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Found 16 hits Enz. Inhib. hit(s) with Target = 'Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154536
PNG
(2-(4-tert-butylphenyl)-1-(4-methylbenzenesulfonyl)...)
Show SMILES Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C)C(O)=O
Show InChI InChI=1/C30H33NO4S/c1-20-6-10-22(11-7-20)27-19-18-26(29(32)33)28(23-12-14-24(15-13-23)30(3,4)5)31(27)36(34,35)25-16-8-21(2)9-17-25/h6-18,27-28H,19H2,1-5H3,(H,32,33)
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PubMed
n/an/a 800n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154529
PNG
(2-(4-fluorophenyl)-1-(4-methylbenzenesulfonyl)-6-[...)
Show SMILES CC(C)c1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(F)cc1)C(O)=O
Show InChI InChI=1/C28H28FNO4S/c1-18(2)20-6-8-21(9-7-20)26-17-16-25(28(31)32)27(22-10-12-23(29)13-11-22)30(26)35(33,34)24-14-4-19(3)5-15-24/h4-16,18,26-27H,17H2,1-3H3,(H,31,32)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154531
PNG
(2-(4-bromophenyl)-6-(4-chlorophenyl)-1-(4-methylbe...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(CC=C(C1c1ccc(Br)cc1)C(O)=O)c1ccc(Cl)cc1
Show InChI InChI=1/C25H21BrClNO4S/c1-16-2-12-21(13-3-16)33(31,32)28-23(17-6-10-20(27)11-7-17)15-14-22(25(29)30)24(28)18-4-8-19(26)9-5-18/h2-14,23-24H,15H2,1H3,(H,29,30)
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n/an/a 1.10E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154534
PNG
(2-(4-bromophenyl)-6-(3,4-dichlorophenyl)-1-(4-meth...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1C(CC=C(C1c1ccc(Br)cc1)C(O)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C25H20BrCl2NO4S/c1-15-2-9-19(10-3-15)34(32,33)29-23(17-6-12-21(27)22(28)14-17)13-11-20(25(30)31)24(29)16-4-7-18(26)8-5-16/h2-12,14,23-24H,13H2,1H3,(H,30,31)
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n/an/a 1.40E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154540
PNG
(2-(4-(tert-butyl)phenyl)-N-(2-methoxyethyl)-6-(p-t...)
Show SMILES COCCNC(=O)C1=CCC(N(C1c1ccc(cc1)C(C)(C)C)S(=O)(=O)c1ccc(C)cc1)c1ccc(C)cc1
Show InChI InChI=1/C33H40N2O4S/c1-23-7-11-25(12-8-23)30-20-19-29(32(36)34-21-22-39-6)31(26-13-15-27(16-14-26)33(3,4)5)35(30)40(37,38)28-17-9-24(2)10-18-28/h7-19,30-31H,20-22H2,1-6H3,(H,34,36)
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154535
PNG
(2-(4-fluorophenyl)-1-(4-methylbenzenesulfonyl)-6-(...)
Show SMILES Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(F)cc1)C(O)=O
Show InChI InChI=1/C26H24FNO4S/c1-17-3-7-19(8-4-17)24-16-15-23(26(29)30)25(20-9-11-21(27)12-10-20)28(24)33(31,32)22-13-5-18(2)6-14-22/h3-15,24-25H,16H2,1-2H3,(H,29,30)
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n/an/a 2.00E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154530
PNG
(1-(4-methylbenzenesulfonyl)-2-(4-methylphenyl)-6-[...)
Show SMILES CC(C)c1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(C)cc1)C(O)=O
Show InChI InChI=1/C29H31NO4S/c1-19(2)22-11-13-23(14-12-22)27-18-17-26(29(31)32)28(24-9-5-20(3)6-10-24)30(27)35(33,34)25-15-7-21(4)8-16-25/h5-17,19,27-28H,18H2,1-4H3,(H,31,32)
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n/an/a 4.50E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154542
PNG
(5-(bromomethyl)-6-(4-(tert-butyl)phenyl)-2-(p-toly...)
Show SMILES Cc1ccc(cc1)C1CC=C(CBr)C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1/C30H34BrNO2S/c1-21-6-10-23(11-7-21)28-19-14-25(20-31)29(24-12-15-26(16-13-24)30(3,4)5)32(28)35(33,34)27-17-8-22(2)9-18-27/h6-18,28-29H,19-20H2,1-5H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154541
PNG
(N-allyl-2-(4-(tert-butyl)phenyl)-6-(p-tolyl)-1-tos...)
Show SMILES Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C)C(=O)NCC=C
Show InChI InChI=1/C33H38N2O3S/c1-7-22-34-32(36)29-20-21-30(25-12-8-23(2)9-13-25)35(39(37,38)28-18-10-24(3)11-19-28)31(29)26-14-16-27(17-15-26)33(4,5)6/h7-20,30-31H,1,21-22H2,2-6H3,(H,34,36)
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PubMed
n/an/a 7.50E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154543
PNG
(N-((2-(4-(tert-butyl)phenyl)-6-(p-tolyl)-1-tosyl-1...)
Show SMILES Cc1ccc(cc1)C1CC=C(CNC2CC2)C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1/C33H40N2O2S/c1-23-6-10-25(11-7-23)31-21-14-27(22-34-29-17-18-29)32(26-12-15-28(16-13-26)33(3,4)5)35(31)38(36,37)30-19-8-24(2)9-20-30/h6-16,19-20,29,31-32,34H,17-18,21-22H2,1-5H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154533
PNG
(2-(3-chlorophenyl)-1-(4-methylbenzenesulfonyl)-6-(...)
Show SMILES Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1/C26H24ClNO4S/c1-17-6-10-19(11-7-17)24-15-14-23(26(29)30)25(20-4-3-5-21(27)16-20)28(24)33(31,32)22-12-8-18(2)9-13-22/h3-14,16,24-25H,15H2,1-2H3,(H,29,30)
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n/an/a 8.20E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154538
PNG
(2-(4-(tert-butyl)phenyl)-N-cyclopropyl-6-(p-tolyl)...)
Show SMILES Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C)C(=O)NC1CC1
Show InChI InChI=1/C33H38N2O3S/c1-22-6-10-24(11-7-22)30-21-20-29(32(36)34-27-16-17-27)31(25-12-14-26(15-13-25)33(3,4)5)35(30)39(37,38)28-18-8-23(2)9-19-28/h6-15,18-20,27,30-31H,16-17,21H2,1-5H3,(H,34,36)
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PubMed
n/an/a 9.30E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154532
PNG
(2-(3-chlorophenyl)-6-(4-ethylphenyl)-1-(4-methylbe...)
Show SMILES CCc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1/C27H26ClNO4S/c1-3-19-9-11-20(12-10-19)25-16-15-24(27(30)31)26(21-5-4-6-22(28)17-21)29(25)34(32,33)23-13-7-18(2)8-14-23/h4-15,17,25-26H,3,16H2,1-2H3,(H,30,31)
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n/an/a 9.40E+3n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154539
PNG
(2-(4-(tert-butyl)phenyl)-N-cyclohexyl-6-(p-tolyl)-...)
Show SMILES Cc1ccc(cc1)C1CC=C(C(N1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(C)(C)C)C(=O)NC1CCCCC1
Show InChI InChI=1/C36H44N2O3S/c1-25-11-15-27(16-12-25)33-24-23-32(35(39)37-30-9-7-6-8-10-30)34(28-17-19-29(20-18-28)36(3,4)5)38(33)42(40,41)31-21-13-26(2)14-22-31/h11-23,30,33-34H,6-10,24H2,1-5H3,(H,37,39)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154537
PNG
(2-(4-(tert-butyl)phenyl)-N-methyl-6-(p-tolyl)-1-to...)
Show SMILES CNC(=O)C1=CCC(N(C1c1ccc(cc1)C(C)(C)C)S(=O)(=O)c1ccc(C)cc1)c1ccc(C)cc1
Show InChI InChI=1/C31H36N2O3S/c1-21-7-11-23(12-8-21)28-20-19-27(30(34)32-6)29(24-13-15-25(16-14-24)31(3,4)5)33(28)37(35,36)26-17-9-22(2)10-18-26/h7-19,28-29H,20H2,1-6H3,(H,32,34)
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair
Platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2)


(Mus musculus (Mouse))
BDBM154544
PNG
(Methyl-2-(4-(tert-butyl)phenyl)-6-(p-tolyl)-1-tosy...)
Show SMILES COC(=O)C1=CCC(N(C1c1ccc(cc1)C(C)(C)C)S(=O)(=O)c1ccc(C)cc1)c1ccc(C)cc1
Show InChI InChI=1/C31H35NO4S/c1-21-7-11-23(12-8-21)28-20-19-27(30(33)36-6)29(24-13-15-25(16-14-24)31(3,4)5)32(28)37(34,35)26-17-9-22(2)10-18-26/h7-19,28-29H,20H2,1-6H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



University of California, Berkeley



Assay Description
For in vitro experiments, proteomes were diluted to 1 mg/mL in PBS (pH 7.5, 50 μL total reaction volume), doped with 1 μM recombinant PAFAH...


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More data for this
Ligand-Target Pair