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Compile Data Set for Download or QSAR

Found 88 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 4A' AND taxid = 9823   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 4A


(Sus scrofa)
BDBM14775
PNG
(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
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n/an/a 1n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041849
PNG
(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(3,5-dichloro-pyr...)
Show SMILES COc1ccc(cc1OC1CC2CCC1C2)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C20H20Cl2N2O3/c1-26-16-5-4-13(20(25)24-19-14(21)9-23-10-15(19)22)8-18(16)27-17-7-11-2-3-12(17)6-11/h4-5,8-12,17H,2-3,6-7H2,1H3,(H,23,24,25)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041849
PNG
(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(3,5-dichloro-pyr...)
Show SMILES COc1ccc(cc1OC1CC2CCC1C2)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C20H20Cl2N2O3/c1-26-16-5-4-13(20(25)24-19-14(21)9-23-10-15(19)22)8-18(16)27-17-7-11-2-3-12(17)6-11/h4-5,8-12,17H,2-3,6-7H2,1H3,(H,23,24,25)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041853
PNG
(3-Cyclopentyloxy-N-(3,5-dichloro-1-oxy-pyridin-4-y...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)c[n+]([O-])cc1Cl
Show InChI InChI=1S/C18H18Cl2N2O4/c1-25-15-7-6-11(8-16(15)26-12-4-2-3-5-12)18(23)21-17-13(19)9-22(24)10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041831
PNG
(3-Cyclopentyloxy-N-(3,5-dibromo-pyridin-4-yl)-4-me...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Br)cncc1Br
Show InChI InChI=1S/C18H18Br2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041846
PNG
(3-Butoxy-N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-b...)
Show SMILES CCCCOc1cc(ccc1OC)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C17H18Cl2N2O3/c1-3-4-7-24-15-8-11(5-6-14(15)23-2)17(22)21-16-12(18)9-20-10-13(16)19/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041886
PNG
(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(2,6-dichloro-phe...)
Show SMILES COc1ccc(cc1OC1CC2CCC1C2)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H21Cl2NO3/c1-26-17-8-7-14(21(25)24-20-15(22)3-2-4-16(20)23)11-19(17)27-18-10-12-5-6-13(18)9-12/h2-4,7-8,11-13,18H,5-6,9-10H2,1H3,(H,24,25)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041847
PNG
(CHEMBL295976 | N-(3-Chloro-pyridin-4-yl)-3-cyclope...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccncc1Cl
Show InChI InChI=1S/C18H19ClN2O3/c1-23-16-7-6-12(10-17(16)24-13-4-2-3-5-13)18(22)21-15-8-9-20-11-14(15)19/h6-11,13H,2-5H2,1H3,(H,20,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041875
PNG
(3-Cyclopentyloxy-N-(3,5-dichloro-2,6-difluoro-pyri...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)c(F)nc(F)c1Cl
Show InChI InChI=1S/C18H16Cl2F2N2O3/c1-26-11-7-6-9(8-12(11)27-10-4-2-3-5-10)18(25)23-15-13(19)16(21)24-17(22)14(15)20/h6-8,10H,2-5H2,1H3,(H,23,24,25)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041838
PNG
(3-(cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C19H19Cl2NO3/c1-24-16-10-9-12(11-17(16)25-13-5-2-3-6-13)19(23)22-18-14(20)7-4-8-15(18)21/h4,7-11,13H,2-3,5-6H2,1H3,(H,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041869
PNG
(3-Cyclopentyloxy-N-(3,5-dimethyl-pyridin-4-yl)-4-m...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(C)cncc1C
Show InChI InChI=1S/C20H24N2O3/c1-13-11-21-12-14(2)19(13)22-20(23)15-8-9-17(24-3)18(10-15)25-16-6-4-5-7-16/h8-12,16H,4-7H2,1-3H3,(H,21,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041824
PNG
(3-Cyclohexyloxy-N-(3,5-dichloro-pyridin-4-yl)-4-me...)
Show SMILES COc1ccc(cc1OC1CCCCC1)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C19H20Cl2N2O3/c1-25-16-8-7-12(9-17(16)26-13-5-3-2-4-6-13)19(24)23-18-14(20)10-22-11-15(18)21/h7-11,13H,2-6H2,1H3,(H,22,23,24)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041844
PNG
(3-(cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C19H19F2NO3/c1-24-16-10-9-12(11-17(16)25-13-5-2-3-6-13)19(23)22-18-14(20)7-4-8-15(18)21/h4,7-11,13H,2-3,5-6H2,1H3,(H,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041879
PNG
(3-Butoxy-N-(3,5-dibromo-pyridin-4-yl)-4-methoxy-be...)
Show SMILES CCCCOc1cc(ccc1OC)C(=O)Nc1c(Br)cncc1Br
Show InChI InChI=1S/C17H18Br2N2O3/c1-3-4-7-24-15-8-11(5-6-14(15)23-2)17(22)21-16-12(18)9-20-10-13(16)19/h5-6,8-10H,3-4,7H2,1-2H3,(H,20,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041877
PNG
(3-Cyclopentyloxy-4-methoxy-N-(2,3,5-trifluoro-pyri...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(F)cnc(F)c1F
Show InChI InChI=1S/C18H17F3N2O3/c1-25-13-7-6-10(8-14(13)26-11-4-2-3-5-11)18(24)23-16-12(19)9-22-17(21)15(16)20/h6-9,11H,2-5H2,1H3,(H,22,23,24)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041873
PNG
(CHEMBL47286 | N-(3-Chloro-2,5,6-trifluoro-pyridin-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(F)c(F)nc(F)c1Cl
Show InChI InChI=1S/C18H16ClF3N2O3/c1-26-11-7-6-9(8-12(11)27-10-4-2-3-5-10)18(25)23-15-13(19)16(21)24-17(22)14(15)20/h6-8,10H,2-5H2,1H3,(H,23,24,25)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041826
PNG
(3-Cyclopentyloxy-N-(2,6-dimethyl-phenyl)-4-methoxy...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C21H25NO3/c1-14-7-6-8-15(2)20(14)22-21(23)16-11-12-18(24-3)19(13-16)25-17-9-4-5-10-17/h6-8,11-13,17H,4-5,9-10H2,1-3H3,(H,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041866
PNG
(CHEMBL48017 | N-(3,5-Dichloro-pyridin-4-yl)-3,4-di...)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C14H12Cl2N2O3/c1-20-11-4-3-8(5-12(11)21-2)14(19)18-13-9(15)6-17-7-10(13)16/h3-7H,1-2H3,(H,17,18,19)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041854
PNG
(CHEMBL294949 | N-(2-Chloro-6-methyl-phenyl)-3-cycl...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C20H22ClNO3/c1-13-6-5-9-16(21)19(13)22-20(23)14-10-11-17(24-2)18(12-14)25-15-7-3-4-8-15/h5-6,9-12,15H,3-4,7-8H2,1-2H3,(H,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041856
PNG
(CHEMBL48048 | N-(4-Chloro-pyridin-3-yl)-3-cyclopen...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1cnccc1Cl
Show InChI InChI=1S/C18H19ClN2O3/c1-23-16-7-6-12(10-17(16)24-13-4-2-3-5-13)18(22)21-15-11-20-9-8-14(15)19/h6-11,13H,2-5H2,1H3,(H,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041845
PNG
(CHEMBL296700 | N-(2-Bromo-phenyl)-3-cyclopentyloxy...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1Br
Show InChI InChI=1S/C19H20BrNO3/c1-23-17-11-10-13(12-18(17)24-14-6-2-3-7-14)19(22)21-16-9-5-4-8-15(16)20/h4-5,8-12,14H,2-3,6-7H2,1H3,(H,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041828
PNG
(CHEMBL289190 | N-(2-Chloro-phenyl)-3-cyclopentylox...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C19H20ClNO3/c1-23-17-11-10-13(12-18(17)24-14-6-2-3-7-14)19(22)21-16-9-5-4-8-15(16)20/h4-5,8-12,14H,2-3,6-7H2,1H3,(H,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041883
PNG
(CHEMBL45359 | N-(2-Chloro-phenyl)-3-cyclopentyloxy...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=S)Nc1ccccc1Cl
Show InChI InChI=1S/C19H20ClNO2S/c1-22-17-11-10-13(12-18(17)23-14-6-2-3-7-14)19(24)21-16-9-5-4-8-15(16)20/h4-5,8-12,14H,2-3,6-7H2,1H3,(H,21,24)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041864
PNG
(CHEMBL47288 | N-(5-Cyano-3-methyl-isothiazol-4-yl)...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(C)nsc1C#N
Show InChI InChI=1S/C18H19N3O3S/c1-11-17(16(10-19)25-21-11)20-18(22)12-7-8-14(23-2)15(9-12)24-13-5-3-4-6-13/h7-9,13H,3-6H2,1-2H3,(H,20,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041855
PNG
(CHEMBL45128 | N-(2-Chloro-6-fluoro-phenyl)-3-cyclo...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(F)cccc1Cl
Show InChI InChI=1S/C19H19ClFNO3/c1-24-16-10-9-12(11-17(16)25-13-5-2-3-6-13)19(23)22-18-14(20)7-4-8-15(18)21/h4,7-11,13H,2-3,5-6H2,1H3,(H,22,23)
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n/an/a 240n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041822
PNG
(3-Cyclopentyloxy-4-methoxy-N-pyrazin-2-yl-benzamid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1cnccn1
Show InChI InChI=1S/C17H19N3O3/c1-22-14-7-6-12(10-15(14)23-13-4-2-3-5-13)17(21)20-16-11-18-8-9-19-16/h6-11,13H,2-5H2,1H3,(H,19,20,21)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041851
PNG
(3-Cyclopentyloxy-4-methoxy-N-(2-nitro-phenyl)-benz...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C19H20N2O5/c1-25-17-11-10-13(12-18(17)26-14-6-2-3-7-14)19(22)20-15-8-4-5-9-16(15)21(23)24/h4-5,8-12,14H,2-3,6-7H2,1H3,(H,20,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041825
PNG
(3-Butoxy-N-(2,6-difluoro-phenyl)-4-methoxy-benzami...)
Show SMILES CCCCOc1cc(ccc1OC)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C18H19F2NO3/c1-3-4-10-24-16-11-12(8-9-15(16)23-2)18(22)21-17-13(19)6-5-7-14(17)20/h5-9,11H,3-4,10H2,1-2H3,(H,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041858
PNG
(3-Cyclopentyloxy-4-methoxy-N-o-tolyl-benzamide | C...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C20H23NO3/c1-14-7-3-6-10-17(14)21-20(22)15-11-12-18(23-2)19(13-15)24-16-8-4-5-9-16/h3,6-7,10-13,16H,4-5,8-9H2,1-2H3,(H,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041881
PNG
(CHEMBL441431 | N-(3-Chloro-pyridin-2-yl)-3-cyclope...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ncccc1Cl
Show InChI InChI=1S/C18H19ClN2O3/c1-23-15-9-8-12(11-16(15)24-13-5-2-3-6-13)18(22)21-17-14(19)7-4-10-20-17/h4,7-11,13H,2-3,5-6H2,1H3,(H,20,21,22)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041872
PNG
(3-(cyclohexyloxy)-N-(2,6-difluorophenyl)-4-methoxy...)
Show SMILES COc1ccc(cc1OC1CCCCC1)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C20H21F2NO3/c1-25-17-11-10-13(12-18(17)26-14-6-3-2-4-7-14)20(24)23-19-15(21)8-5-9-16(19)22/h5,8-12,14H,2-4,6-7H2,1H3,(H,23,24)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041833
PNG
(3-Cyclopentyloxy-N-(2,6-dibromo-phenyl)-4-methoxy-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Br)cccc1Br
Show InChI InChI=1S/C19H19Br2NO3/c1-24-16-10-9-12(11-17(16)25-13-5-2-3-6-13)19(23)22-18-14(20)7-4-8-15(18)21/h4,7-11,13H,2-3,5-6H2,1H3,(H,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041880
PNG
(3-Cyclopentyloxy-N-(2,6-dichloro-6H-pyrimidin-1-yl...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)NN1C(Cl)C=CN=C1Cl
Show InChI InChI=1S/C17H19Cl2N3O3/c1-24-13-7-6-11(10-14(13)25-12-4-2-3-5-12)16(23)21-22-15(18)8-9-20-17(22)19/h6-10,12,15H,2-5H2,1H3,(H,21,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041889
PNG
(3-Cyclopentyloxy-N-(3,5-dimethyl-2,3-dihydro-isoxa...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)NC1(C)NOC(C)=C1
Show InChI InChI=1S/C18H24N2O4/c1-12-11-18(2,20-24-12)19-17(21)13-8-9-15(22-3)16(10-13)23-14-6-4-5-7-14/h8-11,14,20H,4-7H2,1-3H3,(H,19,21)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041859
PNG
(3-Cyclopentyloxy-N-(3,5-dimethyl-isothiazol-4-yl)-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(C)nsc1C
Show InChI InChI=1S/C18H22N2O3S/c1-11-17(12(2)24-20-11)19-18(21)13-8-9-15(22-3)16(10-13)23-14-6-4-5-7-14/h8-10,14H,4-7H2,1-3H3,(H,19,21)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041882
PNG
(CHEMBL297149 | N-(5-Bromo-3-methyl-isothiazol-4-yl...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(C)nsc1Br
Show InChI InChI=1S/C17H19BrN2O3S/c1-10-15(16(18)24-20-10)19-17(21)11-7-8-13(22-2)14(9-11)23-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H,19,21)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041823
PNG
(3-Cyclopentyloxy-N-(2,5-dichloro-phenyl)-4-methoxy...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C19H19Cl2NO3/c1-24-17-9-6-12(10-18(17)25-14-4-2-3-5-14)19(23)22-16-11-13(20)7-8-15(16)21/h6-11,14H,2-5H2,1H3,(H,22,23)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041870
PNG
(3-Cyclopentyloxy-4-methoxy-N-(2,3,5,6-tetrafluoro-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(F)c(F)nc(F)c1F
Show InChI InChI=1S/C18H16F4N2O3/c1-26-11-7-6-9(8-12(11)27-10-4-2-3-5-10)18(25)23-15-13(19)16(21)24-17(22)14(15)20/h6-8,10H,2-5H2,1H3,(H,23,24,25)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041832
PNG
(3-Cyclopentyloxy-4-methoxy-N-pyridin-3-yl-benzamid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H20N2O3/c1-22-16-9-8-13(11-17(16)23-15-6-2-3-7-15)18(21)20-14-5-4-10-19-12-14/h4-5,8-12,15H,2-3,6-7H2,1H3,(H,20,21)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041876
PNG
(CHEMBL45854 | N-(2-Chloro-phenyl)-3,4-dimethoxy-be...)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1ccccc1Cl
Show InChI InChI=1S/C15H14ClNO3/c1-19-13-8-7-10(9-14(13)20-2)15(18)17-12-6-4-3-5-11(12)16/h3-9H,1-2H3,(H,17,18)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041830
PNG
(3-Cyclopentyloxy-4-methoxy-N-pyridin-4-yl-benzamid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C18H20N2O3/c1-22-16-7-6-13(12-17(16)23-15-4-2-3-5-15)18(21)20-14-8-10-19-11-9-14/h6-12,15H,2-5H2,1H3,(H,19,20,21)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041839
PNG
(CHEMBL297333 | N-(2,6-Difluoro-phenyl)-3,4-dimetho...)
Show SMILES COc1ccc(cc1OC)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C15H13F2NO3/c1-20-12-7-6-9(8-13(12)21-2)15(19)18-14-10(16)4-3-5-11(14)17/h3-8H,1-2H3,(H,18,19)
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Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041835
PNG
(3-Cyclopentyloxy-4-methoxy-N-m-tolyl-benzamide | C...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C20H23NO3/c1-14-6-5-7-16(12-14)21-20(22)15-10-11-18(23-2)19(13-15)24-17-8-3-4-9-17/h5-7,10-13,17H,3-4,8-9H2,1-2H3,(H,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041840
PNG
(3-Cyclopentyloxy-4-methoxy-N-pyridin-2-yl-benzamid...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccn1
Show InChI InChI=1S/C18H20N2O3/c1-22-15-10-9-13(12-16(15)23-14-6-2-3-7-14)18(21)20-17-8-4-5-11-19-17/h4-5,8-12,14H,2-3,6-7H2,1H3,(H,19,20,21)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50089814
PNG
(4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-pi...)
Show SMILES COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl
Show InChI InChI=1S/C22H22ClN5O2/c1-30-20-5-3-15(11-19(20)23)13-25-21-18-10-14(12-24)2-4-17(18)22(27-26-21)28-8-6-16(29)7-9-28/h2-5,10-11,16,29H,6-9,13H2,1H3,(H,25,26)
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n/an/a 1.17E+3n/an/an/an/an/an/a



Eisai Company, Ltd.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from porcine liver, range 1.01-1.36


J Med Chem 43: 2523-9 (2000)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041843
PNG
(CHEMBL45231 | N-(2-Acetyl-phenyl)-3-cyclopentyloxy...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1C(C)=O
Show InChI InChI=1S/C21H23NO4/c1-14(23)17-9-5-6-10-18(17)22-21(24)15-11-12-19(25-2)20(13-15)26-16-7-3-4-8-16/h5-6,9-13,16H,3-4,7-8H2,1-2H3,(H,22,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041841
PNG
(3-Cyclopentyloxy-4-methoxy-N-(2-methylsulfanyl-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1SC
Show InChI InChI=1S/C20H23NO3S/c1-23-17-12-11-14(13-18(17)24-15-7-3-4-8-15)20(22)21-16-9-5-6-10-19(16)25-2/h5-6,9-13,15H,3-4,7-8H2,1-2H3,(H,21,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041868
PNG
(3-Cyclopentyloxy-N-(2-hydroxy-phenyl)-4-methoxy-be...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1ccccc1O
Show InChI InChI=1S/C19H21NO4/c1-23-17-11-10-13(12-18(17)24-14-6-2-3-7-14)19(22)20-15-8-4-5-9-16(15)21/h4-5,8-12,14,21H,2-3,6-7H2,1H3,(H,20,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041848
PNG
(CHEMBL48080 | N-(3-Chloro-phenyl)-3-cyclopentyloxy...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C19H20ClNO3/c1-23-17-10-9-13(11-18(17)24-16-7-2-3-8-16)19(22)21-15-6-4-5-14(20)12-15/h4-6,9-12,16H,2-3,7-8H2,1H3,(H,21,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
Phosphodiesterase 4A


(Sus scrofa)
BDBM50041884
PNG
(CHEMBL298000 | N-(2,6-Difluoro-phenyl)-4-methoxy-3...)
Show SMILES CCCOc1cc(ccc1OC)C(=O)Nc1c(F)cccc1F
Show InChI InChI=1S/C17H17F2NO3/c1-3-9-23-15-10-11(7-8-14(15)22-2)17(21)20-16-12(18)5-4-6-13(16)19/h4-8,10H,3,9H2,1-2H3,(H,20,21)
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AffyNet 
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibitory potency against pig aortic PDE IV


J Med Chem 37: 1696-703 (1994)

More data for this
Ligand-Target Pair
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