BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 13 hits Enz. Inhib. hit(s) with Target = 'Phosphorylase kinase' AND taxid = 9986   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2691
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-...)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20N4O2/c24-10-5-11-27-13-17(15-7-2-4-9-19(15)27)21-20(22(28)26-23(21)29)16-12-25-18-8-3-1-6-14(16)18/h1-4,6-9,12-13,25H,5,10-11,24H2,(H,26,28,29)
GoogleScholar
AffyNet 
Purchase

DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 180n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2684
PNG
(3-[3-(dimethylamino)propyl]-3,13,23-triazahexacycl...)
Show SMILES CN(C)CCCn1c2ccccc2c2c3C(=O)NC(=O)c3c3c4ccccc4[nH]c3c12
Show InChI InChI=1S/C25H22N4O2/c1-28(2)12-7-13-29-17-11-6-4-9-15(17)19-21-20(24(30)27-25(21)31)18-14-8-3-5-10-16(14)26-22(18)23(19)29/h3-6,8-11,26H,7,12-13H2,1-2H3,(H,27,30,31)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 200n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


J Biol Chem 266: 15771-81 (1991)

More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2685
PNG
(3-(1H-indol-3-yl)-4-{1-[2-(piperidin-2-yl)ethyl]-1...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1cn(CCC2CCCCN2)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c32-26-24(20-15-29-22-10-3-1-8-18(20)22)25(27(33)30-26)21-16-31(23-11-4-2-9-19(21)23)14-12-17-7-5-6-13-28-17/h1-4,8-11,15-17,28-29H,5-7,12-14H2,(H,30,32,33)
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 400n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


J Biol Chem 266: 15771-81 (1991)

More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2683
PNG
(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a 700n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


J Biol Chem 266: 15771-81 (1991)

More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2694
PNG
(3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...)
Show SMILES CN1CCCC1CCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 750n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2692
PNG
(3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...)
Show SMILES CN1CCCC(Cn2cc(C3=C(C(=O)NC3=O)c3c[nH]c4ccccc34)c3ccccc23)C1
Show InChI InChI=1S/C27H26N4O2/c1-30-12-6-7-17(14-30)15-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-13-28-22-10-4-2-8-18(20)22/h2-5,8-11,13,16-17,28H,6-7,12,14-15H2,1H3,(H,29,32,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.20E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2681
PNG
(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N4O2/c1-28(2)13-8-14-30-16-20(18-10-5-7-12-22(18)30)24-23(25(31)27-26(24)32)19-15-29(3)21-11-6-4-9-17(19)21/h4-7,9-12,15-16H,8,13-14H2,1-3H3,(H,27,31,32)
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.70E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2682
PNG
(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-[1...)
Show SMILES COCCn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN(C)C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C28H30N4O3/c1-30(2)13-8-14-31-17-21(19-9-4-6-11-23(19)31)25-26(28(34)29-27(25)33)22-18-32(15-16-35-3)24-12-7-5-10-20(22)24/h4-7,9-12,17-18H,8,13-16H2,1-3H3,(H,29,33,34)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 1.80E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2693
PNG
(3-(1H-indol-3-yl)-4-{1-[3-(morpholin-4-yl)propyl]-...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1cn(CCCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C27H26N4O3/c32-26-24(20-16-28-22-8-3-1-6-18(20)22)25(27(33)29-26)21-17-31(23-9-4-2-7-19(21)23)11-5-10-30-12-14-34-15-13-30/h1-4,6-9,16-17,28H,5,10-15H2,(H,29,32,33)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 2.00E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2690
PNG
(3-(1-{2-[(dimethylamino)methyl]propyl}-1H-indol-3-...)
Show SMILES CC(CN(C)C)Cn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N4O2/c1-16(13-29(2)3)14-30-15-20(18-9-5-7-11-22(18)30)24-23(25(31)28-26(24)32)19-12-27-21-10-6-4-8-17(19)21/h4-12,15-16,27H,13-14H2,1-3H3,(H,28,31,32)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.00E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2689
PNG
(3-[1-(3-dymethylaminopropyl)-indol-3-yl]-4-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(CNC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H26N4O/c1-28(2)12-7-13-29-16-21(18-9-4-6-11-23(18)29)24-20(15-27-25(24)30)19-14-26-22-10-5-3-8-17(19)22/h3-6,8-11,14,16,26H,7,12-13,15H2,1-2H3,(H,27,30)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 2.75E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2583
PNG
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 3.20E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Citation and Details
More data for this
Ligand-Target Pair
Phosphorylase Kinase


(Oryctolagus cuniculus (rabbit))
BDBM2686
PNG
(3-(1H-indol-3-yl)-4-{1-[3-(piperazin-1-yl)propyl]-...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1cn(CCCN2CCNCC2)c2ccccc12
Show InChI InChI=1S/C27H27N5O2/c33-26-24(20-16-29-22-8-3-1-6-18(20)22)25(27(34)30-26)21-17-32(23-9-4-2-7-19(21)23)13-5-12-31-14-10-28-11-15-31/h1-4,6-9,16-17,28-29H,5,10-15H2,(H,30,33,34)
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 5.70E+3n/an/an/an/a7.030



Laboratoires Glaxo



Assay Description
The activity of PK is measured by its ability to transfer from [gamma-32P]ATP to phosphorylase b.


J Biol Chem 266: 15771-81 (1991)

More data for this
Ligand-Target Pair