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Found 23 hits Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor (PDGFr)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
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n/an/a 42.4n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167952
PNG
(1-(4-(3-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1cccc(c1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-19-6-4-5-17(13-19)26-11-9-25(10-12-26)14-18(27)15-29-22-20-7-2-3-8-21(20)23-16-24-22/h2-8,13,16,18,27H,9-12,14-15H2,1H3
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n/an/a 54.4n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167953
PNG
(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccc(cc1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-19-8-6-17(7-9-19)26-12-10-25(11-13-26)14-18(27)15-29-22-20-4-2-3-5-21(20)23-16-24-22/h2-9,16,18,27H,10-15H2,1H3
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n/an/a 62.7n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167951
PNG
(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C22H26N4O3/c1-28-21-9-5-4-8-20(21)26-12-10-25(11-13-26)14-17(27)15-29-22-18-6-2-3-7-19(18)23-16-24-22/h2-9,16-17,27H,10-15H2,1H3
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n/an/a 69.2n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167956
PNG
(1-(4-(3,4-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C21H22Cl2N4O2/c22-18-6-5-15(11-19(18)23)27-9-7-26(8-10-27)12-16(28)13-29-21-17-3-1-2-4-20(17)24-14-25-21/h1-6,11,14,16,28H,7-10,12-13H2
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n/an/a 74.3n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167954
PNG
(1-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)-3-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1/C22H23F3N4O2/c23-22(24,25)16-4-3-5-17(12-16)29-10-8-28(9-11-29)13-18(30)14-31-21-19-6-1-2-7-20(19)26-15-27-21/h1-7,12,15,18,30H,8-11,13-14H2
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n/an/a 78.9n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167957
PNG
(1-(4-(2,4-Dimethylphenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES Cc1ccc(N2CCN(CC(O)COc3ncnc4ccccc34)CC2)c(C)c1
Show InChI InChI=1/C23H28N4O2/c1-17-7-8-22(18(2)13-17)27-11-9-26(10-12-27)14-19(28)15-29-23-20-5-3-4-6-21(20)24-16-25-23/h3-8,13,16,19,28H,9-12,14-15H2,1-2H3
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n/an/a 102n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167950
PNG
(1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2
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n/an/a 109n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167949
PNG
(1-(4-(4-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1/C21H23FN4O2/c22-16-5-7-17(8-6-16)26-11-9-25(10-12-26)13-18(27)14-28-21-19-3-1-2-4-20(19)23-15-24-21/h1-8,15,18,27H,9-14H2
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n/an/a 119n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167948
PNG
(1-(4-(2-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1F
Show InChI InChI=1/C21H23FN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
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n/an/a 162n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167945
PNG
(1-(4-Phenylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1/C21H24N4O2/c26-18(15-27-21-19-8-4-5-9-20(19)22-16-23-21)14-24-10-12-25(13-11-24)17-6-2-1-3-7-17/h1-9,16,18,26H,10-15H2
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n/an/a 178n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167955
PNG
(1-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1/C21H22Cl2N4O2/c22-17-5-3-7-19(20(17)23)27-10-8-26(9-11-27)12-15(28)13-29-21-16-4-1-2-6-18(16)24-14-25-21/h1-7,14-15,28H,8-13H2
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n/an/a 199n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167947
PNG
(1-(4-(3-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1/C21H23ClN4O2/c22-16-4-3-5-17(12-16)26-10-8-25(9-11-26)13-18(27)14-28-21-19-6-1-2-7-20(19)23-15-24-21/h1-7,12,15,18,27H,8-11,13-14H2
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n/an/a 209n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167946
PNG
(1-(4-(2-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1/C21H23ClN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
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Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167958
PNG
(1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2
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n/an/a 219n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167959
PNG
(1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES CN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C16H22N4O2/c1-19-6-8-20(9-7-19)10-13(21)11-22-16-14-4-2-3-5-15(14)17-12-18-16/h2-5,12-13,21H,6-11H2,1H3
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Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167961
PNG
(1-(Dimethylamino)-3-(quinazolin-4-yloxy)propan-2-o...)
Show SMILES CN(C)CC(O)COc1ncnc2ccccc12
Show InChI InChI=1/C13H17N3O2/c1-16(2)7-10(17)8-18-13-11-5-3-4-6-12(11)14-9-15-13/h3-6,9-10,17H,7-8H2,1-2H3
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Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167960
PNG
(1-(4-Ethylpiperazin-1-yl)-3-(quinazolin-4-yloxy)pr...)
Show SMILES CCN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1/C17H24N4O2/c1-2-20-7-9-21(10-8-20)11-14(22)12-23-17-15-5-3-4-6-16(15)18-13-19-17/h3-6,13-14,22H,2,7-12H2,1H3
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Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167965
PNG
(1-(2-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1nccn1CC(O)COc1ncnc2ccccc12
Show InChI InChI=1/C15H16N4O2/c1-11-16-6-7-19(11)8-12(20)9-21-15-13-4-2-3-5-14(13)17-10-18-15/h2-7,10,12,20H,8-9H2,1H3
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Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167966
PNG
(1-(4-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1cn(CC(O)COc2ncnc3ccccc23)cn1
Show InChI InChI=1/C15H16N4O2/c1-11-6-19(10-18-11)7-12(20)8-21-15-13-4-2-3-5-14(13)16-9-17-15/h2-6,9-10,12,20H,7-8H2,1H3
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n/an/a 269n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167963
PNG
(1-(Piperidin-1-yl)-3-(quinazolin-4-yloxy)propan-2-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCCCC1
Show InChI InChI=1/C16H21N3O2/c20-13(10-19-8-4-1-5-9-19)11-21-16-14-6-2-3-7-15(14)17-12-18-16/h2-3,6-7,12-13,20H,1,4-5,8-11H2
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n/an/a 283n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167964
PNG
(1-(1H-Imidazol-1-yl)-3-(quinazolin-4-yloxy)propan-...)
Show SMILES OC(COc1ncnc2ccccc12)Cn1ccnc1
Show InChI InChI=1/C14H14N4O2/c19-11(7-18-6-5-15-10-18)8-20-14-12-3-1-2-4-13(12)16-9-17-14/h1-6,9-11,19H,7-8H2
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n/an/a 292n/an/an/an/an/an/a



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor (PDGFR)


(Homo sapiens (Human))
BDBM167962
PNG
(1-Morpholino-3-(quinazolin-4-yloxy)propan-2-ol (3r...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCOCC1
Show InChI InChI=1/C15H19N3O3/c19-12(9-18-5-7-20-8-6-18)10-21-15-13-3-1-2-4-14(13)16-11-17-15/h1-4,11-12,19H,5-10H2
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Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Citation and Details
More data for this
Ligand-Target Pair