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Compile Data Set for Download or QSAR

Found 564 hits Enz. Inhib. hit(s) with Target = 'Phospholipase A2, membrane associated' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055371
PNG
((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H22N2O5/c1-16-23(25(31)26(27)32)24-20(12-7-13-21(24)33-15-22(29)30)28(16)14-18-10-5-6-11-19(18)17-8-3-2-4-9-17/h2-13H,14-15H2,1H3,(H2,27,32)(H,29,30)
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n/an/a 3n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161301
PNG
(2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzy...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3CCCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C30H29N3O6S/c1-19-26(29(35)30(31)36)27-24(39-18-25(34)32-40(37,38)22-13-6-3-7-14-22)16-21-12-8-9-15-23(21)28(27)33(19)17-20-10-4-2-5-11-20/h2-7,10-11,13-14,16H,8-9,12,15,17-18H2,1H3,(H2,31,36)(H,32,34)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055374
PNG
(CHEMBL436456 | [3-Aminooxalyl-1-(2-benzyl-benzyl)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C28H26N2O5/c1-2-21-26(27(33)28(29)34)25-22(13-8-14-23(25)35-17-24(31)32)30(21)16-20-12-7-6-11-19(20)15-18-9-4-3-5-10-18/h3-14H,2,15-17H2,1H3,(H2,29,34)(H,31,32)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161305
PNG
((3-Aminooxalyl-1-cyclohexylmethyl-2-methyl-2,3-dih...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3ccccc3c2n1CC1CCCCC1
Show InChI InChI=1S/C24H26N2O5/c1-14-20(23(29)24(25)30)21-18(31-13-19(27)28)11-16-9-5-6-10-17(16)22(21)26(14)12-15-7-3-2-4-8-15/h5-6,9-11,15H,2-4,7-8,12-13H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055374
PNG
(CHEMBL436456 | [3-Aminooxalyl-1-(2-benzyl-benzyl)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C28H26N2O5/c1-2-21-26(27(33)28(29)34)25-22(13-8-14-23(25)35-17-24(31)32)30(21)16-20-12-7-6-11-19(20)15-18-9-4-3-5-10-18/h3-14H,2,15-17H2,1H3,(H2,29,34)(H,31,32)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055387
PNG
((R)-2-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-...)
Show SMILES C[C@@H](Oc1cccc2n(Cc3ccccc3)c(C)c(C(=O)C(N)=O)c12)C(O)=O
Show InChI InChI=1S/C21H20N2O5/c1-12-17(19(24)20(22)25)18-15(23(12)11-14-7-4-3-5-8-14)9-6-10-16(18)28-13(2)21(26)27/h3-10,13H,11H2,1-2H3,(H2,22,25)(H,26,27)/t13-/m1/s1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161293
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydr...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C23H22N2O5/c1-13-19(22(28)23(24)29)20-17(30-12-18(26)27)10-15-8-5-9-16(15)21(20)25(13)11-14-6-3-2-4-7-14/h2-4,6-7,10H,5,8-9,11-12H2,1H3,(H2,24,29)(H,26,27)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055371
PNG
((3-aminooxalyl-1-biphenyl-2-ylmethyl-2-methyl-1H-i...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H22N2O5/c1-16-23(25(31)26(27)32)24-20(12-7-13-21(24)33-15-22(29)30)28(16)14-18-10-5-6-11-19(18)17-8-3-2-4-9-17/h2-13H,14-15H2,1H3,(H2,27,32)(H,29,30)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055401
PNG
((3-Aminooxalyl-1-biphenyl-2-ylmethyl-2-ethyl-1H-in...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H24N2O5/c1-2-20-25(26(32)27(28)33)24-21(13-8-14-22(24)34-16-23(30)31)29(20)15-18-11-6-7-12-19(18)17-9-4-3-5-10-17/h3-14H,2,15-16H2,1H3,(H2,28,33)(H,30,31)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055378
PNG
(CHEMBL345488 | [3-Aminooxalyl-1-(2,6-dichloro-benz...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H16Cl2N2O5/c1-10-17(19(27)20(23)28)18-14(6-3-7-15(18)29-9-16(25)26)24(10)8-11-12(21)4-2-5-13(11)22/h2-7H,8-9H2,1H3,(H2,23,28)(H,25,26)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055401
PNG
((3-Aminooxalyl-1-biphenyl-2-ylmethyl-2-ethyl-1H-in...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H24N2O5/c1-2-20-25(26(32)27(28)33)24-21(13-8-14-22(24)34-16-23(30)31)29(20)15-18-11-6-7-12-19(18)17-9-4-3-5-10-17/h3-14H,2,15-16H2,1H3,(H2,28,33)(H,30,31)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055379
PNG
((3-Aminooxalyl-1-biphenyl-2-ylmethyl-2-cyclopropyl...)
Show SMILES NC(=O)C(=O)c1c(C2CC2)n(Cc2ccccc2-c2ccccc2)c2cccc(OCC(O)=O)c12
Show InChI InChI=1S/C28H24N2O5/c29-28(34)27(33)25-24-21(11-6-12-22(24)35-16-23(31)32)30(26(25)18-13-14-18)15-19-9-4-5-10-20(19)17-7-2-1-3-8-17/h1-12,18H,13-16H2,(H2,29,34)(H,31,32)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161299
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1,6,7,8-tetrahydro...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H24N2O5/c1-2-17-20(23(29)24(25)30)21-18(31-13-19(27)28)11-15-9-6-10-16(15)22(21)26(17)12-14-7-4-3-5-8-14/h3-5,7-8,11H,2,6,9-10,12-13H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161301
PNG
(2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzy...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3CCCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C30H29N3O6S/c1-19-26(29(35)30(31)36)27-24(39-18-25(34)32-40(37,38)22-13-6-3-7-14-22)16-21-12-8-9-15-23(21)28(27)33(19)17-20-10-4-2-5-11-20/h2-7,10-11,13-14,16H,8-9,12,15,17-18H2,1H3,(H2,31,36)(H,32,34)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055367
PNG
(CHEMBL345986 | [3-Aminooxalyl-1-(3-chloro-benzyl)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc(Cl)c1
Show InChI InChI=1S/C21H19ClN2O5/c1-2-14-19(20(27)21(23)28)18-15(7-4-8-16(18)29-11-17(25)26)24(14)10-12-5-3-6-13(22)9-12/h3-9H,2,10-11H2,1H3,(H2,23,28)(H,25,26)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055370
PNG
((3-Aminooxalyl-2-methyl-1-octyl-1H-indol-4-yloxy)-...)
Show SMILES CCCCCCCCn1c(C)c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc12
Show InChI InChI=1S/C21H28N2O5/c1-3-4-5-6-7-8-12-23-14(2)18(20(26)21(22)27)19-15(23)10-9-11-16(19)28-13-17(24)25/h9-11H,3-8,12-13H2,1-2H3,(H2,22,27)(H,24,25)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055380
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-6-methyl-1H-indol-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(CC(O)=O)cc(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c1-3-16-20(21(27)22(23)28)19-15(11-18(25)26)9-13(2)10-17(19)24(16)12-14-7-5-4-6-8-14/h4-10H,3,11-12H2,1-2H3,(H2,23,28)(H,25,26)
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n/an/a 8n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055384
PNG
((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H22N2O5/c1-16-23(25(31)26(27)32)24-20(11-6-12-21(24)33-15-22(29)30)28(16)14-17-7-5-10-19(13-17)18-8-3-2-4-9-18/h2-13H,14-15H2,1H3,(H2,27,32)(H,29,30)
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n/an/a 8n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055380
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-6-methyl-1H-indol-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(CC(O)=O)cc(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c1-3-16-20(21(27)22(23)28)19-15(11-18(25)26)9-13(2)10-17(19)24(16)12-14-7-5-4-6-8-14/h4-10H,3,11-12H2,1-2H3,(H2,23,28)(H,25,26)
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n/an/a 8n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055385
PNG
(2-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-ylox...)
Show SMILES CC(Oc1cccc2n(Cc3ccccc3)c(C)c(C(=O)C(N)=O)c12)C(O)=O
Show InChI InChI=1S/C21H20N2O5/c1-12-17(19(24)20(22)25)18-15(23(12)11-14-7-4-3-5-8-14)9-6-10-16(18)28-13(2)21(26)27/h3-10,13H,11H2,1-2H3,(H2,22,25)(H,26,27)
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n/an/a 9n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055394
PNG
(CHEMBL148795 | [3-Aminooxalyl-1-(2-chloro-benzyl)-...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1Cl
Show InChI InChI=1S/C20H17ClN2O5/c1-11-17(19(26)20(22)27)18-14(7-4-8-15(18)28-10-16(24)25)23(11)9-12-5-2-3-6-13(12)21/h2-8H,9-10H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 9n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055368
PNG
((3-Aminooxalyl-2-methyl-1-naphthalen-1-ylmethyl-1H...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc2ccccc12
Show InChI InChI=1S/C24H20N2O5/c1-14-21(23(29)24(25)30)22-18(10-5-11-19(22)31-13-20(27)28)26(14)12-16-8-4-7-15-6-2-3-9-17(15)16/h2-11H,12-13H2,1H3,(H2,25,30)(H,27,28)
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n/an/a 9n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 9n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055384
PNG
((3-Aminooxalyl-1-biphenyl-3-ylmethyl-2-methyl-1H-i...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H22N2O5/c1-16-23(25(31)26(27)32)24-20(11-6-12-21(24)33-15-22(29)30)28(16)14-17-7-5-10-19(13-17)18-8-3-2-4-9-18/h2-13H,14-15H2,1H3,(H2,27,32)(H,29,30)
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n/an/a 9n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161308
PNG
(CHEMBL179118 | [3-Aminooxalyl-1-(2-fluoro-benzyl)-...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1F
Show InChI InChI=1S/C23H21FN2O5/c1-12-19(22(29)23(25)30)20-17(31-11-18(27)28)9-13-6-4-7-15(13)21(20)26(12)10-14-5-2-3-8-16(14)24/h2-3,5,8-9H,4,6-7,10-11H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055385
PNG
(2-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-ylox...)
Show SMILES CC(Oc1cccc2n(Cc3ccccc3)c(C)c(C(=O)C(N)=O)c12)C(O)=O
Show InChI InChI=1S/C21H20N2O5/c1-12-17(19(24)20(22)25)18-15(23(12)11-14-7-4-3-5-8-14)9-6-10-16(18)28-13(2)21(26)27/h3-10,13H,11H2,1-2H3,(H2,22,25)(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161293
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydr...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C23H22N2O5/c1-13-19(22(28)23(24)29)20-17(30-12-18(26)27)10-15-8-5-9-16(15)21(20)25(13)11-14-6-3-2-4-7-14/h2-4,6-7,10H,5,8-9,11-12H2,1H3,(H2,24,29)(H,26,27)
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n/an/a 10n/an/an/an/an/an/a



The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161294
PNG
(CHEMBL179966 | [3-Aminooxalyl-1-(3-fluoro-benzyl)-...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1cccc(F)c1
Show InChI InChI=1S/C23H21FN2O5/c1-12-19(22(29)23(25)30)20-17(31-11-18(27)28)9-14-5-3-7-16(14)21(20)26(12)10-13-4-2-6-15(24)8-13/h2,4,6,8-9H,3,5,7,10-11H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055305
PNG
(CHEMBL423762 | Sodium; (1-biphenyl-2-ylmethyl-3-ca...)
Show SMILES Cc1c(CC(N)=O)c2c(OCC([O-])=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H24N2O4/c1-17-21(14-24(27)29)26-22(12-7-13-23(26)32-16-25(30)31)28(17)15-19-10-5-6-11-20(19)18-8-3-2-4-9-18/h2-13H,14-16H2,1H3,(H2,27,29)(H,30,31)/p-1
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n/an/a 10n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161298
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-2,3,6,7,8,9-hexah...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H24N2O5/c1-14-20(23(29)24(25)30)21-18(31-13-19(27)28)11-16-9-5-6-10-17(16)22(21)26(14)12-15-7-3-2-4-8-15/h2-4,7-8,11H,5-6,9-10,12-13H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055387
PNG
((R)-2-(3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-...)
Show SMILES C[C@@H](Oc1cccc2n(Cc3ccccc3)c(C)c(C(=O)C(N)=O)c12)C(O)=O
Show InChI InChI=1S/C21H20N2O5/c1-12-17(19(24)20(22)25)18-15(23(12)11-14-7-4-3-5-8-14)9-6-10-16(18)28-13(2)21(26)27/h3-10,13H,11H2,1-2H3,(H2,22,25)(H,26,27)/t13-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055391
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-ind...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC(C)C(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O5/c1-3-15-19(20(25)21(23)26)18-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(18)29-13(2)22(27)28/h4-11,13H,3,12H2,1-2H3,(H2,23,26)(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161305
PNG
((3-Aminooxalyl-1-cyclohexylmethyl-2-methyl-2,3-dih...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3ccccc3c2n1CC1CCCCC1
Show InChI InChI=1S/C24H26N2O5/c1-14-20(23(29)24(25)30)21-18(31-13-19(27)28)11-16-9-5-6-10-17(16)22(21)26(14)12-15-7-3-2-4-8-15/h5-6,9-11,15H,2-4,7-8,12-13H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161296
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-2,3,6,7,8,9-hexahy...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C25H26N2O5/c1-2-18-21(24(30)25(26)31)22-19(32-14-20(28)29)12-16-10-6-7-11-17(16)23(22)27(18)13-15-8-4-3-5-9-15/h3-5,8-9,12H,2,6-7,10-11,13-14H2,1H3,(H2,26,31)(H,28,29)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055383
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-1H-indol-4-yloxy)...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C20H18N2O5/c1-12-17(19(25)20(21)26)18-14(8-5-9-15(18)27-11-16(23)24)22(12)10-13-6-3-2-4-7-13/h2-9H,10-11H2,1H3,(H2,21,26)(H,23,24)
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161299
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1,6,7,8-tetrahydro...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H24N2O5/c1-2-17-20(23(29)24(25)30)21-18(31-13-19(27)28)11-15-9-6-10-16(15)22(21)26(17)12-14-7-4-3-5-8-14/h3-5,7-8,11H,2,6,9-10,12-13H2,1H3,(H2,25,30)(H,27,28)
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The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055391
PNG
(2-(3-(2-amino-2-oxoacetyl)-1-benzyl-2-ethyl-1H-ind...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC(C)C(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C22H22N2O5/c1-3-15-19(20(25)21(23)26)18-16(24(15)12-14-8-5-4-6-9-14)10-7-11-17(18)29-13(2)22(27)28/h4-11,13H,3,12H2,1-2H3,(H2,23,26)(H,27,28)
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n/an/a 13n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055366
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-1H-indol-4-yloxy)-...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Show InChI InChI=1S/C21H20N2O5/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25)
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n/an/a 13n/an/an/an/an/an/a



The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50263003
PNG
(2-(2-ethyl-3-(o-phenylbenzyl)-8-(2-oxopropoxy)indo...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OC)cc3ccccc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H22N2O3/c1-3-18-20(23(27)24(25)28)21-19(29-2)13-16-11-7-8-12-17(16)22(21)26(18)14-15-9-5-4-6-10-15/h4-13H,3,14H2,1-2H3,(H2,25,28)
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n/an/a 14n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of human group2A phospholipase A2 fluorimetric assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055305
PNG
(CHEMBL423762 | Sodium; (1-biphenyl-2-ylmethyl-3-ca...)
Show SMILES Cc1c(CC(N)=O)c2c(OCC([O-])=O)cccc2n1Cc1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H24N2O4/c1-17-21(14-24(27)29)26-22(12-7-13-23(26)32-16-25(30)31)28(17)15-19-10-5-6-11-20(19)18-8-3-2-4-9-18/h2-13H,14-16H2,1H3,(H2,27,29)(H,30,31)/p-1
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n/an/a 14n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against porcine pancreatic Phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50242184
PNG
(SCALARADIAL | Scalaradial)
Show SMILES CC(=O)O[C@H]1C[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3CC[C@@]2(C)[C@@H]2CC=C(C=O)[C@H](C=O)[C@@]12C
Show InChI InChI=1S/C27H40O4/c1-17(30)31-23-14-22-25(4)12-7-11-24(2,3)20(25)10-13-26(22,5)21-9-8-18(15-28)19(16-29)27(21,23)6/h8,15-16,19-23H,7,9-14H2,1-6H3/t19-,20-,21-,22+,23-,25-,26-,27+/m0/s1
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n/an/a 15n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human synovial fluid phospholipase A2 (HSF-PLA2) by monitoring hydrolysis of [3H]-arachidonic acid labeled E. co...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055315
PNG
(CHEMBL359304 | [3-(1-Benzyl-3-carbamoylmethyl-2-et...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)c(C)cc2n1Cc1ccccc1
Show InChI InChI=1S/C23H29N2O5P/c1-3-20-19(14-23(24)26)18-13-22(30-10-7-11-31(27,28)29)16(2)12-21(18)25(20)15-17-8-5-4-6-9-17/h4-6,8-9,12-13H,3,7,10-11,14-15H2,1-2H3,(H2,24,26)(H2,27,28,29)
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n/an/a 15n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055396
PNG
(CHEMBL423219 | [3-Aminooxalyl-2-methyl-1-(2-methyl...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1C
Show InChI InChI=1S/C21H20N2O5/c1-12-6-3-4-7-14(12)10-23-13(2)18(20(26)21(22)27)19-15(23)8-5-9-16(19)28-11-17(24)25/h3-9H,10-11H2,1-2H3,(H2,22,27)(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055355
PNG
(CHEMBL148601 | {3-[3-Carbamoylmethyl-1-(3-chloro-b...)
Show SMILES CCc1c(CC(N)=O)c2cc(OCCCP(O)(O)=O)ccc2n1Cc1cccc(Cl)c1
Show InChI InChI=1S/C22H26ClN2O5P/c1-2-20-19(13-22(24)26)18-12-17(30-9-4-10-31(27,28)29)7-8-21(18)25(20)14-15-5-3-6-16(23)11-15/h3,5-8,11-12H,2,4,9-10,13-14H2,1H3,(H2,24,26)(H2,27,28,29)
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n/an/a 16n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161298
PNG
((3-Aminooxalyl-1-benzyl-2-methyl-2,3,6,7,8,9-hexah...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C24H24N2O5/c1-14-20(23(29)24(25)30)21-18(31-13-19(27)28)11-16-9-5-6-10-17(16)22(21)26(14)12-15-7-3-2-4-8-15/h2-4,7-8,11H,5-6,9-10,12-13H2,1H3,(H2,25,30)(H,27,28)
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n/an/a 16n/an/an/an/an/an/a



The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055368
PNG
((3-Aminooxalyl-2-methyl-1-naphthalen-1-ylmethyl-1H...)
Show SMILES Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1cccc2ccccc12
Show InChI InChI=1S/C24H20N2O5/c1-14-21(23(29)24(25)30)22-18(10-5-11-19(22)31-13-20(27)28)26(14)12-16-8-4-7-15-6-2-3-9-17(15)16/h2-11H,12-13H2,1H3,(H2,25,30)(H,27,28)
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n/an/a 17n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50161296
PNG
((3-Aminooxalyl-1-benzyl-2-ethyl-2,3,6,7,8,9-hexahy...)
Show SMILES CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCCc3c2n1Cc1ccccc1
Show InChI InChI=1S/C25H26N2O5/c1-2-18-21(24(30)25(26)31)22-19(32-14-20(28)29)12-16-10-6-7-11-17(16)23(22)27(18)13-15-8-4-3-5-9-15/h3-5,8-9,12H,2,6-7,10-11,13-14H2,1H3,(H2,26,31)(H,28,29)
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n/an/a 17n/an/an/an/an/an/a



The Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against human nonpancreatic secretory phospholipase A2


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase A2, membrane associated


(Homo sapiens (human))
BDBM50055370
PNG
((3-Aminooxalyl-2-methyl-1-octyl-1H-indol-4-yloxy)-...)
Show SMILES CCCCCCCCn1c(C)c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc12
Show InChI InChI=1S/C21H28N2O5/c1-3-4-5-6-7-8-12-23-14(2)18(20(26)21(22)27)19-15(23)10-9-11-16(19)28-13-17(24)25/h9-11H,3-8,12-13H2,1-2H3,(H2,22,27)(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human nonpancreatic secretory Phospholipase A2 through DOC/PC assay


Citation and Details
More data for this
Ligand-Target Pair
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