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Compile Data Set for Download or QSAR

Found 115 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 4C' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183805
PNG
(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Show SMILES CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)Nc3ccccc3)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C34H30N4O3S/c1-34(2,23-35)27-20-26-11-8-18-36-32(26)31(21-27)25-10-7-9-24(19-25)22-38(33(39)37-28-12-5-4-6-13-28)29-14-16-30(17-15-29)42(3,40)41/h4-21H,22H2,1-3H3,(H,37,39)
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n/an/a 0.0500n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174028
PNG
((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Show SMILES CC(C)c1cc(-c2cccc(\C=C(/c3ccc(cc3)S(C)(=O)=O)c3ccc(C)cn3)c2)c2ncccc2c1
Show InChI InChI=1S/C33H30N2O2S/c1-22(2)28-19-27-9-6-16-34-33(27)31(20-28)26-8-5-7-24(17-26)18-30(32-15-10-23(3)21-35-32)25-11-13-29(14-12-25)38(4,36)37/h5-22H,1-4H3/b30-18+
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n/an/a 0.400n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174031
PNG
((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)
Show SMILES CC(C)c1cc(-c2cccc(\C=C(\c3ccc(cc3)C(C)(C)O)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C36H35NO3S/c1-24(2)30-22-29-10-7-19-37-35(29)34(23-30)28-9-6-8-25(20-28)21-33(26-11-15-31(16-12-26)36(3,4)38)27-13-17-32(18-14-27)41(5,39)40/h6-24,38H,1-5H3/b33-21-
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n/an/a 0.5n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174025
PNG
(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Show SMILES CC(C)c1cc(-c2cccc(\C=C(\c3nccs3)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C30H26N2O2S2/c1-20(2)25-18-24-8-5-13-31-29(24)27(19-25)23-7-4-6-21(16-23)17-28(30-32-14-15-35-30)22-9-11-26(12-10-22)36(3,33)34/h4-20H,1-3H3/b28-17+
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n/an/a 0.700n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183803
PNG
(CHEMBL206968 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Show SMILES Cc1cc(no1)C(=O)N(Cc1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C32H28N4O4S/c1-21-15-29(35-40-21)31(37)36(26-10-12-27(13-11-26)41(4,38)39)19-22-7-5-8-23(16-22)28-18-25(32(2,3)20-33)17-24-9-6-14-34-30(24)28/h5-18H,19H2,1-4H3
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n/an/a 0.900n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174020
PNG
((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)
Show SMILES OC(c1ncc(s1)[C@@H](Cc1ccc[n+]([O-])c1)c1ccc(OC(F)F)c(OC2CC2)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H18F8N2O4S/c24-20(25)37-16-6-3-13(9-17(16)36-14-4-5-14)15(8-12-2-1-7-33(35)11-12)18-10-32-19(38-18)21(34,22(26,27)28)23(29,30)31/h1-3,6-7,9-11,14-15,20,34H,4-5,8H2/t15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183808
PNG
(CHEMBL383225 | N-((3-(6-(2-cyanopropan-2-yl)quinol...)
Show SMILES CC(C)(C#N)c1cc(-c2cccc(CN(C(=O)c3ccccc3)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C34H29N3O3S/c1-34(2,23-35)28-20-27-13-8-18-36-32(27)31(21-28)26-12-7-9-24(19-26)22-37(33(38)25-10-5-4-6-11-25)29-14-16-30(17-15-29)41(3,39)40/h4-21H,22H2,1-3H3
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n/an/a 1n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase Type 4 (PDE4C)


(Homo sapiens)
BDBM14359
PNG
((+)-1 | (S)-(+)-3-{2-[(3-Cyclopropyloxy-4-diflurom...)
Show SMILES OC(c1cnc(s1)[C@@H](Cc1ccc[n+]([O-])c1)c1ccc(OC(F)F)c(OC2CC2)c1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C23H18F8N2O4S/c24-20(25)37-16-6-3-13(9-17(16)36-14-4-5-14)15(8-12-2-1-7-33(35)11-12)19-32-10-18(38-19)21(34,22(26,27)28)23(29,30)31/h1-3,6-7,9-11,14-15,20,34H,4-5,8H2/t15-/m0/s1
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n/an/a 1n/an/an/an/a7.522



University of North Carolina at Chapel Hill



Assay Description
PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...


J Med Chem 49: 1867-73 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174030
PNG
((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Show SMILES CC(C)c1cc(-c2cccc(\C=C(\c3nc(C)no3)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C30H27N3O3S/c1-19(2)25-17-24-9-6-14-31-29(24)27(18-25)23-8-5-7-21(15-23)16-28(30-32-20(3)33-36-30)22-10-12-26(13-11-22)37(4,34)35/h5-19H,1-4H3/b28-16+
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n/an/a 1.20n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183792
PNG
(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Show SMILES CC(C)NC(=O)N(Cc1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H32N4O3S/c1-21(2)34-30(36)35(26-11-13-27(14-12-26)39(5,37)38)19-22-8-6-9-23(16-22)28-18-25(31(3,4)20-32)17-24-10-7-15-33-29(24)28/h6-18,21H,19H2,1-5H3,(H,34,36)
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n/an/a 1.70n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183794
PNG
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-((3-(6-...)
Show SMILES CC(C)NC(=O)N(Cc1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H35N3O5S2/c1-21(2)33-30(35)34(26-12-14-27(15-13-26)40(5,36)37)20-22-9-7-10-23(17-22)28-19-25(31(3,4)41(6,38)39)18-24-11-8-16-32-29(24)28/h7-19,21H,20H2,1-6H3,(H,33,35)
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n/an/a 1.70n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174018
PNG
((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)
Show SMILES CC(C)NC(=O)C(=C\c1cccc(c1)-c1cc(cc2cccnc12)C(C)C)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H32N2O3S/c1-20(2)26-18-25-10-7-15-32-30(25)28(19-26)24-9-6-8-22(16-24)17-29(31(34)33-21(3)4)23-11-13-27(14-12-23)37(5,35)36/h6-21H,1-5H3,(H,33,34)/b29-17+
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n/an/a 2.90n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174017
PNG
(8-(3-(2-(3-methylcyclopenta-1,3-dienyl)-2-(4-(meth...)
Show SMILES COc1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12
Show InChI InChI=1S/C22H18N2O/c1-25-20-6-2-4-18(15-20)21-14-17(12-16-7-10-23-11-8-16)13-19-5-3-9-24-22(19)21/h2-11,13-15H,12H2,1H3
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n/an/a 3.30n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human PDE4C


Bioorg Med Chem Lett 20: 5502-5 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174017
PNG
(8-(3-(2-(3-methylcyclopenta-1,3-dienyl)-2-(4-(meth...)
Show SMILES COc1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12
Show InChI InChI=1S/C22H18N2O/c1-25-20-6-2-4-18(15-20)21-14-17(12-16-7-10-23-11-8-16)13-19-5-3-9-24-22(19)21/h2-11,13-15H,12H2,1H3
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n/an/a 3.30n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174013
PNG
((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)
Show SMILES CC(C)c1cc(-c2cccc(\C=C(\C(O)=O)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C28H25NO4S/c1-18(2)23-16-22-8-5-13-29-27(22)25(17-23)21-7-4-6-19(14-21)15-26(28(30)31)20-9-11-24(12-10-20)34(3,32)33/h4-18H,1-3H3,(H,30,31)/b26-15+
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n/an/a 3.80n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM14775
PNG
(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
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n/an/a 3.80n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4C


J Med Chem 41: 266-70 (1998)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183791
PNG
(CHEMBL209295 | isopropyl (3-(6-(2-cyanopropan-2-yl...)
Show SMILES CC(C)OC(=O)N(Cc1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H31N3O4S/c1-21(2)38-30(35)34(26-11-13-27(14-12-26)39(5,36)37)19-22-8-6-9-23(16-22)28-18-25(31(3,4)20-32)17-24-10-7-15-33-29(24)28/h6-18,21H,19H2,1-5H3
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n/an/a 4.20n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50064858
PNG
((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@H](Cc1ccncc1)c1ccccc1
Show InChI InChI=1S/C25H27NO2/c1-27-24-12-11-21(18-25(24)28-22-9-5-6-10-22)23(20-7-3-2-4-8-20)17-19-13-15-26-16-14-19/h2-4,7-8,11-16,18,22-23H,5-6,9-10,17H2,1H3/t23-/m1/s1
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n/an/a 4.5n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183797
PNG
(CHEMBL207996 | N-(3,5-dichloropyridin-4-yl)-3-(6-(...)
Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2c(Cl)cncc2Cl)c2ncccc2c1)S(C)(=O)=O
Show InChI InChI=1S/C25H21Cl2N3O3S/c1-25(2,34(3,32)33)18-11-16-8-5-9-29-22(16)19(12-18)15-6-4-7-17(10-15)24(31)30-23-20(26)13-28-14-21(23)27/h4-14H,1-3H3,(H,28,30,31)
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n/an/a 5.5n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174023
PNG
((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Show SMILES CC(C)c1cc(-c2cccc(\C=C(\c3nc(C)no3)c3ccccn3)c2)c2ncccc2c1
Show InChI InChI=1S/C28H24N4O/c1-18(2)23-16-22-10-7-13-30-27(22)24(17-23)21-9-6-8-20(14-21)15-25(26-11-4-5-12-29-26)28-31-19(3)32-33-28/h4-18H,1-3H3/b25-15+
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n/an/a 5.70n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183804
PNG
(4-(2-hydroxypropan-2-yl)-N-(4-(methylsulfonyl)phen...)
Show SMILES CC(N(C(=O)c1ccc(cc1)C(C)(C)O)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C38H40N2O6S2/c1-25(40(32-17-19-33(20-18-32)47(6,43)44)36(41)26-13-15-30(16-14-26)37(2,3)42)27-10-8-11-28(22-27)34-24-31(38(4,5)48(7,45)46)23-29-12-9-21-39-35(29)34/h8-25,42H,1-7H3
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n/an/a 5.90n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183798
PNG
(1-((2-fluoro-5-(6-(2-(methylsulfonyl)propan-2-yl)q...)
Show SMILES CC(C)NC(=O)N(Cc1cc(ccc1F)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H34FN3O5S2/c1-20(2)34-30(36)35(25-10-12-26(13-11-25)41(5,37)38)19-23-16-21(9-14-28(23)32)27-18-24(31(3,4)42(6,39)40)17-22-8-7-15-33-29(22)27/h7-18,20H,19H2,1-6H3,(H,34,36)
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n/an/a 6.40n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174029
PNG
((E)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Show SMILES CC(C)NC(=O)C(=C\c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C32H31N3O3S/c1-21(2)35-31(36)29(23-11-13-27(14-12-23)39(5,37)38)17-22-8-6-9-24(16-22)28-19-26(32(3,4)20-33)18-25-10-7-15-34-30(25)28/h6-19,21H,1-5H3,(H,35,36)/b29-17+
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n/an/a 6.80n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183799
PNG
(4-fluoro-N-(4-(methylsulfonyl)phenyl)-N-(1-(3-(6-(...)
Show SMILES CC(N(C(=O)c1ccc(F)cc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C35H33FN2O5S2/c1-23(38(34(39)24-11-13-29(36)14-12-24)30-15-17-31(18-16-30)44(4,40)41)25-8-6-9-26(20-25)32-22-28(35(2,3)45(5,42)43)21-27-10-7-19-37-33(27)32/h6-23H,1-5H3
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n/an/a 7.5n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174022
PNG
((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Show SMILES Cc1noc(n1)C(=C\c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H29N3O5S2/c1-20-33-30(39-34-20)28(22-11-13-26(14-12-22)40(4,35)36)17-21-8-6-9-23(16-21)27-19-25(31(2,3)41(5,37)38)18-24-10-7-15-32-29(24)27/h6-19H,1-5H3/b28-17+
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n/an/a 9.10n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174022
PNG
((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Show SMILES Cc1noc(n1)C(=C\c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H29N3O5S2/c1-20-33-30(39-34-20)28(22-11-13-26(14-12-22)40(4,35)36)17-21-8-6-9-23(16-21)27-19-25(31(2,3)41(5,37)38)18-24-10-7-15-32-29(24)27/h6-19H,1-5H3/b28-17+
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n/an/a 9.10n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human PDE4C


Bioorg Med Chem Lett 20: 5502-5 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183795
PNG
(2-(8-(3-(((4-fluorobenzyl)(4-(methylsulfonyl)pheny...)
Show SMILES CC(C)(C#N)c1cc(-c2cccc(CN(Cc3ccc(F)cc3)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1
Show InChI InChI=1S/C34H30FN3O2S/c1-34(2,23-36)28-19-27-8-5-17-37-33(27)32(20-28)26-7-4-6-25(18-26)22-38(21-24-9-11-29(35)12-10-24)30-13-15-31(16-14-30)41(3,39)40/h4-20H,21-22H2,1-3H3
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n/an/a 9.5n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50397078
PNG
(CHEMBL2171452)
Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)C1(C)C
Show InChI InChI=1S/C30H38N6O4/c1-30(2)27(33-36(29(30)37)23-10-6-4-5-7-11-23)22-14-17-25(38-3)26(20-22)40-19-9-8-18-39-24-15-12-21(13-16-24)28-31-34-35-32-28/h12-17,20,23H,4-11,18-19H2,1-3H3,(H,31,32,34,35)
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n/an/a 10n/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Inhibition of human PDE4C1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay


J Med Chem 55: 8745-56 (2012)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183806
PNG
(4-(methylsulfonyl)-N-(3-(6-(2-(methylsulfonyl)prop...)
Show SMILES CC(C)(c1cc(-c2cccc(NC(=O)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1)S(C)(=O)=O
Show InChI InChI=1S/C27H26N2O5S2/c1-27(2,36(4,33)34)21-15-20-8-6-14-28-25(20)24(17-21)19-7-5-9-22(16-19)29-26(30)18-10-12-23(13-11-18)35(3,31)32/h5-17H,1-4H3,(H,29,30)
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n/an/a 10.6n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174027
PNG
(2-(2-(2-(3-(6-(1-(methylsulfonyl)ethyl)quinolin-8-...)
Show SMILES CC(c1cc(-c2cccc(\C=C(\c3ncc(s3)C(C)(C)O)c3ccc(cc3)S(C)(=O)=O)c2)c2ncccc2c1)S(C)(=O)=O
Show InChI InChI=1S/C33H32N2O5S3/c1-21(42(4,37)38)26-18-25-10-7-15-34-31(25)28(19-26)24-9-6-8-22(16-24)17-29(32-35-20-30(41-32)33(2,3)36)23-11-13-27(14-12-23)43(5,39)40/h6-21,36H,1-5H3/b29-17+
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n/an/a 11n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174021
PNG
((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)
Show SMILES CC(C)NC(=O)C(=C/c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)C#N)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C32H31N3O3S/c1-21(2)35-31(36)29(23-11-13-27(14-12-23)39(5,37)38)17-22-8-6-9-24(16-22)28-19-26(32(3,4)20-33)18-25-10-7-15-34-30(25)28/h6-19,21H,1-5H3,(H,35,36)/b29-17-
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n/an/a 11.4n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174016
PNG
(CHEMBL370220 | N-(3-(6-(pyridin-4-ylmethyl)quinoli...)
Show SMILES O=S(=O)(Nc1cccc(c1)-c1cc(Cc2ccncc2)cc2cccnc12)c1ccccc1
Show InChI InChI=1S/C27H21N3O2S/c31-33(32,25-9-2-1-3-10-25)30-24-8-4-6-22(19-24)26-18-21(16-20-11-14-28-15-12-20)17-23-7-5-13-29-27(23)26/h1-15,17-19,30H,16H2
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n/an/a 11.9n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183799
PNG
(4-fluoro-N-(4-(methylsulfonyl)phenyl)-N-(1-(3-(6-(...)
Show SMILES CC(N(C(=O)c1ccc(F)cc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C35H33FN2O5S2/c1-23(38(34(39)24-11-13-29(36)14-12-24)30-15-17-31(18-16-30)44(4,40)41)25-8-6-9-26(20-25)32-22-28(35(2,3)45(5,42)43)21-27-10-7-19-37-33(27)32/h6-23H,1-5H3
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n/an/a 12n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174015
PNG
((E)-N-isopropyl-2-(4-(methylsulfonyl)phenyl)-3-(3-...)
Show SMILES CC(C)NC(=O)C(=C\c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C32H34N2O5S2/c1-21(2)34-31(35)29(23-12-14-27(15-13-23)40(5,36)37)18-22-9-7-10-24(17-22)28-20-26(32(3,4)41(6,38)39)19-25-11-8-16-33-30(25)28/h7-21H,1-6H3,(H,34,35)/b29-18+
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n/an/a 14n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM14775
PNG
(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4C


J Med Chem 50: 344-9 (2007)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174026
PNG
((Z)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)
Show SMILES Cc1noc(n1)C(=C/c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)\c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C31H29N3O5S2/c1-20-33-30(39-34-20)28(22-11-13-26(14-12-22)40(4,35)36)17-21-8-6-9-23(16-21)27-19-25(31(2,3)41(5,37)38)18-24-10-7-15-32-29(24)27/h6-19H,1-5H3/b28-17-
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n/an/a 14n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183793
PNG
(CHEMBL206592 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...)
Show SMILES CC(N(C(=O)c1cccnc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C34H33N3O5S2/c1-23(37(33(38)27-12-7-17-35-22-27)29-13-15-30(16-14-29)43(4,39)40)24-9-6-10-25(19-24)31-21-28(34(2,3)44(5,41)42)20-26-11-8-18-36-32(26)31/h6-23H,1-5H3
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n/an/a 14n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50062383
PNG
(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)NCC(=O)NO
Show InChI InChI=1S/C15H20N2O5/c1-21-12-7-6-10(15(19)16-9-14(18)17-20)8-13(12)22-11-4-2-3-5-11/h6-8,11,20H,2-5,9H2,1H3,(H,16,19)(H,17,18)
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n/an/a 15.3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4C


J Med Chem 41: 266-70 (1998)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183802
PNG
(CHEMBL379768 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...)
Show SMILES CC(N(C(=O)C1CC1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C32H34N2O5S2/c1-21(34(31(35)22-11-12-22)27-13-15-28(16-14-27)40(4,36)37)23-8-6-9-24(18-23)29-20-26(32(2,3)41(5,38)39)19-25-10-7-17-33-30(25)29/h6-10,13-22H,11-12H2,1-5H3
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n/an/a 17n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183788
PNG
(3-(6-(2-(methylsulfonyl)propan-2-yl)quinolin-8-yl)...)
Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccncc2)c2ncccc2c1)S(C)(=O)=O
Show InChI InChI=1S/C25H23N3O3S/c1-25(2,32(3,30)31)20-15-18-8-5-11-27-23(18)22(16-20)17-6-4-7-19(14-17)24(29)28-21-9-12-26-13-10-21/h4-16H,1-3H3,(H,26,28,29)
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n/an/a 17n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50062387
PNG
(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1=NOC(C1)C(=O)NO
Show InChI InChI=1S/C16H20N2O5/c1-21-13-7-6-10(8-14(13)22-11-4-2-3-5-11)12-9-15(23-18-12)16(19)17-20/h6-8,11,15,20H,2-5,9H2,1H3,(H,17,19)
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n/an/a 18n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4C


J Med Chem 41: 266-70 (1998)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50174024
PNG
(8-(3-(1-(4-chlorophenyl)-2-(pyridin-4-yl)ethyl)phe...)
Show SMILES CC(C)c1cc(-c2cccc(c2)C(Cc2ccncc2)c2ccc(Cl)cc2)c2ncccc2c1
Show InChI InChI=1S/C31H27ClN2/c1-21(2)27-19-26-7-4-14-34-31(26)30(20-27)25-6-3-5-24(18-25)29(17-22-12-15-33-16-13-22)23-8-10-28(32)11-9-23/h3-16,18-21,29H,17H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibitory activity against PDE4C


Bioorg Med Chem Lett 15: 5241-6 (2005)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183800
PNG
(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-(1-(3-(...)
Show SMILES CC(C)NC(=O)N(C(C)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O)c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C32H37N3O5S2/c1-21(2)34-31(36)35(27-13-15-28(16-14-27)41(6,37)38)22(3)23-10-8-11-24(18-23)29-20-26(32(4,5)42(7,39)40)19-25-12-9-17-33-30(25)29/h8-22H,1-7H3,(H,34,36)
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n/an/a 25n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183801
PNG
(CHEMBL208149 | N-(4-(methylsulfonyl)phenyl)-3-(6-(...)
Show SMILES CC(C)(c1cc(-c2cccc(c2)C(=O)Nc2ccc(cc2)S(C)(=O)=O)c2ncccc2c1)S(C)(=O)=O
Show InChI InChI=1S/C27H26N2O5S2/c1-27(2,36(4,33)34)21-16-19-9-6-14-28-25(19)24(17-21)18-7-5-8-20(15-18)26(30)29-22-10-12-23(13-11-22)35(3,31)32/h5-17H,1-4H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50325790
PNG
(CHEMBL1224717 | methyl 2-(4-((8-(3-methoxyphenyl)q...)
Show SMILES COC(=O)Cc1ccc(OCc2cc(-c3cccc(OC)c3)c3ncccc3c2)cc1
Show InChI InChI=1S/C26H23NO4/c1-29-23-7-3-5-20(16-23)24-14-19(13-21-6-4-12-27-26(21)24)17-31-22-10-8-18(9-11-22)15-25(28)30-2/h3-14,16H,15,17H2,1-2H3
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n/an/a 31n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human PDE4C


Bioorg Med Chem Lett 20: 5502-5 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50325788
PNG
(2-(4-((8-(3-(difluoromethoxy)phenyl)quinolin-6-yl)...)
Show SMILES OC(=O)Cc1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1
Show InChI InChI=1S/C25H19F2NO4/c26-25(27)32-21-5-1-3-18(14-21)22-12-17(11-19-4-2-10-28-24(19)22)15-31-20-8-6-16(7-9-20)13-23(29)30/h1-12,14,25H,13,15H2,(H,29,30)
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n/an/a 32n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human PDE4C


Bioorg Med Chem Lett 20: 5502-5 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50325787
PNG
(8-(3-(difluoromethoxy)phenyl)-6-((4-(methylsulfony...)
Show SMILES CS(=O)(=O)c1ccc(OCc2cc(-c3cccc(OC(F)F)c3)c3ncccc3c2)cc1
Show InChI InChI=1S/C24H19F2NO4S/c1-32(28,29)21-9-7-19(8-10-21)30-15-16-12-18-5-3-11-27-23(18)22(13-16)17-4-2-6-20(14-17)31-24(25)26/h2-14,24H,15H2,1H3
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n/an/a 36n/an/an/an/an/an/a



Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human PDE4C


Bioorg Med Chem Lett 20: 5502-5 (2010)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50202531
PNG
(9-cyclopentyl-5,6-dihydro-7-ethyl-3-(tert-butyl)-9...)
Show SMILES CCc1nn(C2CCCC2)c-2c1CCn1c-2nnc1C(C)(C)C
Show InChI InChI=1S/C18H27N5/c1-5-14-13-10-11-22-16(19-20-17(22)18(2,3)4)15(13)23(21-14)12-8-6-7-9-12/h12H,5-11H2,1-4H3
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n/an/a 40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4C


J Med Chem 50: 344-9 (2007)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183789
PNG
(CHEMBL204522 | N-(4-(methylsulfonyl)phenyl)-N-(1-(...)
Show SMILES CC(N(C(C)=O)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C30H32N2O5S2/c1-20(32(21(2)33)26-12-14-27(15-13-26)38(5,34)35)22-9-7-10-23(17-22)28-19-25(30(3,4)39(6,36)37)18-24-11-8-16-31-29(24)28/h7-20H,1-6H3
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n/an/a 41n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
Phosphodiesterase 4 and 5 (PDE4 and PDE5)


(Homo sapiens)
BDBM50183799
PNG
(4-fluoro-N-(4-(methylsulfonyl)phenyl)-N-(1-(3-(6-(...)
Show SMILES CC(N(C(=O)c1ccc(F)cc1)c1ccc(cc1)S(C)(=O)=O)c1cccc(c1)-c1cc(cc2cccnc12)C(C)(C)S(C)(=O)=O
Show InChI InChI=1S/C35H33FN2O5S2/c1-23(38(34(39)24-11-13-29(36)14-12-24)30-15-17-31(18-16-30)44(4,40)41)25-8-6-9-26(20-25)32-22-28(35(2,3)45(5,42)43)21-27-10-7-19-37-33(27)32/h6-23H,1-5H3
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n/an/a 51n/an/an/an/an/an/a



Merck Frosst Center for Therapeutic Research

Curated by ChEMBL


Assay Description
Inhibition of human GST-PDE4C


Bioorg Med Chem Lett 16: 2608-12 (2006)

More data for this
Ligand-Target Pair
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