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Found 23 hits Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor (PDGFr)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290834
PNG
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Show SMILES COc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3
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n/an/a 130n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290847
PNG
(6,7-Dimethoxy-4-(3-methoxy-phenoxy)-quinoline | CH...)
Show SMILES COc1cccc(Oc2ccnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C18H17NO4/c1-20-12-5-4-6-13(9-12)23-16-7-8-19-15-11-18(22-3)17(21-2)10-14(15)16/h4-11H,1-3H3
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n/an/a 440n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290850
PNG
(3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenol | CHEMBL...)
Show SMILES COc1cc2nccc(Oc3cccc(O)c3)c2cc1OC
Show InChI InChI=1S/C17H15NO4/c1-20-16-9-13-14(10-17(16)21-2)18-7-6-15(13)22-12-5-3-4-11(19)8-12/h3-10,19H,1-2H3
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n/an/a 560n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290837
PNG
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinazolin...)
Show SMILES COc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C18H18N2O5/c1-21-14-6-5-11(7-15(14)22-2)25-18-12-8-16(23-3)17(24-4)9-13(12)19-10-20-18/h5-10H,1-4H3
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n/an/a 570n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290848
PNG
(6,7-Dimethoxy-4-(2-methoxy-phenoxy)-quinoline | CH...)
Show SMILES COc1ccccc1Oc1ccnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C18H17NO4/c1-20-15-6-4-5-7-16(15)23-14-8-9-19-13-11-18(22-3)17(21-2)10-12(13)14/h4-11H,1-3H3
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290844
PNG
(6,7-Dimethoxy-4-(3-nitro-phenoxy)-quinoline | CHEM...)
Show SMILES COc1cc2nccc(Oc3cccc(c3)[N+]([O-])=O)c2cc1OC
Show InChI InChI=1S/C17H14N2O5/c1-22-16-9-13-14(10-17(16)23-2)18-7-6-15(13)24-12-5-3-4-11(8-12)19(20)21/h3-10H,1-2H3
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n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290853
PNG
(6,7-Dimethoxy-4-phenoxy-quinoline | CHEMBL327534)
Show SMILES COc1cc2nccc(Oc3ccccc3)c2cc1OC
Show InChI InChI=1S/C17H15NO3/c1-19-16-10-13-14(11-17(16)20-2)18-9-8-15(13)21-12-6-4-3-5-7-12/h3-11H,1-2H3
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n/an/a 760n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290841
PNG
(4-(3-Fluoro-phenoxy)-6,7-dimethoxy-quinoline | CHE...)
Show SMILES COc1cc2nccc(Oc3cccc(F)c3)c2cc1OC
Show InChI InChI=1S/C17H14FNO3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,1-2H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290846
PNG
(3-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine | C...)
Show SMILES COc1cc2nccc(Oc3cccc(N)c3)c2cc1OC
Show InChI InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,18H2,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290842
PNG
(6,7-Dimethoxy-4-(4-methoxy-phenoxy)-quinoline | CH...)
Show SMILES COc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C18H17NO4/c1-20-12-4-6-13(7-5-12)23-16-8-9-19-15-11-18(22-3)17(21-2)10-14(15)16/h4-11H,1-3H3
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n/an/a 1.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290849
PNG
((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinolin-4-y...)
Show SMILES COc1ccc(Nc2ccnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C19H20N2O4/c1-22-16-6-5-12(9-17(16)23-2)21-14-7-8-20-15-11-19(25-4)18(24-3)10-13(14)15/h5-11H,1-4H3,(H,20,21)
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n/an/a 2.60E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290840
PNG
(4-(2,3-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Show SMILES COc1cc2nccc(Oc3cccc(OC)c3OC)c2cc1OC
Show InChI InChI=1S/C19H19NO5/c1-21-15-6-5-7-16(19(15)24-4)25-14-8-9-20-13-11-18(23-3)17(22-2)10-12(13)14/h5-11H,1-4H3
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n/an/a 4.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290835
PNG
((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Show SMILES COc1ccc(Nc2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C18H19N3O4/c1-22-14-6-5-11(7-15(14)23-2)21-18-12-8-16(24-3)17(25-4)9-13(12)19-10-20-18/h5-10H,1-4H3,(H,19,20,21)
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n/an/a 4.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290852
PNG
(4-(3,5-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Show SMILES COc1cc(OC)cc(Oc2ccnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C19H19NO5/c1-21-12-7-13(22-2)9-14(8-12)25-17-5-6-20-16-11-19(24-4)18(23-3)10-15(16)17/h5-11H,1-4H3
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n/an/a 5.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290845
PNG
(6,7-Dimethoxy-4-m-tolyloxy-quinoline | CHEMBL98839)
Show SMILES COc1cc2nccc(Oc3cccc(C)c3)c2cc1OC
Show InChI InChI=1S/C18H17NO3/c1-12-5-4-6-13(9-12)22-16-7-8-19-15-11-18(21-3)17(20-2)10-14(15)16/h4-11H,1-3H3
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n/an/a 6.90E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290843
PNG
(4-(3-Ethyl-phenoxy)-6,7-dimethoxy-quinoline | CHEM...)
Show SMILES CCc1cccc(Oc2ccnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C19H19NO3/c1-4-13-6-5-7-14(10-13)23-17-8-9-20-16-12-19(22-3)18(21-2)11-15(16)17/h5-12H,4H2,1-3H3
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n/an/a 8.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290839
PNG
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline | CHEM...)
Show SMILES COc1cc2nccc(Oc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C17H14BrNO3/c1-20-16-9-13-14(10-17(16)21-2)19-7-6-15(13)22-12-5-3-4-11(18)8-12/h3-10H,1-2H3
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n/an/a 8.40E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290851
PNG
(4-(3-Ethoxy-phenoxy)-6,7-dimethoxy-quinoline | CHE...)
Show SMILES CCOc1cccc(Oc2ccnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C19H19NO4/c1-4-23-13-6-5-7-14(10-13)24-17-8-9-20-16-12-19(22-3)18(21-2)11-15(16)17/h5-12H,4H2,1-3H3
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n/an/a 1.29E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290838
PNG
(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline | CH...)
Show SMILES COc1cc2ncnc(Oc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H13BrN2O3/c1-20-14-7-12-13(8-15(14)21-2)18-9-19-16(12)22-11-5-3-4-10(17)6-11/h3-9H,1-2H3
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n/an/a 1.48E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290836
PNG
((3-Bromo-phenyl)-(6,7-dimethoxy-quinolin-4-yl)-ami...)
Show SMILES COc1cc2nccc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C17H15BrN2O2/c1-21-16-9-13-14(20-12-5-3-4-11(18)8-12)6-7-19-15(13)10-17(16)22-2/h3-10H,1-2H3,(H,19,20)
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n/an/a 2.15E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM3032
PNG
(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
Show InChI InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 2.19E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM50290854
PNG
(4-(2,6-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Show SMILES COc1cc2nccc(Oc3c(OC)cccc3OC)c2cc1OC
Show InChI InChI=1S/C19H19NO5/c1-21-15-6-5-7-16(22-2)19(15)25-14-8-9-20-13-11-18(24-4)17(23-3)10-12(13)14/h5-11H,1-4H3
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n/an/a 6.93E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFr)


(Rattus norvegicus)
BDBM124970
PNG
(US8765747, 2)
Show SMILES Cc1nc(Nc2nc3ccc(nc3s2)-c2cccc(c2)C(=O)Nc2cccc(c2)C(F)(F)F)cc(n1)N1CCNCC1
Show InChI InChI=1S/C29H25F3N8OS/c1-17-34-24(16-25(35-17)40-12-10-33-11-13-40)39-28-38-23-9-8-22(37-27(23)42-28)18-4-2-5-19(14-18)26(41)36-21-7-3-6-20(15-21)29(30,31)32/h2-9,14-16,33H,10-13H2,1H3,(H,36,41)(H,34,35,38,39)
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US Patent
n/an/an/a 1.80n/an/an/an/an/a



Dana-Farber Cancer Institute, Inc.

US Patent


Assay Description
KINOMEscan (Ambit Biosciences, San Diego, Calif.), a high-throughput method for screening small molecular agents against a large panel of human kinas...


US Patent US8765747 (2014)

More data for this
Ligand-Target Pair