 3


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205354
PNG
(US9249139, 1k)
Show SMILES CCOC(=O)c1cc(Cc2ccc(Br)cc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18BrNO3/c1-2-23-18(22)15-11-13(10-12-5-7-14(19)8-6-12)17(21)20-9-3-4-16(15)20/h5-8,11H,2-4,9-10H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 67.3n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074898
PNG
(2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...)
Show SMILES COc1cc2cc(CO)cc(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C31H24N4O4/c1-38-27-14-22-12-19(18-36)13-25(26(22)16-28(27)39-2)20-9-11-33-29(15-20)35-31(37)24-8-4-3-7-23(24)30(34-35)21-6-5-10-32-17-21/h3-17,36H,18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 81n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074886
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4ccncc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N4O5/c1-40-27-14-21-13-22(17-37)26(18-38)30(25(21)16-28(27)41-2)20-9-12-34-29(15-20)36-32(39)24-6-4-3-5-23(24)31(35-36)19-7-10-33-11-8-19/h3-16,37-38H,17-18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50169640
PNG
(5-(2-Ethoxy-phenyl)-3-propyl-1,6-dihydro-pyrazolo[...)
Show SMILES CCCc1[nH]nc2c1nc([nH]c2=O)-c1ccccc1OCC
Show InChI InChI=1S/C16H18N4O2/c1-3-7-11-13-14(20-19-11)16(21)18-15(17-13)10-8-5-6-9-12(10)22-4-2/h5-6,8-9H,3-4,7H2,1-2H3,(H,19,20)(H,17,18,21)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a>100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3 from rabbit platelets


Bioorg Med Chem Lett 6: 1819-1824 (1996)


Article DOI: 10.1016/0960-894X(96)00323-X
BindingDB Entry DOI: 10.7270/Q2G73DQW
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205350
PNG
(US9249139, 1g)
Show SMILES CCOC(=O)c1cc(Cc2ccc(Cl)cc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18ClNO3/c1-2-23-18(22)15-11-13(10-12-5-7-14(19)8-6-12)17(21)20-9-3-4-16(15)20/h5-8,11H,2-4,9-10H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 108n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM14769
PNG
(6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-...)
Show SMILES COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1
Show InChI InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against phosphodiesterase 3 from human platelet


Bioorg Med Chem Lett 14: 2955-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.021
BindingDB Entry DOI: 10.7270/Q2M044W1
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205348
PNG
(US9249139, 1e)
Show SMILES CCOC(=O)c1cc(Cc2ccccc2Cl)c(=O)n2CCCc12
Show InChI InChI=1S/C18H18ClNO3/c1-2-23-18(22)14-11-13(10-12-6-3-4-7-15(12)19)17(21)20-9-5-8-16(14)20/h3-4,6-7,11H,2,5,8-10H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 129n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074894
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4ccccn4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N4O5/c1-40-27-14-20-13-21(17-37)25(18-38)30(24(20)16-28(27)41-2)19-10-12-34-29(15-19)36-32(39)23-8-4-3-7-22(23)31(35-36)26-9-5-6-11-33-26/h3-16,37-38H,17-18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 170n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074884
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ncc4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C27H23N3O5/c1-34-23-10-18-9-19(14-31)22(15-32)26(21(18)12-24(23)35-2)16-7-8-28-25(11-16)30-27(33)20-6-4-3-5-17(20)13-29-30/h3-13,31-32H,14-15H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM14362
PNG
(6-(4-imidazol-1-ylphenyl)-5-methyl-4,5-dihydro-2H-...)
Show SMILES CC1CC(=O)NN=C1c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C14H14N4O/c1-10-8-13(19)16-17-14(10)11-2-4-12(5-3-11)18-7-6-15-9-18/h2-7,9-10H,8H2,1H3,(H,16,19)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50289368
PNG
(Butane-1-sulfonic acid [3-(2,3-dibromo-5-oxo-5,6-d...)
Show SMILES CCCCS(=O)(=O)Nc1cccc(c1)-c1n[nH]c(=O)n2c(Br)c(Br)nc12
Show InChI InChI=1S/C15H15Br2N5O3S/c1-2-3-7-26(24,25)21-10-6-4-5-9(8-10)11-14-18-12(16)13(17)22(14)15(23)20-19-11/h4-6,8,21H,2-3,7H2,1H3,(H,20,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 290n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition of phosphodiesterase (PDE III).


Bioorg Med Chem Lett 7: 89-94 (1997)


Article DOI: 10.1016/S0960-894X(96)00578-1
BindingDB Entry DOI: 10.7270/Q2XP74X9
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074901
PNG
(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC
Show InChI InChI=1S/C32H26N4O5/c1-40-27-13-21-12-22(17-37)26(18-38)30(25(21)15-28(27)41-2)19-9-11-34-29(14-19)36-32(39)24-8-4-3-7-23(24)31(35-36)20-6-5-10-33-16-20/h3-16,37-38H,17-18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50072200
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H34N2O7/c1-33-25-14-23-24(15-26(25)34-10-8-32)29-28(35-9-2-7-31)30-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,31-32H,2-10,16-17H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 310n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE3.


Bioorg Med Chem Lett 8: 2891-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00508-3
BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50075710
PNG
(3-Carbamoyl-6,7-dimethoxy-1-(3,4,5-trimethoxy-phen...)
Show SMILES COC(=O)c1c(cc2cc(OC)c(OC)cc2c1-c1cc(OC)c(OC)c(OC)c1)C(N)=O
Show InChI InChI=1S/C24H25NO8/c1-28-16-8-12-7-15(23(25)26)21(24(27)33-6)20(14(12)11-17(16)29-2)13-9-18(30-3)22(32-5)19(10-13)31-4/h7-11H,1-6H3,(H2,25,26)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle


J Med Chem 42: 1293-305 (1999)


Article DOI: 10.1021/jm9807048
BindingDB Entry DOI: 10.7270/Q27P8XKH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50052090
PNG
(6,7-Dimethoxy-9-(3,4,5-trimethoxy-phenyl)-3H-napht...)
Show SMILES COc1cc(cc(OC)c1OC)-c1c2C(=O)OCc2cc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H22O7/c1-25-16-7-12-6-14-11-30-23(24)21(14)20(15(12)10-17(16)26-2)13-8-18(27-3)22(29-5)19(9-13)28-4/h6-10H,11H2,1-5H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE 3) isolated from cardiac ventricle


J Med Chem 42: 1293-305 (1999)


Article DOI: 10.1021/jm9807048
BindingDB Entry DOI: 10.7270/Q27P8XKH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074889
PNG
(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4ccc3=O)c2cc1OC
Show InChI InChI=1S/C28H24N2O5/c1-34-24-12-19-11-20(15-31)22(16-32)28(21(19)14-25(24)35-2)18-9-10-29-26(13-18)30-23-6-4-3-5-17(23)7-8-27(30)33/h3-14,31-32H,15-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 330n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50072195
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2-ethoxy-...)
Show SMILES CCOc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C27H32N2O6/c1-3-32-27-28-23-14-25(33-9-8-30)24(31-2)13-22(23)26(29-27)19-10-20(34-15-17-4-5-17)12-21(11-19)35-16-18-6-7-18/h10-14,17-18,30H,3-9,15-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE3.


Bioorg Med Chem Lett 8: 2891-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00508-3
BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50072199
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-2,6-dimet...)
Show SMILES COc1nc(-c2cc(OCC3CC3)cc(OCC3CC3)c2)c2cc(OC)c(OCCO)cc2n1
Show InChI InChI=1S/C26H30N2O6/c1-30-23-12-21-22(13-24(23)32-8-7-29)27-26(31-2)28-25(21)18-9-19(33-14-16-3-4-16)11-20(10-18)34-15-17-5-6-17/h9-13,16-17,29H,3-8,14-15H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE3.


Bioorg Med Chem Lett 8: 2891-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00508-3
BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074887
PNG
(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3ccc(=O)c4ccccc34)c2cc1OC
Show InChI InChI=1S/C28H24N2O5/c1-34-25-12-18-11-19(15-31)22(16-32)28(21(18)14-26(25)35-2)17-7-9-29-27(13-17)30-10-8-24(33)20-5-3-4-6-23(20)30/h3-14,31-32H,15-16H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50072211
PNG
(2-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(OCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C27H32N2O7/c1-32-24-13-22-23(14-25(24)33-8-6-30)28-27(34-9-7-31)29-26(22)19-10-20(35-15-17-2-3-17)12-21(11-19)36-16-18-4-5-18/h10-14,17-18,30-31H,2-9,15-16H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE3.


Bioorg Med Chem Lett 8: 2891-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00508-3
BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50072209
PNG
(3-[4-(3,5-Bis-cyclopropylmethoxy-phenyl)-7-(2-hydr...)
Show SMILES COc1cc2c(nc(NCCCO)nc2cc1OCCO)-c1cc(OCC2CC2)cc(OCC2CC2)c1
Show InChI InChI=1S/C28H35N3O6/c1-34-25-14-23-24(15-26(25)35-10-9-33)30-28(29-7-2-8-32)31-27(23)20-11-21(36-16-18-3-4-18)13-22(12-20)37-17-19-5-6-19/h11-15,18-19,32-33H,2-10,16-17H2,1H3,(H,29,30,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Evaluated for its ability to inhibit PDE3.


Bioorg Med Chem Lett 8: 2891-6 (1999)


Article DOI: 10.1016/s0960-894x(98)00508-3
BindingDB Entry DOI: 10.7270/Q2PG1QVX
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205344
PNG
(US9249139, 1a)
Show SMILES CCOC(=O)c1cc(Cc2ccccc2)c(=O)n2CCCc12
Show InChI InChI=1S/C18H19NO3/c1-2-22-18(21)15-12-14(11-13-7-4-3-5-8-13)17(20)19-10-6-9-16(15)19/h3-5,7-8,12H,2,6,9-11H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 435n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50074897
PNG
(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)
Show SMILES CCOc1cc2c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c(CO)c(CO)cc2cc1OC
Show InChI InChI=1S/C33H28N4O5/c1-3-42-29-16-26-22(14-28(29)41-2)13-23(18-38)27(19-39)31(26)20-10-12-35-30(15-20)37-33(40)25-9-5-4-8-24(25)32(36-37)21-7-6-11-34-17-21/h4-17,38-39H,3,18-19H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 490n/an/an/an/an/an/a



Tanabe Seiyaku Company, Ltd.

Curated by ChEMBL


Assay Description
In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricle


J Med Chem 42: 1088-99 (1999)


Article DOI: 10.1021/jm980314l
BindingDB Entry DOI: 10.7270/Q25M66DH
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50111897
PNG
(2-(2-Ethoxy-phenyl)-3,5-dimethyl-7-propyl-3H-imida...)
Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1ccccc1OCC
Show InChI InChI=1S/C17H20N4O2/c1-4-8-14-18-11(3)15-17(22)19-16(20-21(14)15)12-9-6-7-10-13(12)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,19,20,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50111900
PNG
(4-[4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro...)
Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CC[NH+](CC)CC1
Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)/p+1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50111899
PNG
(5-(2-Ethoxy-phenyl)-1-methyl-3-propyl-1,6-dihydro-...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1ccccc1OCC
Show InChI InChI=1S/C17H20N4O2/c1-4-8-12-14-15(21(3)20-12)17(22)19-16(18-14)11-9-6-7-10-13(11)23-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,18,19,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50111902
PNG
(2-(2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phen...)
Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-19-23-15(3)20-22(29)24-21(25-28(19)20)17-14-16(8-9-18(17)32-6-2)33(30,31)27-12-10-26(4)11-13-27/h8-9,14H,5-7,10-13H2,1-4H3,(H,24,25,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50111901
PNG
(2-(5-(4-methylpiperazin-1-ylsulfonyl)-2-propoxyphe...)
Show SMILES CCCOc1ccc(cc1-c1nc2n(CCC)cnc2c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-4-8-27-15-23-19-21(27)24-20(25-22(19)29)17-14-16(6-7-18(17)32-13-5-2)33(30,31)28-11-9-26(3)10-12-28/h6-7,14-15H,4-5,8-13H2,1-3H3,(H,24,25,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50111898
PNG
(2-(2-Propoxy-phenyl)-9-propyl-1,9-dihydro-purin-6-...)
Show SMILES CCCOc1ccccc1-c1nc2n(CCC)cnc2c(=O)[nH]1
Show InChI InChI=1S/C17H20N4O2/c1-3-9-21-11-18-14-16(21)19-15(20-17(14)22)12-7-5-6-8-13(12)23-10-4-2/h5-8,11H,3-4,9-10H2,1-2H3,(H,19,20,22)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>500n/an/an/an/an/an/a



BAYER AG

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 12: 865-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00030-6
BindingDB Entry DOI: 10.7270/Q21V5D80
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM205351
PNG
(US9249139, 1h)
Show SMILES CCOC(=O)c1cc(Cc2ccc(Cl)cc2Cl)c(=O)n2CCCc12
Show InChI InChI=1S/C18H17Cl2NO3/c1-2-24-18(23)14-9-12(17(22)21-7-3-4-16(14)21)8-11-5-6-13(19)10-15(11)20/h5-6,9-10H,2-4,7-8H2,1H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 577n/an/an/an/an/an/a



Council of Scientific & Industrial Research

US Patent


Assay Description
PDE3 inhibition assay was performed a BIOMOL GREEN Quantizyme Assay System (catalogue No. BML-AK800-0001). The Platelets isolated from human blood ...


US Patent US9249139 (2016)


BindingDB Entry DOI: 10.7270/Q27W6B1M
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50146545
PNG
(2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...)
Show SMILES CCOC(=O)c1sc(Nc2nc(NCc3ccc(OC)c(OC)c3)c3n(CC)cnc3n2)nc1OC
Show InChI InChI=1S/C23H27N7O5S/c1-6-30-12-25-19-16(30)18(24-11-13-8-9-14(32-3)15(10-13)33-4)26-22(27-19)29-23-28-20(34-5)17(36-23)21(31)35-7-2/h8-10,12H,6-7,11H2,1-5H3,(H2,24,26,27,28,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 580n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory concentration against phosphodiesterase 3 from human platelet


Bioorg Med Chem Lett 14: 2955-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.021
BindingDB Entry DOI: 10.7270/Q2M044W1
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM50163876
PNG
(2-[6-(3,4-Dimethoxy-benzylamino)-7-ethyl-7H-purin-...)
Show SMILES CCOC(=O)c1sc(Nc2nc(NCc3ccc(OC)c(OC)c3)c3n(CC)cnc3n2)nc1C
Show InChI InChI=1S/C23H27N7O4S/c1-6-30-12-25-20-17(30)19(24-11-14-8-9-15(32-4)16(10-14)33-5)27-22(28-20)29-23-26-13(3)18(35-23)21(31)34-7-2/h8-10,12H,6-7,11H2,1-5H3,(H2,24,26,27,28,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 580n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 3


Bioorg Med Chem Lett 15: 1829-33 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.025
BindingDB Entry DOI: 10.7270/Q2W37X3W
More data for this
Ligand-Target Pair
Phosphodiesterase 3


(Homo sapiens (human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Monash University

Curated by ChEMBL


Assay Description
Inhibition of human platelet phosphodiesterase 3


Bioorg Med Chem Lett 14: 2847-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.043
BindingDB Entry DOI: 10.7270/Q2H70F8N
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 354 total )  |  Next  |  Last  >>
Jump to: