BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 6A' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300972
PNG
(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCc2cnccn2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C23H25N7O3/c1-3-9-33-10-8-30-20-11-18(16-4-5-21(32-2)27-12-16)26-15-19(20)29-22(23(30)31)28-14-17-13-24-6-7-25-17/h4-7,11-13,15H,3,8-10,14H2,1-2H3,(H,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 4.70n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300964
PNG
(CHEMBL584270 | rac-7-(6-methoxypyridin-3-yl)-1-(2-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC2CCCO2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C23H29N5O4/c1-3-9-31-11-8-28-20-12-18(16-6-7-21(30-2)25-13-16)24-15-19(20)27-22(23(28)29)26-14-17-5-4-10-32-17/h6-7,12-13,15,17H,3-5,8-11,14H2,1-2H3,(H,26,27)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 8.60n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300962
PNG
(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCOCC)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H29N5O4/c1-4-10-31-12-9-27-19-13-17(16-6-7-20(29-3)25-14-16)24-15-18(19)26-21(22(27)28)23-8-11-30-5-2/h6-7,13-15H,4-5,8-12H2,1-3H3,(H,23,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300953
PNG
(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-21-13-19(16-4-9-22(32-2)26-14-16)25-15-20(21)28-23(24(29)31)27-17-5-7-18(30)8-6-17/h4,9,13-15,17-18,30H,3,5-8,10-12H2,1-2H3,(H,27,28)/t17-,18-
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.80n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300970
PNG
(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCc2ccccn2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H26N6O3/c1-3-11-33-12-10-30-21-13-19(17-7-8-22(32-2)27-14-17)26-16-20(21)29-23(24(30)31)28-15-18-6-4-5-9-25-18/h4-9,13-14,16H,3,10-12,15H2,1-2H3,(H,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50296256
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-21-15-19(18-4-5-22(32-2)27-16-18)26-17-20(21)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,28)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300987
PNG
(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-3-10-30-11-8-26-18-12-16(15-5-6-19(29-2)24-13-15)23-14-17(18)25-20(21(26)28)22-7-4-9-27/h5-6,12-14,27H,3-4,7-11H2,1-2H3,(H,22,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300989
PNG
((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NC[C@H](C)O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-12-15)22-13-17(18)25-20(21(26)28)24-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,24,25)/t14-/m0/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300976
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)NC)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H26N6O4/c1-4-8-31-9-7-27-17-10-15(14-5-6-19(30-3)24-11-14)23-12-16(17)26-20(21(27)29)25-13-18(28)22-2/h5-6,10-12H,4,7-9,13H2,1-3H3,(H,22,28)(H,25,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300983
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCN(C)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C25H33N7O4/c1-4-12-36-13-11-32-21-14-19(18-5-6-22(35-3)27-15-18)26-16-20(21)29-24(25(32)34)28-17-23(33)31-9-7-30(2)8-10-31/h5-6,14-16H,4,7-13,17H2,1-3H3,(H,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300952
PNG
(3-(trans-4-hydroxycyclohexylamino)-7-(6-methoxypyr...)
Show SMILES CCCOCCn1c2cc(cnc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-20-13-17(16-4-9-21(32-2)25-14-16)15-26-22(20)28-23(24(29)31)27-18-5-7-19(30)8-6-18/h4,9,13-15,18-19,30H,3,5-8,10-12H2,1-2H3,(H,26,27,28)/t18-,19-
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300991
PNG
((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NC[C@@H](C)O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-12-15)22-13-17(18)25-20(21(26)28)24-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,24,25)/t14-/m1/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300980
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H30N6O5/c1-3-9-34-12-8-30-20-13-18(17-4-5-21(33-2)26-14-17)25-15-19(20)28-23(24(30)32)27-16-22(31)29-6-10-35-11-7-29/h4-5,13-15H,3,6-12,16H2,1-2H3,(H,27,28)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300950
PNG
((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@@H](C)CO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-11-15)22-12-17(18)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,24,25)/t14-/m0/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300948
PNG
((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H](C)CO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-11-15)22-12-17(18)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,24,25)/t14-/m1/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300951
PNG
((R)-3-(1-hydroxybutan-2-ylamino)-7-(6-methoxypyrid...)
Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H](CC)CO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H29N5O4/c1-4-9-31-10-8-27-19-11-17(15-6-7-20(30-3)24-12-15)23-13-18(19)26-21(22(27)29)25-16(5-2)14-28/h6-7,11-13,16,28H,4-5,8-10,14H2,1-3H3,(H,25,26)/t16-/m1/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300971
PNG
(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCc2cnccn2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C23H25N7O3/c1-3-9-33-10-8-30-19-11-17(16-4-5-20(32-2)26-12-16)13-27-21(19)29-22(23(30)31)28-15-18-14-24-6-7-25-18/h4-7,11-14H,3,8-10,15H2,1-2H3,(H,27,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300978
PNG
(3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCC(O)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C25H32N6O5/c1-3-11-36-12-10-31-21-13-19(17-4-5-22(35-2)27-14-17)26-15-20(21)29-24(25(31)34)28-16-23(33)30-8-6-18(32)7-9-30/h4-5,13-15,18,32H,3,6-12,16H2,1-2H3,(H,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300960
PNG
(3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H25N5O4/c1-3-9-29-10-7-25-17-11-15(14-4-5-18(28-2)23-12-14)22-13-16(17)24-19(20(25)27)21-6-8-26/h4-5,11-13,26H,3,6-10H2,1-2H3,(H,21,24)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300963
PNG
(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-((t...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N5O4/c1-3-9-32-12-8-29-20-13-19(18-4-5-21(31-2)25-15-18)16-27-22(20)28-23(24(29)30)26-14-17-6-10-33-11-7-17/h4-5,13,15-17H,3,6-12,14H2,1-2H3,(H,26,27,28)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300969
PNG
(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCc2ccccn2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H26N6O3/c1-3-11-33-12-10-30-20-13-18(17-7-8-21(32-2)26-14-17)15-27-22(20)29-23(24(30)31)28-16-19-6-4-5-9-25-19/h4-9,13-15H,3,10-12,16H2,1-2H3,(H,27,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300977
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(pyrrolidin-1...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H30N6O4/c1-3-11-34-12-10-30-20-13-18(17-6-7-21(33-2)26-14-17)25-15-19(20)28-23(24(30)32)27-16-22(31)29-8-4-5-9-29/h6-7,13-15H,3-5,8-12,16H2,1-2H3,(H,27,28)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300966
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(O)=O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H23N5O5/c1-3-7-30-8-6-25-16-9-14(13-4-5-17(29-2)22-10-13)21-11-15(16)24-19(20(25)28)23-12-18(26)27/h4-5,9-11H,3,6-8,12H2,1-2H3,(H,23,24)(H,26,27)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 46n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300990
PNG
((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NC[C@@H](C)O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-12-15)13-24-19(17)25-20(21(26)28)23-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,23,24,25)/t14-/m1/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300988
PNG
((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NC[C@H](C)O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-12-15)13-24-19(17)25-20(21(26)28)23-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,23,24,25)/t14-/m0/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 52n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300985
PNG
(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C26H35N7O4/c1-4-13-37-14-12-33-22-15-20(19-6-7-23(36-3)28-16-19)27-17-21(22)30-25(26(33)35)29-18-24(34)32-10-8-31(5-2)9-11-32/h6-7,15-17H,4-5,8-14,18H2,1-3H3,(H,29,30)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300961
PNG
(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCCOCC)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H29N5O4/c1-4-10-31-12-9-27-18-13-17(16-6-7-19(29-3)24-14-16)15-25-20(18)26-21(22(27)28)23-8-11-30-5-2/h6-7,13-15H,4-5,8-12H2,1-3H3,(H,23,25,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50296257
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-20-15-19(18-4-5-21(32-2)26-16-18)17-27-22(20)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,27,28)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 62n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300947
PNG
((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Show SMILES CCCOCCn1c2cc(cnc2nc(N[C@H](C)CO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-11-15)12-23-19(17)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,23,24,25)/t14-/m1/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 63n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300949
PNG
((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)
Show SMILES CCCOCCn1c2cc(cnc2nc(N[C@@H](C)CO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-11-15)12-23-19(17)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,23,24,25)/t14-/m0/s1
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 68n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300982
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)N2CCN(C)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C25H33N7O4/c1-4-12-36-13-11-32-20-14-19(18-5-6-21(35-3)26-15-18)16-27-23(20)29-24(25(32)34)28-17-22(33)31-9-7-30(2)8-10-31/h5-6,14-16H,4,7-13,17H2,1-3H3,(H,27,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300974
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(N)=O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H24N6O4/c1-3-7-30-8-6-26-16-9-14(13-4-5-18(29-2)23-10-13)22-11-15(16)25-19(20(26)28)24-12-17(21)27/h4-5,9-11H,3,6-8,12H2,1-2H3,(H2,21,27)(H,24,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300968
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N(C)C)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H28N6O4/c1-5-9-32-10-8-28-18-11-16(15-6-7-19(31-4)24-12-15)23-13-17(18)26-21(22(28)30)25-14-20(29)27(2)3/h6-7,11-13H,5,8-10,14H2,1-4H3,(H,25,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 87n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300984
PNG
(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C26H35N7O4/c1-4-13-37-14-12-33-21-15-20(19-6-7-22(36-3)27-16-19)17-28-24(21)30-25(26(33)35)29-18-23(34)32-10-8-31(5-2)9-11-32/h6-7,15-17H,4-5,8-14,18H2,1-3H3,(H,28,29,30)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 99n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300981
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(piperazin-1-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCNCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H31N7O4/c1-3-11-35-12-10-31-20-13-18(17-4-5-21(34-2)27-14-17)26-15-19(20)29-23(24(31)33)28-16-22(32)30-8-6-25-7-9-30/h4-5,13-15,25H,3,6-12,16H2,1-2H3,(H,28,29)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300959
PNG
(3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H25N5O4/c1-3-9-29-10-7-25-16-11-15(14-4-5-17(28-2)22-12-14)13-23-18(16)24-19(20(25)27)21-6-8-26/h4-5,11-13,26H,3,6-10H2,1-2H3,(H,21,23,24)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 114n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300979
PNG
(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)N2CCOCC2)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C24H30N6O5/c1-3-9-34-12-8-30-19-13-18(17-4-5-20(33-2)25-14-17)15-26-22(19)28-23(24(30)32)27-16-21(31)29-6-10-35-11-7-29/h4-5,13-15H,3,6-12,16H2,1-2H3,(H,26,27,28)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 114n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300975
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)NC)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H26N6O4/c1-4-8-31-9-7-27-16-10-15(14-5-6-18(30-3)23-11-14)12-24-19(16)26-20(21(27)29)25-13-17(28)22-2/h5-6,10-12H,4,7-9,13H2,1-3H3,(H,22,28)(H,24,25,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 115n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300986
PNG
(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C21H27N5O4/c1-3-10-30-11-8-26-17-12-16(15-5-6-18(29-2)23-13-15)14-24-19(17)25-20(21(26)28)22-7-4-9-27/h5-6,12-14,27H,3-4,7-11H2,1-2H3,(H,22,24,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 124n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300955
PNG
(3-(2-(dimethylamino)ethylamino)-7-(6-methoxypyridi...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN(C)C)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H30N6O3/c1-5-11-31-12-10-28-19-13-17(16-6-7-20(30-4)25-14-16)24-15-18(19)26-21(22(28)29)23-8-9-27(2)3/h6-7,13-15H,5,8-12H2,1-4H3,(H,23,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 261n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300958
PNG
(3-(2-(2-hydroxyethylamino)ethylamino)-7-(6-methoxy...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCNCCO)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H30N6O4/c1-3-11-32-12-9-28-19-13-17(16-4-5-20(31-2)26-14-16)25-15-18(19)27-21(22(28)30)24-7-6-23-8-10-29/h4-5,13-15,23,29H,3,6-12H2,1-2H3,(H,24,27)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 272n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300973
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(N)=O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H24N6O4/c1-3-7-30-8-6-26-15-9-14(13-4-5-17(29-2)22-10-13)11-23-18(15)25-19(20(26)28)24-12-16(21)27/h4-5,9-11H,3,6-8,12H2,1-2H3,(H2,21,27)(H,23,24,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 398n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300967
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)N(C)C)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H28N6O4/c1-5-9-32-10-8-28-17-11-16(15-6-7-18(31-4)23-12-15)13-24-20(17)26-21(22(28)30)25-14-19(29)27(2)3/h6-7,11-13H,5,8-10,14H2,1-4H3,(H,24,25,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 398n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300965
PNG
(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(O)=O)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H23N5O5/c1-3-7-30-8-6-25-15-9-14(13-4-5-16(29-2)21-10-13)11-22-18(15)24-19(20(25)28)23-12-17(26)27/h4-5,9-11H,3,6-8,12H2,1-2H3,(H,26,27)(H,22,23,24)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 576n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50014718
PNG
(CHEMBL3262027)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2c(nccn12)N1CCOCC1
Show InChI InChI=1S/C19H22N4O4/c1-24-15-10-13(11-16(25-2)17(15)26-3)14-12-21-19-18(20-4-5-23(14)19)22-6-8-27-9-7-22/h4-5,10-12H,6-9H2,1-3H3
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6A (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300957
PNG
(3-(2-aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-...)
Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H26N6O3/c1-3-9-29-10-8-26-17-11-15(14-4-5-18(28-2)24-12-14)23-13-16(17)25-19(20(26)27)22-7-6-21/h4-5,11-13H,3,6-10,21H2,1-2H3,(H,22,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.21E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300954
PNG
(3-(2-(dimethylamino)ethylamino)-7-(6-methoxypyridi...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCCN(C)C)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C22H30N6O3/c1-5-11-31-12-10-28-18-13-17(16-6-7-19(30-4)24-14-16)15-25-20(18)26-21(22(28)29)23-8-9-27(2)3/h6-7,13-15H,5,8-12H2,1-4H3,(H,23,25,26)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.59E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50300956
PNG
(3-(2-aminoethylamino)-7-(6-methoxypyridin-3-yl)-1-...)
Show SMILES CCCOCCn1c2cc(cnc2nc(NCCN)c1=O)-c1ccc(OC)nc1
Show InChI InChI=1S/C20H26N6O3/c1-3-9-29-10-8-26-16-11-15(14-4-5-17(28-2)23-12-14)13-24-18(16)25-19(20(26)27)22-7-6-21/h4-5,11-13H,3,6-10,21H2,1-2H3,(H,22,24,25)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>2.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6


Citation and Details
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50014817
PNG
(CHEMBL3262029)
Show SMILES COCCn1cc(cn1)-c1cnc2c(nccn12)N1CCOCC1
Show InChI InChI=1S/C16H20N6O2/c1-23-7-6-21-12-13(10-19-21)14-11-18-16-15(17-2-3-22(14)16)20-4-8-24-9-5-20/h2-3,10-12H,4-9H2,1H3
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a<1.00E+4n/an/an/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6A (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair