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Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Poly(A)-specific ribonuclease (PARN)' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM92910
PNG
(Nucleoside, A6)
Show SMILES OCC1OC(C(O)C(F)C1O)n1ccc(NC(=O)c2ccccc2)nc1=O
Show InChI InChI=1S/C17H18FN3O6/c18-12-13(23)10(8-22)27-16(14(12)24)21-7-6-11(20-17(21)26)19-15(25)9-4-2-1-3-5-9/h1-7,10,12-14,16,22-24H,8H2,(H,19,20,25,26)
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2.10E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The enzymatic activity was determined by the methylene blue assay.


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM92909
PNG
(Nucleoside, A2)
Show SMILES OC1OC(C(O)C(F)C1O)n1cnc2c(NC(=O)c3ccccc3)ncnc12
Show InChI InChI=1S/C17H16FN5O5/c18-9-11(24)16(28-17(27)12(9)25)23-7-21-10-13(19-6-20-14(10)23)22-15(26)8-4-2-1-3-5-8/h1-7,9,11-12,16-17,24-25,27H,(H,19,20,22,26)
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5.10E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The enzymatic activity was determined by the methylene blue assay.


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM92911
PNG
(Nucleoside, C6)
Show SMILES Nc1ccn(C2OC(CO)C(O)C(F)C2O)c(=O)n1
Show InChI InChI=1S/C10H14FN3O5/c11-6-7(16)4(3-15)19-9(8(6)17)14-2-1-5(12)13-10(14)18/h1-2,4,6-9,15-17H,3H2,(H2,12,13,18)
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6.45E+5n/an/an/an/an/an/an/an/a



University of Thessaly



Assay Description
The enzymatic activity was determined by the methylene blue assay.


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM50119716
PNG
(CHEMBL3616525)
Show SMILES CN(C)CCCn1c2ncn(CCc3ccccc3)c2c(=O)n(O)c1=O
Show InChI InChI=1S/C18H23N5O3/c1-20(2)10-6-11-22-16-15(17(24)23(26)18(22)25)21(13-19-16)12-9-14-7-4-3-5-8-14/h3-5,7-8,13,26H,6,9-12H2,1-2H3
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n/an/a 2.39E+4n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of PARN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM50119651
PNG
(CHEMBL3616505)
Show SMILES On1c(=O)[nH]c2ncn(Cc3ccccc3)c2c1=O
Show InChI InChI=1S/C12H10N4O3/c17-11-9-10(14-12(18)16(11)19)13-7-15(9)6-8-4-2-1-3-5-8/h1-5,7,19H,6H2,(H,14,18)
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n/an/a 8.41E+4n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of PARN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM50119654
PNG
(CHEMBL3616507)
Show SMILES On1c(=O)[nH]c2ncn(Cc3ccccn3)c2c1=O
Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-3-1-2-4-12-7/h1-4,6,19H,5H2,(H,14,18)
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n/an/a 1.19E+5n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of PARN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM50119655
PNG
(CHEMBL3616508)
Show SMILES On1c(=O)[nH]c2ncn(Cc3cccnc3)c2c1=O
Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-2-1-3-12-4-7/h1-4,6,19H,5H2,(H,14,18)
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n/an/a 1.25E+5n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of PARN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Poly(A)-specific ribonuclease (PARN)


(Homo sapiens (Human))
BDBM50119656
PNG
(CHEMBL3616509)
Show SMILES On1c(=O)[nH]c2ncn(Cc3ccncc3)c2c1=O
Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-1-3-12-4-2-7/h1-4,6,19H,5H2,(H,14,18)
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n/an/a 2.45E+5n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of PARN (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair