BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 20 hits Enz. Inhib. hit(s) with Target = 'Poliovirus type 1 polyprotein' AND taxid = 12081   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50193060
PNG
(3-cyclohexyl-2-(furan-3-yl)-1H-indole-6-carboxylic...)
Show SMILES OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)-c1ccoc1
Show InChI InChI=1S/C19H19NO3/c21-19(22)13-6-7-15-16(10-13)20-18(14-8-9-23-11-14)17(15)12-4-2-1-3-5-12/h6-12,20H,1-5H2,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.25E+5n/an/an/an/an/an/a



Boehringer Ingelheim

Curated by ChEMBL


Assay Description
Inhibition of poliovirus RNA dependent RNA polymerase


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50193054
PNG
(3-cyclohexyl-2-(furan-3-yl)-1-methyl-1H-indole-6-c...)
Show SMILES Cn1c(-c2ccoc2)c(C2CCCCC2)c2ccc(cc12)C(O)=O
Show InChI InChI=1S/C20H21NO3/c1-21-17-11-14(20(22)23)7-8-16(17)18(13-5-3-2-4-6-13)19(21)15-9-10-24-12-15/h7-13H,2-6H2,1H3,(H,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 1.25E+5n/an/an/an/an/an/a



Boehringer Ingelheim

Curated by ChEMBL


Assay Description
Inhibition of poliovirus RNA dependent RNA polymerase


Citation and Details
Checked by Author
More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137481
PNG
(1-Cyclohexyl-2-(1H-imidazol-2-yl)-1H-benzoimidazol...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ncc[nH]1
Show InChI InChI=1S/C17H18N4O2/c22-17(23)11-6-7-14-13(10-11)20-16(15-18-8-9-19-15)21(14)12-4-2-1-3-5-12/h6-10,12H,1-5H2,(H,18,19)(H,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137479
PNG
(1-Cyclohexyl-2-phenyl-1H-benzoimidazole-5-carboxyl...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccccc1
Show InChI InChI=1S/C20H20N2O2/c23-20(24)15-11-12-18-17(13-15)21-19(14-7-3-1-4-8-14)22(18)16-9-5-2-6-10-16/h1,3-4,7-8,11-13,16H,2,5-6,9-10H2,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a 2.50E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137488
PNG
(1-Cyclohexyl-2-furan-3-yl-1H-benzoimidazole-5-carb...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccoc1
Show InChI InChI=1S/C18H18N2O3/c21-18(22)12-6-7-16-15(10-12)19-17(13-8-9-23-11-13)20(16)14-4-2-1-3-5-14/h6-11,14H,1-5H2,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137490
PNG
(1-Cyclohexyl-2-thiophen-3-yl-1H-benzoimidazole-5-c...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccsc1
Show InChI InChI=1S/C18H18N2O2S/c21-18(22)12-6-7-16-15(10-12)19-17(13-8-9-23-11-13)20(16)14-4-2-1-3-5-14/h6-11,14H,1-5H2,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137467
PNG
(1-Cyclohexyl-2-thiophen-2-yl-1H-benzoimidazole-5-c...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1cccs1
Show InChI InChI=1S/C18H18N2O2S/c21-18(22)12-8-9-15-14(11-12)19-17(16-7-4-10-23-16)20(15)13-5-2-1-3-6-13/h4,7-11,13H,1-3,5-6H2,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137472
PNG
(1-Cyclohexyl-2-pyridin-3-yl-1H-benzoimidazole-5-ca...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1cccnc1
Show InChI InChI=1S/C19H19N3O2/c23-19(24)13-8-9-17-16(11-13)21-18(14-5-4-10-20-12-14)22(17)15-6-2-1-3-7-15/h4-5,8-12,15H,1-3,6-7H2,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>2.50E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137462
PNG
(1-Cyclohexyl-2-thiazol-2-yl-1H-benzoimidazole-5-ca...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1nccs1
Show InChI InChI=1S/C17H17N3O2S/c21-17(22)11-6-7-14-13(10-11)19-15(16-18-8-9-23-16)20(14)12-4-2-1-3-5-12/h6-10,12H,1-5H2,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137480
PNG
(1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-ca...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C19H19N3O2/c23-19(24)13-9-10-17-16(12-13)21-18(15-8-4-5-11-20-15)22(17)14-6-2-1-3-7-14/h4-5,8-12,14H,1-3,6-7H2,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137475
PNG
(1-Cyclohexyl-2-(1-methyl-1H-pyrrol-2-yl)-1H-benzoi...)
Show SMILES Cn1cccc1-c1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C19H21N3O2/c1-21-11-5-8-17(21)18-20-15-12-13(19(23)24)9-10-16(15)22(18)14-6-3-2-4-7-14/h5,8-12,14H,2-4,6-7H2,1H3,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137458
PNG
(1-Cyclohexyl-2-(1H-pyrrol-2-yl)-1H-benzoimidazole-...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccc[nH]1
Show InChI InChI=1S/C18H19N3O2/c22-18(23)12-8-9-16-15(11-12)20-17(14-7-4-10-19-14)21(16)13-5-2-1-3-6-13/h4,7-11,13,19H,1-3,5-6H2,(H,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137484
PNG
(1-Cyclohexyl-2-(2-methyl-propenyl)-1H-benzoimidazo...)
Show SMILES CC(C)=Cc1nc2cc(ccc2n1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C18H22N2O2/c1-12(2)10-17-19-15-11-13(18(21)22)8-9-16(15)20(17)14-6-4-3-5-7-14/h8-11,14H,3-7H2,1-2H3,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137464
PNG
(1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-ca...)
Show SMILES COc1ccc(CCNC(=O)c2ccc3n(C4CCCCC4)c(nc3c2)-c2ccccn2)cc1OC
Show InChI InChI=1S/C29H32N4O3/c1-35-26-14-11-20(18-27(26)36-2)15-17-31-29(34)21-12-13-25-24(19-21)32-28(23-10-6-7-16-30-23)33(25)22-8-4-3-5-9-22/h6-7,10-14,16,18-19,22H,3-5,8-9,15,17H2,1-2H3,(H,31,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137487
PNG
(1-Cyclopentyl-2-pyridin-2-yl-1H-benzoimidazole-5-c...)
Show SMILES OC(=O)c1ccc2n(C3CCCC3)c(nc2c1)-c1ccccn1
Show InChI InChI=1S/C18H17N3O2/c22-18(23)12-8-9-16-15(11-12)20-17(14-7-3-4-10-19-14)21(16)13-5-1-2-6-13/h3-4,7-11,13H,1-2,5-6H2,(H,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137473
PNG
(1-Cyclohexyl-2-pyridin-4-yl-1H-benzoimidazole-5-ca...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccncc1
Show InChI InChI=1S/C19H19N3O2/c23-19(24)14-6-7-17-16(12-14)21-18(13-8-10-20-11-9-13)22(17)15-4-2-1-3-5-15/h6-12,15H,1-5H2,(H,23,24)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137504
PNG
(1-Cyclohexyl-2-furan-2-yl-1H-benzoimidazole-5-carb...)
Show SMILES OC(=O)c1ccc2n(C3CCCCC3)c(nc2c1)-c1ccco1
Show InChI InChI=1S/C18H18N2O3/c21-18(22)12-8-9-15-14(11-12)19-17(16-7-4-10-23-16)20(15)13-5-2-1-3-6-13/h4,7-11,13H,1-3,5-6H2,(H,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137499
PNG
(1-(2-Methyl-cyclohexyl)-2-pyridin-2-yl-1H-benzoimi...)
Show SMILES CC1CCCCC1n1c(nc2cc(ccc12)C(O)=O)-c1ccccn1
Show InChI InChI=1S/C20H21N3O2/c1-13-6-2-3-8-17(13)23-18-10-9-14(20(24)25)12-16(18)22-19(23)15-7-4-5-11-21-15/h4-5,7,9-13,17H,2-3,6,8H2,1H3,(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50137468
PNG
(1-Cyclohexyl-2-pyridin-2-yl-1H-benzoimidazole-5-ca...)
Show SMILES COc1ccc(CNC(=O)c2ccc3n(C4CCCCC4)c(nc3c2)-c2ccccn2)cc1OC
Show InChI InChI=1S/C28H30N4O3/c1-34-25-14-11-19(16-26(25)35-2)18-30-28(33)20-12-13-24-23(17-20)31-27(22-10-6-7-15-29-22)32(24)21-8-4-3-5-9-21/h6-7,10-17,21H,3-5,8-9,18H2,1-2H3,(H,30,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against polio virus RNA polymerase


Bioorg Med Chem Lett 14: 119-24 (2003)

More data for this
Ligand-Target Pair
Poliovirus type 1 polyprotein


(Poliovirus type 1 (strain Mahoney))
BDBM50370764
PNG
(CHEMBL609725)
Show SMILES Nc1nc(=O)n(cc1[N+]([O-])=O)C1OC(COP(O)(=O)OP(O)(=O)O[P+](O)(O)[O-])C(O)C1O
Show InChI InChI=1S/C9H15N4O16P3/c10-7-3(13(17)18)1-12(9(16)11-7)8-6(15)5(14)4(27-8)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h1,4-6,8,14-15H,2H2,(H,22,23)(H,24,25)(H2,10,11,16)(H2,19,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/an/a 1.08E+3n/an/an/an/an/a



The Pennsylvania State University

Curated by ChEMBL


Assay Description
Binding affinity to poliovirus RNA dependent RNA polymerase


Citation and Details
More data for this
Ligand-Target Pair