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Found 147 hits Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446319
PNG
(CHEMBL3109343)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3(F)CCNCC3)c2n1
Show InChI InChI=1S/C25H27FN4O3/c1-31-13-14-32-19-7-12-30-21(16-28-23(30)15-19)20-6-5-18-3-2-4-22(24(18)29-20)33-17-25(26)8-10-27-11-9-25/h2-7,12,15-16,27H,8-11,13-14,17H2,1H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446312
PNG
(CHEMBL3109350)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3CCNC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-11-12-30-19-8-10-28-21(15-26-23(28)13-19)20-6-5-18-3-2-4-22(24(18)27-20)31-16-17-7-9-25-14-17/h2-6,8,10,13,15,17,25H,7,9,11-12,14,16H2,1H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446315
PNG
(CHEMBL3109347)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@@H]3O)c2n1
Show InChI InChI=1S/C24H26N4O4/c1-30-11-12-31-17-8-10-28-19(14-26-23(28)13-17)18-6-5-16-3-2-4-22(24(16)27-18)32-21-7-9-25-15-20(21)29/h2-6,8,10,13-14,20-21,25,29H,7,9,11-12,15H2,1H3/t20-,21+/m0/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50384726
PNG
(CHEMBL2037208)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C27H19F3N4O2/c28-27(29,30)17-5-1-4-16(12-17)25(35)33-20-7-2-6-19(13-20)32-21-9-10-22-23(14-18-8-3-11-31-18)26(36)34-24(22)15-21/h1-15,31-32H,(H,33,35)(H,34,36)/b23-14-
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TBA

Assay Description
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446303
PNG
(CHEMBL3109338)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CCNC[C@@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m0/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446304
PNG
(CHEMBL3109337)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m1/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446316
PNG
(CHEMBL3109346)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@H]3O)c2n1
Show InChI InChI=1S/C24H26N4O4/c1-30-11-12-31-17-8-10-28-19(14-26-23(28)13-17)18-6-5-16-3-2-4-22(24(16)27-18)32-21-7-9-25-15-20(21)29/h2-6,8,10,13-14,20-21,25,29H,7,9,11-12,15H2,1H3/t20-,21-/m1/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446306
PNG
(CHEMBL3109340)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OC3CCNCC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-13-14-30-19-9-12-28-21(16-26-23(28)15-19)20-6-5-17-3-2-4-22(24(17)27-20)31-18-7-10-25-11-8-18/h2-6,9,12,15-16,18,25H,7-8,10-11,13-14H2,1H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446305
PNG
(CHEMBL3109356)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21+/m0/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446304
PNG
(CHEMBL3109337)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m1/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446318
PNG
(CHEMBL3109344)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CCCNC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-12-13-30-18-9-11-28-21(16-26-23(28)14-18)20-8-7-17-4-2-6-22(24(17)27-20)31-19-5-3-10-25-15-19/h2,4,6-9,11,14,16,19,25H,3,5,10,12-13,15H2,1H3/t19-/m0/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185169
PNG
(2-(5-phenoxy-1H-indazol-3-yl)-5-(4-(piperidin-1-yl...)
Show SMILES C1CCN(CC1)C1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccc(Oc3ccccc3)cc12
Show InChI InChI=1S/C30H32N6O/c1-3-7-23(8-4-1)37-24-10-12-26-25(20-24)29(34-33-26)30-31-27-11-9-22(19-28(27)32-30)36-17-13-21(14-18-36)35-15-5-2-6-16-35/h1,3-4,7-12,19-21H,2,5-6,13-18H2,(H,31,32)(H,33,34)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446321
PNG
(CHEMBL3109341)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OC3CCN(C)CC3)c2n1
Show InChI InChI=1S/C25H28N4O3/c1-28-11-8-19(9-12-28)32-23-5-3-4-18-6-7-21(27-25(18)23)22-17-26-24-16-20(10-13-29(22)24)31-15-14-30-2/h3-7,10,13,16-17,19H,8-9,11-12,14-15H2,1-2H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446311
PNG
(CHEMBL3109351)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CNC[C@H]3OC)c2n1
Show InChI InChI=1S/C24H26N4O4/c1-29-10-11-31-17-8-9-28-19(13-26-23(28)12-17)18-7-6-16-4-3-5-20(24(16)27-18)32-22-15-25-14-21(22)30-2/h3-9,12-13,21-22,25H,10-11,14-15H2,1-2H3/t21-,22-/m1/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181306
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccncc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-10-21-4-3-13(12)24-19(26)16(17)18-22-14-2-1-11(9-15(14)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446322
PNG
(CHEMBL3109339)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC(C)(C)CN)c2n1
Show InChI InChI=1S/C24H28N4O3/c1-24(2,15-25)16-31-21-6-4-5-17-7-8-19(27-23(17)21)20-14-26-22-13-18(9-10-28(20)22)30-12-11-29-3/h4-10,13-14H,11-12,15-16,25H2,1-3H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181314
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)quinolin-...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C15H11N5O/c16-12-8-4-1-2-5-9(8)19-15(21)11(12)14-18-10-6-3-7-17-13(10)20-14/h1-7H,(H3,16,19,21)(H,17,18,20)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446305
PNG
(CHEMBL3109356)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21+/m0/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446306
PNG
(CHEMBL3109340)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OC3CCNCC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-13-14-30-19-9-12-28-21(16-26-23(28)15-19)20-6-5-17-3-2-4-22(24(17)27-20)31-18-7-10-25-11-8-18/h2-6,9,12,15-16,18,25H,7-8,10-11,13-14H2,1H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181320
PNG
(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C21H22N6O/c1-26-8-10-27(11-9-26)13-6-7-16-17(12-13)24-20(23-16)18-19(22)14-4-2-3-5-15(14)25-21(18)28/h2-7,12H,8-11H2,1H3,(H,23,24)(H3,22,25,28)
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Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446314
PNG
(CHEMBL3109348)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CC[C@H](N)CC3)c2n1
Show InChI InChI=1S/C25H28N4O3/c1-30-13-14-31-20-11-12-29-22(16-27-24(29)15-20)21-10-5-17-3-2-4-23(25(17)28-21)32-19-8-6-18(26)7-9-19/h2-5,10-12,15-16,18-19H,6-9,13-14,26H2,1H3/t18-,19-
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446312
PNG
(CHEMBL3109350)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3CCNC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-11-12-30-19-8-10-28-21(15-26-23(28)13-19)20-6-5-18-3-2-4-22(24(18)27-20)31-16-17-7-9-25-14-17/h2-6,8,10,13,15,17,25H,7,9,11-12,14,16H2,1H3
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181315
PNG
(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]c(nc2n1)-c1c(N)c2ccccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-8-10-27(11-9-26)15-7-6-14-18(24-15)25-19(22-14)16-17(21)12-4-2-3-5-13(12)23-20(16)28/h2-7H,8-11H2,1H3,(H3,21,23,28)(H,22,24,25)
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n/an/a 30n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446320
PNG
(CHEMBL3109342)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3CCNCC3)c2n1
Show InChI InChI=1S/C25H28N4O3/c1-30-13-14-31-20-9-12-29-22(16-27-24(29)15-20)21-6-5-19-3-2-4-23(25(19)28-21)32-17-18-7-10-26-11-8-18/h2-6,9,12,15-16,18,26H,7-8,10-11,13-14,17H2,1H3
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181311
PNG
(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C20H19N5O2/c21-18-13-3-1-2-4-14(13)24-20(26)17(18)19-22-15-6-5-12(11-16(15)23-19)25-7-9-27-10-8-25/h1-6,11H,7-10H2,(H,22,23)(H3,21,24,26)
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n/an/a 38n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181308
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ccncc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-6-8-27(9-7-26)12-2-3-14-15(10-12)24-19(23-14)17-18(21)13-4-5-22-11-16(13)25-20(17)28/h2-5,10-11H,6-9H2,1H3,(H,23,24)(H3,21,25,28)
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n/an/a 43n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181312
PNG
(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Show SMILES Nc1c(-c2nc3nc(ccc3[nH]2)N2CCOCC2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C19H18N6O2/c20-16-11-3-1-2-4-12(11)22-19(26)15(16)18-21-13-5-6-14(23-17(13)24-18)25-7-9-27-10-8-25/h1-6H,7-10H2,(H3,20,22,26)(H,21,23,24)
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n/an/a 48n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181303
PNG
(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Show SMILES Nc1c(-c2nc3ncccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C14H10N6O/c15-11-7-3-5-16-6-9(7)19-14(21)10(11)13-18-8-2-1-4-17-12(8)20-13/h1-6H,(H3,15,19,21)(H,17,18,20)
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n/an/a 49n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181307
PNG
(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2ncccc2[nH]c1=O
Show InChI InChI=1S/C20H21N7O/c1-26-7-9-27(10-8-26)12-4-5-13-15(11-12)24-19(23-13)16-17(21)18-14(25-20(16)28)3-2-6-22-18/h2-6,11H,7-10H2,1H3,(H,23,24)(H3,21,25,28)
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n/an/a 55n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446303
PNG
(CHEMBL3109338)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@H]3CCNC[C@@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m0/s1
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n/an/a 55n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/a 57n/an/an/an/a7.522



Bayer Pharmaceuticals Corporation



Assay Description
Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...


Cancer Res 64: 7099-109 (2004)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181313
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C15H11N5O/c16-13-8-5-6-17-7-11(8)20-15(21)12(13)14-18-9-3-1-2-4-10(9)19-14/h1-7H,(H,18,19)(H3,16,20,21)
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n/an/a 57n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185181
PNG
(5-(4-(piperidin-1-yl)piperidin-1-yl)-2-(6-(trifluo...)
Show SMILES FC(F)(F)c1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C25H27F3N6/c26-25(27,28)16-4-6-19-21(14-16)31-32-23(19)24-29-20-7-5-18(15-22(20)30-24)34-12-8-17(9-13-34)33-10-2-1-3-11-33/h4-7,14-15,17H,1-3,8-13H2,(H,29,30)(H,31,32)
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n/an/a 62n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446304
PNG
(CHEMBL3109337)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m1/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185183
PNG
(CHEMBL380372 | methyl 3-(5-(4-(piperidin-1-yl)pipe...)
Show SMILES COC(=O)c1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C26H30N6O2/c1-34-26(33)17-5-7-21-20(15-17)24(30-29-21)25-27-22-8-6-19(16-23(22)28-25)32-13-9-18(10-14-32)31-11-3-2-4-12-31/h5-8,15-16,18H,2-4,9-14H2,1H3,(H,27,28)(H,29,30)
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n/an/a 63n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181319
PNG
(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Nc1c(-c2nc3ccc(cc3[nH]2)N2CCOCC2)c(=O)[nH]c2cnccc12
Show InChI InChI=1S/C19H18N6O2/c20-17-12-3-4-21-10-15(12)24-19(26)16(17)18-22-13-2-1-11(9-14(13)23-18)25-5-7-27-8-6-25/h1-4,9-10H,5-8H2,(H,22,23)(H3,20,24,26)
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n/an/a 64n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446304
PNG
(CHEMBL3109337)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCNC[C@H]3F)c2n1
Show InChI InChI=1S/C24H25FN4O3/c1-30-11-12-31-17-8-10-29-20(15-27-23(29)13-17)19-6-5-16-3-2-4-22(24(16)28-19)32-21-7-9-26-14-18(21)25/h2-6,8,10,13,15,18,21,26H,7,9,11-12,14H2,1H3/t18-,21-/m1/s1
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TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446317
PNG
(CHEMBL3109345)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(O[C@@H]3CCCNC3)c2n1
Show InChI InChI=1S/C24H26N4O3/c1-29-12-13-30-18-9-11-28-21(16-26-23(28)14-18)20-8-7-17-4-2-6-22(24(17)27-20)31-19-5-3-10-25-15-19/h2,4,6-9,11,14,16,19,25H,3,5,10,12-13,15H2,1H3/t19-/m1/s1
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n/an/a 72n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185178
PNG
(1-tert-butyl-3-(3-(5-(4-(piperidin-1-yl)piperidin-...)
Show SMILES CC(C)(C)NC(=O)Nc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1
Show InChI InChI=1S/C29H38N8O/c1-29(2,3)33-28(38)30-19-7-9-23-22(17-19)26(35-34-23)27-31-24-10-8-21(18-25(24)32-27)37-15-11-20(12-16-37)36-13-5-4-6-14-36/h7-10,17-18,20H,4-6,11-16H2,1-3H3,(H,31,32)(H,34,35)(H2,30,33,38)
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n/an/a 81n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185182
PNG
(2-(5-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2[nH]nc(-c3nc4ccc(cc4[nH]3)N3CCC(CC3)N3CCCCC3)c2c1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-12-27-26(20-25)30(35-34-27)31-32-28-11-9-24(19-29(28)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 83n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50384725
PNG
(CHEMBL2037209)
Show SMILES Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(Nc2ccc3\C(=C\c4ccc[nH]4)C(=O)Nc3c2)c1
Show InChI InChI=1S/C31H23F3N6O2/c1-18-16-40(17-36-18)25-11-19(10-20(12-25)31(32,33)34)29(41)38-23-5-2-4-22(13-23)37-24-7-8-26-27(14-21-6-3-9-35-21)30(42)39-28(26)15-24/h2-17,35,37H,1H3,(H,38,41)(H,39,42)/b27-14-
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n/an/a 100n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181305
PNG
(4-amino-3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2ccccc12
Show InChI InChI=1S/C16H12N4O/c17-14-9-5-1-2-6-10(9)20-16(21)13(14)15-18-11-7-3-4-8-12(11)19-15/h1-8H,(H,18,19)(H3,17,20,21)
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n/an/a 102n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50384721
PNG
(CHEMBL2037224)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(Nc3ccc4\C(=C\c5ccc[nH]5)C(=O)Nc4c3)c2)c1
Show InChI InChI=1S/C27H20F3N5O2/c28-27(29,30)16-4-1-5-18(12-16)33-26(37)34-20-7-2-6-19(13-20)32-21-9-10-22-23(14-17-8-3-11-31-17)25(36)35-24(22)15-21/h1-15,31-32H,(H,35,36)(H2,33,34,37)/b23-14-
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n/an/a 120n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Tel-fused PDGFRbeta in mouse BA/F3 cells


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50181304
PNG
(7-amino-6-(1H-benzo[d]imidazol-2-yl)-3H-imidazo[4,...)
Show SMILES Nc1c(-c2nc3ccccc3[nH]2)c(=O)[nH]c2nc[nH]c12
Show InChI InChI=1S/C13H10N6O/c14-9-8(13(20)19-12-10(9)15-5-16-12)11-17-6-3-1-2-4-7(6)18-11/h1-5H,(H,17,18)(H4,14,15,16,19,20)
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n/an/a 154n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibitory activity against PDGFRbeta


Bioorg Med Chem Lett 16: 2247-51 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM6167
PNG
(1,6-naphthyridine 36 | 1-[3-(2,6-dichlorophenyl)-7...)
Show SMILES CCNC(=O)Nc1nc2cc(NCCCCN(CC)CC)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C25H32Cl2N6O/c1-4-28-25(34)32-24-18(23-19(26)10-9-11-20(23)27)14-17-16-30-22(15-21(17)31-24)29-12-7-8-13-33(5-2)6-3/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,29,30)(H2,28,31,32,34)
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n/an/a 160n/an/an/an/a7.425



University of Auckland



Assay Description
Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...


J Med Chem 48: 4628-53 (2005)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446313
PNG
(CHEMBL3109349)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCC3CNCCO3)c2n1
Show InChI InChI=1S/C24H26N4O4/c1-29-11-12-31-18-7-9-28-21(15-26-23(28)13-18)20-6-5-17-3-2-4-22(24(17)27-20)32-16-19-14-25-8-10-30-19/h2-7,9,13,15,19,25H,8,10-12,14,16H2,1H3
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n/an/a 160n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185174
PNG
(2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1n[nH]c2ccccc12
Show InChI InChI=1S/C19H20N6/c1-24-8-10-25(11-9-24)13-6-7-16-17(12-13)21-19(20-16)18-14-4-2-3-5-15(14)22-23-18/h2-7,12H,8-11H2,1H3,(H,20,21)(H,22,23)
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n/an/a 170n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50446307
PNG
(CHEMBL3109355)
Show SMILES COCCOc1ccn2c(cnc2c1)-c1ccc2cccc(OCCN)c2n1
Show InChI InChI=1S/C21H22N4O3/c1-26-11-12-27-16-7-9-25-18(14-23-20(25)13-16)17-6-5-15-3-2-4-19(21(15)24-17)28-10-8-22/h2-7,9,13-14H,8,10-12,22H2,1H3
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n/an/a 176n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PDGF-induced PDGFRbeta phosphorylation in mouse NIH3T3 cells incubated for 1 hr prior to PDGF induction measured after 15 mins by fluor...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50185184
PNG
(2-(6-(benzyloxy)-1H-indazol-3-yl)-5-(4-(piperidin-...)
Show SMILES C(Oc1ccc2c(n[nH]c2c1)-c1nc2ccc(cc2[nH]1)N1CCC(CC1)N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C31H34N6O/c1-3-7-22(8-4-1)21-38-25-10-11-26-28(20-25)34-35-30(26)31-32-27-12-9-24(19-29(27)33-31)37-17-13-23(14-18-37)36-15-5-2-6-16-36/h1,3-4,7-12,19-20,23H,2,5-6,13-18,21H2,(H,32,33)(H,34,35)
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n/an/a 180n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 16: 3595-9 (2006)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Mus musculus (mouse))
BDBM50202219
PNG
(5-hydroxybenzo[b]furan-2-yl-(5-hydroxy-1Hindol-2-y...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C17H11NO4/c19-11-1-3-13-9(5-11)7-14(18-13)17(21)16-8-10-6-12(20)2-4-15(10)22-16/h1-8,18-20H
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n/an/a 200n/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts


Bioorg Med Chem 15: 2187-97 (2007)

More data for this
Ligand-Target Pair
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