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Compile Data Set for Download or QSAR

Found 497 hits Enz. Inhib. hit(s) with Target = 'Phospholipase D (PLD)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87192
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H27N5O2/c1-16(25-23(30)21-14-17-6-2-3-7-19(17)26-21)15-28-12-10-18(11-13-28)29-22-9-5-4-8-20(22)27-24(29)31/h2-9,14,16,18,26H,10-13,15H2,1H3,(H,25,30)(H,27,31)/t16-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258084
PNG
((1R,2R)-N-(2-(4-(5-chloro-2-oxo-2,3-dihydro-1H-ben...)
Show SMILES Clc1ccc2n(C3CCN(CCNC(=O)C4C[C@H]4c4ccccc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C24H27ClN4O2/c25-17-6-7-22-21(14-17)27-24(31)29(22)18-8-11-28(12-9-18)13-10-26-23(30)20-15-19(20)16-4-2-1-3-5-16/h1-7,14,18-20H,8-13,15H2,(H,26,30)(H,27,31)/t19-,20?/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87193
PNG
(5-fluoranyl-N-[(2S)-1-[4-(2-oxidanylidene-3H-benzi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C24H26FN5O2/c1-15(26-23(31)21-13-16-12-17(25)6-7-19(16)27-21)14-29-10-8-18(9-11-29)30-22-5-3-2-4-20(22)28-24(30)32/h2-7,12-13,15,18,27H,8-11,14H2,1H3,(H,26,31)(H,28,32)/t15-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM36423
PNG
(4-Methyl-N-(2-(4-(2-oxo-2,3-dihydro-1H-benzo[d]imi...)
Show SMILES Cc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H26N4O2/c1-16-6-8-17(9-7-16)21(27)23-12-15-25-13-10-18(11-14-25)26-20-5-3-2-4-19(20)24-22(26)28/h2-9,18H,10-15H2,1H3,(H,23,27)(H,24,28)
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Article
PubMed
n/an/a 1.70n/an/an/an/an/a37



Vanderbilt University



Assay Description
Phopholipase D1(PLD)enzymatic inhibition assay using PLD1.d311


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87226
PNG
(4-fluoranyl-N-[(2S)-1-[4-(6-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-12-17(24)6-7-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87190
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C24H26N4O2S/c1-16(25-23(29)22-14-17-6-2-5-9-21(17)31-22)15-27-12-10-18(11-13-27)28-20-8-4-3-7-19(20)26-24(28)30/h2-9,14,16,18H,10-13,15H2,1H3,(H,25,29)(H,26,30)/t16-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50423651
PNG
(CHEMBL2304616)
Show SMILES Clc1ccc2n(C3CCN(CCNC(=O)C4C[C@@H]4c4ccccc4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C24H27ClN4O2/c25-17-6-7-22-21(14-17)27-24(31)29(22)18-8-11-28(12-9-18)13-10-26-23(30)20-15-19(20)16-4-2-1-3-5-16/h1-7,14,18-20H,8-13,15H2,(H,26,30)(H,27,31)/t19-,20?/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257542
PNG
((S)-N-(1-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-benzo[d...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27FN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-15-21(27)8-9-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87201
PNG
(N-[(1S)-2-[4-(2-keto-3H-benzimidazol-1-yl)piperidi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)COc1ccccc1
Show InChI InChI=1S/C23H28N4O3/c1-17(24-22(28)16-30-19-7-3-2-4-8-19)15-26-13-11-18(12-14-26)27-21-10-6-5-9-20(21)25-23(27)29/h2-10,17-18H,11-16H2,1H3,(H,24,28)(H,25,29)/t17-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87183
PNG
(N-[(1R)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H26ClN5O2/c1-15(26-23(31)21-12-16-4-2-3-5-19(16)27-21)14-29-10-8-18(9-11-29)30-22-7-6-17(25)13-20(22)28-24(30)32/h2-7,12-13,15,18,27H,8-11,14H2,1H3,(H,26,31)(H,28,32)/t15-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87179
PNG
(5-fluoranyl-N-[(2R)-1-(4-oxidanylidene-1-phenyl-1,...)
Show SMILES C[C@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C25H28FN5O2/c1-17(28-23(32)22-14-18-13-19(26)7-8-21(18)29-22)15-30-11-9-25(10-12-30)24(33)27-16-31(25)20-5-3-2-4-6-20/h2-8,13-14,17,29H,9-12,15-16H2,1H3,(H,27,33)(H,28,32)/t17-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257530
PNG
((S)-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23ClF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87219
PNG
(N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23ClF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258131
PNG
(CHEMBL492561 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrClN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87159
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C25H27F2N5O2/c1-16(29-23(33)22-12-17-4-2-3-5-21(17)30-22)14-31-10-8-25(9-11-31)24(34)28-15-32(25)18-6-7-19(26)20(27)13-18/h2-7,12-13,16,30H,8-11,14-15H2,1H3,(H,28,34)(H,29,33)/t16-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258131
PNG
(CHEMBL492561 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrClN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87228
PNG
(N-[(1S)-2-[4-(6-fluoro-2-keto-3H-benzimidazol-1-yl...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27FN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-15-21(27)8-9-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257531
PNG
((S)-N-(1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM247410
PNG
(US9453017, 2)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20+,21+/m0/s1
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US Patent
n/an/a 3.70n/an/an/an/an/an/a



Vanderbilt University

US Patent


Assay Description
The ability of representative disclosed to block influenza infection was assessed in a cell-based assay using A549 human epithelial cells (ATCC CCL-1...


US Patent US9453017 (2016)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257541
PNG
((1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87119
PNG
((1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidaz...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87225
PNG
(4-chloranyl-N-[(2S)-1-[4-(6-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-12-17(24)6-7-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87214
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-5-3-15(23)11-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87213
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H24BrFN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87211
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24BrClN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87119
PNG
((1R,2R)-N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidaz...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C25H29BrN4O2/c1-16(27-24(31)21-14-20(21)17-5-3-2-4-6-17)15-29-11-9-19(10-12-29)30-23-8-7-18(26)13-22(23)28-25(30)32/h2-8,13,16,19-21H,9-12,14-15H2,1H3,(H,27,31)(H,28,32)/t16-,20-,21+/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257540
PNG
((S)-N-(1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24BrClN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258181
PNG
(3,4-difluoro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(F)c(F)c4)CC3)c2c1
Show InChI InChI=1S/C21H21F3N4O2/c22-14-2-4-18-19(12-14)28(21(30)26-18)15-5-8-27(9-6-15)10-7-25-20(29)13-1-3-16(23)17(24)11-13/h1-4,11-12,15H,5-10H2,(H,25,29)(H,26,30)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258179
PNG
(CHEMBL521990 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258128
PNG
(CHEMBL493010 | N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro...)
Show SMILES Fc1ccc2n(C3CCN(CCNC(=O)c4ccc5ccccc5c4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C25H25FN4O2/c26-20-7-8-23-22(16-20)28-25(32)30(23)21-9-12-29(13-10-21)14-11-27-24(31)19-6-5-17-3-1-2-4-18(17)15-19/h1-8,15-16,21H,9-14H2,(H,27,31)(H,28,32)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258128
PNG
(CHEMBL493010 | N-(2-(4-(5-fluoro-2-oxo-2,3-dihydro...)
Show SMILES Fc1ccc2n(C3CCN(CCNC(=O)c4ccc5ccccc5c4)CC3)c(=O)[nH]c2c1
Show InChI InChI=1S/C25H25FN4O2/c26-20-7-8-23-22(16-20)28-25(32)30(23)21-9-12-29(13-10-21)14-11-27-24(31)19-6-5-17-3-1-2-4-18(17)15-19/h1-8,15-16,21H,9-14H2,(H,27,31)(H,28,32)
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n/an/a 4n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258179
PNG
(CHEMBL521990 | N-(2-(4-(5-bromo-2-oxo-2,3-dihydro-...)
Show SMILES Fc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O
Show InChI InChI=1S/C21H22BrFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258181
PNG
(3,4-difluoro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(F)c(F)c4)CC3)c2c1
Show InChI InChI=1S/C21H21F3N4O2/c22-14-2-4-18-19(12-14)28(21(30)26-18)15-5-8-27(9-6-15)10-7-25-20(29)13-1-3-16(23)17(24)11-13/h1-4,11-12,15H,5-10H2,(H,25,29)(H,26,30)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87211
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24BrClN4O2/c1-14(25-21(29)15-2-5-17(24)6-3-15)13-27-10-8-18(9-11-27)28-20-7-4-16(23)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87127
PNG
(4-chloranyl-N-[2-[4-(5-iodanyl-2-oxidanylidene-3H-...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCC(CC1)n1c2ccc(I)cc2[nH]c1=O
Show InChI InChI=1S/C21H22ClIN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-6-5-16(23)13-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87227
PNG
(3,4-bis(fluoranyl)-N-[(2S)-1-[4-(6-fluoranyl-2-oxi...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2cc(F)ccc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C22H23F3N4O2/c1-13(26-21(30)14-2-4-17(24)18(25)10-14)12-28-8-6-16(7-9-28)29-20-11-15(23)3-5-19(20)27-22(29)31/h2-5,10-11,13,16H,6-9,12H2,1H3,(H,26,30)(H,27,31)/t13-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87158
PNG
(N-[(1S)-2-[1-(3,4-difluorophenyl)-4-keto-1,3,8-tri...)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccc(F)c(F)c1)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C25H26F3N5O2/c1-15(30-23(34)22-11-16-10-17(26)2-5-21(16)31-22)13-32-8-6-25(7-9-32)24(35)29-14-33(25)18-3-4-19(27)20(28)12-18/h2-5,10-12,15,31H,6-9,13-14H2,1H3,(H,29,35)(H,30,34)/t15-/m0/s1
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Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM123745
PNG
(1-(4-methoxyphenyl)-3-(naphthalen-1-yl)-1H-pyrazol...)
Show SMILES COc1ccc(cc1)-n1nc(-c2cccc3ccccc23)c2c(N)ncnc12
Show InChI InChI=1S/C22H17N5O/c1-28-16-11-9-15(10-12-16)27-22-19(21(23)24-13-25-22)20(26-27)18-8-4-6-14-5-2-3-7-17(14)18/h2-13H,1H3,(H2,23,24,25)
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n/an/a 5n/an/an/an/an/a37



University of Massachusetts Boston



Assay Description
PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257581
PNG
((S)-N-(1-(4-(5-bromo-2-oxo-2,3-dihydro-1H-benzo[d]...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27BrN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 5.5n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50427800
PNG
(CHEMBL2325485)
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(C)c1)NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C24H29BrN4O2/c1-17-4-3-5-21(14-17)29-16-26-23(31)24(29)10-12-28(13-11-24)15-18(2)27-22(30)19-6-8-20(25)9-7-19/h3-9,14,18H,10-13,15-16H2,1-2H3,(H,26,31)(H,27,30)/t18-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured af...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87215
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H27BrN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87217
PNG
(4-chloranyl-N-[(2S)-1-[4-(5-chloranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50039461
PNG
(CHEMBL3357311)
Show SMILES CC(CNC(=O)c1cc2ccccc2[nH]1)N1CCC2(CC1)N(CNC2=O)c1ccccc1
Show InChI InChI=1/C25H29N5O2/c1-18(16-26-23(31)22-15-19-7-5-6-10-21(19)28-22)29-13-11-25(12-14-29)24(32)27-17-30(25)20-8-3-2-4-9-20/h2-10,15,18,28H,11-14,16-17H2,1H3,(H,26,31)(H,27,32)
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n/an/a 6n/an/an/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Inhibition of PLD2 (unknown origin) expressed in HEK293-gfp cells by cell-based assay


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM154517
PNG
(ML299 (5))
Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Vanderbilt University



Assay Description
Cells were seeded into 12-well tissue culture plates to reach 90% confluence at the time of assay. All cell types, aside from the HEK293-gfpPLD2 cell...


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50257528
PNG
((S)-4-chloro-N-(1-(4-(5-chloro-2-oxo-2,3-dihydro-1...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24Cl2N4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 6.40n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87216
PNG
(N-[(1S)-2-[4-(5-bromo-2-keto-3H-benzimidazol-1-yl)...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(Br)cc2[nH]c1=O)NC(=O)c1ccc(C)cc1
Show InChI InChI=1S/C23H27BrN4O2/c1-15-3-5-17(6-4-15)22(29)25-16(2)14-27-11-9-19(10-12-27)28-21-8-7-18(24)13-20(21)26-23(28)30/h3-8,13,16,19H,9-12,14H2,1-2H3,(H,25,29)(H,26,30)/t16-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87222
PNG
(4-chloranyl-N-[(2S)-1-[4-(5-fluoranyl-2-oxidanylid...)
Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccc(F)cc2[nH]c1=O)NC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H24ClFN4O2/c1-14(25-21(29)15-2-4-16(23)5-3-15)13-27-10-8-18(9-11-27)28-20-7-6-17(24)12-19(20)26-22(28)30/h2-7,12,14,18H,8-11,13H2,1H3,(H,25,29)(H,26,30)/t14-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258180
PNG
(4-chloro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(Cl)cc4)CC3)c2c1
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-13-16(23)5-6-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM87236
PNG
(N-[2-[4-(6-fluoranyl-2-oxidanylidene-3H-benzimidaz...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4cccc5-c6ccccc6C(=O)c45)CC3)c2c1
Show InChI InChI=1S/C28H25FN4O3/c29-17-8-9-23-24(16-17)33(28(36)31-23)18-10-13-32(14-11-18)15-12-30-27(35)22-7-3-6-20-19-4-1-2-5-21(19)26(34)25(20)22/h1-9,16,18H,10-15H2,(H,30,35)(H,31,36)
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt Specialized Chemistry Center

Curated by PubChem BioAssay


Assay Description
Phospholipase D (PLD) generates the lipid second messenger phosphatidic acid as part of a plethora of cellular functions. Phosphatidic acid (PtdOH) i...


PubChem Bioassay (2011)

More data for this
Ligand-Target Pair
Phospholipase D (PLD)


(Homo sapiens (Human))
BDBM50258180
PNG
(4-chloro-N-(2-(4-(6-fluoro-2-oxo-2,3-dihydro-1H-be...)
Show SMILES Fc1ccc2[nH]c(=O)n(C3CCN(CCNC(=O)c4ccc(Cl)cc4)CC3)c2c1
Show InChI InChI=1S/C21H22ClFN4O2/c22-15-3-1-14(2-4-15)20(28)24-9-12-26-10-7-17(8-11-26)27-19-13-16(23)5-6-18(19)25-21(27)29/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
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n/an/a 7n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Inhibition of human PLD1 in Calu1 cells


Citation and Details
More data for this
Ligand-Target Pair
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