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Compile Data Set for Download or QSAR

Found 14 hits Enz. Inhib. hit(s) with Target = 'Phospholipase C-gamma-1' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50037076
PNG
(CHEMBL3355737)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(cc(Nc2cc([nH]n2)C2CCCC2)n1)S(=O)(=O)c1ccccc1
Show InChI InChI=1/C25H31N5O3S/c31-19-12-10-18(11-13-19)26-23-14-21(34(32,33)20-8-2-1-3-9-20)15-24(27-23)28-25-16-22(29-30-25)17-6-4-5-7-17/h1-3,8-9,14-19,31H,4-7,10-13H2,(H3,26,27,28,29,30)/t18-,19-
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n/an/a 180n/an/an/an/an/an/a



Evotec UK Ltd

Curated by ChEMBL


Assay Description
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50037063
PNG
(CHEMBL3355726)
Show SMILES Cc1cc(Nc2cc(cc(N[C@H]3CC[C@H](O)CC3)n2)S(=O)(=O)c2ccccc2)n[nH]1
Show InChI InChI=1/C21H25N5O3S/c1-14-11-21(26-25-14)24-20-13-18(30(28,29)17-5-3-2-4-6-17)12-19(23-20)22-15-7-9-16(27)10-8-15/h2-6,11-13,15-16,27H,7-10H2,1H3,(H3,22,23,24,25,26)/t15-,16-
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n/an/a 540n/an/an/an/an/an/a



Evotec UK Ltd

Curated by ChEMBL


Assay Description
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50037060
PNG
(CHEMBL3355311)
Show SMILES Cc1cc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)n[nH]1
Show InChI InChI=1/C21H26N6O/c1-14-11-20(27-26-14)24-19-13-17(12-15-5-3-2-4-6-15)23-21(25-19)22-16-7-9-18(28)10-8-16/h2-6,11,13,16,18,28H,7-10,12H2,1H3,(H3,22,23,24,25,26,27)/t16-,18-
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n/an/a 2.60E+3n/an/an/an/an/an/a



Evotec UK Ltd

Curated by ChEMBL


Assay Description
Inhibition of PLC gamma-1 phosphorylation in human Jurkat T cells after 30 mins


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269158
PNG
(3-beta-hydroxy-27-p-(E)-coumaroyloxyurs-12-en-28-o...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(CC(=O)C=Cc4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-24-15-20-38(34(43)44)21-22-39(23-28(41)12-9-26-7-10-27(40)11-8-26)29(33(38)25(24)2)13-14-31-36(5)18-17-32(42)35(3,4)30(36)16-19-37(31,39)6/h7-13,24-25,30-33,40,42H,14-23H2,1-6H3,(H,43,44)/t24-,25+,30+,31-,32+,33+,36+,37-,38+,39+/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269154
PNG
(3-beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic ...)
Show SMILES COc1cc(C=CC(=O)C[C@@]23CC[C@]4(CC[C@@H](C)[C@H](C)[C@H]4C2=CC[C@@H]2[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C40H56O6/c1-24-14-19-39(35(44)45)20-21-40(23-27(41)10-8-26-9-12-29(42)30(22-26)46-7)28(34(39)25(24)2)11-13-32-37(5)17-16-33(43)36(3,4)31(37)15-18-38(32,40)6/h8-12,22,24-25,31-34,42-43H,13-21,23H2,1-7H3,(H,44,45)/t24-,25+,31+,32-,33+,34+,37+,38-,39+,40+/m1/s1
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n/an/a 1.43E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269156
PNG
(3-beta-hydroxy-27-p-(E)-coumaroyloxyolean-12-en-28...)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(CC(=O)C=Cc4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-20-38(33(43)44)21-22-39(23-27(41)12-9-25-7-10-26(40)11-8-25)28(29(38)24-34)13-14-31-36(5)17-16-32(42)35(3,4)30(36)15-18-37(31,39)6/h7-13,29-32,40,42H,14-24H2,1-6H3,(H,43,44)/t29-,30-,31+,32-,36-,37+,38-,39-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269158
PNG
(3-beta-hydroxy-27-p-(E)-coumaroyloxyurs-12-en-28-o...)
Show SMILES C[C@@H]1CC[C@@]2(CC[C@]3(CC(=O)C=Cc4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-24-15-20-38(34(43)44)21-22-39(23-28(41)12-9-26-7-10-27(40)11-8-26)29(33(38)25(24)2)13-14-31-36(5)18-17-32(42)35(3,4)30(36)16-19-37(31,39)6/h7-13,24-25,30-33,40,42H,14-23H2,1-6H3,(H,43,44)/t24-,25+,30+,31-,32+,33+,36+,37-,38+,39+/m1/s1
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n/an/a 2.45E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269156
PNG
(3-beta-hydroxy-27-p-(E)-coumaroyloxyolean-12-en-28...)
Show SMILES CC1(C)CC[C@@]2(CC[C@]3(CC(=O)C=Cc4ccc(O)cc4)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O
Show InChI InChI=1S/C39H54O5/c1-34(2)19-20-38(33(43)44)21-22-39(23-27(41)12-9-25-7-10-26(40)11-8-25)28(29(38)24-34)13-14-31-36(5)17-16-32(42)35(3,4)30(36)15-18-37(31,39)6/h7-13,29-32,40,42H,14-24H2,1-6H3,(H,43,44)/t29-,30-,31+,32-,36-,37+,38-,39-/m0/s1
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n/an/a 2.77E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50129952
PNG
(2-(3-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-c...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(O)cc4=O)o3)c2o1
Show InChI InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-33,35-37H
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n/an/a 2.90E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50077775
PNG
((4aS,6aR,6bR,10S,12aR,14bS)-10-Hydroxy-6a-[(E)-3-(...)
Show SMILES COc1cc(\C=C\C(=O)OC[C@@]23CC[C@]4(CCC(C)(C)C[C@H]4C2=CCC2[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C40H56O7/c1-35(2)18-19-39(34(44)45)20-21-40(24-47-33(43)13-9-25-8-11-28(41)29(22-25)46-7)26(27(39)23-35)10-12-31-37(5)16-15-32(42)36(3,4)30(37)14-17-38(31,40)6/h8-11,13,22,27,30-32,41-42H,12,14-21,23-24H2,1-7H3,(H,44,45)/b13-9+/t27-,30?,31?,32-,37-,38+,39-,40-/m0/s1
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n/an/a 3.57E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against phospholipase C-gamma1


Bioorg Med Chem Lett 9: 1429-32 (1999)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269160
PNG
((4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS,E)-10-hydroxy-...)
Show SMILES COc1cc(C=CC(=O)C[C@@]23CC[C@]4(CCC(C)(C)C[C@H]4C2=CC[C@@H]2[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C40H56O6/c1-35(2)18-19-39(34(44)45)20-21-40(23-26(41)10-8-25-9-12-29(42)30(22-25)46-7)27(28(39)24-35)11-13-32-37(5)16-15-33(43)36(3,4)31(37)14-17-38(32,40)6/h8-12,22,28,31-33,42-43H,13-21,23-24H2,1-7H3,(H,44,45)/t28-,31-,32+,33-,37-,38+,39-,40-/m0/s1
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n/an/a 3.57E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269154
PNG
(3-beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic ...)
Show SMILES COc1cc(C=CC(=O)C[C@@]23CC[C@]4(CC[C@@H](C)[C@H](C)[C@H]4C2=CC[C@@H]2[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C40H56O6/c1-24-14-19-39(35(44)45)20-21-40(23-27(41)10-8-26-9-12-29(42)30(22-26)46-7)28(34(39)25(24)2)11-13-32-37(5)17-16-33(43)36(3,4)31(37)15-18-38(32,40)6/h8-12,22,24-25,31-34,42-43H,13-21,23H2,1-7H3,(H,44,45)/t24-,25+,31+,32-,33+,34+,37+,38-,39+,40+/m1/s1
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n/an/a 4.41E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50077774
PNG
((4aS,6aR,6bR,10S,12aR,14bS)-10-Hydroxy-6a-[(Z)-3-(...)
Show SMILES COc1cc(\C=C/C(=O)OC[C@@]23CC[C@]4(CCC(C)(C)C[C@H]4C2=CCC2[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C40H56O7/c1-35(2)18-19-39(34(44)45)20-21-40(24-47-33(43)13-9-25-8-11-28(41)29(22-25)46-7)26(27(39)23-35)10-12-31-37(5)16-15-32(42)36(3,4)30(37)14-17-38(31,40)6/h8-11,13,22,27,30-32,41-42H,12,14-21,23-24H2,1-7H3,(H,44,45)/b13-9-/t27-,30?,31?,32-,37-,38+,39-,40-/m0/s1
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n/an/a 4.46E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was evaluated against phospholipase C-gamma1


Bioorg Med Chem Lett 9: 1429-32 (1999)

More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM50269161
PNG
((2R,4aS,6aR,6bR,8aR,10S,12aR,12bR,14bS,Z)-10-hydro...)
Show SMILES COc1cc(C=CC(=O)C[C@@]23CC[C@]4(CC[C@@H](C)C[C@H]4C2=CC[C@@H]2[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]32C)C(O)=O)ccc1O
Show InChI InChI=1S/C39H54O6/c1-24-13-18-38(34(43)44)19-20-39(23-26(40)9-7-25-8-11-29(41)30(22-25)45-6)27(28(38)21-24)10-12-32-36(4)16-15-33(42)35(2,3)31(36)14-17-37(32,39)5/h7-11,22,24,28,31-33,41-42H,12-21,23H2,1-6H3,(H,43,44)/t24-,28+,31+,32-,33+,36+,37-,38+,39+/m1/s1
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n/an/a 4.46E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Inhibition of PLCgamma1 (unknown origin)


J Nat Prod 63: 753-6 (2000)

More data for this
Ligand-Target Pair